Syntaxin-16 (STX16) belongs to the syntaxin family, which is a group of the membrane integrated proteins participating in exocytosis. Syntaxins are associated with various intracellular membrane compartments and have been implicated in various physiological processes such as axonal growth and cell division []. This entry includes STX16 from mammals and it's homologue, Tlg2, from yeasts. Human STX16 is a component of a soluble NSF attachment protein receptor (SNARE) complex (consisting of STX10, STX16, Vti1a, and VAMP3) that is required for the mannose 6-phosphate receptor transport from early endosomes to the Golgi []. Budding yeast Tlg2 is a Syntaxin-like t-SNARE that regulates membrane traffic through the endocytic system [, ].
