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Search results 501 to 552 out of 552 for Lmo2

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Type

Details

Score

Publication

- | J:144087

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform

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Publication

- | J:144086

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform

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Publication

- | J:91388

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations

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Publication

- | J:155221

First Author:	Mouse Genome Informatics
Year:	2010
Journal:	Database Release
Title:	Protein Ontology Association Load.

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Publication

26764384 | J:229901

First Author:	Sincennes MC
Year:	2016
Journal:	Proc Natl Acad Sci U S A
Title:	The LMO2 oncogene regulates DNA replication in hematopoietic cells.
Volume:	113
Issue:	5
Pages:	1393-8

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Publication

32181817 | J:300575

First Author:	Li L
Year:	2020
Journal:	Blood
Title:	Ldb1 is required for Lmo2 oncogene-induced thymocyte self-renewal and T-cell acute lymphoblastic leukemia.
Volume:	135
Issue:	25
Pages:	2252-2265

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Publication

25721045 | J:258899

First Author:	Kim SH
Year:	2015
Journal:	Cell Death Differ
Title:	The LIM-only transcription factor LMO2 determines tumorigenic and angiogenic traits in glioma stem cells.
Volume:	22
Issue:	9
Pages:	1517-25

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Publication

8605871 | J:102013

First Author:	Larson RC
Year:	1996
Journal:	EMBO J
Title:	Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice.
Volume:	15
Issue:	5
Pages:	1021-7

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Publication

20457870 | J:163500

First Author:	Zhou S
Year:	2010
Journal:	Blood
Title:	A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells.
Volume:	116
Issue:	6
Pages:	900-8

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Publication

9707419 | J:52668

First Author:	Grütz GG
Year:	1998
Journal:	EMBO J
Title:	The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells.
Volume:	17
Issue:	16
Pages:	4594-605

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Interaction Experiment

Sincennes MC (2016)

Description:

The LMO2 oncogene regulates DNA replication in hematopoietic cells.

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Publication

30962539 | J:279022

First Author:	Pais H
Year:	2019
Journal:	Sci Rep
Title:	Surfaceome interrogation using an RNA-seq approach highlights leukemia initiating cell biomarkers in an LMO2 T cell transgenic model.
Volume:	9
Issue:	1
Pages:	5760

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Publication

20519628 | -

First Author:	Hirose K
Year:	2010
Journal:	Blood
Title:	Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).
Volume:	116
Issue:	6
Pages:	962-70

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DO Term

DOID:0080997 | diffuse large B-cell lymphoma germinal center B-cell type

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Publication

12727888 | -

First Author:	Deane JE
Year:	2003
Journal:	EMBO J
Title:	Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4.
Volume:	22
Issue:	9
Pages:	2224-33

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GO Term

GO:0070353 | GATA1-TAL1-TCF3-Lmo2 complex

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GO Term

GO:0070354 | GATA2-TAL1-TCF3-Lmo2 complex

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Allele

Tg(Lmo2-EGFP)NK30Gsat | MGI:4940661

Name:	transgene insertion NK30, GENSAT Project at Rockefeller University
Allele Type:	Transgenic
Attribute String:	Reporter

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Publication

20676125 | -

First Author:	Oram SH
Year:	2010
Journal:	Oncogene
Title:	A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients.
Volume:	29
Issue:	43
Pages:	5796-808

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Publication

24874989 | J:211332

First Author:	Krivega I
Year:	2014
Journal:	Genes Dev
Title:	Role of LDB1 in the transition from chromatin looping to transcription activation.
Volume:	28
Issue:	12
Pages:	1278-90

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Strain

MGI:5004341 | STOCK Tg(Lmo2-EGFP)NK30Gsat/Mmucd

Attribute String:

mutant stock, transgenic

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Protein Domain

IPR030167 | LDB1

Type:

Family

Description:

LIM domain-binding protein 1 (LDB1) binds to the LIM domain of LIM homeodomain proteins which are transcriptional regulators. LDB1 is a multi-adaptor protein that mediates interactions between different classes of transcription factors and their co-regulators, and hence determine cell fate and differentiation []. In erythroid cells LDB1 is recruited to the beta-globin locus via LMO2 and is required for looping of the beta-globin locus control region (LCR) to the active beta-globin promoter [].

