|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 2501 to 2577 out of 2577 for Psen1

<< First    < Previous  |  Next >    Last >>
0.029s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Strain
MGI:5301853 | FVB.Cg-Abcb1b<tm1Bor> Abcb1a<tm1Bor> Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Attribute String: transgenic, mutant strain, targeted mutation, congenic
•
•
•
•
•
Publication
20520819 | J:160898
First Author: Fisher Y
Year: 2010
Journal: PLoS One
Title: T cells specifically targeted to amyloid plaques enhance plaque clearance in a mouse model of Alzheimer's disease.
Volume: 5
Issue: 5
Pages: e10830
•
•
•
•
•
Publication
28007893 | J:240183
First Author: Daria A
Year: 2017
Journal: EMBO J
Title: Young microglia restore amyloid plaque clearance of aged microglia.
Volume: 36
Issue: 5
Pages: 583-603
•
•
•
•
•
Publication
22159114 | J:178910
First Author: Kim J
Year: 2011
Journal: J Neurosci
Title: Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis.
Volume: 31
Issue: 49
Pages: 18007-12
•
•
•
•
•
Publication
25209291 | J:216289
First Author: Lee S
Year: 2014
Journal: J Neurosci
Title: Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway.
Volume: 34
Issue: 37
Pages: 12538-46
•
•
•
•
•
Publication
33627648 | J:303941
First Author: Colombo A
Year: 2021
Journal: Nat Commun
Title: Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia.
Volume: 12
Issue: 1
Pages: 1158
•
•
•
•
•
Publication
21191042 | J:174830
First Author: Kuczera T
Year: 2011
Journal: Learn Mem
Title: The anaphase promoting complex is required for memory function in mice.
Volume: 18
Issue: 1
Pages: 49-57
•
•
•
•
•
Publication
19838177 | J:154603
First Author: Grathwohl SA
Year: 2009
Journal: Nat Neurosci
Title: Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia.
Volume: 12
Issue: 11
Pages: 1361-3
•
•
•
•
•
Publication
32007397 | J:293293
 
First Author: Krishnamurthy K
Year: 2020
Journal: Brain Res
Title: ApoE mimetic improves pathology and memory in a model of Alzheimer's disease.
Volume: 1733
Pages: 146685
•
•
•
•
•
Publication
30692699 | J:338091
First Author: Yin C
Year: 2019
Journal: Nat Med
Title: ApoE attenuates unresolvable inflammation by complex formation with activated C1q.
Volume: 25
Issue: 3
Pages: 496-506
•
•
•
•
•
Publication
35666874 | J:336511
First Author: Eninger T
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Signatures of glial activity can be detected in the CSF proteome.
Volume: 119
Issue: 24
Pages: e2119804119
•
•
•
•
•
Publication
33848635 | J:306424
 
First Author: Janssens J
Year: 2021
Journal: Neurobiol Dis
Title: Passive immunotherapy with a novel antibody against 3pE-modified Aβ demonstrates potential for enhanced efficacy and favorable safety in combination with BACE inhibitor treatment in plaque-depositing mice.
Volume: 154
Pages: 105365
•
•
•
•
•
Publication
31831046 | J:293335
First Author: Poppe L
Year: 2019
Journal: Alzheimers Res Ther
Title: EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer's disease.
Volume: 11
Issue: 1
Pages: 102
•
•
•
•
•
Publication
32469469 | J:297566
First Author: Li KY
Year: 2020
Journal: Glia
Title: Morphological and molecular alterations of reactive astrocytes without proliferation in cerebral cortex of an APP/PS1 transgenic mouse model and Alzheimer's patients.
Volume: 68
Issue: 11
Pages: 2361-2376
•
•
•
•
•
Publication
36385530 | J:340482
First Author: Wagner J
Year: 2022
Journal: Nature
Title: Medin co-aggregates with vascular amyloid-β in Alzheimer's disease.
Volume: 612
Issue: 7938
Pages: 123-131
•
•
•
•
•
Publication
23577177 | J:199932
First Author: Krabbe G
Year: 2013
Journal: PLoS One
Title: Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology.
Volume: 8
Issue: 4
Pages: e60921
•
•
•
•
•
Publication
36076283 | J:330823
First Author: Shi H
Year: 2022
Journal: Acta Neuropathol Commun
Title: Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer's-induced retinal vasculopathy by limiting Clec7a/Galectin-3(+) neurodegenerative microglia.
Volume: 10
Issue: 1
Pages: 136
•
•
•
•
•
Publication
19556514 | J:149962
First Author: Wegenast-Braun BM
Year: 2009
Journal: Am J Pathol
Title: Independent effects of intra- and extracellular Abeta on learning-related gene expression.
Volume: 175
Issue: 1
Pages: 271-82
•
•
•
•
•
Publication
32213711 | J:312217
First Author: Zimmermann HR
Year: 2020
Journal: J Clin Invest
Title: Brain-specific repression of AMPKα1 alleviates pathophysiology in Alzheimer's model mice.
Volume: 130
Issue: 7
Pages: 3511-3527
•
•
•
•
•
Publication
29216448 | J:256096
First Author: Huynh TV
Year: 2017
Journal: Neuron
Title: Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis.
Volume: 96
Issue: 5
Pages: 1013-1023.e4
•
•
•
•
•
Publication
34671235 | J:312678
 
