|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 201 to 249 out of 249 for Clcnkb

<< First    < Previous  |  Next >    Last >>
0.02s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:1713712
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1867928
Stage: TS28
Assay Id: MGI:5538907
Age: postnatal day 84
Image: GUDMAP:14621
Specimen Label: GUDMAP:14621
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1713712
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1927926
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5538907
Age: embryonic day 17.5
Image: GUDMAP:14620
Specimen Label: GUDMAP:14620
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1713712
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1927928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5538907
Age: postnatal day 84
Image: GUDMAP:14621
Specimen Label: GUDMAP:14621
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691351
Age: postnatal adult
Image: MRC Harwell_2133241
Specimen Label: MRC Harwell_2133241
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1713712
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3128126
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5538907
Age: embryonic day 17.5
Image: GUDMAP:14620
Specimen Label: GUDMAP:14620
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1713712
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2837026
Stage: TS26
Assay Id: MGI:5538907
Age: embryonic day 17.5
Image: GUDMAP:14620
Specimen Label: GUDMAP:14620
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1713712
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2837028
Stage: TS28
Assay Id: MGI:5538907
Age: postnatal day 84
Image: GUDMAP:14621
Specimen Label: GUDMAP:14621
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1713712
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2848528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5538907
Age: postnatal day 84
Image: GUDMAP:14621
Specimen Label: GUDMAP:14621
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1713712
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2832226
Pattern: Spotted
Stage: TS26
Assay Id: MGI:5538907
Age: embryonic day 17.5
Image: GUDMAP:14620
Specimen Label: GUDMAP:14620
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1713712
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2832228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5538907
Age: postnatal day 84
Image: GUDMAP:14621
Specimen Label: GUDMAP:14621
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1713712
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2834626
Stage: TS26
Assay Id: MGI:5538907
Age: embryonic day 17.5
Image: GUDMAP:14620
Specimen Label: GUDMAP:14620
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1713712
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1897626
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5538907
Age: embryonic day 17.5
Image: GUDMAP:14620
Specimen Label: GUDMAP:14620
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1713712
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1897628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5538907
Age: postnatal day 84
Image: GUDMAP:14621
Specimen Label: GUDMAP:14621
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1713712
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2850628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5538907
Age: postnatal day 84
Image: GUDMAP:14621
Specimen Label: GUDMAP:14621
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1713712
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2967128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5538907
Age: postnatal day 84
Image: GUDMAP:14621
Specimen Label: GUDMAP:14621
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1713712
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2852728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5538907
Age: postnatal day 84
Image: GUDMAP:14621
Specimen Label: GUDMAP:14621
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1713712
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2831026
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5538907
Age: embryonic day 17.5
Image: GUDMAP:14620
Specimen Label: GUDMAP:14620
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1713712
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2831028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5538907
Age: postnatal day 84
Image: GUDMAP:14621
Specimen Label: GUDMAP:14621
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1713712
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2823626
Stage: TS26
Assay Id: MGI:5538907
Age: embryonic day 17.5
Image: GUDMAP:14620
Specimen Label: GUDMAP:14620
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1713712
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2823628
Stage: TS28
Assay Id: MGI:5538907
Age: postnatal day 84
Image: GUDMAP:14621
Specimen Label: GUDMAP:14621
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1713712
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2801126
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5538907
Age: embryonic day 17.5
Image: GUDMAP:14620
Specimen Label: GUDMAP:14620
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1713712
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2801128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5538907
Age: postnatal day 84
Image: GUDMAP:14621
Specimen Label: GUDMAP:14621
Detected: true
Specimen Num: 2
•
•
•
•
•
Publication
- | J:67245
   
