Multiciliate cells (MCCs) employ hundreds of motile cilia to produce a vigorous directed flow in a variety of organ systems. Basal body-orientation factor 1 (Bbof1) is a basal body protein required in MMCs to align and maintain cilia orientation in response to flow [].
This domain contains two completely conserved L residues that may be functionally important. Proteins with this domain include basal body-orientation factor 1 (bbof1), and coiled-coil domain-containing protein 166 and 121. Bbof1 is required to maintain cilia orientation [].
