Sorting nexins (SNXs) or phox homology (PX) domain-containing proteins are central regulators of cell trafficking and signalling []. SNX19, like SNX13, SNX14, and SNX25, possesses two unique PX-associated domains, but lacks the G protein-coupled receptor signaling (RGS) domain present in the others []. It plays a critical role in cartilage formation (chondrogenesis) and may be a protective factor against the progression of cartilage degradation in osteoarthritis []. SNX19 is related to several diseases, including thyroid tumors and coronary heart disease [, ].
Sorting nexins (SNXs) or phox homology (PX) domain-containing proteins are central regulators of cell trafficking and signalling []. SNX19, like SNX13, SNX14, and SNX25, possesses two unique PX-associated domains, but lacks the G protein-coupled receptor signaling (RGS) domain present in the others []. It plays a critical role in cartilage formation (chondrogenesis) and may be a protective factor againstthe progression of cartilage degradation in osteoarthritis []. SNX19 is related to several diseases, including thyroid tumors and coronary heart disease [, ].This entry represents the PX domain of SNX19.