First Author: Willuweit A
Year: 2021
Journal: Front Neurosci
Title: Comparison of the Amyloid Load in the Brains of Two Transgenic Alzheimer's Disease Mouse Models Quantified by Florbetaben Positron Emission Tomography.
Volume: 15
Pages: 699926
•
•
•
•
•
Publication
16400027 | J:104442
First Author: Van Dooren T
Year: 2006
Journal: Am J Pathol
Title: Neuronal or glial expression of human apolipoprotein e4 affects parenchymal and vascular amyloid pathology differentially in different brain regions of double- and triple-transgenic mice.
Volume: 168
Issue: 1
Pages: 245-60
•
•
•
•
•
Publication
35649351 | J:337819
First Author: Dhandapani R
Year: 2022
Journal: Cell Rep
Title: Sustained Trem2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer's disease.
Volume: 39
Issue: 9
Pages: 110883
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/? Tg(Thy1-MAPT*P301S)2541Godt/?
Background: B6.Cg-Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr Tg(Thy1-MAPT*P301S)2541Godt
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: App/App Psen1/Psen1
Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Psen1/Psen1
Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Zygosity: ht
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Abcb1a/Abcb1a Abcb1b/Abcb1b Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Background: FVB.Cg-Abcb1b Abcb1a Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: App/App Psen1/Psen1 Tg(MAPT)8cPdav/?
Background: B6.Cg-Tg(MAPT)8cPdav Psen1 App
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Publication
28483841 | J:243588
First Author: Mazaheri F
Year: 2017
Journal: EMBO Rep
Title: TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.
Volume: 18
Issue: 7
Pages: 1186-1198
•
•
•
•
•
Publication
30617325 | J:295032
First Author: Lourenco MV
Year: 2019
Journal: Nat Med
Title: Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models.
Volume: 25
Issue: 1
Pages: 165-175
•
•
•
•
•
Publication
18566467 | J:141764
First Author: Ning A
Year: 2008
Journal: Invest Ophthalmol Vis Sci
Title: Amyloid-beta deposits lead to retinal degeneration in a mouse model of Alzheimer disease.
Volume: 49
Issue: 11
Pages: 5136-43
•
•
•
•
•
Publication
22323736 | J:181688
First Author: Cramer PE
Year: 2012
Journal: Science
Title: ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models.
Volume: 335
Issue: 6075
Pages: 1503-6
•
•
•
•
•
Publication
32508844 | J:305735
 
First Author: Joly-Amado A
Year: 2020
Journal: Front Immunol
Title: CCL2 Overexpression in the Brain Promotes Glial Activation and Accelerates Tau Pathology in a Mouse Model of Tauopathy.
Volume: 11
Pages: 997
•
•
•
•
•
Publication
14637096 | J:86694
First Author: Blanchard V
Year: 2003
Journal: Exp Neurol
Title: Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice.
Volume: 184
Issue: 1
Pages: 247-63
•
•
•
•
•
Publication
20813165 | J:169720
First Author: Mei X
Year: 2010
Journal: Neuroscience
Title: Astroglial connexin immunoreactivity is specifically altered at β-amyloid plaques in β-amyloid precursor protein/presenilin1 mice.
Volume: 171
Issue: 1
Pages: 92-105
•
•
•
•
•
Publication
26468326 | J:234065
First Author: Huang Y
Year: 2015
Journal: Sci Transl Med
Title: Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models.
Volume: 7
Issue: 309
Pages: 309ra164
•
•
•
•
•
Publication
35110643 | J:324404
First Author: McKee CA
Year: 2022
Journal: Sci Rep
Title: Astrocytes deficient in circadian clock gene Bmal1 show enhanced activation responses to amyloid-beta pathology without changing plaque burden.
Volume: 12
Issue: 1
Pages: 1796
•
•
•
•
•
Publication
27292537 | J:239634
First Author: Bacioglu M
Year: 2016
Journal: Neuron
Title: Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.
Volume: 91
Issue: 1
Pages: 56-66
•
•
•
•
•
Publication
19299585 | J:147990
First Author: Serneels L
Year: 2009
Journal: Science
Title: gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease.
Volume: 324
Issue: 5927
Pages: 639-42
•
•
•
•
•
Publication
27723233 | J:238754
First Author: Martin E
Year: 2017
Journal: Aging Cell
Title: Distinct inflammatory phenotypes of microglia and monocyte-derived macrophages in Alzheimer's disease models: effects of aging and amyloid pathology.
Volume: 16
Issue: 1
Pages: 27-38
•
•
•
•
•
Publication
29483128 | J:261602
First Author: Ulrich JD
Year: 2018
Journal: J Exp Med
Title: ApoE facilitates the microglial response to amyloid plaque pathology.
Volume: 215
Issue: 4
Pages: 1047-1058
•
•
•
•
•
Publication
27318144 | J:239037
 
