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Search results 401 to 493 out of 493 for Mfng

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Type Details Score
Publication
31789590 | J:299728
   
First Author: Travisano SI
Year: 2019
Journal: Elife
Title: Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade.
Volume: 8
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Publication
24552588 | J:213069
First Author: Vanorny DA
Year: 2014
Journal: Mol Endocrinol
Title: Notch signaling regulates ovarian follicle formation and coordinates follicular growth.
Volume: 28
Issue: 4
Pages: 499-511
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Publication
24391519 | J:226670
First Author: Moayedi Y
Year: 2014
Journal: PLoS Genet
Title: The candidate splicing factor Sfswap regulates growth and patterning of inner ear sensory organs.
Volume: 10
Issue: 1
Pages: e1004055
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Publication
27869233 | J:244597
 
First Author: Cui W
Year: 2016
Journal: Sci Rep
Title: Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos.
Volume: 6
Pages: 37396
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Publication
33053343 | J:305279
First Author: Morello F
Year: 2020
Journal: Cell Rep
Title: Molecular Fingerprint and Developmental Regulation of the Tegmental GABAergic and Glutamatergic Neurons Derived from the Anterior Hindbrain.
Volume: 33
Issue: 2
Pages: 108268
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Publication
14660441 | J:87048
First Author: Gu G
Year: 2004
Journal: Development
Title: Global expression analysis of gene regulatory pathways during endocrine pancreatic development.
Volume: 131
Issue: 1
Pages: 165-79
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Publication
18725516 | J:138815
First Author: Kawaguchi A
Year: 2008
Journal: Development
Title: Single-cell gene profiling defines differential progenitor subclasses in mammalian neurogenesis.
Volume: 135
Issue: 18
Pages: 3113-24
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Publication
33798452 | J:314103
First Author: Ulmke PA
Year: 2021
Journal: Stem Cell Reports
Title: Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex.
Volume: 16
Issue: 4
Pages: 968-984
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Publication
- | J:94077
     
First Author: Mutant Mouse Regional Resource Centers
Year: 2004
Journal: Unpublished
Title: Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC)
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Publication
20436479 | J:157819
First Author: Shimogori T
Year: 2010
Journal: Nat Neurosci
Title: A genomic atlas of mouse hypothalamic development.
Volume: 13
Issue: 6
Pages: 767-75
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Allele
Mfng<tm1.1Heed> | MGI:3842454
Name: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; targeted mutation 1.1, Helena Edlund
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Genotype
Genotype
Symbol: Mfng/Mfng
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Allele
Mfng<+> | MGI:2434611
   
Name: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; wild type
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GXD Expression
GXD Expression
Probe: MGI:1332538
Assay Type: RNA in situ
Annotation Date: 1999-06-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:1337815
Age: embryonic day 10.5
Image: 4.H
Note: Expression pattern is coincident with expression of Mfng (Manic Fringe).
Specimen Label: 4.H
Detected: true
Specimen Num: 2
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Allele
Mfng<tm1Cjg> | MGI:3838347
Name: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; targeted mutation 1, Cynthia J Guidos
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Mfng<em1Cya> | MGI:7585041
Name: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; endonuclease-mediated mutation 1, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Mfng<tm1Heed> | MGI:3842453
Name: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; targeted mutation 1, Helena Edlund
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Mfng<em1(IMPC)Ccpcz> | MGI:7425823
Name: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; endonuclease-mediated mutation 1, Institute of Molecular Genetics
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Mfng<tm1Seco> | MGI:3849429
Name: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; targeted mutation 1, Susan E Cole
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Mfng<tm1a(EUCOMM)Hmgu> | MGI:5050226
Name: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Mfng<tm1.1Cfg> | MGI:5052270
Name: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; targeted mutation 1.1, Consortium for Functional Glycomics
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Mfng<tm1e(EUCOMM)Hmgu> | MGI:5050255
Name: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Mfng<Gt(OST395633)Lex> | MGI:4304907
 
