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Search results 701 to 800 out of 933 for Parp1

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Type Details Score
Strain
Attribute String: congenic, gene trap, mutant strain
Publication
First Author: Krastev DB
Year: 2022
Journal: Nat Cell Biol
Title: The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.
Volume: 24
Issue: 1
Pages: 62-73
Publication  
First Author: Mashimo M
Year: 2019
Journal: JCI Insight
Title: PARP1 inhibition alleviates injury in ARH3-deficient mice and human cells.
Volume: 4
Issue: 4
Publication  
First Author: Mochizuki AL
Year: 2017
Journal: Mol Cell Biol
Title: PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice.
Volume: 37
Issue: 23
Allele  
Name: PARP1 binding protein; wild type
Allele Type: Not Specified
Publication
First Author: Pettitt SJ
Year: 2018
Journal: Nat Commun
Title: Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance.
Volume: 9
Issue: 1
Pages: 1849
Publication
First Author: Wang C
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors.
Volume: 117
Issue: 42
Pages: 26356-26365
Publication
First Author: Komulainen E
Year: 2021
Journal: EMBO Rep
Title: Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures.
Volume: 22
Issue: 5
Pages: e51851
Publication
First Author: Adamowicz M
Year: 2021
Journal: Nat Cell Biol
Title: XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair.
Volume: 23
Issue: 12
Pages: 1287-1298
Publication  
First Author: Wan Y
Year: 2023
Journal: J Cell Biol
Title: KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway.
Volume: 222
Issue: 2
Publication
First Author: Sakthianandeswaren A
Year: 2018
Journal: Cancer Discov
Title: MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors.
Volume: 8
Issue: 8
Pages: 988-1005
Publication
First Author: Shang F
Year: 2016
Journal: PLoS One
Title: Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade.
Volume: 11
Issue: 3
Pages: e0151845
Publication
First Author: Sullivan-Reed K
Year: 2023
Journal: Mol Cancer Res
Title: Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination-Deficient Leukemia Cells.
Volume: 21
Issue: 10
Pages: 1017-1022
Allele
Name: PARP1 binding protein; targeted mutation 1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele
Name: PARP1 binding protein; targeted mutation 1.1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Publication
First Author: Jing CB
Year: 2020
Journal: Leukemia
Title: Synthetic lethal targeting of TET2-mutant hematopoietic stem and progenitor cells (HSPCs) with TOP1-targeted drugs and PARP1 inhibitors.
Volume: 34
Issue: 11
Pages: 2992-3006
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1603920
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6692116
Age: embryonic day 12.5
Image: JAX_1263811
Specimen Label: JAX_1263811
Detected: true
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1603920
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6692116
Age: embryonic day 12.5
Image: JAX_1263813
Specimen Label: JAX_1263813
Detected: true
Specimen Num: 2
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1603920
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6692116
Age: embryonic day 12.5
Image: JAX_1263815
Specimen Label: JAX_1263815
Detected: true
Specimen Num: 3
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1603920
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6692116
Age: embryonic day 12.5
Image: JAX_1263817
Specimen Label: JAX_1263817
Detected: true
Specimen Num: 4
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1603920
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6692116
Age: embryonic day 12.5
Image: JAX_1263795
Specimen Label: JAX_1263795
Detected: true
Specimen Num: 5
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1603920
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6692116
Age: embryonic day 12.5
Image: JAX_1263797
Specimen Label: JAX_1263797
Detected: true
Specimen Num: 6
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1603920
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6692116
Age: embryonic day 12.5
Image: JAX_1263799
Specimen Label: JAX_1263799
Detected: true
Specimen Num: 7
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1603920
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6692116
Age: embryonic day 12.5
Image: JAX_1263801
Specimen Label: JAX_1263801
Detected: true
Specimen Num: 8
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3273028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692116
Age: postnatal adult
Image: JAX_1632851
Specimen Label: JAX_1632851
Detected: true
Specimen Num: 9
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692116
Age: postnatal adult
Image: JAX_1632852
Specimen Label: JAX_1632852
Detected: true
Specimen Num: 10
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692116
Age: postnatal adult
Image: JAX_1632854
Specimen Label: JAX_1632854
Detected: true
Specimen Num: 11
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1929028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692116
Age: postnatal adult
Image: JAX_1632855
Specimen Label: JAX_1632855
Detected: true
Specimen Num: 12
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3276028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692116
Age: postnatal adult
Image: JAX_1632856
Specimen Label: JAX_1632856
Detected: true
Specimen Num: 13
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1832128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692116
Age: postnatal adult
Image: JAX_1632857
Specimen Label: JAX_1632857
Detected: true
Specimen Num: 14
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1902828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692116
Age: postnatal adult
Image: JAX_1632858
Specimen Label: JAX_1632858
Detected: true
Specimen Num: 15
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1876728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692116
Age: postnatal adult
Image: JAX_1632859
Specimen Label: JAX_1632859
Detected: true
Specimen Num: 16
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1750328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692116
Age: postnatal adult
Image: JAX_1632860
Specimen Label: JAX_1632860
Detected: true
Specimen Num: 17
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1672828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692116
Age: postnatal adult
Image: JAX_1632861
Specimen Label: JAX_1632861
Detected: true
Specimen Num: 18
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3283428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692116
Age: postnatal adult
Image: JAX_1632862
Specimen Label: JAX_1632862
Detected: true