First Author: Zhao L
Year: 2016
Journal: Neurobiol Aging
Title: Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.
Volume: 44
Pages: 159-172
•
•
•
•
•
Publication
20385796 | J:159279
First Author: Coomaraswamy J
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.
Volume: 107
Issue: 17
Pages: 7969-74
•
•
•
•
•
Publication
20864679 | J:166257
First Author: Lee S
Year: 2010
Journal: Am J Pathol
Title: CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.
Volume: 177
Issue: 5
Pages: 2549-62
•
•
•
•
•
Publication
30675529 | J:278079
 
First Author: Murano T
Year: 2019
Journal: Commun Biol
Title: Transcriptomic immaturity inducible by neural hyperexcitation is shared by multiple neuropsychiatric disorders.
Volume: 2
Pages: 32
•
•
•
•
•
Strain
MGI:4440866 | B6;129-Soat1<tm1Far> Psen1<tm1Mpm> Tg(APPSwe,tauP301L)1Lfa/J
Attribute String: transgenic, targeted mutation, mutant stock
•
•
•
•
•
Strain
MGI:2673730 | B6;129-Tg(APPSwe,tauP301L)1Lfa Psen1<tm1Mpm>/Mmjax
Attribute String: targeted mutation, transgenic, mutant stock
•
•
•
•
•
Strain
MGI:6503832 | B6.Cg-Tg(APPSwe,tauP301L)1Lfa Psen1<tm1Mpm>/2J
Attribute String: congenic, mutant strain, targeted mutation, transgenic
•
•
•
•
•
Strain
MGI:5003441 | B6.Cg-Psen1<tm1Mpm> Tg(APPSwe,tauP301L)1Lfa
Attribute String: congenic, mutant strain, targeted mutation, transgenic
•
•
•
•
•
Strain
MGI:6392809 | 129S4.Cg-Tg(APPSwe,tauP301L)1Lfa Psen1<tm1Mpm>/LfaJ
Attribute String: mutant strain, congenic, targeted mutation, transgenic
•
•
•
•
•
Strain
MGI:6159260 | B6.Cg-Tg(APPSwe,tauP301L)1Lfa Psen1<tm1Mpm>/J
Attribute String: congenic, mutant strain, targeted mutation, transgenic
•
•
•
•
•
Genotype
Genotype
Symbol: Psen1/Psen1 Tg(APPSwe,tauP301L)1Lfa/Tg(APPSwe,tauP301L)1Lfa
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Psen1/Psen1 Tg(APPSwe,tauP301L)1Lfa/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Psen1/Psen1 Tg(APPSwe,tauP301L)1Lfa/?
Background: B6.Cg-Psen1 Tg(APPSwe,tauP301L)1Lfa
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Publication
33508229 | J:303669
First Author: Rustenhoven J
Year: 2021
Journal: Cell
Title: Functional characterization of the dural sinuses as a neuroimmune interface.
Volume: 184
Issue: 4
Pages: 1000-1016.e27
•
•
•
•
•
Protein Coding Gene
MGI:1891700 | Ncstn
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Publication
16244651 | J:102879
First Author: Jiang D
Year: 2005
Journal: Nat Med
Title: Regulation of lung injury and repair by Toll-like receptors and hyaluronan.
Volume: 11
Issue: 11
Pages: 1173-9
•
•
•
•
•
Publication
22608241 | J:191360
First Author: Morales-Corraliza J
Year: 2013
Journal: Neurobiol Aging
Title: Immunization targeting a minor plaque constituent clears β-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model.
Volume: 34
Issue: 1
Pages: 137-45
•
•
•
•
•
Publication
24307730 | J:207169
First Author: Fisher Y
Year: 2014
Journal: J Immunol
Title: Th1 polarization of T cells injected into the cerebrospinal fluid induces brain immunosurveillance.
Volume: 192
Issue: 1
Pages: 92-102
•
•
•
•
•
Publication
35909315 | J:334648
First Author: Luo Q
Year: 2022
Journal: Aging Cell
Title: p38α-MAPK-deficient myeloid cells ameliorate symptoms and pathology of APP-transgenic Alzheimer's disease mice.
Volume: 21
Issue: 8
Pages: e13679
•
•
•
•
•
Publication
33637522 | J:327683
 