First Author: Zimniak L
Year: 1999
Journal: GenBank Submission
Title: Mus musculus putative basolateral cTAL chloride channel ClC-Ka mRNA, complete cds
Pages: AF124848
•
•
•
•
•
Publication
8021279 | -
First Author: Adachi S
Year: 1994
Journal: J Biol Chem
Title: Two isoforms of a chloride channel predominantly expressed in thick ascending limb of Henle's loop and collecting ducts of rat kidney.
Volume: 269
Issue: 26
Pages: 17677-83
•
•
•
•
•
Publication
9326936 | -
First Author: Simon DB
Year: 1997
Journal: Nat Genet
Title: Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III.
Volume: 17
Issue: 2
Pages: 171-8
•
•
•
•
•
Publication
8041726 | -
First Author: Kieferle S
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Two highly homologous members of the ClC chloride channel family in both rat and human kidney.
Volume: 91
Issue: 15
Pages: 6943-7
•
•
•
•
•
Protein Domain
IPR002250 | Cl_channel-K
Type: Family
Description: Chloride channels (CLCs) constitute an evolutionarily well-conserved family of voltage-gated channels that are structurally unrelated to the other known voltage-gated channels. They are found in organisms ranging from bacteria to yeasts and plants, and also to animals. Their functions in higher animals likely include the regulation of cell volume, control of electrical excitability and trans-epithelial transport [].The first member of the family (CLC-0) was expression-cloned from the electric organ of Torpedo marmorata [], and subsequently nine CLC-like proteins have been cloned from mammals. They are thought to function as multimers of two or more identical or homologous subunits, and they have varying tissue distributions and functional properties. To date, CLC-0, CLC-1, CLC-2, CLC-4 and CLC-5 have been demonstrated to form functional Cl- channels; whether the remaining isoforms do so is either contested or unproven. One possible explanation for the difficulty in expressing activatable Cl- channels is that some of the isoforms may function as Cl- channels of intracellular compartments, rather than of the plasma membrane. However, they are all thought to have a similar transmembrane (TM) topology, initial hydropathy analysis suggesting 13 hydrophobic stretches long enough to form putative TM domains []. Recently, the postulated TM topology has been revised, and it now seems likely that the CLCs have 10 (or possibly 12) TM domains, with both N- and C-termini residing in the cytoplasm [].A number of human disease-causingmutations have been identified in the genes encoding CLCs. Mutations in CLCN1, the gene encoding CLC-1, the major skeletal muscle Cl- channel, lead to both recessively and dominantly-inherited forms of muscle stiffness or myotonia []. Similarly, mutations in CLCN5, which encodes CLC-5, a renal Cl- channel, lead to several forms of inherited kidney stone disease []. These mutations have been demonstrated to reduce or abolish CLC function.Two highly similar members of the CLC family have been cloned that appearto be kidney-specific isoforms. These are known as CLC-Ka and CLC-Kb inhumans and are ~90% identical (at the amino acid level); in other species,they are named CLC-K1 and CLC-K2 [, ]. Within species, the two isoformsshow differing distribution patterns in the kidney, possibly suggestingdiferent roles in renal function. To date, attempts at functional expressionof CLC-K isoforms have not yielded measurable Cl-currents; however, thatthey play a key role in normal kidney function had been made clear by thefact that naturally occurring mutations in the human gene CLCNKB (encodingCLC-Kb) lead to a form of Bartter's syndrome, an inherited kidney diseasecharacterised by hypokalaemic alkalosis []. Similarly, transgenic mice,whose CLC-K1 channel has been rendered dysfunctional by targeted genedisruption, develop overt diabetes, suggesting that these channels areimportant for urinary concentration [].
•
•
•
•
•
Publication
15713911 | J:98932
First Author: Morris RG
Year: 2005
Journal: Am J Physiol Renal Physiol
Title: Altered expression profile of transporters in the inner medullary collecting duct of aquaporin-1 knockout mice.
Volume: 289
Issue: 1
Pages: F194-9
•
•
•
•
•
Publication
29326302 | J:271965
 
First Author: Nomura N
Year: 2018
Journal: Biosci Rep
Title: Role of ClC-K and barttin in low potassium-induced sodium chloride cotransporter activation and hypertension in mouse kidney.
Volume: 38
Issue: 1
•
•
•
•
•
Protein
A2ADB4
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: true
•
•
•
•
•
Protein
Q9WUB7
Organism: Mus musculus/domesticus
Length: 687  
Fragment?: false
•
•
•
•
•
Protein
Q9WUB6
Organism: Mus musculus/domesticus
Length: 687  
Fragment?: false
•
•
•
•
•
Publication
25993027 | J:235417
First Author: Kim YM
Year: 2015
Journal: PLoS One
Title: Role of Prox1 in the Transforming Ascending Thin Limb of Henle's Loop during Mouse Kidney Development.
Volume: 10
Issue: 5
Pages: e0127429
•
•
•
•
•
Publication
23684652 | J:198739
First Author: Rossier BC
Year: 2013
Journal: FEBS Lett
Title: Genetic dissection of sodium and potassium transport along the aldosterone-sensitive distal nephron: importance in the control of blood pressure and hypertension.
Volume: 587
Issue: 13
Pages: 1929-41
•
•
•
•
•
Publication
18485340 | J:137524
First Author: Mugford JW
Year: 2008
Journal: Dev Biol
Title: Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo.
Volume: 319
Issue: 2
Pages: 396-405
•
•
•
•
•
Publication
9046241 | -
First Author: Jentsch TJ
Year: 1997
Journal: Bioessays
Title: Chloride channels: an emerging molecular picture.
Volume: 19
Issue: 2
Pages: 117-26
•
•
•
•
•
Publication
7581380 | -
First Author: Lehmann-Horn F
Year: 1995
Journal: Hum Mol Genet
Title: Myotonia levior is a chloride channel disorder.
Volume: 4
Issue: 8
Pages: 1397-402
•
•
•
•
•
Publication
2174129 | -
First Author: Jentsch TJ
Year: 1990
Journal: Nature
Title: Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes.
Volume: 348
Issue: 6301
Pages: 510-4
•
•
•
•
•
Publication
8559248 | -
First Author: Lloyd SE
Year: 1996
Journal: Nature
Title: A common molecular basis for three inherited kidney stone diseases.
Volume: 379
Issue: 6564
Pages: 445-9
•
•
•
•
•
Publication
9207144 | -
First Author: Schmidt-Rose T
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Transmembrane topology of a CLC chloride channel.
Volume: 94
Issue: 14
Pages: 7633-8
•
•
•
•
•
Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
•
•
•
•
•
Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
•
•
•
•
•
Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
•
•
•
•
•
Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
•
•
•
•
•
Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom