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Search results 901 to 1000 out of 1060 for Smo

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0.053s

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Type Details Score
Publication
19638572 | J:150937
First Author: Veiseh O
Year: 2009
Journal: Cancer Res
Title: Specific targeting of brain tumors with an optical/magnetic resonance imaging nanoprobe across the blood-brain barrier.
Volume: 69
Issue: 15
Pages: 6200-7
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Publication
28031228 | J:239740
First Author: Ward SA
Year: 2017
Journal: Cancer Res
Title: Reprogramming Medulloblastoma-Propagating Cells by a Combined Antagonism of Sonic Hedgehog and CXCR4.
Volume: 77
Issue: 6
Pages: 1416-1426
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Publication
32123231 | J:293139
First Author: Xin Y
Year: 2020
Journal: Sci Rep
Title: PET imaging of medulloblastoma with an 18F-labeled tryptophan analogue in a transgenic mouse model.
Volume: 10
Issue: 1
Pages: 3800
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Publication
24469054 | J:218631
First Author: Knight ER
Year: 2015
Journal: Oncogene
Title: ASC deficiency suppresses proliferation and prevents medulloblastoma incidence.
Volume: 34
Issue: 3
Pages: 394-402
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Publication
18339857 | J:133312
First Author: Hatton BA
Year: 2008
Journal: Cancer Res
Title: The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread.
Volume: 68
Issue: 6
Pages: 1768-76
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Publication
26446920 | J:237594
First Author: Malhotra A
Year: 2016
Journal: Mol Cancer Res
Title: Sonic Hedgehog Signaling Drives Mitochondrial Fragmentation by Suppressing Mitofusins in Cerebellar Granule Neuron Precursors and Medulloblastoma.
Volume: 14
Issue: 1
Pages: 114-24
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Publication
30224541 | J:272040
First Author: Wei Y
Year: 2019
Journal: Mol Cancer Res
Title: p53 Function Is Compromised by Inhibitor 2 of Phosphatase 2A in Sonic Hedgehog Medulloblastoma.
Volume: 17
Issue: 1
Pages: 186-198
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Publication
26938241 | J:259817
First Author: Singh AR
Year: 2016
Journal: PLoS One
Title: PI-3K Inhibitors Preferentially Target CD15+ Cancer Stem Cell Population in SHH Driven Medulloblastoma.
Volume: 11
Issue: 3
Pages: e0150836
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Publication
23452854 | J:194038
First Author: Snuderl M
Year: 2013
Journal: Cell
Title: Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma.
Volume: 152
Issue: 5
Pages: 1065-76
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Genotype
Genotype
Symbol: Tg(Neurod2-Smo*A1)199Jols/?
Background: C57BL/6-Tg(Neurod2-Smo*A1)199Jols
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Neurod2-Smo*A1)199Jols/Tg(Neurod2-Smo*A1)199Jols
Background: C57BL/6-Tg(Neurod2-Smo*A1)199Jols
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Neurod2-Smo*A1)199Jols/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Protein Coding Gene
MGI:99474 | Arrb2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:87940 | Grk2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:99473 | Arrb1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8BWG8
Organism: Mus musculus/domesticus
Length: 418  
Fragment?: false
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Protein
Q91YI4
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: false
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Protein
Q99MK8
Organism: Mus musculus/domesticus
Length: 689  
Fragment?: false
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Strain
MGI:5447647 | C57BL/6-Tg(Neurod2-Smo*A2)#Jols
Attribute String: coisogenic, mutant strain, transgenic
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Publication
20520772 | J:160902
First Author: Castellino RC
Year: 2010
Journal: PLoS One
Title: Heterozygosity for Pten promotes tumorigenesis in a mouse model of medulloblastoma.
Volume: 5
Issue: 5
Pages: e10849
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Genotype
Genotype
Symbol: Tg(Col2a1-GAL4)1Amc/? Tg(UAS-Smo*W539L)1Amc/?
Background: Not Specified
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Neurod2-Smo*A2)#Jols/?
Background: C57BL/6-Tg(Neurod2-Smo*A2)#Jols
Zygosity: ot
Has Mutant Allele: true
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Publication
28275010 | J:240027
First Author: Monkkonen T
Year: 2017
Journal: Development
Title: Epithelial and non-epithelial Ptch1 play opposing roles to regulate proliferation and morphogenesis of the mouse mammary gland.
Volume: 144
Issue: 7
Pages: 1317-1327
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Publication
15239825 | -
First Author: Huang HC
Year: 2004
Journal: Genome Biol
Title: The Frizzled family: receptors for multiple signal transduction pathways.
Volume: 5
Issue: 7
Pages: 234
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HT Experiment
E-GEOD-17473 | Transcription profiling of mouse embryonic E16.5 temporomandibular joint
Series Id: GSE17473
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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Publication
20890301 | J:168813
First Author: Bhatia B
Year: 2011
Journal: Oncogene
Title: Mitogenic Sonic hedgehog signaling drives E2F1-dependent lipogenesis in progenitor cells and medulloblastoma.
Volume: 30
Issue: 4
Pages: 410-22
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Publication
24068730 | J:209539
First Author: Abad C
Year: 2014
Journal: J Leukoc Biol
Title: Targeted STAT3 disruption in myeloid cells alters immunosuppressor cell abundance in a murine model of spontaneous medulloblastoma.
Volume: 95
Issue: 2
Pages: 357-67
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Publication
30778099 | J:275403
First Author: Paine MRL
Year: 2019
Journal: Sci Rep
Title: Three-Dimensional Mass Spectrometry Imaging Identifies Lipid Markers of Medulloblastoma Metastasis.
Volume: 9
Issue: 1
Pages: 2205
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Publication
19048113 | J:331046
First Author: Michael LE
Year: 2008
Journal: Neoplasia
Title: Bmi1 is required for Hedgehog pathway-driven medulloblastoma expansion.
