Type |
Details |
Score |
Strain |
Attribute String: |
congenic, gene trap, mutant strain |
|
•
•
•
•
•
|
Publication |
First Author: |
Krastev DB |
Year: |
2022 |
Journal: |
Nat Cell Biol |
Title: |
The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin. |
Volume: |
24 |
Issue: |
1 |
Pages: |
62-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mashimo M |
Year: |
2019 |
Journal: |
JCI Insight |
Title: |
PARP1 inhibition alleviates injury in ARH3-deficient mice and human cells. |
Volume: |
4 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mochizuki AL |
Year: |
2017 |
Journal: |
Mol Cell Biol |
Title: |
PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice. |
Volume: |
37 |
Issue: |
23 |
|
|
•
•
•
•
•
|
Allele |
Name: |
PARP1 binding protein; wild type |
Allele Type: |
Not Specified |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Pettitt SJ |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance. |
Volume: |
9 |
Issue: |
1 |
Pages: |
1849 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang C |
Year: |
2020 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors. |
Volume: |
117 |
Issue: |
42 |
Pages: |
26356-26365 |
|
•
•
•
•
•
|
Publication |
First Author: |
Komulainen E |
Year: |
2021 |
Journal: |
EMBO Rep |
Title: |
Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures. |
Volume: |
22 |
Issue: |
5 |
Pages: |
e51851 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adamowicz M |
Year: |
2021 |
Journal: |
Nat Cell Biol |
Title: |
XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair. |
Volume: |
23 |
Issue: |
12 |
Pages: |
1287-1298 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wan Y |
Year: |
2023 |
Journal: |
J Cell Biol |
Title: |
KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway. |
Volume: |
222 |
Issue: |
2 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Sakthianandeswaren A |
Year: |
2018 |
Journal: |
Cancer Discov |
Title: |
MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors. |
Volume: |
8 |
Issue: |
8 |
Pages: |
988-1005 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shang F |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade. |
Volume: |
11 |
Issue: |
3 |
Pages: |
e0151845 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sullivan-Reed K |
Year: |
2023 |
Journal: |
Mol Cancer Res |
Title: |
Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination-Deficient Leukemia Cells. |
Volume: |
21 |
Issue: |
10 |
Pages: |
1017-1022 |
|
•
•
•
•
•
|
Allele |
Name: |
PARP1 binding protein; targeted mutation 1, Velocigene |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
PARP1 binding protein; targeted mutation 1.1, Velocigene |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Publication |
First Author: |
Jing CB |
Year: |
2020 |
Journal: |
Leukemia |
Title: |
Synthetic lethal targeting of TET2-mutant hematopoietic stem and progenitor cells (HSPCs) with TOP1-targeted drugs and PARP1 inhibitors. |
Volume: |
34 |
Issue: |
11 |
Pages: |
2992-3006 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1603920 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:6692116 |
Age: |
embryonic day 12.5 |
Image: |
JAX_1263811 |
|
Specimen Label: |
JAX_1263811 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1603920 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:6692116 |
Age: |
embryonic day 12.5 |
Image: |
JAX_1263813 |
|
Specimen Label: |
JAX_1263813 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1603920 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:6692116 |
Age: |
embryonic day 12.5 |
Image: |
JAX_1263815 |
|
Specimen Label: |
JAX_1263815 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1603920 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:6692116 |
Age: |
embryonic day 12.5 |
Image: |
JAX_1263817 |
|
Specimen Label: |
JAX_1263817 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1603920 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:6692116 |
Age: |
embryonic day 12.5 |
Image: |
JAX_1263795 |
|
Specimen Label: |
JAX_1263795 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1603920 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:6692116 |
Age: |
embryonic day 12.5 |
Image: |
JAX_1263797 |
|
Specimen Label: |
JAX_1263797 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1603920 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:6692116 |
Age: |
embryonic day 12.5 |
Image: |
JAX_1263799 |
|
Specimen Label: |
JAX_1263799 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1603920 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:6692116 |
Age: |
embryonic day 12.5 |
Image: |
JAX_1263801 |
|
Specimen Label: |
JAX_1263801 |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3273028 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692116 |
Age: |
postnatal adult |
Image: |
JAX_1632851 |
|
Specimen Label: |
JAX_1632851 |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2991528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692116 |
Age: |
postnatal adult |
Image: |
JAX_1632852 |
|
Specimen Label: |
JAX_1632852 |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692116 |
Age: |
postnatal adult |
Image: |
JAX_1632854 |
|
Specimen Label: |
JAX_1632854 |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1929028 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692116 |
Age: |
postnatal adult |
Image: |
JAX_1632855 |
|
Specimen Label: |
JAX_1632855 |
Detected: |
true |
Specimen Num: |
12 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3276028 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692116 |
Age: |
postnatal adult |
Image: |
JAX_1632856 |
|
Specimen Label: |
JAX_1632856 |
Detected: |
true |
Specimen Num: |
13 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1832128 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692116 |
Age: |
postnatal adult |
Image: |
JAX_1632857 |
|
Specimen Label: |
JAX_1632857 |
Detected: |
true |
Specimen Num: |
14 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1902828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692116 |
Age: |
postnatal adult |
Image: |
JAX_1632858 |
|
Specimen Label: |
JAX_1632858 |
Detected: |
true |
Specimen Num: |
15 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1876728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692116 |
Age: |
postnatal adult |
Image: |
JAX_1632859 |
|
Specimen Label: |
JAX_1632859 |
Detected: |
true |
Specimen Num: |
16 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1750328 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692116 |
Age: |
postnatal adult |
Image: |
JAX_1632860 |
|
Specimen Label: |
JAX_1632860 |
Detected: |
true |
Specimen Num: |
17 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1672828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692116 |
Age: |
postnatal adult |
Image: |
JAX_1632861 |
|
Specimen Label: |
JAX_1632861 |
Detected: |
true |
Specimen Num: |
18 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3283428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692116 |
Age: |
postnatal adult |
Image: |
JAX_1632862 |
|
Specimen Label: |
JAX_1632862 |
Detected: |
true |
Specimen Num: |
19 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3599828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692116 |
Age: |
postnatal adult |
Image: |
JAX_1632863 |
|
Specimen Label: |
JAX_1632863 |
Detected: |
true |
Specimen Num: |
20 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1757728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692116 |
Age: |
postnatal adult |
Image: |
JAX_1632864 |
|
Specimen Label: |
JAX_1632864 |
Detected: |
true |
Specimen Num: |
21 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1683328 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692116 |
Age: |
postnatal adult |
Image: |
JAX_1632865 |
|
Specimen Label: |
JAX_1632865 |
Detected: |
true |
Specimen Num: |
22 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1925228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692116 |
Age: |
postnatal adult |
Image: |
JAX_1632866 |
|
Specimen Label: |
JAX_1632866 |
Detected: |
true |
Specimen Num: |
23 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1685328 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692116 |
Age: |
postnatal adult |
Image: |
JAX_1632867 |
|
Specimen Label: |
JAX_1632867 |
Detected: |
true |
Specimen Num: |
24 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1876828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692116 |
Age: |
postnatal adult |
Image: |
JAX_1632868 |
|
Specimen Label: |
JAX_1632868 |
Detected: |
true |
Specimen Num: |
25 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1797228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692116 |
Age: |
postnatal adult |
Image: |
JAX_1632869 |
|
Specimen Label: |
JAX_1632869 |
Detected: |
true |
Specimen Num: |
26 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1702128 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692116 |
Age: |
postnatal adult |
Image: |
JAX_1632870 |
|
Specimen Label: |
JAX_1632870 |
Detected: |
true |
Specimen Num: |
27 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1752528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692116 |
Age: |
postnatal adult |
Image: |
JAX_1632871 |
|
Specimen Label: |
JAX_1632871 |
Detected: |
true |
Specimen Num: |
28 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1737328 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692116 |
Age: |
postnatal adult |
Image: |
JAX_1632872 |
Note: |
kidney |
Specimen Label: |
JAX_1632872 |
Detected: |
true |
Specimen Num: |
