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Search results 201 to 267 out of 267 for Epx

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Type Details Score
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
9256347 | J:42032
First Author: Branford WW
Year: 1997
Journal: Mech Dev
Title: Spx1, a novel X-linked homeobox gene expressed during spermatogenesis.
Volume: 65
Issue: 1-2
Pages: 87-98
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Publication
9245514 | J:42272
First Author: Li Y
Year: 1997
Journal: Dev Biol
Title: Esx1, a novel X chromosome-linked homeobox gene expressed in mouse extraembryonic tissues and male germ cells.
Volume: 188
Issue: 1
Pages: 85-95
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Publication
10611245 | -
First Author: Yan YT
Year: 2000
Journal: Mol Cell Biol
Title: A novel PF/PN motif inhibits nuclear localization and DNA binding activity of the ESX1 homeoprotein.
Volume: 20
Issue: 2
Pages: 661-71
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Allele
Epx<em1Smoc> | MGI:7263390
Name: eosinophil peroxidase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Epx<em3(cre)Smoc> | MGI:6514733
Name: eosinophil peroxidase; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout, Recombinase
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Strain
MGI:6428599 | C57BL/6J-Epx<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6475209 | C57BL/6-Epx<em3(cre)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
7068848 | -
First Author: Locksley RM
Year: 1982
Journal: J Clin Invest
Title: Role for endogenous and acquired peroxidase in the toxoplasmacidal activity of murine and human mononuclear phagocytes.
Volume: 69
Issue: 5
Pages: 1099-111
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Publication
6281334 | -
First Author: Henderson WR
Year: 1982
Journal: J Immunol
Title: Eosinophil peroxidase-mediated inactivation of leukotrienes B4, C4, and D4.
Volume: 128
Issue: 6
Pages: 2609-13
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Publication
6987310 | -
First Author: Henderson WR
Year: 1980
Journal: J Immunol
Title: Binding of eosinophil peroxidase to mast cell granules with retention of peroxidatic activity.
Volume: 124
Issue: 3
Pages: 1383-8
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Publication
12208372 | -
First Author: Aldridge RE
Year: 2002
Journal: Free Radic Biol Med
Title: Eosinophil peroxidase produces hypobromous acid in the airways of stable asthmatics.
Volume: 33
Issue: 6
Pages: 847-56
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Publication
10811853 | -
First Author: Wu W
Year: 2000
Journal: J Clin Invest
Title: Eosinophils generate brominating oxidants in allergen-induced asthma.
Volume: 105
Issue: 10
Pages: 1455-63
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Protein Domain
IPR029599 | EPX/EPO
Type: Family
Description: Eosinophil peroxidase (EPX or EPO) is an eosinophil-derived granule protein that utilises H2O2 as an oxidising substrate to generate potent oxidising species. This mechanism is used by eosinophils to kill parasites and microbes [, ]. Besides using bromide as substrates to generate hypobromite (hypobromous acid), EPX can also oxidise thiocyanate (SCN-) ions to generate HOSCN-, which may induce the prothrombotic and proinflammatory endothelial and endocardial phenotypes responsible for thrombotic complications in the hypereosinophilic syndrome (HES) []. EPX is involved in both anti-inflammatory and pro-inflammatory activities [, ]. It may also play an important role through the production of reactive brominating species in asthma [, ]. It is required for eosinophilopoiesis in mice [].
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Publication
24802755 | -
First Author: Acharya KR
Year: 2014
Journal: J Biol Chem
Title: Eosinophil granule proteins: form and function.
