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Search results 301 to 373 out of 373 for Jak3

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Type Details Score
Protein
A0A0R4J0R7
Organism: Mus musculus/domesticus
Length: 1100  
Fragment?: false
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Publication
11340172 | J:69504
First Author: Yamada M
Year: 2001
Journal: Mol Cell Biol
Title: Loss of hippocampal CA3 pyramidal neurons in mice lacking STAM1.
Volume: 21
Issue: 11
Pages: 3807-19
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Allele
Jak3<m8Btlr> | MGI:6305331
Name: Janus kinase 3; mutation 8, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Allele
Jak3<M7Btlr> | MGI:6284812
Name: Janus kinase 3; mutation 7, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Strain
MGI:6284813 | C57BL/6J-Jak3<M7Btlr>
Attribute String: chemically induced mutation, mutant strain, coisogenic
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Allele
Jak3<M5Btlr> | MGI:6284802
Name: Janus kinase 3; mutation 5, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Strain
MGI:6284803 | C57BL/6J-Jak3<M5Btlr>
Attribute String: chemically induced mutation, mutant strain, coisogenic
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Allele
Jak3<m6Btlr> | MGI:6284807
Name: Janus kinase 3; mutation 6, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Strain
MGI:6284808 | C57BL/6J-Jak3<m6Btlr>
Attribute String: mutant strain, chemically induced mutation, coisogenic
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Allele
Jak3<m4Btlr> | MGI:6284798
Name: Janus kinase 3; mutation 4, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Strain
MGI:6284799 | C57BL/6J-Jak3<m4Btlr>
Attribute String: mutant strain, chemically induced mutation, coisogenic
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Genotype
Genotype
Symbol: Jak3/Jak3
Background: C57BL/6J-Jak3
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Jak3/Jak3
Background: C57BL/6J-Jak3
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Jak3/Jak3
Background: C57BL/6J-Jak3
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Jak3/Jak3
Background: C57BL/6J-Jak3
Zygosity: hm
Has Mutant Allele: true
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Publication
19275641 | -
First Author: Sharma PS
Year: 2009
Journal: Curr Pharm Des
Title: Receptor tyrosine kinase inhibitors as potent weapons in war against cancers.
Volume: 15
Issue: 7
Pages: 758-76
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Publication
16700535 | -
First Author: Li E
Year: 2006
Journal: Biochemistry
Title: Role of receptor tyrosine kinase transmembrane domains in cell signaling and human pathologies.
Volume: 45
Issue: 20
Pages: 6241-51
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Publication
15845350 | -
First Author: Roskoski R Jr
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Src kinase regulation by phosphorylation and dephosphorylation.
Volume: 331
Issue: 1
Pages: 1-14
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Strain
MGI:6305340 | C57BL/6J-Jak3<m8Btlr>
Attribute String: mutant strain, coisogenic, chemically induced mutation
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Genotype
Genotype
Symbol: Jak3/Jak3 Trdc/Trdc
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Jak3/Jak3 Tg(Lck-Jak3)2Ljb/?
Background: involves: 129S4/SvJae * C3H * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Jak3/Jak3 Tg(Lck-Jak3)1Ljb/?
Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/10
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Jak3/Jak3 Tg(Lck-Jak3)2Ljb/?
Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/10
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Jak3/Jak3
Background: C57BL/6J-Jak3
Zygosity: hm
Has Mutant Allele: true
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Publication
12446783 | J:80617
First Author: Yamada M
Year: 2002
Journal: Mol Cell Biol
Title: Signal-transducing adaptor molecules STAM1 and STAM2 are required for T-cell development and survival.
Volume: 22
Issue: 24
Pages: 8648-58
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Publication
21187078 | -
First Author: Lim J
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Solution structure of UIM and interaction of tandem ubiquitin binding domains in STAM1 with ubiquitin.
Volume: 405
Issue: 1
Pages: 24-30
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Publication
26101075 | J:226940
 
First Author: Kapuralin K
Year: 2015
Journal: Mol Cell Neurosci
Title: STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons.
