Type |
Details |
Score |
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Sincennes MC |
Year: |
2016 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The LMO2 oncogene regulates DNA replication in hematopoietic cells. |
Volume: |
113 |
Issue: |
5 |
Pages: |
1393-8 |
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•
•
•
•
•
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Publication |
First Author: |
Li L |
Year: |
2020 |
Journal: |
Blood |
Title: |
Ldb1 is required for Lmo2 oncogene-induced thymocyte self-renewal and T-cell acute lymphoblastic leukemia. |
Volume: |
135 |
Issue: |
25 |
Pages: |
2252-2265 |
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•
•
•
•
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Publication |
First Author: |
Kim SH |
Year: |
2015 |
Journal: |
Cell Death Differ |
Title: |
The LIM-only transcription factor LMO2 determines tumorigenic and angiogenic traits in glioma stem cells. |
Volume: |
22 |
Issue: |
9 |
Pages: |
1517-25 |
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•
•
•
•
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Publication |
First Author: |
Larson RC |
Year: |
1996 |
Journal: |
EMBO J |
Title: |
Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice. |
Volume: |
15 |
Issue: |
5 |
Pages: |
1021-7 |
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•
•
•
•
•
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Publication |
First Author: |
Zhou S |
Year: |
2010 |
Journal: |
Blood |
Title: |
A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells. |
Volume: |
116 |
Issue: |
6 |
Pages: |
900-8 |
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•
•
•
•
•
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Publication |
First Author: |
Grütz GG |
Year: |
1998 |
Journal: |
EMBO J |
Title: |
The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells. |
Volume: |
17 |
Issue: |
16 |
Pages: |
4594-605 |
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Interaction Experiment |
Description: |
The LMO2 oncogene regulates DNA replication in hematopoietic cells. |
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•
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Publication |
First Author: |
Pais H |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
Surfaceome interrogation using an RNA-seq approach highlights leukemia initiating cell biomarkers in an LMO2 T cell transgenic model. |
Volume: |
9 |
Issue: |
1 |
Pages: |
5760 |
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•
•
•
•
•
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Publication |
First Author: |
Hirose K |
Year: |
2010 |
Journal: |
Blood |
Title: |
Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19). |
Volume: |
116 |
Issue: |
6 |
Pages: |
962-70 |
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DO Term |
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Publication |
First Author: |
Deane JE |
Year: |
2003 |
Journal: |
EMBO J |
Title: |
Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4. |
Volume: |
22 |
Issue: |
9 |
Pages: |
2224-33 |
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GO Term |
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GO Term |
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•
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Allele |
Name: |
transgene insertion NK30, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
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•
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Publication |
First Author: |
Oram SH |
Year: |
2010 |
Journal: |
Oncogene |
Title: |
A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients. |
Volume: |
29 |
Issue: |
43 |
Pages: |
5796-808 |
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•
•
•
•
•
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Publication |
First Author: |
Krivega I |
Year: |
2014 |
Journal: |
Genes Dev |
Title: |
Role of LDB1 in the transition from chromatin looping to transcription activation. |
Volume: |
28 |
Issue: |
12 |
Pages: |
1278-90 |
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•
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Strain |
Attribute String: |
mutant stock, transgenic |
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Protein Domain |
Type: |
Family |
Description: |
LIM domain-binding protein 1 (LDB1) binds to the LIM domain of LIM homeodomain proteins which are transcriptional regulators. LDB1 is a multi-adaptor protein that mediates interactions between different classes of transcription factors and their co-regulators, and hence determine cell fate and differentiation []. In erythroid cells LDB1 is recruited to the beta-globin locus via LMO2 and is required for looping of the beta-globin locus control region (LCR) to the active beta-globin promoter []. |