Volume: 289
Issue: 25
Pages: 17406-15
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Allele
Tg(Epx-EYFP/cre)#Voeh | MGI:6790413
Name: transgene insertion, David Voehringer
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Epx<tm1.1(cre)Jlee> | MGI:5498555
Name: eosinophil peroxidase; targeted mutation 1.1, James J Lee
Allele Type: Targeted
Attribute String: Recombinase
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Allele
Tg(Epo-DTA)#Nal | MGI:3779020
Name: transgene insertion, Nancy A Lee
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:6432799 | B6.Cg-Epx<tm1.1(cre)Jlee>/Jlee
Attribute String: mutant strain, targeted mutation, congenic
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Strain
MGI:6832813 | B6.Cg-Tg(Epo-DTA)#Nal/JleeJ
Attribute String: congenic, mutant strain, transgenic
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Publication
18922934 | J:140660
First Author: Taranova AG
Year: 2008
Journal: Cancer Res
Title: Allergic pulmonary inflammation promotes the recruitment of circulating tumor cells to the lung.
Volume: 68
Issue: 20
Pages: 8582-9
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Publication
21217761 | J:168251
First Author: Chu VT
Year: 2011
Journal: Nat Immunol
Title: Eosinophils are required for the maintenance of plasma cells in the bone marrow.
Volume: 12
Issue: 2
Pages: 151-9
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Publication
31415658 | J:278011
First Author: Gorski SA
Year: 2019
Journal: PLoS One
Title: Expression of IL-5 receptor alpha by murine and human lung neutrophils.
Volume: 14
Issue: 8
Pages: e0221113
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Genotype
Genotype
Symbol: Epx/Epx
Background: B6.Cg-Epx/Jlee
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
GSE65753 | Analysis of wildtype and Xbp1-deficient hematopoietic progenitor cell transcriptomes
Series Id: E-GEOD-65753
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
23986549 | J:209545
First Author: Kim JD
Year: 2013
Journal: J Leukoc Biol
Title: An essential role for Rab27a GTPase in eosinophil exocytosis.
Volume: 94
Issue: 6
Pages: 1265-74
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Publication
24379296 | J:209409
First Author: Lilly LM
Year: 2014
Journal: Infect Immun
Title: Eosinophil deficiency compromises lung defense against Aspergillus fumigatus.
Volume: 82
Issue: 3
Pages: 1315-25
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Publication
25504587 | J:223247
First Author: Hashiguchi M
Year: 2015
Journal: Eur J Immunol
Title: IL-33 activates eosinophils of visceral adipose tissue both directly and via innate lymphoid cells.
Volume: 45
Issue: 3
Pages: 876-85
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Publication
20976099 | J:167364
First Author: Babayan SA
Year: 2010
Journal: PLoS Biol
Title: Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy.
Volume: 8
Issue: 10
Pages: e1000525
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Publication
35985335 | J:328550
First Author: Cao YG
Year: 2022
Journal: Cell Host Microbe
Title: Faecalibaculum rodentium remodels retinoic acid signaling to govern eosinophil-dependent intestinal epithelial homeostasis.
Volume: 30
Issue: 9
Pages: 1295-1310.e8
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Genotype
Genotype
Symbol: Epx/Epx<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Epx-EYFP/cre)#Voeh/?
Background: involves: 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Publication
12515729 | J:110006
First Author: Gombart AF
Year: 2003
Journal: Blood
Title: Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1.
Volume: 101
Issue: 8
Pages: 3265-73
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Publication
27259856 | J:299331
First Author: Harakal J
Year: 2016
Journal: J Immunol
Title: Regulatory T Cells Control Th2-Dominant Murine Autoimmune Gastritis.
Volume: 197
Issue: 1
Pages: 27-41
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Publication
18316417 | J:133142
First Author: Jacobsen EA
Year: 2008
Journal: J Exp Med
Title: Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells.
Volume: 205
Issue: 3
Pages: 699-710
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Publication
30185653 | J:267044
 
First Author: Drake MG
Year: 2018
Journal: Sci Transl Med
Title: Eosinophils increase airway sensory nerve density in mice and in human asthma.
Volume: 10
Issue: 457
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Publication
15375267 | J:92831
First Author: Lee JJ
Year: 2004
Journal: Science
Title: Defining a link with asthma in mice congenitally deficient in eosinophils.
Volume: 305
Issue: 5691
Pages: 1773-6
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Publication
24745334 | J:209950
First Author: Chu VT
Year: 2014
Journal: Immunity
Title: Eosinophils promote generation and maintenance of immunoglobulin-A-expressing plasma cells and contribute to gut immune homeostasis.
