Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Tsuboi M |
Year: |
2010 |
Journal: |
Int J Oncol |
Title: |
Secreted form of EphA7 in lung cancer. |
Volume: |
36 |
Issue: |
3 |
Pages: |
635-40 |
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•
•
•
•
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Publication |
First Author: |
Guan M |
Year: |
2009 |
Journal: |
Int J Cancer |
Title: |
Aberrant methylation of EphA7 in human prostate cancer and its relation to clinicopathologic features. |
Volume: |
124 |
Issue: |
1 |
Pages: |
88-94 |
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•
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Publication |
First Author: |
Nakanishi H |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
ALL1 fusion proteins induce deregulation of EphA7 and ERK phosphorylation in human acute leukemias. |
Volume: |
104 |
Issue: |
36 |
Pages: |
14442-7 |
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Allele |
Name: |
Eph receptor A7; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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GXD Expression |
Probe: |
MGI:1336944 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-06-21 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1629713 |
Pattern: |
Uniform |
Stage: |
TS13 |
Assay Id: |
MGI:1338287 |
Age: |
embryonic day 8.5 |
Image: |
6. H |
Note: |
Specimen was double hydridized with Egr2 and Epha7 probes and expression was inferred from previous specimens. |
Specimen Label: |
6. H |
Detected: |
true |
Specimen Num: |
2 |
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•
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•
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GXD Expression |
Probe: |
MGI:1336944 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-06-21 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1630513 |
Pattern: |
Uniform |
Stage: |
TS13 |
Assay Id: |
MGI:1338287 |
Age: |
embryonic day 8.5 |
Image: |
6. H |
Note: |
Specimen was double hydridized with Egr2 and Epha7 probes and expression was inferred from previous specimens. |
Specimen Label: |
6. H |
Detected: |
true |
Specimen Num: |
2 |
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Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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GXD Expression |
Probe: |
MGI:4453649 |
Assay Type: |
RNA in situ |
Annotation Date: |
2015-11-12 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754022 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5695630 |
Age: |
embryonic day 14.5 |
Image: |
1F/I/J |
Note: |
Expression was detected in a lateral-medial band within the dorsal thalamus. Expressing cells were largely distinct from cells expressing Efna5. Co-localization with Epha7 was noted in discrete portions of the positive expression domain. |
Specimen Label: |
1F/I/J |
Detected: |
true |
Specimen Num: |
2 |
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Allele |
Name: |
transgene insertion FX17, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
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Strain |
Attribute String: |
mutant stock, transgenic |
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Publication |
First Author: |
Miller K |
Year: |
2006 |
Journal: |
J Comp Neurol |
Title: |
EphA7-ephrin-A5 signaling in mouse somatosensory cortex: developmental restriction of molecular domains and postnatal maintenance of functional compartments. |
Volume: |
496 |
Issue: |
5 |
Pages: |
627-42 |
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents the ligand-binding domain found in ephrin type-A receptor 7 (EphA7). EphA7 has been implicated in various cancers, including lung, prostate, as well as leukemia [, , ]. EphA7 has also been suggested to play a role in the development and maintenance of cortical domains within the cerebral cortex [].Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands [, ]. Ephrin receptors (EphRs) comprise the largest subfamily of receptor tyrosine kinases (RTKs). EphRs contain a ligand binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyrosine kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling) []. |
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Publication |
First Author: |
Mansour MR |
Year: |
2011 |
Journal: |
Cancer Cell |
Title: |
Discovery of a secreted tumor suppressor provides a promising therapeutic strategy for follicular lymphoma. |
Volume: |
20 |
Issue: |
5 |
Pages: |
559-61 |
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Publication |
First Author: |
Yan Y |
Year: |
2022 |
Journal: |
Neuron |
Title: |
ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder. |
Volume: |
110 |
Issue: |
7 |
Pages: |
1156-1172.e9 |
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Publication |
First Author: |
Park E |
Year: |
2013 |
Journal: |
Cell Death Differ |
Title: |
EphA/ephrin-A signaling is critically involved in region-specific apoptosis during early brain development. |
Volume: |
20 |
Issue: |
1 |
Pages: |
169-80 |
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Publication |
First Author: |
Wurzman R |
Year: |
2015 |
Journal: |
Behav Brain Res |
Title: |
Repetitive grooming and sensorimotor abnormalities in an ephrin-A knockout model for Autism Spectrum Disorders. |
Volume: |
278 |
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Pages: |
115-28 |
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Publication |
First Author: |
Katoh M |
Year: |
2006 |
Journal: |
Int J Oncol |
Title: |
Comparative integromics on Eph family. |
Volume: |
28 |
Issue: |
5 |
Pages: |
1243-7 |
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Publication |
First Author: |
López-Nieva P |
Year: |
2012 |
Journal: |
Carcinogenesis |
Title: |
EPHA7, a new target gene for 6q deletion in T-cell lymphoblastic lymphomas. |
Volume: |
33 |
Issue: |
2 |
Pages: |
452-8 |
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Publication |
First Author: |
Herath NI |
Year: |
2012 |
Journal: |
Eur J Cancer |
Title: |
Complex expression patterns of Eph receptor tyrosine kinases and their ephrin ligands in colorectal carcinogenesis. |
Volume: |
48 |
Issue: |
5 |
Pages: |
753-62 |
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Publication |
First Author: |
Iguchi T |
Year: |
2021 |
Journal: |
J Neurosci |
Title: |
Mutually Repulsive EphA7-EfnA5 Organize Region-to-Region Corticopontine Projection by Inhibiting Collateral Extension. |
Volume: |
41 |
Issue: |
22 |
Pages: |
4795-4808 |
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Publication |
First Author: |
Glendining KA |
Year: |
2017 |
Journal: |
BMC Neurosci |
Title: |
Downstream mediators of Ten-m3 signalling in the developing visual pathway. |
Volume: |
18 |
Issue: |
1 |
Pages: |
78 |
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Publication |
First Author: |
Lackmann M |
Year: |
2008 |
Journal: |
Sci Signal |
Title: |
Eph, a protein family coming of age: more confusion, insight, or complexity? |
Volume: |
1 |
Issue: |
15 |
Pages: |
re2 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
610
|
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
451
|
Fragment?: |
false |
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•
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Publication |
First Author: |
Himanen JP |
Year: |
2003 |
Journal: |
Trends Neurosci |
Title: |
Eph signaling: a structural view. |
Volume: |
26 |
Issue: |
1 |
Pages: |
46-51 |
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•
•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
998
|
Fragment?: |
false |
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•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
994
|
Fragment?: |
false |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
994
|
Fragment?: |
false |
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•
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Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
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