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Search results 101 to 200 out of 306 for Lrrk2

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Type Details Score
Publication
28930069 | J:245087
   
First Author: Volta M
Year: 2017
Journal: Elife
Title: Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice.
Volume: 6
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27378696 | J:237862
First Author: Ma B
Year: 2016
Journal: Hum Mol Genet
Title: LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways.
Volume: 25
Issue: 16
Pages: 3515-3523
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Publication
29434188 | J:331017
First Author: Tozzi A
Year: 2018
Journal: Cell Death Dis
Title: Dopamine D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson's disease.
Volume: 9
Issue: 2
Pages: 204
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Publication
21983832 | J:177641
First Author: Liu Z
Year: 2011
Journal: Nat Immunol
Title: The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease.
Volume: 12
Issue: 11
Pages: 1063-70
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Publication
32374202 | J:332757
First Author: Guevara CA
Year: 2020
Journal: J Neurophysiol
Title: LRRK2 mutation alters behavioral, synaptic, and nonsynaptic adaptations to acute social stress.
Volume: 123
Issue: 6
Pages: 2382-2389
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Publication
21390248 | J:196255
First Author: Li X
Year: 2011
Journal: PLoS One
Title: Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease.
Volume: 6
Issue: 3
Pages: e17153
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Publication
37269951 | J:337941
First Author: Pajarillo E
Year: 2023
Journal: J Biol Chem
Title: The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction.
Volume: 299
Issue: 7
Pages: 104879
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Publication
22647713 | J:188435
 
First Author: Hinkle KM
Year: 2012
Journal: Mol Neurodegener
Title: LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors.
Volume: 7
Pages: 25
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Publication
30398148 | J:316366
   
First Author: Dhekne HS
Year: 2018
Journal: Elife
Title: A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain.
Volume: 7
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Publication
21828077 | J:176679
First Author: Herzig MC
Year: 2011
Journal: Hum Mol Genet
Title: LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice.
Volume: 20
Issue: 21
Pages: 4209-23
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Publication
32111741 | J:300123
First Author: Levy DR
Year: 2020
Journal: J Biol Chem
Title: The Parkinson's disease-associated kinase LRRK2 regulates genes required for cell adhesion, polarization, and chemotaxis in activated murine macrophages.
Volume: 295
Issue: 31
Pages: 10857-10867
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Publication
29908325 | J:268598
 
First Author: Tozzi A
Year: 2018
Journal: Neurobiol Dis
Title: Dopamine D2 receptor activation potently inhibits striatal glutamatergic transmission in a G2019S LRRK2 genetic model of Parkinson's disease.
Volume: 118
Pages: 1-8
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Publication
27357661 | J:235302
First Author: Guaitoli G
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.
Volume: 113
Issue: 30
Pages: E4357-66
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Publication
33459343 | J:305195
First Author: Malik AU
Year: 2021
Journal: Biochem J
Title: Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms.
Volume: 478
Issue: 3
Pages: 553-578
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Publication
30209220 | J:266343
First Author: Eguchi T
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis.
Volume: 115
Issue: 39
Pages: E9115-E9124
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Publication
25107341 | J:218326
 
First Author: Longo F
Year: 2014
Journal: Neurobiol Dis
Title: Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging.
Volume: 71
Pages: 62-73
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Publication
34419621 | J:312977
 