Volume: 40
Issue: 4
Pages: 582-93
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Publication
21908591 | J:180029
First Author: Weng M
Year: 2011
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Eosinophils are necessary for pulmonary arterial remodeling in a mouse model of eosinophilic inflammation-induced pulmonary hypertension.
Volume: 301
Issue: 6
Pages: L927-36
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Publication
19542471 | J:149965
First Author: Percopo CM
Year: 2009
Journal: J Immunol
Title: Pulmonary eosinophils and their role in immunopathologic responses to formalin-inactivated pneumonia virus of mice.
Volume: 183
Issue: 1
Pages: 604-12
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Publication
19155506 | J:144323
First Author: Fabre V
Year: 2009
Journal: J Immunol
Title: Eosinophil deficiency compromises parasite survival in chronic nematode infection.
Volume: 182
Issue: 3
Pages: 1577-83
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Publication
18981162 | J:141072
First Author: Ahrens R
Year: 2008
Journal: J Immunol
Title: Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis.
Volume: 181
Issue: 10
Pages: 7390-9
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Publication
29327730 | J:278078
First Author: Zhang C
Year: 2018
Journal: Cell Res
Title: Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis.
Volume: 28
Issue: 3
Pages: 323-335
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Publication
19703974 | J:154126
First Author: Linch SN
Year: 2009
Journal: Infect Immun
Title: Mouse eosinophils possess potent antibacterial properties in vivo.
Volume: 77
Issue: 11
Pages: 4976-82
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Publication
24616476 | J:210233
First Author: Wong TW
Year: 2014
Journal: J Immunol
Title: Eosinophils regulate peripheral B cell numbers in both mice and humans.
Volume: 192
Issue: 8
Pages: 3548-58
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Genotype
Genotype
Symbol: Epx/Epx<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Publication
29645346 | J:265358
First Author: Bolden JE
Year: 2018
Journal: J Leukoc Biol
Title: Identification of a Siglec-F+ granulocyte-macrophage progenitor.
Volume: 104
Issue: 1
Pages: 123-133
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Publication
25862560 | J:224642
First Author: Schwartz C
Year: 2015
Journal: Blood
Title: Eosinophil-specific deletion of IκBα in mice reveals a critical role of NF-κB-induced Bcl-xL for inhibition of apoptosis.
Volume: 125
Issue: 25
Pages: 3896-904
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Publication
22048766 | J:179701
First Author: Jacobsen EA
Year: 2011
Journal: J Immunol
Title: Eosinophils regulate dendritic cells and Th2 pulmonary immune responses following allergen provocation.
Volume: 187
Issue: 11
Pages: 6059-68
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Protein
P49290
Organism: Mus musculus/domesticus
Length: 716  
Fragment?: false
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Protein
Q3V1J3
Organism: Mus musculus/domesticus
Length: 403  
Fragment?: false
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Publication
20038636 | J:159534
First Author: Blanchet MR
Year: 2010
Journal: J Immunol
Title: Loss of CD34 leads to exacerbated autoimmune arthritis through increased vascular permeability.
Volume: 184
Issue: 3
Pages: 1292-9
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Publication
23752044 | J:202870
First Author: Ando T
Year: 2013
Journal: J Invest Dermatol
Title: Mast cells are required for full expression of allergen/SEB-induced skin inflammation.
Volume: 133
Issue: 12
Pages: 2695-2705
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Publication
19734227 | J:152787
First Author: McKee AS
Year: 2009
Journal: J Immunol
Title: Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity.
Volume: 183
Issue: 7
Pages: 4403-14
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Publication
20876456 | J:167390
First Author: Munks MW
Year: 2010
Journal: Blood
Title: Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo.
Volume: 116
Issue: 24
Pages: 5191-9
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Publication
34099918 | J:308669
First Author: Jacquelot N
Year: 2021
Journal: Nat Immunol
Title: Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma.
Volume: 22
Issue: 7
Pages: 851-864
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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