This entry represents a domain found in RECQ5. RecQ helicases is a group of highly conserved 3'-5' DNA helicases involved in maintaining genomic stability. RECQ5 plays an important role in DNA replication, transcription and repair [, ]. It interacts with RNA polymerase II to reduce transcription-associated replication impairment and recombination []. As a helicase, it can disrupt RAD51 filaments assembled on ssDNA, thereby inhibiting homologous recombination []. It also participates in psoralen-induced interstrand cross-link repair []. It stimulates DNA decatenation mediated by TOP2A [].
