LYRIC (Lysine-rich CEACAM1 co-isolated protein), also known as Astrocyte-elevated gene-1 (AEG-1), is a type-1b membrane protein with a single transmembrane domain and localises to the endoplasmic reticulum and the nuclear envelope. It is also found in the nucleolus, suggesting functional relationships between these two cellular compartments []. It is found to be colocalised with tight junction proteins ZO-1 and occludin in polarised epithelial cells, suggesting that LYRIC is part of the tight junction complex []. LYRIC has been shown to promote angiogenesis []and tumour cell migration and invasion by activating the transcription factor NF-kappaB [, , ].
