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Search results 501 to 600 out of 605 for Ryr2

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Type Details Score
Publication
First Author: Santulli G
Year: 2015
Journal: J Clin Invest
Title: Calcium release channel RyR2 regulates insulin release and glucose homeostasis.
Volume: 125
Issue: 5
Pages: 1968-78
Publication
First Author: Huang G
Year: 2007
Journal: J Biol Chem
Title: Ca2+ signaling in microdomains: Homer1 mediates the interaction between RyR2 and Cav1.2 to regulate excitation-contraction coupling.
Volume: 282
Issue: 19
Pages: 14283-90
Publication
First Author: Wang Y
Year: 2020
Journal: Circulation
Title: Integrin β1D Deficiency-Mediated RyR2 Dysfunction Contributes to Catecholamine-Sensitive Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy.
Volume: 141
Issue: 18
Pages: 1477-1493
Publication
First Author: Beavers DL
Year: 2013
Journal: J Am Coll Cardiol
Title: Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization.
Volume: 62
Issue: 21
Pages: 2010-9
Protein
Organism: Mus musculus/domesticus
Length: 4966  
Fragment?: false
Allele  
Name: ryanodine receptor 2, cardiac; targeted mutation 4.1, Andrew R Marks
Allele Type: Targeted
Allele
Name: ryanodine receptor 2, cardiac; targeted mutation 3.1, Andrew R Marks
Allele Type: Targeted
Attribute String: Humanized sequence
Allele
Name: ryanodine receptor 2, cardiac; targeted mutation 2, Hector H Valdivia
Allele Type: Targeted
Attribute String: Humanized sequence, Null/knockout
Allele
Name: ryanodine receptor 2, cardiac; targeted mutation 3.1, Hector H Valdivia
Allele Type: Targeted
Attribute String: Hypomorph
Allele
Name: ryanodine receptor 2, cardiac; targeted mutation 1, Silvia G Priori
Allele Type: Targeted
Attribute String: Humanized sequence, Modified isoform(s)
Allele
Name: ryanodine receptor 2, cardiac; targeted mutation 2, Andrew R Marks
Allele Type: Targeted
Attribute String: Humanized sequence
Allele
Name: ryanodine receptor 2, cardiac; targeted mutation 1.1, Christopher Huang
Allele Type: Targeted
Attribute String: Humanized sequence
Allele  
Name: ryanodine receptor 2, cardiac; targeted mutation 1, Susan L Hamilton
Allele Type: Targeted
Genotype
Symbol: Ryr2/Ryr2<+>
Background: involves: 129/Sv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Ryr2/Ryr2<+>
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Ryr2/Ryr2<+>
Background: C57BL/6J-Ryr2
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Ryr2/Ryr2
Background: 129S/SvEv-Ryr2
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Ryr2/Ryr2<+>
Background: involves: 129 * C57BL/6
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Ryr2/Ryr2<+>
Background: involves: C57BL/6
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Ryr2/Ryr2<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Ryr2/Ryr2<+>
Background: involves: 129 * C57BL/6
Zygosity: ht
Has Mutant Allele: true
DO Term
Genotype
Symbol: Ryr2/Ryr2<+>
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Ryr2/Ryr2<+>
Background: involves: 129S7/SvEvBrd * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
Publication
First Author: Dulhunty AF
Year: 2005
Journal: Biochem J
Title: A recently identified member of the glutathione transferase structural family modifies cardiac RyR2 substate activity, coupled gating and activation by Ca2+ and ATP.
Volume: 390
Issue: Pt 1
Pages: 333-43
Allele
Name: ryanodine receptor 2, cardiac; mutation 3, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
Allele
Name: ryanodine receptor 2, cardiac; endonuclease-mediated mutation 1, S R Wayne Chen
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
Allele
Name: ryanodine receptor 2, cardiac; mutation 2, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
Allele
Name: transgene insertion 1, Jeffery Molkentin
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
Publication
First Author: Cabra V
Year: 2016
Journal: Biophys J
Title: Ultrastructural Analysis of Self-Associated RyR2s.
Volume: 110
Issue: 12
Pages: 2651-2662
Protein Domain
Type: Domain
Description: This SPRY domain is the first of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR) []. There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3 []. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs []. The first domain may be involved in RyR2 dimerization [].
