Type |
Details |
Score |
Interaction Experiment |
Description: |
Mouse NIPK interacts with ATF4 and affects its transcriptional activity. |
|
•
•
•
•
•
|
Allele |
Name: |
activating transcription factor 4; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Fei Y |
Year: |
2011 |
Journal: |
Biochem Biophys Res Commun |
Title: |
The impaired bone anabolic effect of PTH in the absence of endogenous FGF2 is partially due to reduced ATF4 expression. |
Volume: |
412 |
Issue: |
1 |
Pages: |
160-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tsukumo Y |
Year: |
2016 |
Journal: |
J Cell Biochem |
Title: |
TBL2 Associates With ATF4 mRNA Via Its WD40 Domain and Regulates Its Translation During ER Stress. |
Volume: |
117 |
Issue: |
2 |
Pages: |
500-9 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Rhythmic Control of the ARF-MDM2 Pathway by ATF4 Underlies Circadian Accumulation of p53 in Malignant Cells. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment. |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 4, Shizuo Akira |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
The GABA(B) receptor subunits R1 and R2 interact differentially with the activation transcription factor ATF4 in mouse brain during the postnatal development. |
|
•
•
•
•
•
|
Publication |
First Author: |
Vattem KM |
Year: |
2004 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. |
Volume: |
101 |
Issue: |
31 |
Pages: |
11269-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jousse C |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
TRB3 inhibits the transcriptional activation of stress-regulated genes by a negative feedback on the ATF4 pathway. |
Volume: |
282 |
Issue: |
21 |
Pages: |
15851-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang X |
Year: |
2019 |
Journal: |
Mol Psychiatry |
Title: |
Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders. |
|
|
|
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Atf4/Atf4 Tg(Cryaa-Atf4)4Aki/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Antonell A |
Year: |
2005 |
Journal: |
Genome Res |
Title: |
Evolutionary mechanisms shaping the genomic structure of the Williams-Beuren syndrome chromosomal region at human 7q11.23. |
Volume: |
15 |
Issue: |
9 |
Pages: |
1179-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tsukumo Y |
Year: |
2015 |
Journal: |
Biochem Biophys Res Commun |
Title: |
The endoplasmic reticulum-localized protein TBL2 interacts with the 60S ribosomal subunit. |
Volume: |
462 |
Issue: |
4 |
Pages: |
383-8 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Transducin beta-like protein 2 (TBL2), also known as WBSCR13, has been linked to Williams-Beuren syndrome []. It contains an N-terminal transmembrane region and the C-terminal WD40 domain []. Under endoplasmic reticulum (ER) stress, TBL2 is involved in ATF4 translation through its association with the mRNA []. |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Pseudogene |
Type: |
pseudogene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Ord D |
Year: |
2005 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions. |
Volume: |
330 |
Issue: |
1 |
Pages: |
210-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dobrikov M |
Year: |
2011 |
Journal: |
Mol Cell Biol |
Title: |
Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1. |
Volume: |
31 |
Issue: |
14 |
Pages: |
2947-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chartier-Harlin MC |
Year: |
2011 |
Journal: |
Am J Hum Genet |
Title: |
Translation initiator EIF4G1 mutations in familial Parkinson disease. |
Volume: |
89 |
Issue: |
3 |
Pages: |
398-406 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ventoso I |
Year: |
2001 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
HIV-1 protease cleaves eukaryotic initiation factor 4G and inhibits cap-dependent translation. |
Volume: |
98 |
Issue: |
23 |
Pages: |
12966-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Foeger N |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Human rhinovirus 2 2Apro recognition of eukaryotic initiation factor 4GI. Involvement of an exosite. |
Volume: |
278 |
Issue: |
35 |
Pages: |
33200-7 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Tribbles encode an evolutionarily conserved protein family that influences proliferation, motility, metabolism, and oncogenic transformation. Originally identified in Drosophila, tribbles homologues are characterised by a central serine/threonine kinase-like domain (KD) and a C-terminal binding site for E3 ubiquitin ligases. Although the KD is the defining feature of the tribbles family, these proteins are considered to be catalytically inactive because they lack conserved residues from the characteristic adenosine triphosphate binding site and catalytic core motif within the KD [].TRB-1, TRB-2 and TRB-3 are the mammalian homologues of Drosophila tribbles. This entry represents TRB-3, which binds to ATF4 and inhibits its transcriptional activation activity []. It also interacts with and regulates activation of MAP kinases []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents eukaryotic translation initiation factor 4 gamma 1 (EIF4G1), which is a component of the eIF4F complex. The eIF4F complex is required for recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Mitogen-activated protein kinases control translation by post-translational modification of translation initiation factors, and eIF4G1 is a substrate for protein kinase C []. As part of the eIF4F complex, EIF4G1 mediates endoplasmic reticulum stress-induced ATF4 (a master stress-induced transcription factor) mRNA translation []. Mutations in the EIF4G1 gene cause Parkinson disease 18, which is a neurodegenerative disorder with the following symptoms: bradykinesia, resting tremor, muscular rigidity and postural instability, and loss of dopaminergic neurons from the substantia nigra []. Viral infection can lead to the shutdown of translation by cleavage of EIF4G1, for example, by HIV-1 retropepsin [], rhinovirus picornain 2A []and foot-and-mouth disease virus L-peptidase []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Ye J |
Year: |
2015 |
Journal: |
Genes Dev |
Title: |
GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2. |
Volume: |
29 |
Issue: |
22 |
Pages: |
2331-6 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Scortegagna M |
Year: |
2014 |
Journal: |
PLoS Genet |
Title: |
Fine tuning of the UPR by the ubiquitin ligases Siah1/2. |
Volume: |
10 |
Issue: |
5 |
Pages: |
e1004348 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen MB |
Year: |
2002 |
Journal: |
Genomics |
Title: |
Mouse Atf5: molecular cloning of two novel mRNAs, genomic organization, and odorant sensory neuron localization. |
Volume: |
80 |
Issue: |
3 |
Pages: |
344-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brina D |
Year: |
2015 |
Journal: |
Nat Commun |
Title: |
eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription. |
Volume: |
6 |
|
Pages: |
8261 |
|
•
•
•
•
•
|
Publication |
First Author: |
Clavarino G |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells. |
Volume: |
109 |
Issue: |
8 |
Pages: |
3006-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Piao J |
Year: |
2013 |
Journal: |
Sci Rep |
Title: |
Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling. |
Volume: |
3 |
|
Pages: |
3022 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaspar S |
Year: |
2021 |
Journal: |
Sci Adv |
Title: |
Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR. |
Volume: |
7 |
Issue: |
22 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Sasaki K |
Year: |
2017 |
Journal: |
EBioMedicine |
Title: |
p32 is Required for Appropriate Interleukin-6 Production Upon LPS Stimulation and Protects Mice from Endotoxin Shock. |
Volume: |
20 |
|
Pages: |
161-172 |
|
•
•
•
•
•
|
Publication |
First Author: |
Linares JF |
Year: |
2017 |
Journal: |
Cell Metab |
Title: |
ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma. |
Volume: |
26 |
Issue: |
6 |
Pages: |
817-829.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang M |
Year: |
2017 |
Journal: |
FEBS Lett |
Title: |
NDRG2 acts as a PERK co-factor to facilitate PERK branch and ERS-induced cell death. |
Volume: |
591 |
Issue: |
21 |
Pages: |
3670-3681 |
|
•
•
•
•
•
|
Publication |
First Author: |
Szabat M |
Year: |
2016 |
Journal: |
Cell Metab |
Title: |
Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation. |
Volume: |
23 |
Issue: |
1 |
Pages: |
179-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miyake M |
Year: |
2021 |
Journal: |
iScience |
Title: |
Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity. |
Volume: |
24 |
Issue: |
12 |
Pages: |
103448 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ozcan L |
Year: |
2013 |
Journal: |
Cell Metab |
Title: |
Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling. |
Volume: |
18 |
Issue: |
6 |
Pages: |
803-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stone AEL |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection. |
Volume: |
10 |
Issue: |
1 |
Pages: |
3649 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou J |
Year: |
2018 |
Journal: |
Mol Cell |
Title: |
N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response. |
Volume: |
69 |
Issue: |
4 |
Pages: |
636-647.e7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo Q |
Year: |
2022 |
Journal: |
Sci Adv |
Title: |
Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4. |
Volume: |
8 |
Issue: |
30 |
Pages: |
eabo0340 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sbodio JI |
Year: |
2016 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Transcriptional control of amino acid homeostasis is disrupted in Huntington's disease. |
Volume: |
113 |
Issue: |
31 |
Pages: |
8843-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kato Y |
Year: |
1999 |
Journal: |
Mol Cell Endocrinol |
Title: |
Presence of activating transcription factor 4 (ATF4) in the porcine anterior pituitary. |
Volume: |
154 |
Issue: |
1-2 |
Pages: |
151-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Clavarino G |
Year: |
2012 |
Journal: |
PLoS Pathog |
Title: |