First Author: Albanese F
Year: 2021
Journal: Neurobiol Dis
Title: Constitutive silencing of LRRK2 kinase activity leads to early glucocerebrosidase deregulation and late impairment of autophagy in vivo.
Volume: 159
Pages: 105487
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Publication
37904222 | J:342232
First Author: Mazaki Y
Year: 2023
Journal: Cell Commun Signal
Title: LRRK2 is involved in the chemotaxis of neutrophils and differentiated HL-60 cells, and the inhibition of LRRK2 kinase activity increases fMLP-induced chemotactic activity.
Volume: 21
Issue: 1
Pages: 300
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Publication
20659021 | J:196268
First Author: Dzamko N
Year: 2010
Journal: Biochem J
Title: Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization.
Volume: 430
Issue: 3
Pages: 405-13
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Publication
34313548 | J:321684
First Author: Nabar NR
Year: 2022
Journal: Autophagy
Title: LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells.
Volume: 18
Issue: 1
Pages: 204-222
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Publication
30089035 | J:283162
First Author: Lanning NJ
Year: 2018
Journal: Am J Physiol Renal Physiol
Title: LRRK2 deficiency impairs trans-Golgi to lysosome trafficking and endocytic cargo degradation in human renal proximal tubule epithelial cells.
Volume: 315
Issue: 5
Pages: F1465-F1477
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Publication
24794857 | J:213877
First Author: Dusonchet J
Year: 2014
Journal: Hum Mol Genet
Title: A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity.
Volume: 23
Issue: 18
Pages: 4887-905
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Publication
25830304 | J:233432
First Author: Garcia-Miralles M
Year: 2015
Journal: PLoS One
Title: No dopamine cell loss or changes in cytoskeleton function in transgenic mice expressing physiological levels of wild type or G2019S mutant LRRK2 and in human fibroblasts.
Volume: 10
Issue: 4
Pages: e0118947
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30983487 | J:297708
First Author: Ho PW
Year: 2020
Journal: Autophagy
Title: Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA).
Volume: 16
Issue: 2
Pages: 347-370
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Publication
32247534 | J:297147
 
First Author: Dwyer Z
Year: 2020
Journal: Neurobiol Aging
Title: Leucine-rich repeat kinase-2 (LRRK2) modulates microglial phenotype and dopaminergic neurodegeneration.
Volume: 91
Pages: 45-55
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Publication
31554740 | J:293628
 
First Author: Shutinoski B
Year: 2019
Journal: Sci Transl Med
Title: Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner.
Volume: 11
Issue: 511
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Publication
27872856 | J:316245
 
First Author: Wu B
Year: 2016
Journal: Biomed Res Int
Title: Altered Expression of EPO Might Underlie Hepatic Hemangiomas in LRRK2 Knockout Mice.
Volume: 2016
Pages: 7681259
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27798112 | J:241450
First Author: Han KA
Year: 2017
Journal: Hum Mol Genet
Title: Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation.
Volume: 26
Issue: 1
Pages: 1-18
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Publication
36358985 | J:331902
 
First Author: Sitzia G
Year: 2022
Journal: Biomolecules
Title: Neuronal Firing and Glutamatergic Synapses in the Substantia Nigra Pars Reticulata of LRRK2-G2019S Mice.
Volume: 12
Issue: 11
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Publication
27413152 | J:311063
First Author: Volpicelli-Daley LA
Year: 2016
Journal: J Neurosci
Title: G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons.
Volume: 36
Issue: 28
Pages: 7415-27
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Publication
31046837 | J:277876
First Author: Lee JH
Year: 2019
Journal: Acta Neuropathol Commun
Title: Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes.
Volume: 7
Issue: 1
Pages: 68
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Publication
17623048 | J:128036
First Author: Li X
Year: 2007
Journal: J Neurochem
Title: Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants.
Volume: 103
Issue: 1
Pages: 238-47
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25301747 | J:221458
 
First Author: Caesar M
Year: 2015
Journal: Neuroscience
Title: Changes in actin dynamics and F-actin structure both in synaptoneurosomes of LRRK2(R1441G) mutant mice and in primary human fibroblasts of LRRK2(G2019S) mutation carriers.
Volume: 284
Pages: 311-24
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35907404 | J:327629
First Author: Weindel CG
Year: 2022
Journal: Cell
Title: Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis.
Volume: 185
Issue: 17
Pages: 3214-3231.e23
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22357653 | J:183780
First Author: Daher JP
Year: 2012
Journal: Hum Mol Genet
Title: Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.
Volume: 21
Issue: 11
Pages: 2420-31
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24652679 | J:210972
First Author: Caesar M
Year: 2014
Journal: Glia
Title: Changes in matrix metalloprotease activity and progranulin levels may contribute to the pathophysiological function of mutant leucine-rich repeat kinase 2.
Volume: 62
Issue: 7
Pages: 1075-92
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20729864 | J:164440
First Author: Lee BD
Year: 2010
Journal: Nat Med
Title: Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.
Volume: 16
Issue: 9
Pages: 998-1000
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18367605 | J:133490
First Author: Wang L
Year: 2008
Journal: J Neurosci
Title: The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.
Volume: 28
Issue: 13
Pages: 3384-91
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30571694 | J:269924
First Author: Bardai FH
Year: 2018
Journal: PLoS Biol
Title: Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics.
Volume: 16
Issue: 12
Pages: e2006265
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20064389 | J:156512
First Author: Lin X
Year: 2009
Journal: Neuron
Title: Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.
Volume: 64
Issue: 6
Pages: 807-27
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26123485 | J:222392
First Author: Liu G
Year: 2015
Journal: Hum Mol Genet
Title: Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression.
Volume: 24
Issue: 18
Pages: 5299-312
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29125462 | J:255588
   
