Neuromedin S (NmS) is a neuromedin U-related peptide. It has shown to possess anorexigenic and circadian rhythm-modulating properties in mammals. NmS expression is localised predominantly in the core region of the suprachiasmatic nucleus within the hypothalamus, but also in spleen and testis []. Other biological functions include antidiuretic action via release of vasopressin, milk ejection via release of oxytocin and regulation of the circulatory system, immune reactions and insulin secretion. NmU (neuromedin U) and NmS are involved in thermoregulation via the sympathetic nervous system (beta3 adrenergic receptors) and prostaglandin E2 [].
This entry represents a domain found in the kinetochore protein Ndc80. Ndc80 acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. It has been shown that Ndc80 from yeast is part of a complex called the Ndc80p complex []. The four Ndc80 complex subunits associate as two rod-like heterodimers (Ndc80:Nuf2 and Spc24:Spc25) []. This complex is thought to bind to the microtubules of the spindle.
Members of this family are components of the mitotic spindle. Ndc80 acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. It has been shown that Ndc80 from yeast is part of a complex called the Ndc80p complex []. The four Ndc80 complex subunits associate as two rod-like heterodimers (Ndc80:Nuf2 and Spc24:Spc25) []. This complex is thought to bind to the microtubules of the spindle.
This domain is found in cell division proteins which are required for kinetochore-spindle association []. Proteins containing this domain include budding yeast Spc105 and fission yeast Spc7.Spc7 is a component of the NMS (Ndc80-MIND-Spc7) super complex, which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle []. Spc105 and Kre28 forms a kinetochore complex, which is required for kinetochore binding by a discrete subset of kMAPs (BIM1, BIK1 and SLK19) and motors (CIN8, KAR3) [].
Attachment of sister chromatids to microtubules in the fission yeast Schizosaccharomyces pombe is mediated by the kinetochore complex NMS (Ndc80-MIND-Spc7). Sos7 is a component of the MIND complex and is required for kinetochore targeting of Spc7 []. This fungal kinetochore family represented by Sos7 is not present in yeasts belonging to the Saccharomyces complex. Instead, these organisms have proteins homologous to the S. cerevisiae Spc105 interaction partner Kre28.
This entry includes Mis14 from S. pombe, Nsl1 from S. cerevisiae and Nsl1 homologues from animals. MIs14 is a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle []. Nsl1 is an essential component of the kinetochore MIND complex, which is required for the spindle checkpoint and kinetochore integrity [].
This entry includes Spc105 from budding yeasts and Spc7 from fission yeasts. Spc7 is a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle []. Spc105 and Kre28 forms a kinetochore complex, which is required for kinetochore binding by a discrete subset of kMAPs (BIM1, BIK1 and SLK19) and motors (CIN8, KAR3) [].
This entry represents the kinetochore-associated protein Dsn1/Mis13.In Saccharomyces cerevisiae, Dsn1 acts as essential component of the kinetochore MIND complex, which is required for the spindle checkpoint and kinetochore integrity. MIND plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules [, ].In Schizosaccharomyces pombe, Mis13 acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. It is required for correct segregation of chromosomes and for maintaining the inner centromere structure [, ].