Induction of GADD34 is necessary for dsRNA-dependent interferon-β production and participates in the control of Chikungunya virus infection. |
Volume: |
8 |
Issue: |
5 |
Pages: |
e1002708 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu J |
Year: |
2015 |
Journal: |
Am J Physiol Cell Physiol |
Title: |
Impact of ER stress-regulated ATF4/p16 signaling on the premature senescence of renal tubular epithelial cells in diabetic nephropathy. |
Volume: |
308 |
Issue: |
8 |
Pages: |
C621-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Martina JA |
Year: |
2016 |
Journal: |
EMBO J |
Title: |
TFEB and TFE3 are novel components of the integrated stress response. |
Volume: |
35 |
Issue: |
5 |
Pages: |
479-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kiss-Toth E |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. |
Volume: |
279 |
Issue: |
41 |
Pages: |
42703-8 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
137
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
188
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
471
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
186
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
209
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
129
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
119
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
170
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
79
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
61
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
202
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
175
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Podust LM |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA. |
Volume: |
276 |
Issue: |
1 |
Pages: |
505-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Costa-Mattioli M |
Year: |
2005 |
Journal: |
Nature |
Title: |
Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2. |
Volume: |
436 |
Issue: |
7054 |
Pages: |
1166-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carpio MA |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress. |
Volume: |
112 |
Issue: |
23 |
Pages: |
7201-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Latreille M |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress. |
Volume: |
281 |
Issue: |
36 |
Pages: |
26633-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Galichon P |
Year: |
2017 |
Journal: |
J Am Soc Nephrol |
Title: |
Stress Response Gene Nupr1 Alleviates Cyclosporin A Nephrotoxicity In Vivo. |
Volume: |
28 |
Issue: |
2 |
Pages: |
545-556 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim MH |
Year: |
2017 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Hepatic ZIP14-mediated zinc transport is required for adaptation to endoplasmic reticulum stress. |
Volume: |
114 |
Issue: |
29 |
Pages: |
E5805-E5814 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pereira CM |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation. |
Volume: |
280 |
Issue: |
31 |
Pages: |
28316-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu VW |
Year: |
2009 |
Journal: |
J Cell Biochem |
Title: |
FIAT inhibition increases osteoblast activity by modulating Atf4-dependent functions. |
Volume: |
106 |
Issue: |
1 |
Pages: |
186-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Isaac R |
Year: |
2017 |
Journal: |
Cell Death Differ |
Title: |
TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response. |
Volume: |
24 |
Issue: |
1 |
Pages: |
132-143 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nerlich A |
Year: |
2015 |
Journal: |
Biochim Biophys Acta |
Title: |
C/EBPβ is a transcriptional key regulator of IL-36α in murine macrophages. |
Volume: |
1849 |
Issue: |
8 |
Pages: |
966-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lehman SL |
Year: |
2015 |
Journal: |
Sci Rep |
Title: |
Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma. |
Volume: |
5 |
|
Pages: |
11781 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guridi M |
Year: |
2015 |
Journal: |
Sci Signal |
Title: |
Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21. |
Volume: |
8 |
Issue: |
402 |
Pages: |
ra113 |
|
•
•
•
•
•
|
Publication |
First Author: |
Krawczyk KK |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Assessing the contribution of thrombospondin-4 induction and ATF6α activation to endoplasmic reticulum expansion and phenotypic modulation in bladder outlet obstruction. |
Volume: |
6 |
|
Pages: |
32449 |
|
•
•
•
•
•
|
Publication |
First Author: |
Briggs DI |
Year: |
2017 |
Journal: |
eNeuro |
Title: |
Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APPSwe Mouse Models of Tauopathy and Amyloidosis. |
Volume: |
4 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Chang PC |
Year: |
2015 |
Journal: |
Biochim Biophys Acta |
Title: |
TRC8 downregulation contributes to the development of non-alcoholic steatohepatitis by exacerbating hepatic endoplasmic reticulum stress. |
Volume: |
1852 |
Issue: |
11 |
Pages: |
2339-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ding W |
Year: |
2023 |
Journal: |
FASEB J |
Title: |
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