Volume: 67
Pages: 104-15
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Protein Domain
IPR035657 | STAM1_SH3
Type: Domain
Description: This entry represents the SH3 domain of STAM1 (signal transducing adapter molecule 1). STAM1 is part of the endosomal sorting complex required for transport (ESCRT-0) and is involved in sorting ubiquitinated cargo proteins from the endosome []. It may also be involved in the regulation of IL2 and GM-CSF mediated signaling, and has been implicated in neural cell survival [, ]. STAMs were discovered as proteins that are highly phosphorylated following cytokine and growth factor stimulation []. They function in cytokine signaling and surface receptor degradation, as well as regulate Golgi morphology. They associate with many proteins including Jak2 and Jak3 tyrosine kinases [], Hrs, AMSH, and UBPY. STAM adaptor proteins contain VHS (Vps27, Hrs, STAM homology), ubiquitin interacting (UIM), and SH3 domains [].
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Protein Domain
IPR035675 | STAM2_SH3
Type: Domain
Description: This entry represents the SH3 domain of STAM2 (signal transducing adapter molecule 2). STAM2, a subunit of the ESCRT-0 complex, is an endosomal protein acting as a regulator of receptor signaling and trafficking. It contains an N-terminal VHS domain (Vps-27/Hrs/Stam), UIM (ubiquitin-interacting motif), SH3 (Src homology 3), CC ("coiled coil"), SSM (STAM-specific motif) and C-terminal ITAM (immunoreceptor tyrosine-based activation motif) domain. It may play a regulatory role in the endosomal sorting of ubiquitinated membrane proteins []. STAMs were discovered as proteins that are highly phosphorylated following cytokine and growth factor stimulation []. They function in cytokine signaling and surface receptor degradation, as well as regulate Golgi morphology. They associate with many proteins including Jak2 and Jak3 tyrosine kinases [], Hrs, AMSH, and UBPY. STAM adaptor proteins contain VHS (Vps27, Hrs, STAM homology), ubiquitin interacting (UIM), and SH3 domains [].
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Publication
9407053 | J:44869
First Author: Asao H
Year: 1997
Journal: J Biol Chem
Title: Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth.
Volume: 272
Issue: 52
Pages: 32785-91
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Publication
11728436 | -
First Author: Lohi O
Year: 2001
Journal: FEBS Lett
Title: STAM/EAST/Hbp adapter proteins--integrators of signalling pathways.
Volume: 508
Issue: 3
Pages: 287-90
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Publication
10899310 | -
First Author: Endo K
Year: 2000
Journal: FEBS Lett
Title: STAM2, a new member of the STAM family, binding to the Janus kinases.
Volume: 477
Issue: 1-2
Pages: 55-61
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Publication
3291115 | J:31015
First Author: Hanks SK
Year: 1988
Journal: Science
Title: The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
Volume: 241
Issue: 4861
Pages: 42-52
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Publication
12368087 | -
First Author: Manning G
Year: 2002
Journal: Trends Biochem Sci
Title: Evolution of protein kinase signaling from yeast to man.
Volume: 27
Issue: 10
Pages: 514-20
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Publication
12471243 | -
First Author: Manning G
Year: 2002
Journal: Science
Title: The protein kinase complement of the human genome.
Volume: 298
Issue: 5600
Pages: 1912-34
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Publication
15078142 | -
First Author: Stout TJ
Year: 2004
Journal: Curr Pharm Des
Title: High-throughput structural biology in drug discovery: protein kinases.
Volume: 10
Issue: 10
Pages: 1069-82
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Publication
15320712 | -
First Author: Li B
Year: 2004
Journal: Comb Chem High Throughput Screen
Title: Creating chemical diversity to target protein kinases.
Volume: 7
Issue: 5
Pages: 453-72
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Publication
9202126 | J:43733
First Author: Endo TA
Year: 1997
Journal: Nature
Title: A new protein containing an SH2 domain that inhibits JAK kinases.