29 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1610528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692116 |
Age: |
postnatal adult |
Image: |
JAX_1632873 |
|
Specimen Label: |
JAX_1632873 |
Detected: |
true |
Specimen Num: |
30 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1619828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692116 |
Age: |
postnatal adult |
Image: |
JAX_1632874 |
|
Specimen Label: |
JAX_1632874 |
Detected: |
true |
Specimen Num: |
31 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1842628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692116 |
Age: |
postnatal adult |
Image: |
JAX_1632875 |
|
Specimen Label: |
JAX_1632875 |
Detected: |
true |
Specimen Num: |
32 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4424322 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-08-11 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754722 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7516923 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
Supplementary table 2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Luijsterburg MS |
Year: |
2016 |
Journal: |
Mol Cell |
Title: |
PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining. |
Volume: |
61 |
Issue: |
4 |
Pages: |
547-562 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6276025 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-05-15 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:2762122 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7481327 |
Age: |
embryonic day 14.5 |
Image: |
S3B |
Note: |
There were cells coexpressed with cleaved Parp1 in the mutant. |
Specimen Label: |
S3B |
Detected: |
true |
Specimen Num: |
32 |
|
•
•
•
•
•
|
Allele |
Name: |
poly (ADP-ribose) polymerase family, member 1; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
PARP1 binding protein; targeted mutation 1e, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
PARP1 binding protein; gene trap OST390942, Lexicon Genetics |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
PARP1 binding protein; targeted mutation 1a, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
PARP1 binding protein; targeted mutation 1.1, Shinichiro Chuma |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
PARP1 binding protein; gene trap OST325567, Lexicon Genetics |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
PARP1 binding protein; targeted mutation 2e, Helmholtz Zentrum Muenchen GmbH |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
PARP1 binding protein; targeted mutation 1, Shinichiro Chuma |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready |
|
•
•
•
•
•
|
Allele |
Name: |
PARP1 binding protein; endonuclease-mediated mutation 14, GemPharmatech Co., Ltd |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain, coisogenic, targeted mutation |
|
•
•
•
•
•
|
Allele |
Name: |
PARP1 binding protein; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
PARP1 binding protein; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
FAF1 mediates regulated necrosis through PARP1 activation upon oxidative stress leading to dopaminergic neurodegeneration. |
|
•
•
•
•
•
|
Allele |
Name: |
PARP1 binding protein; gene trap IST14841F12, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling. |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Allele |
Name: |
poly (ADP-ribose) polymerase family, member 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Parpbp/Parpbp<+> |
Background: |
C57BL/6N-Parpbp/J |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu C |
Year: |
2016 |
Journal: |
Cell Death Differ |
Title: |
FAF1 mediates regulated necrosis through PARP1 activation upon oxidative stress leading to dopaminergic neurodegeneration. |
Volume: |
23 |
Issue: |
11 |
Pages: |
1873-1885 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1013
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
492
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang N |
Year: |
2020 |
Journal: |
Cell Death Differ |
Title: |
Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling. |
Volume: |
27 |
Issue: |
9 |
Pages: |
2605-2619 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
TXK is a member of the Tec family, which is a group of nonreceptor tyrosine kinases containing Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. It also contains an N-terminal cysteine-rich region. TXK forms a complex with EF-1alpha and PARP1 that regulates interferon-gamma gene transcription in Th1 cells []. This entry represents the SH3 domain of TXK. |
|
•
•
•
•
•
|
Publication |
First Author: |
Gresakova V |
Year: |
2021 |
Journal: |
Exp Cell Res |
Title: |
Dual role of Fam208a during zygotic cleavage and early embryonic development. |
Volume: |
406 |
Issue: |
2 |
Pages: |
112723 |
|
•
•
•
•
•
|