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Publication |
First Author: |
Inaba T |
Year: |
1992 |
Journal: |
Science |
Title: |
Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. |
Volume: |
257 |
Issue: |
5069 |
Pages: |
531-4 |
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•
•
•
•
•
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Publication |
First Author: |
Waters KM |
Year: |
2013 |
Journal: |
Toxicol Appl Pharmacol |
Title: |
Hepatic leukemia factor promotes resistance to cell death: implications for therapeutics and chronotherapy. |
Volume: |
268 |
Issue: |
2 |
Pages: |
141-8 |
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•
•
•
•
•
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Protein Domain |
Type: |
Family |
Description: |
Hepatic leukemia factor (HLF) belongs to the PAR (Proline and Acidic amino acid-Rich basic leucine ZIPper) transcription factor family, which consists of HLF, DBP and TEF proteins []. HLF binds DNA specifically as a homodimer or as a heterodimer with other PAR factors. It binds to the consensus sequence 5'-GTTACGTAAT-3' []. In B-precursor acute lymphoblastic leukemia (ALL), it fuses to the N terminus of the E2A protein [], and this chimeric protein promotes cell survival of t(17;19)-ALL cells by aberrantly up-regulating the expression of hematopoiesis transcription regulator LMO2 []. HLF regulates a complex multi-gene transcriptional program that involves upregulation of anti-apoptotic genes and downregulation of pro-apoptotic genes []. |
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•
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•
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Publication |
First Author: |
Hoang T |
Year: |
2010 |
Journal: |
Sci Transl Med |
Title: |
Of mice and men: how an oncogene transgresses the limits and predisposes to T cell acute lymphoblastic leukemia. |
Volume: |
2 |
Issue: |
21 |
Pages: |
21ps10 |
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•
•
•
•
•
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Publication |
First Author: |
Song SH |
Year: |
2010 |
Journal: |
Blood |
Title: |
Multiple functions of Ldb1 required for beta-globin activation during erythroid differentiation. |
Volume: |
116 |
Issue: |
13 |
Pages: |
2356-64 |
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•
•
•
•
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Publication |
First Author: |
Li L |
Year: |
2011 |
Journal: |
Nat Immunol |
Title: |
Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells. |
Volume: |
12 |
Issue: |
2 |
Pages: |
129-36 |
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•
•
•
•
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Publication |
First Author: |
Li L |
Year: |
2010 |
Journal: |
J Exp Med |
Title: |
A requirement for Lim domain binding protein 1 in erythropoiesis. |
Volume: |
207 |
Issue: |
12 |
Pages: |
2543-50 |
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•
•
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•
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Publication |
First Author: |
Themis M |
Year: |
2005 |
Journal: |
Mol Ther |
Title: |
Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice. |
Volume: |
12 |
Issue: |
4 |
Pages: |
763-71 |
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•
•
•
•
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Publication |
First Author: |
Pike-Overzet K |
Year: |
2006 |
Journal: |
Nature |
Title: |
Gene therapy: is IL2RG oncogenic in T-cell development? |
Volume: |
443 |
Issue: |
7109 |
Pages: |
E5; discussion E6-7 |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
142
|
Fragment?: |
true |
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•
•
•
•
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Publication |
First Author: |
Shutler G |
Year: |
1996 |
Journal: |
Genomics |
Title: |
Genomic structure of the human D-site binding protein (DBP) gene. |
Volume: |
34 |
Issue: |
3 |
Pages: |
334-9 |
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•
•
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•
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Publication |
First Author: |
Hunger SP |
Year: |
1996 |
Journal: |
Blood |
Title: |
The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties. |
Volume: |
87 |
Issue: |
11 |
Pages: |
4607-17 |
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•
|
HT Experiment |
Series Id: |
E-GEOD-48048 |
Experiment Type: |
RNA-Seq |
Study Type: |
Baseline |
Source: |
GEO |
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•
•
•
•
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Publication |
First Author: |
Grutz G |
Year: |
1998 |
Journal: |
Oncogene |
Title: |
Identification of the LMO4 gene encoding an interaction partner of the LIM-binding protein LDB1/NLI1: a candidate for displacement by LMO proteins in T cell acute leukaemia. |
Volume: |
17 |
Issue: |
21 |
Pages: |
2799-803 |
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•
•
•
•
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Publication |
First Author: |
Treanor LM |
Year: |
2014 |
Journal: |
J Exp Med |
Title: |
Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential. |
Volume: |
211 |
Issue: |
4 |
Pages: |
701-13 |
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•
•
•
•
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Publication |
First Author: |
Tse E |
Year: |
2004 |
Journal: |
Mol Cell Biol |
Title: |
Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice. |
Volume: |
24 |
Issue: |
5 |
Pages: |
2063-73 |
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•
•
•
•
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Publication |
First Author: |
Lee SK |
Year: |
2005 |
Journal: |
Mol Cell Neurosci |
Title: |
The LIM domain-only protein LMO4 is required for neural tube closure. |
Volume: |
28 |
Issue: |
2 |
Pages: |
205-14 |
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•
•
•
•
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Publication |
First Author: |
Rabbitts TH |
Year: |
2001 |
Journal: |
Oncogene |
Title: |
Chromosomal translocation master genes, mouse models and experimental therapeutics. |
Volume: |
20 |
Issue: |
40 |
Pages: |
5763-77 |
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•
•
•
•
•
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Publication |
First Author: |
Tse E |
Year: |
1999 |
Journal: |
Mamm Genome |
Title: |
Characterization of the Lmo4 gene encoding a LIM-only protein: genomic organization and comparative chromosomal mapping. |
Volume: |
10 |
Issue: |
11 |
Pages: |
1089-94 |
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•
•
•
•
•
|
Publication |
First Author: |
Davenport J |
Year: |
2000 |
Journal: |
Leukemia |
Title: |
Identification of genes potentially involved in LMO2-induced leukemogenesis. |
Volume: |
14 |
Issue: |
11 |
Pages: |
1986-96 |
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•
•
•
•
•
|
Publication |
First Author: |
Xu Z |
Year: |
2006 |
Journal: |
Biochem J |
Title: |
Recruitment of the SWI/SNF protein Brg1 by a multiprotein complex effects transcriptional repression in murine erythroid progenitors. |
Volume: |
399 |
Issue: |
2 |
Pages: |
297-304 |
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•
•
•
•
•
|
Publication |
First Author: |
Calero-Nieto FJ |
Year: |
2010 |
Journal: |
Nucleic Acids Res |
Title: |
Transcriptional regulation of Elf-1: locus-wide analysis reveals four distinct promoters, a tissue-specific enhancer, control by PU.1 and the importance of Elf-1 downregulation for erythroid maturation. |
Volume: |
38 |
Issue: |
19 |
Pages: |
6363-74 |
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•
•
•
•
•
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Publication |
First Author: |
Joshi A |
Year: |
2013 |
Journal: |
Exp Hematol |
Title: |
Gene set control analysis predicts hematopoietic control mechanisms from genome-wide transcription factor binding data. |
Volume: |
41 |
Issue: |
4 |
Pages: |
354-66.e14 |
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•
•
•
•
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Publication |
First Author: |
Abdulla H |
Year: |
2021 |
Journal: |
Leukemia |
Title: |
T-ALL can evolve to oncogene independence. |
Volume: |
35 |
Issue: |
8 |
Pages: |
2205-2219 |
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•
•
•
•
•
|
Publication |
First Author: |
Almeida A |
Year: |
2024 |
Journal: |
Hemasphere |
Title: |
Myb overexpression synergizes with the loss of Pten and is a dependency factor and therapeutic target in T-cell lymphoblastic leukemia. |
Volume: |
8 |
Issue: |
3 |
Pages: |
e51 |
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•
•
•
•
|
Publication |
First Author: |
O'Connor KW |
Year: |
2024 |
Journal: |
Leukemia |
Title: |
The role of quiescent thymic progenitors in TAL/LMO2-induced T-ALL chemotolerance. |
Volume: |
38 |
Issue: |
5 |
Pages: |
951-962 |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
295
|
Fragment?: |
false |
|
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
299
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Matthews JM |
Year: |
2003 |
Journal: |
EMBO Rep |
Title: |
LIM-domain-binding protein 1: a multifunctional cofactor that interacts with diverse proteins. |
Volume: |
4 |
Issue: |
12 |
Pages: |
1132-7 |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
411
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
373
|
Fragment?: |
false |
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•
•
•
•
|
Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
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•
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