Volume: 387
Issue: 6636
Pages: 921-4
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Publication
25029551 | J:259156
First Author: Yi Z
Year: 2014
Journal: Nat Immunol
Title: The adaptor TRAF3 restrains the lineage determination of thymic regulatory T cells by modulating signaling via the receptor for IL-2.
Volume: 15
Issue: 9
Pages: 866-74
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Publication
23263556 | J:192612
First Author: Patra AK
Year: 2013
Journal: Nat Immunol
Title: An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development.
Volume: 14
Issue: 2
Pages: 127-35
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Publication
10502458 | J:156077
First Author: Hellgren G
Year: 1999
Journal: Growth Horm IGF Res
Title: The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver.
Volume: 9
Issue: 3
Pages: 212-8
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Publication
8999817 | J:38457
First Author: Grunewald SM
Year: 1997
Journal: J Biol Chem
Title: A murine interleukin-4 antagonistic mutant protein completely inhibits interleukin-4-induced cell proliferation, differentiation, and signal transduction.
Volume: 272
Issue: 3
Pages: 1480-3
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Publication
15778359 | J:97951
First Author: Li Y
Year: 2005
Journal: J Immunol
Title: IL-15 activates telomerase and minimizes telomere loss and may preserve the replicative life span of memory CD8+ T cells in vitro.
Volume: 174
Issue: 7
Pages: 4019-24
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Publication
29666307 | J:284392
 
First Author: Rollings CM
Year: 2018
Journal: Sci Signal
Title: Interleukin-2 shapes the cytotoxic T cell proteome and immune environment-sensing programs.
Volume: 11
Issue: 526
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Publication
32631903 | J:306048
 
First Author: Lim M
Year: 2020
Journal: Mol Cell Biol
Title: Janus Kinase Mutations in Mice Lacking PU.1 and Spi-B Drive B Cell Leukemia through Reactive Oxygen Species-Induced DNA Damage.
Volume: 40
Issue: 18
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Publication
11909529 | J:115366
First Author: Simoncic PD
Year: 2002
Journal: Curr Biol
Title: The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3.
Volume: 12
Issue: 6
Pages: 446-53
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Publication
31085588 | J:276865
First Author: Ding Y
Year: 2019
Journal: J Immunol
Title: CD25 and Protein Phosphatase 2A Cooperate to Enhance IL-2R Signaling in Human Regulatory T Cells.
Volume: 203
Issue: 1
Pages: 93-104
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Publication
10962026 | J:92738
First Author: Tsujino S
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Differential requirement of the cytoplasmic subregions of gamma c chain in T cell development and function.
Volume: 97
Issue: 19
Pages: 10514-9
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Publication
15661890 | J:96417
First Author: Huang Z
Year: 2005
Journal: J Immunol
Title: IFN-gamma suppresses STAT6 phosphorylation by inhibiting its recruitment to the IL-4 receptor.
Volume: 174
Issue: 3
Pages: 1332-7
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Publication
11287618 | J:68832
First Author: Hoffmeyer A
Year: 2001
Journal: Mol Cell Biol
Title: Gadd45gamma is dispensable for normal mouse development and T-cell proliferation.
Volume: 21
Issue: 9
Pages: 3137-43
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Publication
26408659 | J:231491
First Author: Martín-Lorenzo A
Year: 2015
Journal: Cancer Discov
Title: Infection Exposure is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of Pax5-Inherited Susceptibility.
Volume: 5
Issue: 12
Pages: 1328-43
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Publication
26269126 | J:298028
 
First Author: van der Weyden L
Year: 2015
Journal: BMC Cancer
Title: Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5(+/-) leukemia.
Volume: 15
Pages: 585
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Publication
23359502 | J:193464
First Author: Sa Q
Year: 2013
Journal: J Immunol
Title: IL-2 produced by CD8+ immune T cells can augment their IFN-γ production independently from their proliferation in the secondary response to an intracellular pathogen.