Name: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; gene trap OST395633, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Mfng<tm1.2Cfg> | MGI:5052271
Name: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; targeted mutation 1.2, Consortium for Functional Glycomics
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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GXD Expression
GXD Expression
Probe: MGI:1332540
Assay Type: RNA in situ
Annotation Date: 1999-06-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616417
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:1337795
Age: embryonic day 10.5
Image: 4.G
Note: Expression pattern is complementary to expression pattern of Mfng (Manic Fringe).
Specimen Label: 4.G
Detected: true
Specimen Num: 1
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Strain
MGI:5614056 | B6.Cg-Mfng<tm1Cjg>
Attribute String: targeted mutation, mutant strain, congenic
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Strain
MGI:7593223 | C57BL/6J-Mfng<em1Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7471531 | C57BL/6NCrl-Mfng<em1(IMPC)Ccpcz>/Ccpcz
Attribute String: coisogenic
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Strain
MGI:4456443 | STOCK Mfng<tm1Seco>/J
Attribute String: targeted mutation, mutant stock
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Strain
MGI:5056312 | B6.Cg-Mfng<tm1.1Cfg>/Mmucd
Attribute String: mutant strain, targeted mutation
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Strain
MGI:6440344 | B6;129S5-Mfng<Gt(OST395633)Lex>/Tac
Attribute String: mutant stock, gene trap
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Strain
MGI:5056313 | C57BL/6-Mfng<tm1.2Cfg>/Mmucd
Attribute String: targeted mutation, mutant strain, coisogenic
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Genotype
Genotype
Symbol: Mfng/Mfng
Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mfng/Mfng
Background: B6.Cg-Mfng
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mfng/Mfng
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mfng/Mfng
Background: C57BL/6NCrl-Mfng/Ccpcz
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mfng/Mfng
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mfng/Mfng<+>
Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Zygosity: ht
Has Mutant Allele: true
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Strain
MGI:4360330 | B6.Cg-Lfng<tm1Rjo> Mfng<tm1Cjg>
Attribute String: targeted mutation, mutant strain, congenic
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Genotype
Genotype
Symbol: Lfng/Lfng Mfng/Mfng
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lfng/Lfng Mfng/Mfng
Background: B6.Cg-Lfng Mfng
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lfng/Lfng Mfng/Mfng Rfng/Rfng
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ
Zygosity: cx
Has Mutant Allele: true
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HT Experiment
E-GEOD-67889 | Sequential Notch activation regulates ventricular chamber development
Series Id: GSE67889
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein Domain
IPR017374 | Fringe
Type: Family
Description: The Notch receptor is a large, cell surface transmembrane protein involved in a wide variety of developmental processes in higher organisms []. It becomes activated when its extracellular region binds to ligands located on adjacent cells. Much of this extracellular region is composed of EGF-like repeats, many of which can be O-fucosylated. A number of these O-fucosylated repeats can in turn be further modified by the action of a beta-1,3-N-acetylglucosaminyltransferase enzyme known as Fringe []. Fringe potentiates the activation of Notch by Delta ligands, while inhibiting activation by Serrate/Jagged ligands. This regulation of Notch signalling by Fringe is important in many processes [].Four distinct Fringe proteins have so far been studied in detail; Drosophila Fringe (Dfng) and its three mammalian homologues Lunatic Fringe (Lfng), Radical Fringe (Rfng) and Manic Fringe (Mfng). Dfng, Lfng and Rfng have all been shown to play important roles in developmental processes within their host, though the phenotype of mutants can vary between species eg Rfng mutants are retarded in wing development in chickens, but have no obvious phenotype in mice [, , ]. Mfng mutants have not, so far, been charcterised. Biochemical studies indicate that the Fringe proteins are fucose-specific transferases requiring manganese for activity and utilising UDP-N-acetylglucosamine as a donor substrate []. The three mammalian proteins show distinct variations in their catalytic efficiencies with different substrates.
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Protein
O09009
Organism: Mus musculus/domesticus
Length: 332  
Fragment?: false
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Protein
O09010
Organism: Mus musculus/domesticus
Length: 378  
Fragment?: false
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Protein
O09008
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: false
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Protein
Q3UPI0
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: false
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Protein