Specimen Num: 19
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3599828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692116
Age: postnatal adult
Image: JAX_1632863
Specimen Label: JAX_1632863
Detected: true
Specimen Num: 20
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692116
Age: postnatal adult
Image: JAX_1632864
Specimen Label: JAX_1632864
Detected: true
Specimen Num: 21
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1683328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692116
Age: postnatal adult
Image: JAX_1632865
Specimen Label: JAX_1632865
Detected: true
Specimen Num: 22
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1925228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692116
Age: postnatal adult
Image: JAX_1632866
Specimen Label: JAX_1632866
Detected: true
Specimen Num: 23
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1685328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692116
Age: postnatal adult
Image: JAX_1632867
Specimen Label: JAX_1632867
Detected: true
Specimen Num: 24
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1876828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692116
Age: postnatal adult
Image: JAX_1632868
Specimen Label: JAX_1632868
Detected: true
Specimen Num: 25
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692116
Age: postnatal adult
Image: JAX_1632869
Specimen Label: JAX_1632869
Detected: true
Specimen Num: 26
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1702128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692116
Age: postnatal adult
Image: JAX_1632870
Specimen Label: JAX_1632870
Detected: true
Specimen Num: 27
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1752528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692116
Age: postnatal adult
Image: JAX_1632871
Specimen Label: JAX_1632871
Detected: true
Specimen Num: 28
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692116
Age: postnatal adult
Image: JAX_1632872
Note: kidney
Specimen Label: JAX_1632872
Detected: true
Specimen Num: 29
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1610528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692116
Age: postnatal adult
Image: JAX_1632873
Specimen Label: JAX_1632873
Detected: true
Specimen Num: 30
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1619828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692116
Age: postnatal adult
Image: JAX_1632874
Specimen Label: JAX_1632874
Detected: true
Specimen Num: 31
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1842628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692116
Age: postnatal adult
Image: JAX_1632875
Specimen Label: JAX_1632875
Detected: true
Specimen Num: 32
GXD Expression    
Probe: MGI:4424322
Assay Type: RNA in situ
Annotation Date: 2023-08-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7516923
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
Publication
First Author: Luijsterburg MS
Year: 2016
Journal: Mol Cell
Title: PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining.
Volume: 61
Issue: 4
Pages: 547-562
GXD Expression
Probe: MGI:6276025
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2762122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7481327
Age: embryonic day 14.5
Image: S3B
Note: There were cells coexpressed with cleaved Parp1 in the mutant.
Specimen Label: S3B
Detected: true
Specimen Num: 32
Allele
Name: poly (ADP-ribose) polymerase family, member 1; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: PARP1 binding protein; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele  
Name: PARP1 binding protein; gene trap OST390942, Lexicon Genetics
Allele Type: Gene trapped
Allele
Name: PARP1 binding protein; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
Allele
Name: PARP1 binding protein; targeted mutation 1.1, Shinichiro Chuma
Allele Type: Targeted
Attribute String: Null/knockout
Allele  
Name: PARP1 binding protein; gene trap OST325567, Lexicon Genetics
Allele Type: Gene trapped
Allele
Name: PARP1 binding protein; targeted mutation 2e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele
Name: PARP1 binding protein; targeted mutation 1, Shinichiro Chuma
Allele Type: Targeted
Attribute String: Conditional ready
Allele
Name: PARP1 binding protein; endonuclease-mediated mutation 14, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Strain
Attribute String: coisogenic, targeted mutation
Strain
Attribute String: mutant strain, targeted mutation
Strain
Attribute String: mutant strain, coisogenic, targeted mutation
Allele
Name: PARP1 binding protein; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele
Name: PARP1 binding protein; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Interaction Experiment
Description: Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality.
Interaction Experiment
Description: FAF1 mediates regulated necrosis through PARP1 activation upon oxidative stress leading to dopaminergic neurodegeneration.
Allele  
Name: PARP1 binding protein; gene trap IST14841F12, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Strain
Attribute String: congenic, mutant strain, targeted mutation
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Interaction Experiment
Description: Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling.
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Allele
Name: poly (ADP-ribose) polymerase family, member 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Genotype
Symbol: Parpbp/Parpbp<+>
Background: C57BL/6N-Parpbp/J
Zygosity: ht
Has Mutant Allele: true
Publication
First Author: Yu C
Year: 2016
Journal: Cell Death Differ
Title: FAF1 mediates regulated necrosis through PARP1 activation upon oxidative stress leading to dopaminergic neurodegeneration.
Volume: 23
Issue: 11
Pages: 1873-1885
Protein
Organism: Mus musculus/domesticus
Length: 1013  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
Publication
First Author: Zhang N
Year: 2020
Journal: Cell Death Differ
Title: Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling.
Volume: 27
Issue: 9
Pages: 2605-2619
Protein Domain
Type: Domain
Description: TXK is a member of the Tec family, which is a group of nonreceptor tyrosine kinases containing Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. It also contains an N-terminal cysteine-rich region. TXK forms a complex with EF-1alpha and PARP1 that regulates interferon-gamma gene transcription in Th1 cells []. This entry represents the SH3 domain of TXK.
Publication
First Author: Gresakova V
Year: 2021
Journal: Exp Cell Res
Title: Dual role of Fam208a during zygotic cleavage and early embryonic development.
Volume: 406
Issue: 2
Pages: 112723