Strain
Attribute String: coisogenic, mutant strain, transgenic
Publication
First Author: Correll RN
Year: 2017
Journal: Sci Rep
Title: Mitsugumin 29 regulates t-tubule architecture in the failing heart.
Volume: 7
Issue: 1
Pages: 5328
Strain
Attribute String: chemically induced mutation, coisogenic, mutant strain
Allele
Name: ryanodine receptor 2, cardiac; mutation 1, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
Strain
Attribute String: chemically induced mutation, coisogenic, mutant strain
Strain
Attribute String: mutant strain, chemically induced mutation, coisogenic
Genotype
Symbol: Ryr2/Ryr2
Background: C57BL/6J-Ryr2
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Ryr2/Ryr2
Background: C57BL/6J-Ryr2
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Ryr2/Ryr2
Background: C57BL/6J-Ryr2
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Ryr2/Ryr2
Background: involves: 129 * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Ryr2/Ryr2<+>
Background: involves: 129 * C57BL/6
Zygosity: ht
Has Mutant Allele: true
Publication
First Author: Lanner JT
Year: 2010
Journal: Cold Spring Harb Perspect Biol
Title: Ryanodine receptors: structure, expression, molecular details, and function in calcium release.
Volume: 2
Issue: 11
Pages: a003996
Publication
First Author: Tae H
Year: 2009
Journal: Eur Biophys J
Title: Ubiquitous SPRY domains and their role in the skeletal type ryanodine receptor.
Volume: 39
Issue: 1
Pages: 51-9
Publication
First Author: Tae HS
Year: 2009
Journal: Clin Exp Pharmacol Physiol
Title: Molecular recognition of the disordered dihydropyridine receptor II-III loop by a conserved spry domain of the type 1 ryanodine receptor.
Volume: 36
Issue: 3
Pages: 346-9
Publication
First Author: Tae H
Year: 2011
Journal: Channels (Austin)
Title: The elusive role of the SPRY2 domain in RyR1.
Volume: 5
Issue: 2
Pages: 148-60
Protein Domain
Type: Domain
Description: This SPRY domain is the third of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR) []. There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3 []. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, but no specific function has been found for this third SPRY domain of the RyRs [].
Protein Domain
Type: Domain
Description: This SPRY domain (SPRY2) is the second of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR). There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, The SPRY2 domain has been shown to bind to the dihydropryidine receptor (DHPR) II-III loop and the ASI region of RyR1 [, ].
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Wright NT
Year: 2008
Journal: J Biol Chem
Title: S100A1 and calmodulin compete for the same binding site on ryanodine receptor.
Volume: 283
Issue: 39
Pages: 26676-83
Publication  
First Author: Aschar-Sobbi R
Year: 2015
Journal: Nat Commun
Title: Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFα.
Volume: 6
Pages: 6018
Publication
First Author: Han RW
Year: 2020
Journal: Mol Brain
Title: Role of lateral amygdala calstabin2 in regulation of fear memory.
Volume: 13
Issue: 1
Pages: 35
Publication
First Author: Ling H
Year: 2009
Journal: J Clin Invest
Title: Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.
Volume: 119
Issue: 5
Pages: 1230-40
Publication
First Author: Benson MA
Year: 2017
Journal: Sci Rep
Title: Ryanodine receptors are part of the myospryn complex in cardiac muscle.
Volume: 7
Issue: 1
Pages: 6312
Publication
First Author: Song L
Year: 2007
Journal: J Clin Invest
Title: Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardia.
Volume: 117
Issue: 7
Pages: 1814-23
Publication
First Author: Roux-Buisson N
Year: 2012
Journal: Hum Mol Genet
Title: Absence of triadin, a protein of the calcium release complex, is responsible for cardiac arrhythmia with sudden death in human.
Volume: 21
Issue: 12
Pages: 2759-67
Publication
First Author: Okada H
Year: 2013
Journal: J Clin Invest
Title: Integrins protect cardiomyocytes from ischemia/reperfusion injury.
Volume: 123
Issue: 10
Pages: 4294-308
Publication
First Author: Chakroborty S
Year: 2009
Journal: J Neurosci
Title: Deviant ryanodine receptor-mediated calcium release resets synaptic homeostasis in presymptomatic 3xTg-AD mice.
Volume: 29
Issue: 30
Pages: 9458-70
Publication
First Author: Cerrone M
Year: 2017
Journal: Nat Commun
Title: Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm.