First Author: Zarb Y
Year: 2021
Journal: Sci Adv
Title: Microglia control small vessel calcification via TREM2.
Volume: 7
Issue: 9
•
•
•
•
•
Publication
20689579 | J:163067
First Author: Ghosal K
Year: 2010
Journal: PLoS One
Title: APP intracellular domain impairs adult neurogenesis in transgenic mice by inducing neuroinflammation.
Volume: 5
Issue: 7
Pages: e11866
•
•
•
•
•
Publication
28930663 | J:256695
First Author: Krasemann S
Year: 2017
Journal: Immunity
Title: The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.
Volume: 47
Issue: 3
Pages: 566-581.e9
•
•
•
•
•
Publication
21881209 | J:178230
First Author: Krohn M
Year: 2011
Journal: J Clin Invest
Title: Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice.
Volume: 121
Issue: 10
Pages: 3924-31
•
•
•
•
•
Publication
28846081 | J:258024
First Author: Füger P
Year: 2017
Journal: Nat Neurosci
Title: Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging.
Volume: 20
Issue: 10
Pages: 1371-1376
•
•
•
•
•
Publication
18026102 | J:130211
First Author: Kaeser SA
Year: 2007
Journal: Nat Genet
Title: Cystatin C modulates cerebral beta-amyloidosis.
Volume: 39
Issue: 12
Pages: 1437-9
•
•
•
•
•
Publication
29382695 | J:261595
First Author: Kress GJ
Year: 2018
Journal: J Exp Med
Title: Regulation of amyloid-β dynamics and pathology by the circadian clock.
Volume: 215
Issue: 4
Pages: 1059-1068
•
•
•
•
•
Publication
24440716 | J:208793
First Author: Sun X
Year: 2014
Journal: Cell Rep
Title: miR-342-5p decreases ankyrin G levels in Alzheimer's disease transgenic mouse models.
Volume: 6
Issue: 2
Pages: 264-70
•
•
•
•
•
Genotype
Genotype
Symbol: Cx3cr1/Cx3cr1 Psen1/Psen1 Tg(APPSwe,tauP301L)1Lfa/? Tg(Thy1-YFP)HJrs/?
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Cx3cr1/Cx3cr1<+> Psen1/Psen1 Tg(APPSwe,tauP301L)1Lfa/? Tg(Thy1-YFP)HJrs/?
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Publication
30659012 | J:276927
First Author: Goodwin LO
Year: 2019
Journal: Genome Res
Title: Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis.
Volume: 29
Issue: 3
Pages: 494-505
•
•
•
•
•
Publication
19041304 | J:174270
First Author: Levine S
Year: 2009
Journal: Exp Mol Pathol
Title: Systemic pathology in aged mouse models of Down's syndrome and Alzheimer's disease.
Volume: 86
Issue: 1
Pages: 18-22
•
•
•
•
•
Publication
31061494 | J:281547
First Author: Van Hove H
Year: 2019
Journal: Nat Neurosci
Title: A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment.
Volume: 22
Issue: 6
Pages: 1021-1035
•
•
•
•
•
Publication
30414727 | J:272048
 
First Author: Midani-Kurçak JS
Year: 2019
Journal: Brain Res
Title: Effect of tau-pathology on charged multivesicular body protein 2b (CHMP2B).
Volume: 1706
Pages: 224-236
•
•
•
•
•
Protein Coding Gene
MGI:109284 | Psen2
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Publication
31501572 | J:281635
First Author: Fecher C
Year: 2019
Journal: Nat Neurosci
Title: Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity.
Volume: 22
Issue: 10
Pages: 1731-1742
•
•
•
•
•
Publication
37130781 | J:335458
 
First Author: Stroo E
Year: 2023
Journal: Life Sci Alliance
Title: Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain.
Volume: 6
Issue: 7
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom