HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function []. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding []. This domain contains the ATP-binding region. Proteins containing this domain also includes Irc5 from budding yeasts and DDM1 from Arabidopsis. DDM1 acts as a chromatin-remodeling factor required for the maintenance of genomic methylation [, ].
