|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 201 to 300 out of 339 for Vav2

0.037s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Publication
First Author: Acton SE
Year: 2012
Journal: Immunity
Title: Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2.
Volume: 37
Issue: 2
Pages: 276-89
Publication
First Author: Sauzeau V
Year: 2011
Journal: J Biol Chem
Title: Transcriptional factor aryl hydrocarbon receptor (Ahr) controls cardiovascular and respiratory functions by regulating the expression of the Vav3 proto-oncogene.
Volume: 286
Issue: 4
Pages: 2896-909
Publication
First Author: Liu JY
Year: 2009
Journal: J Cell Sci
Title: Vav proteins are necessary for correct differentiation of mouse cecal and colonic enterocytes.
Volume: 122
Issue: Pt 3
Pages: 324-34
Publication
First Author: Chang KH
Year: 2012
Journal: Blood
Title: Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival.
Volume: 120
Issue: 4
Pages: 800-11
Publication
First Author: Stephenson LM
Year: 2006
Journal: J Immunol
Title: Vav proteins regulate the plasma cell program and secretory Ig production.
Volume: 177
Issue: 12
Pages: 8620-5
Publication
First Author: Bhavsar PJ
Year: 2009
Journal: Exp Cell Res
Title: Vav GEFs regulate macrophage morphology and adhesion-induced Rac and Rho activation.
Volume: 315
Issue: 19
Pages: 3345-58
Publication
First Author: Graham DB
Year: 2007
Journal: J Clin Invest
Title: Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice.
Volume: 117
Issue: 11
Pages: 3445-52
Publication
First Author: Mattila PK
Year: 2013
Journal: Immunity
Title: The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling.
Volume: 38
Issue: 3
Pages: 461-74
Publication
First Author: Roth S
Year: 2016
Journal: Cell Rep
Title: Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity.
Volume: 17
Issue: 10
Pages: 2572-2583
Publication
First Author: Gmyrek GB
Year: 2013
Journal: PLoS One
Title: Loss of DAP12 and FcRγ drives exaggerated IL-12 production and CD8(+) T cell response by CCR2(+) Mo-DCs.
Volume: 8
Issue: 10
Pages: e76145
Publication
First Author: Graham DB
Year: 2007
Journal: J Exp Med
Title: An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells.
Volume: 204
Issue: 12
Pages: 2889-97
Publication
First Author: Arana E
Year: 2008
Journal: Immunity
Title: Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation.
Volume: 28
Issue: 1
Pages: 88-99
Publication
First Author: Kant S
Year: 2011
Journal: Genes Dev
Title: TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway.
Volume: 25
Issue: 19
Pages: 2069-78
Publication
First Author: Dumont C
Year: 2009
Journal: Blood
Title: Rac GTPases play critical roles in early T-cell development.
Volume: 113
Issue: 17
Pages: 3990-8
Publication
First Author: Janas ML
Year: 2011
Journal: J Immunol
Title: Interaction of Ras with p110γ is required for thymic β-selection in the mouse.
Volume: 187
Issue: 9
Pages: 4667-75
Publication
First Author: Vigorito E
Year: 2005
Journal: Blood
Title: Vav proteins regulate peripheral B-cell survival.
Volume: 106
Issue: 7
Pages: 2391-8
Publication
First Author: Damoulakis G
Year: 2014
Journal: J Cell Sci
Title: P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils.
Volume: 127
Issue: Pt 11
Pages: 2589-600
Publication
First Author: Rahaman SO
Year: 2011
Journal: J Biol Chem
Title: Vav family Rho guanine nucleotide exchange factors regulate CD36-mediated macrophage foam cell formation.
Volume: 286
Issue: 9
Pages: 7010-7
Publication
First Author: Hall AB
Year: 2006
Journal: Immunity
Title: Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis.
Volume: 24
Issue: 3
Pages: 305-16
Publication
First Author: Henderson RB
Year: 2010
Journal: J Exp Med
Title: A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival.
Volume: 207
Issue: 4
Pages: 837-53
Publication
First Author: Martin H
Year: 2013
Journal: J Clin Invest
Title: Pak and Rac GTPases promote oncogenic KIT-induced neoplasms.
Volume: 123
Issue: 10
Pages: 4449-63
Publication
First Author: Pan D
Year: 2015
Journal: Blood
Title: P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation.
Volume: 125
Issue: 7
Pages: 1146-58
Publication
First Author: Lawson CD
Year: 2011
Journal: J Immunol
Title: P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses.
Volume: 186
Issue: 3
Pages: 1467-76
Publication
First Author: Kant S
Year: 2017
Journal: Cell Rep
Title: A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress.
Volume: 20
Issue: 12
Pages: 2775-2783
Publication
First Author: Nordstrand LM
Year: 2010
Journal: PLoS One
Title: Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects.
Volume: 5
Issue: 11
Pages: e13827
Publication
First Author: Dong Z
Year: 2012
Journal: Immunity
Title: The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells.
Volume: 36
Issue: 6
Pages: 974-85
Publication
First Author: Johansson MH
Year: 2006
Journal: J Immunol
Title: Mapping of quantitative trait loci determining NK cell-mediated resistance to MHC class I-deficient bone marrow grafts in perforin-deficient mice.
Volume: 177
Issue: 11
Pages: 7923-9
Publication
First Author: Glassmann A
Year: 2009
Journal: Neuroscience
Title: Basic molecular fingerprinting of immature cerebellar cortical inhibitory interneurons and their precursors.
Volume: 159
Issue: 1
Pages: 69-82
Publication
First Author: Spies T
Year: 1991
Journal: Nature
Title: Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter.
Volume: 351
Issue: 6324
Pages: 323-4
Publication
First Author: Boyle KB
Year: 2011
Journal: J Immunol
Title: Class IA phosphoinositide 3-kinase β and δ regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae.
Volume: 186
Issue: 5
Pages: 2978-89
Publication
First Author: Quesnel-Vallières M
Year: 2016
Journal: Mol Cell
Title: Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders.
Volume: 64
Issue: 6
Pages: 1023-1034
Publication
First Author: Quesnel-Vallières M
Year: 2015
Journal: Genes Dev
Title: Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.
Volume: 29
Issue: 7
Pages: 746-59
Publication
First Author: Lee CG
Year: 1999
Journal: Mamm Genome
Title: Genetic mapping of eight SH3 domain genes on seven mouse chromosomes.
Volume: 10
Issue: 4
Pages: 402-4
Publication
First Author: Pilz A
Year: 1995
Journal: Genomics
Title: Comparative mapping of 50 human chromosome 9 loci in the laboratory mouse.
Volume: 25
Issue: 1
Pages: 139-49
Publication
First Author: Quina LA
Year: 2009
Journal: J Neurosci
Title: Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development.
Volume: 29
Issue: 45
Pages: 14309-22
Publication
First Author: Miller JA
Year: 2013
Journal: Development
Title: Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.
Volume: 140
Issue: 22
Pages: 4633-44
Publication      
First Author: Freeman TC
Year: 1998
Journal: MGI Direct Data Submission
Title: Expression Mapping of Mouse Genes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
Publication
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication
First Author: Moon MS
Year: 2010
Journal: Mol Cell Neurosci
Title: Balanced Vav2 GEF activity regulates neurite outgrowth and branching in vitro and in vivo.
Volume: 44
Issue: 2
Pages: 118-28
Protein
Organism: Mus musculus/domesticus
Length: 868  
Fragment?: false
UniProt Feature
Begin: 1
Description: Guanine nucleotide exchange factor VAV2
Type: chain
End: 868
Protein Domain
Type: Domain
Description: VAV2 is widely expressed and functions as a guanine nucleotide exchange factor (GEF) for RhoA, RhoB and RhoG and also activates Rac1 and Cdc42 []. It is implicated in many cellular and physiological functions including blood pressure control, eye development, neurite outgrowth and branching, EGFR endocytosis and degradation, and cell cluster morphology, among others [, , , , ]. It has been reported to associate with Nek3. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The SH3 domain of VAV is involved in the localization of proteins to specific sites within the cell, by interacting with proline-rich sequences within target proteins [, , ].This entry represents the second SH3 domain of VAV2.
