PHF12, also known as Pf1, is a PHD zinc finger protein that binds TLE (transducin-like enhancer) in an mSin3A-independent manner and recruits functional TLE complexes to repress transcription [].
This domain found in PHF12 (PHD finger protein 12, also known as Pf1) binds to the MRG domain of mortality factor 4-like protein 1 (MORF4L1, also known as MRG15) []. In mammals, the corepressor Sin3B, the histone deacetylase HDAC1, MRG15 and Pf1 form a complex that plays important roles in regulation of transcription [].
This superfamily represents a domain found in PHF12 (PHD finger protein 12, also known as Pf1) binds to the MRG domain of mortality factor 4-like protein 1 (MORF4L1, also known as MRG15) []. In mammals, the corepressor Sin3B, the histone deacetylase HDAC1, MRG15 and Pf1 form a complex that plays important roles in regulation of transcription [].
