This domain is found towards the C-terminal the U3 small nucleolar RNA-associated protein 20 (UTP20) from yeast and its human homologue, also known as DRIM (Down-Regulated In Metastasis) (). DRIM is differentially expressed in metastatic and non-metastatic human breast carcinoma cells []. Proteins of this entry are involved in processing of non-coding RNA as components of the small-subunit (SSU) processome; SSU processome is involved in the biogenesis of the 18S rRNA [, ]. UTP20 is a huge α-solenoid that functions as a scaffold [, ].
This entry represents a domain found towards the N-terminal of eukaryotic proteins including U3 small nucleolar RNA-associated protein 20 from yeast and the human homologue, also known as DRIM (Down-Regulated In Metastasis) (). DRIM is differentially expressed in metastatic and non-metastatic human breast carcinoma cells []. Proteins of this entry are involved in processing of non-coding RNA as components of the small-subunit (SSU) processome; SSU processome is involved in the biogenesis of the 18S rRNA [, ]. UTP20 is a huge α-solenoid that functions as a scaffold [, ].