Volume: 8
Issue: 1
Pages: 106
Publication
First Author: Matsuki K
Year: 2018
Journal: Am J Physiol Cell Physiol
Title: Negative regulation of cellular Ca2+ mobilization by ryanodine receptor type 3 in mouse mesenteric artery smooth muscle.
Volume: 315
Issue: 1
Pages: C1-C9
Publication
First Author: Sawada K
Year: 2008
Journal: Neuroscience
Title: Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya.
Volume: 152
Issue: 3
Pages: 609-17
Publication
First Author: Fritz N
Year: 2007
Journal: J Cell Sci
Title: RyR1-specific requirement for depolarization-induced Ca2+ sparks in urinary bladder smooth muscle.
Volume: 120
Issue: Pt 21
Pages: 3784-91
Publication
First Author: Delgado C
Year: 2015
Journal: Cardiovasc Res
Title: NOD1, a new player in cardiac function and calcium handling.
Volume: 106
Issue: 3
Pages: 375-86
Publication
First Author: Wang H
Year: 2010
Journal: J Physiol
Title: Regulation of myocyte contraction via neuronal nitric oxide synthase: role of ryanodine receptor S-nitrosylation.
Volume: 588
Issue: Pt 15
Pages: 2905-17
Publication
First Author: Griffin CS
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: The intracellular Ca2+ release channel TRPML1 regulates lower urinary tract smooth muscle contractility.
Volume: 117
Issue: 48
Pages: 30775-30786
Publication
First Author: Batiste SM
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic.
Volume: 116
Issue: 11
Pages: 4810-4815
Publication
First Author: Kalyanasundaram A
Year: 2013
Journal: Cardiovasc Res
Title: Up-regulation of sarcoplasmic reticulum Ca(2+) uptake leads to cardiac hypertrophy, contractile dysfunction and early mortality in mice deficient in CASQ2.
Volume: 98
Issue: 2
Pages: 297-306
Publication
First Author: Yan J
Year: 2018
Journal: Circ Res
Title: Stress Signaling JNK2 Crosstalk With CaMKII Underlies Enhanced Atrial Arrhythmogenesis.
Volume: 122
Issue: 6
Pages: 821-835
Publication
First Author: Radwański PB
Year: 2015
Journal: Cardiovasc Res
Title: Neuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release.
Volume: 106
Issue: 1
Pages: 143-52
Publication  
First Author: Blackwell DJ
Year: 2022
Journal: JCI Insight
Title: The Purkinje-myocardial junction is the anatomic origin of ventricular arrhythmia in CPVT.
Volume: 7
Issue: 3
Publication  
First Author: Brandenburg S
Year: 2019
Journal: JCI Insight
Title: Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis.
Volume: 4
Issue: 12
Publication
First Author: Zhang T
Year: 2010
Journal: Circ Res
Title: Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice.
Volume: 106
Issue: 2
Pages: 354-62
Publication
First Author: Zhang IX
Year: 2023
Journal: J Biol Chem
Title: ER stress increases expression of intracellular calcium channel RyR1 to modify Ca(2+) homeostasis in pancreatic beta cells.
Volume: 299
Issue: 8
Pages: 105065
Publication
First Author: Liu Y
Year: 2011
Journal: Assay Drug Dev Technol
Title: Transgenic analysis of the role of FKBP12.6 in cardiac function and intracellular calcium release.
Volume: 9
Issue: 6
Pages: 620-7
Publication
First Author: Yamamoto T
Year: 2022
Journal: J Mol Med (Berl)
Title: I536T variant of RBM20 affects splicing of cardiac structural proteins that are causative for developing dilated cardiomyopathy.
Volume: 100
Issue: 12
Pages: 1741-1754
Publication
First Author: Little SC
Year: 2015
Journal: Sci Signal
Title: Protein phosphatase 2A regulatory subunit B56α limits phosphatase activity in the heart.
Volume: 8
Issue: 386
Pages: ra72
Publication
First Author: Gellen B
Year: 2008
Journal: Circulation
Title: Conditional FKBP12.6 overexpression in mouse cardiac myocytes prevents triggered ventricular tachycardia through specific alterations in excitation-contraction coupling.
Volume: 117
Issue: 14
Pages: 1778-86
Publication
First Author: Valdivia CR
Year: 2010
Journal: Cardiovasc Res
Title: Loss-of-function mutation of the SCN3B-encoded sodium channel {beta}3 subunit associated with a case of idiopathic ventricular fibrillation.
