This entry represents a group of WD repeat-containing proteins, including Ipi3 from yeasts, WDR18 from animals and RID3 from Arabidopsis. Ipi3 is part of the Rix1 complex required for the processing of 35S pre-rRNA in pre-60S ribosomal particles and for the initiation of DNA replication []. It interacts with pre-RC proteins, binds chromatin predominantly at ARS sequences in a cell cycle-regulated and ORC- and Noc3-dependent manner []. WDR18, the human Ipi3 homologue, is a component of the Five Friends of Methylated CHTOP (5FMC) complex, which is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes []. It is also involved in human DNA replication licensing [, ]. RID3 acts as negative regulator of the CUC-STM pathway in shoot apical meristem (SAM) neo-formation [].