Volume: 10
Issue: 12
Pages: 1343-9, 5p following 1349
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Publication
25879388 | J:309638
First Author: Bhatia S
Year: 2015
Journal: Oncotarget
Title: Knockdown of EphB1 receptor decreases medulloblastoma cell growth and migration and increases cellular radiosensitization.
Volume: 6
Issue: 11
Pages: 8929-46
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Genotype
Genotype
Symbol: Mir34a/Mir34a<+> Tg(Neurod2-Smo*A1)199Jols/?
Background: involves: C57BL/6 * C57BL/6N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mir34a/Mir34a Tg(Neurod2-Smo*A1)199Jols/?
Background: involves: C57BL/6 * C57BL/6N
Zygosity: cx
Has Mutant Allele: true
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HT Experiment
E-GEOD-11063 | Expression data from E11.5 mouse embryonic forelimbs - various mutant conditions or dissected limb domains
Series Id: GSE11063
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein
Q8BS35
Organism: Mus musculus/domesticus
Length: 447  
Fragment?: false
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Protein
Q9Z0F5
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: false
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Protein
Q9CRA4
Organism: Mus musculus/domesticus
Length: 293  
Fragment?: false
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Protein
O88822
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: false
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Protein
A0A1W2P846
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
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Protein
Q8R1S3
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: false
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Protein
A0A1W2P8B8
Organism: Mus musculus/domesticus
Length: 313  
Fragment?: false
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Protein
A0A1W2P6W1
Organism: Mus musculus/domesticus
Length: 311  
Fragment?: false
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Protein
A0A1L1SSH0
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: true
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Publication
8718622 | -
First Author: Aarts MG
Year: 1995
Journal: Plant Cell
Title: Molecular characterization of the CER1 gene of arabidopsis involved in epicuticular wax biosynthesis and pollen fertility.
Volume: 7
Issue: 12
Pages: 2115-27
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Publication
12880870 | -
First Author: Darnet S
Year: 2003
Journal: Biochim Biophys Acta
Title: Enzymological properties of sterol-C4-methyl-oxidase of yeast sterol biosynthesis.
Volume: 1633
Issue: 2
Pages: 106-17
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Publication
10344195 | -
First Author: Husselstein T
Year: 1999
Journal: Plant Mol Biol
Title: Delta7-sterol-C5-desaturase: molecular characterization and functional expression of wild-type and mutant alleles.
Volume: 39
Issue: 5
Pages: 891-906
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Publication
14653780 | -
First Author: Darnet S
Year: 2004
Journal: Biochem J
Title: Plant sterol biosynthesis: identification of two distinct families of sterol 4alpha-methyl oxidases.
Volume: 378
Issue: Pt 3
Pages: 889-98
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Publication
26515067 | -
First Author: Zhu G
Year: 2015
Journal: J Biol Chem
Title: The Crystal Structure of an Integral Membrane Fatty Acid α-Hydroxylase.
Volume: 290
Issue: 50
Pages: 29820-33
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Protein Domain
IPR006694 | Fatty_acid_hydroxylase
Type: Domain
Description: This entry includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways []. This family includes C-5 sterol desaturase []and C-4 sterol methyl oxidase (SMO) [, ]. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif, involved in coordination of two iron atoms in the catalytic centre. Members of this family are ER integral membrane proteins with a mushroom-like structure consisting of four transmembrane helices (TM1-TM4) that anchor them to the membrane, capped by a cytosolic domain containing the unique histidine-coordinating di metal centre [].The plant SMO amino acid sequences possess three histidine-rich motifs (HX3H, HX2HH and HX2HH), characteristic of the small family of membrane-bound non-haem iron oxygenases that are involved in lipid oxidation [].
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Publication
21215705 | J:168256
First Author: Wang GY
Year: 2011
Journal: Cancer Cell
Title: Basal cell carcinomas arise from hair follicle stem cells in Ptch1(+/-) mice.
Volume: 19
Issue: 1
Pages: 114-24
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Publication
20440271 | J:168168
First Author: Hatton BA
Year: 2010
Journal: Oncogene
Title: Notch signaling is not essential in sonic hedgehog-activated medulloblastoma.
Volume: 29
Issue: 26
Pages: 3865-72
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Publication
15520185 | J:93861
First Author: Hallahan AR
Year: 2004
Journal: Cancer Res
Title: The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas.
Volume: 64
Issue: 21
Pages: 7794-800
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Publication
30659230 | J:275488
First Author: Lim Y
Year: 2019
Journal: Sci Rep
Title: Arx Expression Suppresses Ventralization of the Developing Dorsal Forebrain.
Volume: 9
Issue: 1
Pages: 226
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Publication
28515149 | J:242568
First Author: Tech K
Year: 2017
Journal: Cancer Res
Title: Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation.
Volume: 77
Issue: 12
Pages: 3217-3230
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Publication
25082897 | J:213930
First Author: Gate D
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: T-cell TGF-β signaling abrogation restricts medulloblastoma progression.
Volume: 111
Issue: 33
Pages: E3458-66
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Publication
19738049 | J:152687
First Author: Bhatia B
Year: 2009
Journal: Cancer Res
Title: Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of rapamycin activity and p27 Kip1 localization.
Volume: 69
Issue: 18
Pages: 7224-34
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Publication
29168692 | J:254972
   
First Author: Klisch TJ
Year: 2017
Journal: Elife
Title: Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth.
Volume: 6
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Publication
33926529 | J:331043
First Author: Kim H
Year: 2021
Journal: Genome Biol
Title: Ten-eleven translocation protein 1 modulates medulloblastoma progression.
Volume: 22
Issue: 1
Pages: 125
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Publication
35680976 | J:325596
First Author: Pokrajac NT
Year: 2022
Journal: Commun Biol
Title: Three dimensional reconstruction of the mouse cerebellum in Hedgehog-driven medulloblastoma models to identify Norrin-dependent effects on preneoplasia.
Volume: 5
Issue: 1
Pages: 569
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Publication
25348795 | J:221990
First Author: Thor T
Year: 2015
Journal: Int J Cancer
Title: MiR-34a deficiency accelerates medulloblastoma formation in vivo.
Volume: 136
Issue: 10
Pages: 2293-303
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Publication
32332736 | J:291852
First Author: Kim Y
Year: 2020
Journal: Nat Commun
Title: Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration.
Volume: 11
Issue: 1
Pages: 1994
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Publication
29103956 | J:253967
First Author: Wu CC
Year: 2017
Journal: Dev Cell
Title: mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma.
Volume: 43
Issue: 6
Pages: 673-688.e5
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Publication
21321207 | J:170482
First Author: Wong SY
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Wounding mobilizes hair follicle stem cells to form tumors.
Volume: 108
Issue: 10
Pages: 4093-8
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Publication
31851932 | J:298884
First Author: Aiello G
Year: 2019
Journal: Cell Rep
Title: Truncated BRPF1 Cooperates with Smoothened to Promote Adult Shh Medulloblastoma.
Volume: 29
Issue: 12
Pages: 4036-4052.e10
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Publication
25834022 | J:221426
First Author: Liu J
Year: 2015
Journal: Development
Title: The loss of Hh responsiveness by a non-ciliary Gli2 variant.
Volume: 142
Issue: 9
Pages: 1651-60
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Publication
34326333 | J:308909
First Author: Sun J
Year: 2021
Journal: Nat Commun
Title: SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts.
Volume: 12
Issue: 1
Pages: 4611
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Publication
34551292 | J:328728
First Author: Wang Y
Year: 2021
Journal: Cell Rep
Title: A long-range, recurrent neuronal network linking the emotion regions with the somatic motor cortex.
Volume: 36
Issue: 12
Pages: 109733
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Publication
20385363 | J:158946
First Author: Kim J
Year: 2010
Journal: Cancer Cell
Title: Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth.
Volume: 17
Issue: 4
Pages: 388-99
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Publication
17095302 | J:116115
First Author: Khan M
Year: 2007
Journal: Gene Expr Patterns
Title: Hedgehog pathway gene expression during early development of the molar tooth root in the mouse.
Volume: 7
Issue: 3
Pages: 239-43
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Publication
20956384 | J:165480
First Author: Tukachinsky H
Year: 2010
Journal: J Cell Biol
Title: A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes.
Volume: 191
Issue: 2
Pages: 415-28
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Publication
23063129 | J:189068
First Author: Teperino R
Year: 2012
Journal: Cell
Title: Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat.
Volume: 151
Issue: 2
Pages: 414-26
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Publication
26863604 | J:231364
First Author: Jiang K
Year: 2016
Journal: PLoS Biol
Title: PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail.
Volume: 14
Issue: 2
Pages: e1002375
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Publication
27001906 | J:236745
 
First Author: Hyun J
Year: 2016
Journal: Nat Commun
Title: MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression.
Volume: 7
Pages: 10993
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Publication
28134340 | J:244178
 
First Author: Schou KB
Year: 2017
Journal: Nat Commun
Title: KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling.
Volume: 8
Pages: 14177
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Publication
28846093 | J:252237
First Author: Shi X
Year: 2017
Journal: Nat Cell Biol
Title: Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome.
Volume: 19
Issue: 10
Pages: 1178-1188
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Publication
29425683 | J:257801
 
First Author: Li XY
Year: 2018
Journal: Cancer Lett
Title: Cynanbungeigenin C and D, a pair of novel epimers from Cynanchum bungei, suppress hedgehog pathway-dependent medulloblastoma by blocking signaling at the level of Gli.
Volume: 420
Pages: 195-207
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Publication
29167177 | J:258452
First Author: Lu W
Year: 2018
Journal: Blood
Title: Smoothened signaling in the mouse osteoblastoid lineage is required for efficient B lymphopoiesis.
Volume: 131
Issue: 3
Pages: 323-327
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Publication
31539380 | J:279958
First Author: Chahal KK
Year: 2019
Journal: PLoS One
Title: Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma.
Volume: 14
Issue: 9
Pages: e0214901
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Publication
33864885 | J:307764
 
