This entry represents a domain found in Nucleolus and neural progenitor protein from mouse (Nepro) and similar eukaryotic sequences. Nepro may play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors []. It may also be involved in preimplentation embryo development []. NEPRO interacts with multiple protein subunits of RMRP and is implicated in Anauxetic dysplasia 3 []. The specific function of this domain, which is predicted to have a four-helix bundle structure, is still unknown.