Volume: 86
Issue: 3
Pages: 392-400
Publication
First Author: Seidler T
Year: 2011
Journal: J Mol Cell Cardiol
Title: Limitations of FKBP12.6-directed treatment strategies for maladaptive cardiac remodeling and heart failure.
Volume: 50
Issue: 1
Pages: 33-42
Publication
First Author: Zissimopoulos S
Year: 2012
Journal: J Cell Sci
Title: Disparities in the association of the ryanodine receptor and the FK506-binding proteins in mammalian heart.
Volume: 125
Issue: Pt 7
Pages: 1759-69
Publication
First Author: Lewarchik CM
Year: 2014
Journal: Am J Physiol Gastrointest Liver Physiol
Title: The ryanodine receptor is expressed in human pancreatic acinar cells and contributes to acinar cell injury.
Volume: 307
Issue: 5
Pages: G574-81
Publication  
First Author: Yuen GK
Year: 2017
Journal: J Mol Cell Cardiol
Title: Subcellular localization of Na/K-ATPase isoforms in ventricular myocytes.
Volume: 108
Pages: 158-169
Publication  
First Author: Liu B
Year: 2020
Journal: Int J Mol Sci
Title: Conditional Up-Regulation of SERCA2a Exacerbates RyR2-Dependent Ventricular and Atrial Arrhythmias.
Volume: 21
Issue: 7
Publication
First Author: Dridi H
Year: 2021
Journal: Hum Mol Genet
Title: Ryanodine receptor remodeling in cardiomyopathy and muscular dystrophy caused by lamin A/C gene mutation.
Volume: 29
Issue: 24
Pages: 3919-3934
Protein
Organism: Mus musculus/domesticus
Length: 5035  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 4863  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 4868  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 4966  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 5033  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 4858  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 5061  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 4888  
Fragment?: false
Publication
First Author: Tow BD
Year: 2022
Journal: Cardiovasc Res
Title: SR-Mitochondria Crosstalk Shapes Ca Signalling to Impact Pathophenotype in Disease Models Marked by Dysregulated Intracellular Ca Release.
Volume: 118
Issue: 13
Pages: 2819-2832
Publication
First Author: Chakroborty S
Year: 2012
Journal: PLoS One
Title: Stabilizing ER Ca2+ channel function as an early preventative strategy for Alzheimer's disease.
Volume: 7
Issue: 12
Pages: e52056
Publication
First Author: Huang W
Year: 2011
Journal: Exp Eye Res
Title: Localization and phenotype-specific expression of ryanodine calcium release channels in C57BL6 and DBA/2J mouse strains.
Volume: 93
Issue: 5
Pages: 700-9
Publication
First Author: Matsuki K
Year: 2017
Journal: Pflugers Arch
Title: Ryanodine receptor type 3 does not contribute to contractions in the mouse myometrium regardless of pregnancy.
Volume: 469
Issue: 2
Pages: 313-326
Publication
First Author: Kadosaka T
Year: 2023
Journal: Am J Physiol Heart Circ Physiol
Title: Empagliflozin attenuates arrhythmogenesis in diabetic cardiomyopathy by normalizing intracellular Ca(2+) handling in ventricular cardiomyocytes.
Volume: 324
Issue: 3
Pages: H341-H354
Publication
First Author: Liu X
Year: 2021
Journal: Circulation
Title: Increased Reactive Oxygen Species-Mediated Ca(2+)/Calmodulin-Dependent Protein Kinase II Activation Contributes to Calcium Handling Abnormalities and Impaired Contraction in Barth Syndrome.
Volume: 143
Issue: 19
Pages: 1894-1911
Publication  
First Author: Zhang JC
Year: 2018
Journal: Front Physiol
Title: Calcium-Mediated Oscillation in Membrane Potentials and Atrial-Triggered Activity in Atrial Cells of Casq2R33Q/R33Q Mutation Mice.
Volume: 9
Pages: 1447
Publication  
First Author: Chen M
Year: 2018
Journal: J Mol Cell Cardiol
Title: Phospholamban regulates nuclear Ca2+ stores and inositol 1,4,5-trisphosphate mediated nuclear Ca2+ cycling in cardiomyocytes.
Volume: 123
Pages: 185-197