B2RRW2
Organism: Mus musculus/domesticus
Length: 378  
Fragment?: false
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Publication
12417415 | -
First Author: Haltiwanger RS
Year: 2002
Journal: Biochim Biophys Acta
Title: Modulation of receptor signaling by glycosylation: fringe is an O-fucose-beta1,3-N-acetylglucosaminyltransferase.
Volume: 1573
Issue: 3
Pages: 328-35
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Publication
14570055 | -
First Author: Haines N
Year: 2003
Journal: Nat Rev Mol Cell Biol
Title: Glycosylation regulates Notch signalling.
Volume: 4
Issue: 10
Pages: 786-97
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Publication
7954826 | -
First Author: Irvine KD
Year: 1994
Journal: Cell
Title: fringe, a Boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development.
Volume: 79
Issue: 4
Pages: 595-606
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Publication
12001066 | J:77247
First Author: Zhang N
Year: 2002
Journal: Genesis
Title: Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice.
Volume: 33
Issue: 1
Pages: 21-8
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Publication
9121551 | -
First Author: Rodriguez-Esteban C
Year: 1997
Journal: Nature
Title: Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb.
Volume: 386
Issue: 6623
Pages: 360-6
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Publication
16899492 | -
First Author: Sato T
Year: 2006
Journal: Glycobiology
Title: Molecular cloning and characterization of a novel human beta1,3-glucosyltransferase, which is localized at the endoplasmic reticulum and glucosylates O-linked fucosylglycan on thrombospondin type 1 repeat domain.
Volume: 16
Issue: 12
Pages: 1194-206
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Protein
Q08EF2
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: false
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Publication
10899003 | -
First Author: Munro S
Year: 2000
Journal: Curr Biol
Title: The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD.
Volume: 10
Issue: 14
Pages: 813-20
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Publication
11673471 | -
First Author: Ju T
Year: 2002
Journal: J Biol Chem
Title: Purification, characterization, and subunit structure of rat core 1 Beta1,3-galactosyltransferase.
Volume: 277
Issue: 1
Pages: 169-77
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Protein Domain
IPR003378 | Fringe-like
Type: Family
Description: The Notch receptor is a large, cell surface transmembrane protein involved in a wide variety of developmental processes in higher organisms []. It becomes activated when its extracellular region binds to ligands located on adjacent cells. Much of this extracellular region is composed of EGF-like repeats, many of which can be O-fucosylated. A number of these O-fucosylated repeats can in turn be further modified by the action of a beta-1,3-N-acetylglucosaminyltransferase enzyme known as Fringe []. Fringe potentiates the activation of Notch by Delta ligands, while inhibiting activation by Serrate/Jagged ligands. This regulation of Notch signalling by Fringe is important in many processes [].Four distinct Fringe proteins have so far been studied in detail; Drosophila Fringe (Dfng) and its three mammalian homologues Lunatic Fringe (Lfng), Radical Fringe (Rfng) and Manic Fringe (Mfng). Dfng, Lfng and Rfng have all been shown to play important roles in developmental processes within their host, though the phenotype of mutants can vary between species e.g. Rfng mutants are retarded in wing development in chickens, but have no obvious phenotype in mice [, , ]. Mfng mutants have not, so far, been charcterised. Biochemical studies indicate that the Fringe proteins are fucose-specific transferases requiring manganese for activity and utilising UDP-N-acetylglucosamine as a donor substrate []. The three mammalian proteins show distinct variations in their catalytic efficiencies with different substrates.Dfng is a glucosaminyltransferase that controls the response of the Notch receptor to specific ligands which is localised to the Golgi apparatus [](not secreted as previously thought). Modification of Notch occurs through glycosylation by Dfng. This entry consists of Fringe proteins and related glycosyltransferase enzymes including:Beta-1,3-glucosyltransferase, which glucosylates O-linked fucosylglycan on thrombospondin type 1 repeat domains [].Core 1 beta1,3-galactosyltransferase 1, generates the core T antigen, which is a precursor for many extended O-glycans in glycoproteins and plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development [].
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Protein
Q9JJ06
Organism: Mus musculus/domesticus
Length: 363  
Fragment?: false
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Protein
Q8BHT6
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
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Publication
10221902 | -
First Author: Artavanis-Tsakonas S
Year: 1999
Journal: Science
Title: Notch signaling: cell fate control and signal integration in development.
Volume: 284
Issue: 5415
Pages: 770-6
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