First Author: Kothandapani A
Year: 2021
Journal: Mol Cell Endocrinol
Title: Distinctive functioning of STARD1 in the fetal Leydig cells compared to adult Leydig and adrenal cells. Impact of Hedgehog signaling via the primary cilium.
Volume: 531
Pages: 111265
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Publication
34764263 | J:314740
First Author: Shao F
Year: 2021
Journal: Nat Commun
Title: Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis.
Volume: 12
Issue: 1
Pages: 6540
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Publication
35899529 | J:344145
 
First Author: Lv B
Year: 2022
Journal: J Cell Sci
Title: Arih2 regulates Hedgehog signaling through smoothened ubiquitylation and ER-associated degradation.
Volume: 135
Issue: 16
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Publication
24092238 | J:205413
First Author: Dey J
Year: 2013
Journal: Cancer Res
Title: MyoD is a tumor suppressor gene in medulloblastoma.
Volume: 73
Issue: 22
Pages: 6828-37
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Publication
27823583 | J:239107
   
First Author: Bassett EA
Year: 2016
Journal: Elife
Title: Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation.
Volume: 5
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Publication
29234490 | J:256436
First Author: Sankar S
Year: 2017
Journal: Genes Cancer
Title: Geminin deficiency enhances survival in a murine medulloblastoma model by inducing apoptosis of preneoplastic granule neuron precursors.
Volume: 8
Issue: 9-10
Pages: 725-744
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Publication
22052462 | J:181045
First Author: Sengupta R
Year: 2012
Journal: Cancer Res
Title: CXCR4 activation defines a new subgroup of Sonic hedgehog-driven medulloblastoma.
Volume: 72
Issue: 1
Pages: 122-32
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Publication
23775842 | J:203346
First Author: Milla LA
Year: 2014
Journal: Int J Cancer
Title: Neogenin1 is a Sonic Hedgehog target in medulloblastoma and is necessary for cell cycle progression.
Volume: 134
Issue: 1
Pages: 21-31
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Publication
21646478 | J:174223
First Author: Colvin Wanshura LE
Year: 2011
Journal: Cancer Res
Title: Sequential activation of Snail1 and N-Myc modulates sonic hedgehog-induced transformation of neural cells.
Volume: 71
Issue: 15
Pages: 5336-45
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Publication
25531316 | J:224247
First Author: Lindsey JC
Year: 2015
Journal: Oncogene
Title: Cross-species epigenetics identifies a critical role for VAV1 in SHH subgroup medulloblastoma maintenance.
Volume: 34
Issue: 36
Pages: 4746-57
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Publication
29921697 | J:264274
First Author: Pallavicini G
Year: 2018
Journal: Cancer Res
Title: Inactivation of Citron Kinase Inhibits Medulloblastoma Progression by Inducing Apoptosis and Cell Senescence.
Volume: 78
Issue: 16
Pages: 4599-4612
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Publication
24280485 | J:210113
First Author: Gershon TR
Year: 2013
Journal: Cancer Metab
Title: Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma.
Volume: 1
Issue: 1
Pages: 2
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Publication
29378965 | J:258284
First Author: Bay SN
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Disruption of the ciliary GTPase Arl13b suppresses Sonic hedgehog overactivation and inhibits medulloblastoma formation.
Volume: 115
Issue: 7
Pages: 1570-1575
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Publication
28379358 | J:242833
First Author: Wu C
Year: 2017
Journal: Hum Mol Genet
Title: Loss of dynein-2 intermediate chain Wdr34 results in defects in retrograde ciliary protein trafficking and Hedgehog signaling in the mouse.
Volume: 26
Issue: 13
Pages: 2386-2397
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Publication
17660199 | J:124105
First Author: Ruiz-Perez VL
Year: 2007
Journal: Development
Title: Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia.
Volume: 134
Issue: 16
Pages: 2903-12
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Publication
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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