This entry represent the RhoGAP domain found in ARHGAP6 and ARHGAP36.Rho GTPase activating protein 6 (ARHGAP6/RHOGAP6) shows GAP activity towards RhoA, but not towards Cdc42 and Rac1 []. ARHGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder []. ARHGAP36 is a potent antagonist of PKAsignalling [].
Rho GTPase-activating protein 6 (RhoGAP6, also known as ARHGAP6) is both a GTPase-activating protein (GAP) with specificity for RhoA and a cytoskeletal protein that promotes actinremodelling []. It binds to and upregulates phospholipase C-delta, indicating a role for ARHGAP6 in enhanced activity of phospholipase C in hypertension [].
Rho GTPase activating protein 6 (ArhGAP6/RHOGAP6) shows GAP activity towards RhoA, but not towards Cdc42 and Rac1 []. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder [].This family also includes ARHGAP36, which is a potent antagonist of PKA signalling [].
