This entry includes Ena/VASP-like (EVL) proteins. EVL is a member of the ENA/VASP family, which is involved in actin-remodeling processes []. EVL phosphorylation by cAMP-dependent protein kinase regulates several of the interactions between EVL and its ligands []. EVL may also function in homologous recombination [, ].
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity, such as axon guidance and lamellipodial and filopodial dynamics in migrating cells [, ]. Ena/VASP proteins possess a modular domain organization, including a conserved tetramerization domain (TD) mediates the formation of Ena/VASP tetramers []. In vertebrates there are three Ena-VASP family members: Mena (Mammalian enabled), VASP, and EVL (Ena-VASP like).This entry includes VASP and Ena/VASP-like (EVL) proteins.
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity, such as axon guidance and lamellipodial and filopodial dynamics in migrating cells [, ]. Ena/VASP proteins possess a modular domain organization, including a conserved tetramerization domain (TD) mediates the formation of Ena/VASP tetramers []. In vertebrates there are three Ena-VASP family members: Mena (Mammalian enabled), VASP, and EVL (Ena-VASP like).Vasodilator-stimulated phosphoproteins (VASP) is one of the founding members of the Ena/VASP family. VASP promotes actin nucleation and increases the rate of actin polymerisation in the presence of capping protein [].
