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Search results 501 to 556 out of 556 for Lmo2

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0.025s
Type Details Score
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication
First Author: Sincennes MC
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: The LMO2 oncogene regulates DNA replication in hematopoietic cells.
Volume: 113
Issue: 5
Pages: 1393-8
Publication
First Author: Li L
Year: 2020
Journal: Blood
Title: Ldb1 is required for Lmo2 oncogene-induced thymocyte self-renewal and T-cell acute lymphoblastic leukemia.
Volume: 135
Issue: 25
Pages: 2252-2265
Publication
First Author: Kim SH
Year: 2015
Journal: Cell Death Differ
Title: The LIM-only transcription factor LMO2 determines tumorigenic and angiogenic traits in glioma stem cells.
Volume: 22
Issue: 9
Pages: 1517-25
Publication
First Author: Larson RC
Year: 1996
Journal: EMBO J
Title: Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice.
Volume: 15
Issue: 5
Pages: 1021-7
Publication
First Author: Zhou S
Year: 2010
Journal: Blood
Title: A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells.
Volume: 116
Issue: 6
Pages: 900-8
Publication
First Author: Grütz GG
Year: 1998
Journal: EMBO J
Title: The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells.
Volume: 17
Issue: 16
Pages: 4594-605
Interaction Experiment
Description: The LMO2 oncogene regulates DNA replication in hematopoietic cells.
Publication
First Author: Pais H
Year: 2019
Journal: Sci Rep
Title: Surfaceome interrogation using an RNA-seq approach highlights leukemia initiating cell biomarkers in an LMO2 T cell transgenic model.
Volume: 9
Issue: 1
Pages: 5760
Publication
First Author: Hirose K
Year: 2010
Journal: Blood
Title: Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).
Volume: 116
Issue: 6
Pages: 962-70
DO Term
Publication
First Author: Deane JE
Year: 2003
Journal: EMBO J
Title: Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4.
Volume: 22
Issue: 9
Pages: 2224-33
GO Term
GO Term
Allele
Name: transgene insertion NK30, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
Publication
First Author: Oram SH
Year: 2010
Journal: Oncogene
Title: A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients.
Volume: 29
Issue: 43
Pages: 5796-808
Publication
First Author: Krivega I
Year: 2014
Journal: Genes Dev
Title: Role of LDB1 in the transition from chromatin looping to transcription activation.
Volume: 28
Issue: 12
Pages: 1278-90
Strain
Attribute String: mutant stock, transgenic
Protein Domain
Type: Family
Description: LIM domain-binding protein 1 (LDB1) binds to the LIM domain of LIM homeodomain proteins which are transcriptional regulators. LDB1 is a multi-adaptor protein that mediates interactions between different classes of transcription factors and their co-regulators, and hence determine cell fate and differentiation []. In erythroid cells LDB1 is recruited to the beta-globin locus via LMO2 and is required for looping of the beta-globin locus control region (LCR) to the active beta-globin promoter [].
Publication
First Author: Inaba T
Year: 1992
Journal: Science
Title: Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia.
Volume: 257
Issue: 5069
Pages: 531-4
Publication
First Author: Waters KM
Year: 2013
Journal: Toxicol Appl Pharmacol
Title: Hepatic leukemia factor promotes resistance to cell death: implications for therapeutics and chronotherapy.
Volume: 268
Issue: 2
Pages: 141-8
Protein Domain
Type: Family
Description: Hepatic leukemia factor (HLF) belongs to the PAR (Proline and Acidic amino acid-Rich basic leucine ZIPper) transcription factor family, which consists of HLF, DBP and TEF proteins []. HLF binds DNA specifically as a homodimer or as a heterodimer with other PAR factors. It binds to the consensus sequence 5'-GTTACGTAAT-3' []. In B-precursor acute lymphoblastic leukemia (ALL), it fuses to the N terminus of the E2A protein [], and this chimeric protein promotes cell survival of t(17;19)-ALL cells by aberrantly up-regulating the expression of hematopoiesis transcription regulator LMO2 []. HLF regulates a complex multi-gene transcriptional program that involves upregulation of anti-apoptotic genes and downregulation of pro-apoptotic genes [].
Publication
First Author: Hoang T
Year: 2010
Journal: Sci Transl Med
Title: Of mice and men: how an oncogene transgresses the limits and predisposes to T cell acute lymphoblastic leukemia.
Volume: 2
Issue: 21
Pages: 21ps10
Publication
First Author: Song SH
Year: 2010
Journal: Blood
Title: Multiple functions of Ldb1 required for beta-globin activation during erythroid differentiation.