Protein Domain
Type: Domain
Description: VAV2 is widely expressed and functions as a guanine nucleotide exchange factor (GEF) for RhoA, RhoB and RhoG and also activates Rac1 and Cdc42 []. It is implicated in many cellular and physiological functions including blood pressure control, eye development, neurite outgrowth and branching, EGFR endocytosis and degradation, and cell cluster morphology, among others [, , , , ]. It has been reported to associate with Nek3. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The SH3 domain of VAV is involved in the localization of proteins to specific sites within the cell, by interacting with proline-rich sequences within target proteins [, , ].This entry represents the first SH3 domain of VAV2.
Publication  
First Author: Krause-Gruszczynska M
Year: 2011
Journal: Cell Commun Signal
Title: The signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor Vav2.
Volume: 9
Pages: 32
Publication
First Author: Holthusen K
Year: 2009
Journal: Am J Ther
Title: Guanine exchange factor Vav2: a novel potential target for the development of drugs effective in the prevention of papillomavirus infection and disease.
Volume: 16
Issue: 6
Pages: 496-507
Publication
First Author: Arora PD
Year: 2008
Journal: Am J Physiol Cell Physiol
Title: Collagen phagocytosis is regulated by the guanine nucleotide exchange factor Vav2.
Volume: 295
Issue: 1
Pages: C130-7
Publication
First Author: Heo J
Year: 2005
Journal: Biochemistry
Title: Recognition and activation of Rho GTPases by Vav1 and Vav2 guanine nucleotide exchange factors.
Volume: 44
Issue: 17
Pages: 6573-85
Publication
First Author: Romero F
Year: 1996
Journal: Cell Signal
Title: Structure and function of vav.
Volume: 8
Issue: 8
Pages: 545-53
Publication
First Author: Tybulewicz VL
Year: 2005
Journal: Curr Opin Immunol
Title: Vav-family proteins in T-cell signalling.
Volume: 17
Issue: 3
Pages: 267-74
Publication
First Author: Hornstein I
Year: 2004
Journal: Cell Signal
Title: Vav proteins, masters of the world of cytoskeleton organization.
Volume: 16
Issue: 1
Pages: 1-11
Allele
Name: vav 2 oncogene; targeted mutation 1.1, Xose R Bustelo
Allele Type: Targeted
Attribute String: Constitutively active, Inserted expressed sequence
Allele
Name: vav 2 oncogene; targeted mutation 1, Xose R Bustelo
Allele Type: Targeted
Attribute String: Conditional ready, Constitutively active, Inserted expressed sequence
Publication
First Author: Liu S
Year: 2016
Journal: FEBS Lett
Title: Structural basis for a novel interaction between TXNIP and Vav2.
Volume: 590
Issue: 6
Pages: 857-65
Protein Domain
Type: Domain
Description: This entry represents the SH2 domain of VAV2, which is a member of the VAV family. The SH2 domain of VAV2 has been shown to interact with PPxY motifs of TXNIP (thioredoxin-interacting protein) []. The VAV protein family members are multiple domain proteins, including Vav from flies and VAV1/2/3 from mammals. VAV1 predominates in hematopoietic cells, whereas VAV2 and VAV3 are more broadly expressed. They have a calponin homology (CH) domain, an acidic domain (AC), a Dbl homology (DH) domain, a pleckstrin homology (PH) domain, a cysteine-rich (CR) domain containing a zinc finger, and a complex region with SH2 and SH3 domains. Therefore they may participate in the activity of several pathways [, ]. They are signal transducer proteins that couple tyrosine kinase signals with the activation of the Rho/Rac GTPases, [, , ].