First Author: Steger M
Year: 2017
Journal: Elife
Title: Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.
Volume: 6
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Publication
23318930 | J:197757
 
First Author: Caesar M
Year: 2013
Journal: Neurobiol Dis
Title: Leucine-rich repeat kinase 2 functionally interacts with microtubules and kinase-dependently modulates cell migration.
Volume: 54
Pages: 280-8
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19176810 | J:144828
First Author: Ho CC
Year: 2009
Journal: J Neurosci
Title: The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration.
Volume: 29
Issue: 4
Pages: 1011-6
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Publication
29056298 | J:243749
     
First Author: Giaime E
Year: 2017
Journal: Neuron
Title: Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice.
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19196961 | J:248244
First Author: Ko HS
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity.
Volume: 106
Issue: 8
Pages: 2897-902
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24687852 | J:209576
First Author: Piccoli G
Year: 2014
Journal: Mol Cell Biol
Title: Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain.
Volume: 34
Issue: 12
Pages: 2147-61
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Publication
27474410 | J:237182
First Author: Ito G
Year: 2016
Journal: Biochem J
Title: Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors.
Volume: 473
Issue: 17
Pages: 2671-85
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31166814 | J:294022
First Author: Yan J
Year: 2019
Journal: FASEB J
Title: Leucine-rich repeat kinase 2 regulates mouse dendritic cell migration by ORAI2.
Volume: 33
Issue: 9
Pages: 9775-9784
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28120865 | J:275127
 
First Author: Hosseinzadeh Z
Year: 2017
Journal: Sci Rep
Title: Leucine-Rich Repeat Kinase 2 (Lrrk2)-Sensitive Na+/K+ ATPase Activity in Dendritic Cells.
Volume: 7
Pages: 41117
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34030727 | J:337359
First Author: Sarkar S
Year: 2021
Journal: Mol Neurodegener
Title: Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo.
Volume: 16
Issue: 1
Pages: 33
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21695257 | J:174288
First Author: Schulz C
Year: 2011
Journal: PLoS One
Title: Leucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cells.
Volume: 6
Issue: 6
Pages: e20820
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28168579 | J:328374
First Author: Maekawa T
Year: 2017
Journal: Dig Dis Sci
Title: LRRK2: An Emerging New Molecule in the Enteric Neuronal System That Quantitatively Regulates Neuronal Peptides and IgA in the Gut.
Volume: 62
Issue: 4
Pages: 903-912
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Publication
32164260 | J:297976
 
First Author: Kubo M
Year: 2020
Journal: Int J Mol Sci
Title: Leucine-Rich Repeat Kinase 2 Controls Inflammatory Cytokines Production through NF-κB Phosphorylation and Antigen Presentation in Bone Marrow-Derived Dendritic Cells.
Volume: 21
Issue: 5
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31555076 | J:284326
 