Volume: 190
Issue: 5
Pages: 2199-207
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Publication
10421845 | J:92739
First Author: Tsujino S
Year: 1999
Journal: Genes Cells
Title: Critical role of the membrane-proximal, proline-rich motif of the interleukin-2 receptor gammac chain in the Jak3-independent signal transduction.
Volume: 4
Issue: 6
Pages: 363-73
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Publication
30257940 | J:266607
First Author: Jamrog L
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: PAX5-ELN oncoprotein promotes multistep B-cell acute lymphoblastic leukemia in mice.
Volume: 115
Issue: 41
Pages: 10357-10362
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Publication
26411368 | J:234309
First Author: Chen Y
Year: 2016
Journal: Oncogene
Title: Identification of an orally available compound with potent and broad FLT3 inhibition activity.
Volume: 35
Issue: 23
Pages: 2971-8
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Publication
9916733 | J:52014
First Author: Matsumoto M
Year: 1999
Journal: J Immunol
Title: IgE hyperproduction through enhanced tyrosine phosphorylation of Janus kinase 3 in NC/Nga mice, a model for human atopic dermatitis.
Volume: 162
Issue: 2
Pages: 1056-63
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Publication
8631883 | J:60010
First Author: Lin JX
Year: 1996
Journal: J Biol Chem
Title: Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells.
Volume: 271
Issue: 18
Pages: 10738-44
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Publication
17688077 | J:126670
First Author: Uckun FM
Year: 2007
Journal: Arzneimittelforschung
Title: Effect of targeting janus kinase 3 on the development of intestinal tumors in the adenomatous polyposis coli(min) mouse model of familial adenomatous polyposis.
Volume: 57
Issue: 6
Pages: 320-9
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Publication
24368807 | J:208276
First Author: Montresor A
Year: 2013
Journal: J Cell Biol
Title: JAK tyrosine kinases promote hierarchical activation of Rho and Rap modules of integrin activation.
Volume: 203
Issue: 6
Pages: 1003-19
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Publication
30323341 | J:282664
First Author: Inoue M
Year: 2018
Journal: Nat Immunol
Title: Arginine methylation controls the strength of γc-family cytokine signaling in T cell maintenance.
Volume: 19
Issue: 11
Pages: 1265-1276
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Publication
34324649 | J:344040
First Author: Lee-Sundlov MM
Year: 2021
Journal: Blood
Title: Immune cells surveil aberrantly sialylated O-glycans on megakaryocytes to regulate platelet count.
Volume: 138
Issue: 23
Pages: 2408-2424
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Publication
35395675 | J:327830
First Author: Tachibana H
Year: 2022
Journal: Carcinogenesis
Title: Genomic profile of radiation-induced early-onset mouse B-cell lymphoma recapitulates features of Philadelphia chromosome-like acute lymphoblastic leukemia in humans.
Volume: 43
Issue: 7
Pages: 693-703
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Publication
30671064 | J:273156
 
First Author: Witalisz-Siepracka A
Year: 2018
Journal: Front Immunol
Title: Loss of JAK1 Drives Innate Immune Deficiency.
Volume: 9
Pages: 3108
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Publication
10839803 | J:62700
First Author: Yamashita M
Year: 2000
Journal: J Exp Med
Title: T cell receptor-induced calcineurin activation regulates T helper type 2 cell development by modifying the interleukin 4 receptor signaling complex.
Volume: 191
Issue: 11
Pages: 1869-79
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Protein
O88811
Organism: Mus musculus/domesticus
Length: 523  
Fragment?: false
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Protein
P70297
Organism: Mus musculus/domesticus
Length: 548  
Fragment?: false
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Protein
Q3TQ49
Organism: Mus musculus/domesticus
Length: 548  
Fragment?: false
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Protein
Q3UGN9
Organism: Mus musculus/domesticus
Length: 462  
Fragment?: false
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Protein
Q3UMC8
Organism: Mus musculus/domesticus
Length: 553  
Fragment?: false
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Protein
Q3TGH8
Organism: Mus musculus/domesticus
Length: 523  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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