Publication
First Author: Hawkins MB
Year: 2021
Journal: Cell
Title: Latent developmental potential to form limb-like skeletal structures in zebrafish.
Volume: 184
Issue: 4
Pages: 899-911.e13
Publication
First Author: Liu Y
Year: 2013
Journal: J Cell Biol
Title: A novel pathway spatiotemporally activates Rac1 and redox signaling in response to fluid shear stress.
Volume: 201
Issue: 6
Pages: 863-73
Publication  
First Author: Erasmus JC
Year: 2016
Journal: Nat Commun
Title: Defining functional interactions during biogenesis of epithelial junctions.
Volume: 7
Pages: 13542
Publication
First Author: Faccio R
Year: 2005
Journal: Nat Med
Title: Vav3 regulates osteoclast function and bone mass.
Volume: 11
Issue: 3
Pages: 284-90
Publication
First Author: Ulc A
Year: 2017
Journal: Biol Chem
Title: Involvement of the guanine nucleotide exchange factor Vav3 in central nervous system development and plasticity.
Volume: 398
Issue: 5-6
Pages: 663-675
Protein Domain
Type: Domain
Description: This entry represents the SH2 domain of VAV3, which belongs to the VAV family. VAV3 is involved in the regulation of osteoclast function []and in central nervous system development and plasticity [].The VAV protein family members are multiple domain proteins, including Vav from flies and VAV1/2/3 from mammals. VAV1 predominates in hematopoietic cells, whereas VAV2 and VAV3 are more broadly expressed. They have a calponin homology (CH) domain, an acidic domain (AC), a Dbl homology (DH) domain, a pleckstrin homology (PH) domain, a cysteine-rich (CR) domain containing a zinc finger, and a complex region with SH2 and SH3 domains. Therefore they may participate in the activity of several pathways [, ]. They are signal transducer proteins that couple tyrosine kinase signals with the activation of the Rho/Rac GTPases, [, , ].
Publication
First Author: Trenkle T
Year: 2000
Journal: Gene
Title: Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors.
Volume: 245
Issue: 1
Pages: 139-49
Publication
First Author: Dekel I
Year: 2000
Journal: FEBS Lett
Title: Identification of the Drosophila melanogaster homologue of the mammalian signal transducer protein, Vav.
Volume: 472
Issue: 1
Pages: 99-104
Publication
First Author: Fernández-Espartero CH
Year: 2013
Journal: J Cell Sci
Title: GTP exchange factor Vav regulates guided cell migration by coupling guidance receptor signalling to local Rac activation.
Volume: 126
Issue: Pt 10
Pages: 2285-93
Publication
First Author: Swat W
Year: 2005
Journal: Immunol Res
Title: The Vav family: at the crossroads of signaling pathways.
Volume: 32
Issue: 1-3
Pages: 259-65
Publication
First Author: Fang WB
Year: 2008
Journal: J Biol Chem
Title: Identification and functional analysis of phosphorylated tyrosine residues within EphA2 receptor tyrosine kinase.
Volume: 283
Issue: 23
Pages: 16017-26
Publication
First Author: Angibaud J
Year: 2011
Journal: J Neurochem
Title: The immune molecule CD3zeta and its downstream effectors ZAP-70/Syk mediate ephrin signaling in neurons to regulate early neuritogenesis.
Volume: 119
Issue: 4
Pages: 708-22
Publication
First Author: Takahashi M
Year: 2008
Journal: Genes Cells
Title: Sequential activation of Rap1 and Rac1 small G proteins by PDGF locally at leading edges of NIH3T3 cells.
Volume: 13
Issue: 6
Pages: 549-69
Publication
First Author: Donnelly SK
Year: 2017
Journal: J Cell Biol
Title: Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation.
Volume: 216
Issue: 12
Pages: 4331-4349
Publication
First Author: Huang R
Year: 2019
Journal: J Lipid Res
Title: The three members of the Vav family proteins form complexes that concur to foam cell formation and atherosclerosis.
Volume: 60
Issue: 12
Pages: 2006-2019