First Author: Maekawa T
Year: 2019
Journal: Front Neurosci
Title: Leucine-Rich Repeat Kinase 2 Is Associated With Activation of the Paraventricular Nucleus of the Hypothalamus and Stress-Related Gastrointestinal Dysmotility.
Volume: 13
Pages: 905
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22423108 | J:183238
First Author: Xiong Y
Year: 2012
Journal: J Neurosci
Title: ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2.
Volume: 32
Issue: 11
Pages: 3877-86
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19740074 | J:157807
First Author: Nichols RJ
Year: 2009
Journal: Biochem J
Title: Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease.
Volume: 424
Issue: 1
Pages: 47-60
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22612223 | J:187526
First Author: Rudenko IN
Year: 2012
Journal: Biochem J
Title: The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation.
Volume: 446
Issue: 1
Pages: 99-111
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23125283 | J:191213
First Author: Cho HJ
Year: 2013
Journal: Hum Mol Genet
Title: MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein.
Volume: 22
Issue: 3
Pages: 608-20
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31813996 | J:288260
First Author: Arbez N
Year: 2020
Journal: Hum Mol Genet
Title: G2019S-LRRK2 mutation enhances MPTP-linked Parkinsonism in mice.
Volume: 29
Issue: 4
Pages: 580-590
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26237551 | J:233100
First Author: Zhang Q
Year: 2015
Journal: Nat Immunol
Title: Commensal bacteria direct selective cargo sorting to promote symbiosis.
Volume: 16
Issue: 9
Pages: 918-26
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25201882 | J:216361
First Author: Cho HJ
Year: 2014
Journal: EMBO J
Title: Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export.
Volume: 33
Issue: 20
Pages: 2314-31
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26375402 | J:228527
First Author: Civiero L
Year: 2015
Journal: J Neurochem
Title: Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.
Volume: 135
Issue: 6
Pages: 1242-56
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21370995 | J:190279
First Author: Cui J
Year: 2011
Journal: Biosci Rep
Title: Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system.
Volume: 31
Issue: 5
Pages: 429-37
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22736029 | J:187412
First Author: Papkovskaia TD
Year: 2012
Journal: Hum Mol Genet
Title: G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization.
Volume: 21
Issue: 19
Pages: 4201-13
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20403420 | J:161970
First Author: Zechel S
Year: 2010
Journal: Int J Dev Neurosci
Title: Expression of leucine-rich-repeat-kinase 2 (LRRK2) during embryonic development.
Volume: 28
Issue: 5
Pages: 391-9
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26067490 | J:237696
First Author: Wandu WS
Year: 2015
Journal: PLoS One
Title: Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response.
Volume: 10
Issue: 6
Pages: e0128906
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32075681 | J:305501
First Author: Chen X
Year: 2020
Journal: Mol Neurodegener
Title: Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging.
Volume: 15
Issue: 1
Pages: 12
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25609428 | J:220995
First Author: Yan J
Year: 2015
Journal: FASEB J
Title: Leucine-rich repeat kinase 2-sensitive Na+/Ca2+ exchanger activity in dendritic cells.
Volume: 29
Issue: 5
Pages: 1701-10
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22952686 | J:196230
First Author: Civiero L
Year: 2012
Journal: PLoS One
Title: Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers.
Volume: 7
Issue: 8
Pages: e43472
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20146535 | J:161666
First Author: Liu M
Year: 2010
Journal: Biochemistry
Title: Kinetic mechanistic studies of wild-type leucine-rich repeat kinase 2: characterization of the kinase and GTPase activities.
Volume: 49
Issue: 9
Pages: 2008-17
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34555357 | J:334103
First Author: Scheiblich H
Year: 2021
Journal: Cell
Title: Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes.
Volume: 184
Issue: 20
Pages: 5089-5106.e21
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24510904 | J:206826
First Author: Beilina A
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.
Volume: 111
Issue: 7
Pages: 2626-31
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20457918 | J:160542
First Author: Tong Y
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice.
Volume: 107
Issue: 21
Pages: 9879-84
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19545277 | J:152261
First Author: Gillardon F
Year: 2009
Journal: J Neurochem
Title: Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?
Volume: 110
Issue: 5
Pages: 1514-22
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17101029 | J:121093
First Author: Higashi S
Year: 2007
Journal: J Neurochem
Title: Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain.
Volume: 100
Issue: 2
Pages: 368-81
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29743203 | J:263679
First Author: Mir R
Year: 2018
Journal: Biochem J
Title: The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.
Volume: 475
Issue: 11
Pages: 1861-1883
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17341485 | J:121772
First Author: Hatano T
Year: 2007
Journal: Hum Mol Genet
Title: Leucine-rich repeat kinase 2 associates with lipid rafts.
Volume: 16
Issue: 6
Pages: 678-90
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22639965 | J:186257
First Author: Niu J
Year: 2012
Journal: J Neurochem
Title: Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein.
Volume: 122
Issue: 3
Pages: 650-8
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35534227 | J:341309
First Author: Huang G
Year: 2022
Journal: J Neurosci
Title: Motor Impairments and Dopaminergic Defects Caused by Loss of Leucine-Rich Repeat Kinase Function in Mice.
Volume: 42
Issue: 23
Pages: 4755-4765
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27383589 | J:234639
First Author: Matikainen-Ankney BA
Year: 2016
Journal: J Neurosci
Title: Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S Mutation.
Volume: 36
Issue: 27
Pages: 7128-41
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Publication
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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