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Publication

1386162 | J:18114

First Author:	Inaba T
Year:	1992
Journal:	Science
Title:	Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia.
Volume:	257
Issue:	5069
Pages:	531-4

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Publication

23415677 | -

First Author:	Waters KM
Year:	2013
Journal:	Toxicol Appl Pharmacol
Title:	Hepatic leukemia factor promotes resistance to cell death: implications for therapeutics and chronotherapy.
Volume:	268
Issue:	2
Pages:	141-8

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Protein Domain

IPR029829 | HLF

Type:

Family

Description:

Hepatic leukemia factor (HLF) belongs to the PAR (Proline and Acidic amino acid-Rich basic leucine ZIPper) transcription factor family, which consists of HLF, DBP and TEF proteins []. HLF binds DNA specifically as a homodimer or as a heterodimer with other PAR factors. It binds to the consensus sequence 5'-GTTACGTAAT-3' []. In B-precursor acute lymphoblastic leukemia (ALL), it fuses to the N terminus of the E2A protein [], and this chimeric protein promotes cell survival of t(17;19)-ALL cells by aberrantly up-regulating the expression of hematopoiesis transcription regulator LMO2 []. HLF regulates a complex multi-gene transcriptional program that involves upregulation of anti-apoptotic genes and downregulation of pro-apoptotic genes [].

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Publication

20374994 | J:167882

First Author:	Hoang T
Year:	2010
Journal:	Sci Transl Med
Title:	Of mice and men: how an oncogene transgresses the limits and predisposes to T cell acute lymphoblastic leukemia.
Volume:	2
Issue:	21
Pages:	21ps10

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Publication

20570862 | J:164497

First Author:	Song SH
Year:	2010
Journal:	Blood
Title:	Multiple functions of Ldb1 required for beta-globin activation during erythroid differentiation.
Volume:	116
Issue:	13
Pages:	2356-64

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Publication

21186366 | J:170572

First Author:	Li L
Year:	2011
Journal:	Nat Immunol
Title:	Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells.
Volume:	12
Issue:	2
Pages:	129-36

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Publication

21041453 | J:176875

First Author:	Li L
Year:	2010
Journal:	J Exp Med
Title:	A requirement for Lim domain binding protein 1 in erythropoiesis.
Volume:	207
Issue:	12
Pages:	2543-50

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Publication

16084128 | J:102125

First Author:	Themis M
Year:	2005
Journal:	Mol Ther
Title:	Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice.
Volume:	12
Issue:	4
Pages:	763-71

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Publication

16988660 | J:116806

First Author:	Pike-Overzet K
Year:	2006
Journal:	Nature
Title:	Gene therapy: is IL2RG oncogenic in T-cell development?
Volume:	443
Issue:	7109
Pages:	E5; discussion E6-7

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Protein

H3BKN8

Organism:	Mus musculus/domesticus
Length:	142
Fragment?:	true

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Publication

8786133 | J:33853

First Author:	Shutler G
Year:	1996
Journal:	Genomics
Title:	Genomic structure of the human D-site binding protein (DBP) gene.
Volume:	34
Issue:	3
Pages:	334-9

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Publication

8639829 | -

First Author:	Hunger SP
Year:	1996
Journal:	Blood
Title:	The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties.
Volume:	87
Issue:	11
Pages:	4607-17

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HT Experiment

GSE48048 | Gene expression profiling normal murine myeloid cells and myeloid leukemia cells induced by CNTRL-FGFR1

Series Id:	E-GEOD-48048
Experiment Type:	RNA-Seq
Study Type:	Baseline
Source:	GEO