Volume: 116
Issue: 13
Pages: 2356-64
Publication
First Author: Li L
Year: 2011
Journal: Nat Immunol
Title: Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells.
Volume: 12
Issue: 2
Pages: 129-36
Publication
First Author: Li L
Year: 2010
Journal: J Exp Med
Title: A requirement for Lim domain binding protein 1 in erythropoiesis.
Volume: 207
Issue: 12
Pages: 2543-50
Publication
First Author: Themis M
Year: 2005
Journal: Mol Ther
Title: Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice.
Volume: 12
Issue: 4
Pages: 763-71
Publication
First Author: Pike-Overzet K
Year: 2006
Journal: Nature
Title: Gene therapy: is IL2RG oncogenic in T-cell development?
Volume: 443
Issue: 7109
Pages: E5; discussion E6-7
Protein
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: true
Publication
First Author: Shutler G
Year: 1996
Journal: Genomics
Title: Genomic structure of the human D-site binding protein (DBP) gene.
Volume: 34
Issue: 3
Pages: 334-9
Publication
First Author: Hunger SP
Year: 1996
Journal: Blood
Title: The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties.
Volume: 87
Issue: 11
Pages: 4607-17
HT Experiment
Series Id: E-GEOD-48048
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
Publication
First Author: Grutz G
Year: 1998
Journal: Oncogene
Title: Identification of the LMO4 gene encoding an interaction partner of the LIM-binding protein LDB1/NLI1: a candidate for displacement by LMO proteins in T cell acute leukaemia.
Volume: 17
Issue: 21
Pages: 2799-803
Publication
First Author: Treanor LM
Year: 2014
Journal: J Exp Med
Title: Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential.
Volume: 211
Issue: 4
Pages: 701-13
Publication
First Author: Tse E
Year: 2004
Journal: Mol Cell Biol
Title: Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice.
Volume: 24
Issue: 5
Pages: 2063-73
Publication
First Author: Lee SK
Year: 2005
Journal: Mol Cell Neurosci
Title: The LIM domain-only protein LMO4 is required for neural tube closure.
Volume: 28
Issue: 2
Pages: 205-14
Publication
First Author: Rabbitts TH
Year: 2001
Journal: Oncogene
Title: Chromosomal translocation master genes, mouse models and experimental therapeutics.
Volume: 20
Issue: 40
Pages: 5763-77
Publication
First Author: Tse E
Year: 1999
Journal: Mamm Genome
Title: Characterization of the Lmo4 gene encoding a LIM-only protein: genomic organization and comparative chromosomal mapping.
Volume: 10
Issue: 11
Pages: 1089-94
Publication
First Author: Davenport J
Year: 2000
Journal: Leukemia
Title: Identification of genes potentially involved in LMO2-induced leukemogenesis.
Volume: 14
Issue: 11
Pages: 1986-96
Publication
First Author: Xu Z
Year: 2006
Journal: Biochem J
Title: Recruitment of the SWI/SNF protein Brg1 by a multiprotein complex effects transcriptional repression in murine erythroid progenitors.
Volume: 399
Issue: 2
Pages: 297-304
Publication
First Author: Calero-Nieto FJ
Year: 2010
Journal: Nucleic Acids Res
Title: Transcriptional regulation of Elf-1: locus-wide analysis reveals four distinct promoters, a tissue-specific enhancer, control by PU.1 and the importance of Elf-1 downregulation for erythroid maturation.
Volume: 38
Issue: 19
Pages: 6363-74
Publication
First Author: Joshi A
Year: 2013
Journal: Exp Hematol
Title: Gene set control analysis predicts hematopoietic control mechanisms from genome-wide transcription factor binding data.
Volume: 41
Issue: 4
Pages: 354-66.e14
Publication
First Author: Abdulla H
Year: 2021
Journal: Leukemia
Title: T-ALL can evolve to oncogene independence.
Volume: 35
Issue: 8
Pages: 2205-2219
Publication
First Author: Almeida A
Year: 2024
Journal: Hemasphere
Title: Myb overexpression synergizes with the loss of Pten and is a dependency factor and therapeutic target in T-cell lymphoblastic leukemia.
Volume: 8
Issue: 3
Pages: e51
Publication
First Author: O'Connor KW
Year: 2024
Journal: Leukemia
Title: The role of quiescent thymic progenitors in TAL/LMO2-induced T-ALL chemotolerance.
Volume: 38
Issue: 5
Pages: 951-962
Protein
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: true
Publication
First Author: Matthews JM
Year: 2003
Journal: EMBO Rep
Title: LIM-domain-binding protein 1: a multifunctional cofactor that interacts with diverse proteins.
Volume: 4
Issue: 12
Pages: 1132-7
Protein
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
Publication      
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data