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Publication

9840944 | J:52152

First Author:	Grutz G
Year:	1998
Journal:	Oncogene
Title:	Identification of the LMO4 gene encoding an interaction partner of the LIM-binding protein LDB1/NLI1: a candidate for displacement by LMO proteins in T cell acute leukaemia.
Volume:	17
Issue:	21
Pages:	2799-803

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Publication

24687960 | J:212408

First Author:	Treanor LM
Year:	2014
Journal:	J Exp Med
Title:	Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential.
Volume:	211
Issue:	4
Pages:	701-13

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Publication

14966285 | J:88167

First Author:	Tse E
Year:	2004
Journal:	Mol Cell Biol
Title:	Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice.
Volume:	24
Issue:	5
Pages:	2063-73

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Publication

15691703 | J:96957

First Author:	Lee SK
Year:	2005
Journal:	Mol Cell Neurosci
Title:	The LIM domain-only protein LMO4 is required for neural tube closure.
Volume:	28
Issue:	2
Pages:	205-14

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Publication

11607826 | J:72274

First Author:	Rabbitts TH
Year:	2001
Journal:	Oncogene
Title:	Chromosomal translocation master genes, mouse models and experimental therapeutics.
Volume:	20
Issue:	40
Pages:	5763-77

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Publication

10556429 | J:58215

First Author:	Tse E
Year:	1999
Journal:	Mamm Genome
Title:	Characterization of the Lmo4 gene encoding a LIM-only protein: genomic organization and comparative chromosomal mapping.
Volume:	10
Issue:	11
Pages:	1089-94

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Publication

11069036 | J:65345

First Author:	Davenport J
Year:	2000
Journal:	Leukemia
Title:	Identification of genes potentially involved in LMO2-induced leukemogenesis.
Volume:	14
Issue:	11
Pages:	1986-96

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Publication

16800816 | J:116030

First Author:	Xu Z
Year:	2006
Journal:	Biochem J
Title:	Recruitment of the SWI/SNF protein Brg1 by a multiprotein complex effects transcriptional repression in murine erythroid progenitors.
Volume:	399
Issue:	2
Pages:	297-304

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Publication

20525788 | J:173422

First Author:	Calero-Nieto FJ
Year:	2010
Journal:	Nucleic Acids Res
Title:	Transcriptional regulation of Elf-1: locus-wide analysis reveals four distinct promoters, a tissue-specific enhancer, control by PU.1 and the importance of Elf-1 downregulation for erythroid maturation.
Volume:	38
Issue:	19
Pages:	6363-74

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Publication

23220237 | J:214575

First Author:	Joshi A
Year:	2013
Journal:	Exp Hematol
Title:	Gene set control analysis predicts hematopoietic control mechanisms from genome-wide transcription factor binding data.
Volume:	41
Issue:	4
Pages:	354-66.e14

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Publication

33483615 | J:308179

First Author:	Abdulla H
Year:	2021
Journal:	Leukemia
Title:	T-ALL can evolve to oncogene independence.
Volume:	35
Issue:	8
Pages:	2205-2219

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Protein

Q8BW74

Organism:	Mus musculus/domesticus
Length:	295
Fragment?:	false

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Protein

Q8BVB2

Organism:	Mus musculus/domesticus
Length:	299
Fragment?:	true

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Publication

14647207 | -

First Author:	Matthews JM
Year:	2003
Journal:	EMBO Rep
Title:	LIM-domain-binding protein 1: a multifunctional cofactor that interacts with diverse proteins.
Volume:	4
Issue:	12
Pages:	1132-7

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Protein

P70662

Organism:	Mus musculus/domesticus
Length:	411
Fragment?:	false

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Protein

D3Z1C5

Organism:	Mus musculus/domesticus
Length:	373
Fragment?:	false

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Publication

- | J:100256

First Author:	The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year:	2005
Journal:	Database Download
Title:	MGI download of GENSAT transgene data

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