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Search results 201 to 290 out of 290 for Setd2

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Type Details Score
Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: Histone-lysine N-methyltransferase SETD2
Type: chain
End: 2537
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Protein
A0A0G2JEW8
Organism: Mus musculus/domesticus
Length: 169  
Fragment?: true
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Publication
24509477 | J:258985
First Author: Zhu X
Year: 2014
Journal: Nat Genet
Title: Identification of functional cooperative mutations of SETD2 in human acute leukemia.
Volume: 46
Issue: 3
Pages: 287-93
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HT Experiment
GSE131588 | H3K36 methyltransferase SETD2 regulates lymphoid and neural development [RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE130904 | H3K36 methyltransferase SETD2 regulates lymphoid and neural development [seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
29777171 | J:263721
First Author: Skucha A
Year: 2018
Journal: Nat Commun
Title: MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.
Volume: 9
Issue: 1
Pages: 1983
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Protein
A0A0G2JH06
Organism: Mus musculus/domesticus
Length: 1263  
Fragment?: true
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Protein
A0A0G2JDZ6
Organism: Mus musculus/domesticus
Length: 72  
Fragment?: true
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Publication
31407364 | J:282282
First Author: Li C
Year: 2020
Journal: J Cell Biochem
Title: SETD2 reduction adversely affects the development of mouse early embryos.
Volume: 121
Issue: 1
Pages: 797-803
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Protein
A0A0G2JEZ4
Organism: Mus musculus/domesticus
Length: 760  
Fragment?: true
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Protein
A0A0G2JDY1
Organism: Mus musculus/domesticus
Length: 238  
Fragment?: true
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Publication
32619406 | J:296312
First Author: Yuan H
Year: 2020
Journal: Cancer Cell
Title: SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways.
Volume: 38
Issue: 3
Pages: 350-365.e7
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Publication
36899051 | J:334061
First Author: Walter DM
Year: 2023
Journal: Commun Biol
Title: Setd2 inactivation sensitizes lung adenocarcinoma to inhibitors of oxidative respiration and mTORC1 signaling.
Volume: 6
Issue: 1
Pages: 255
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HT Experiment
GSE138153 | Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
24843002 | -
 
First Author: Carvalho S
Year: 2014
Journal: Elife
Title: SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint.
Volume: 3
Pages: e02482
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Publication
24662245 | -
 
First Author: Mar BG
Year: 2014
Journal: Nat Commun
Title: Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia.
Volume: 5
Pages: 3469
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HT Sample
GSM3813919
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal week 6-8
Stage: 28
Structure . Name: bone marrow
Notes: LSK cells from Setd2 KO; the authors were not clear on which Cre allele was used to generate this sample; it is possible another was used
Curation Status: Curated
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HT Sample
GSM3813920
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal week 6-8
Stage: 28
Structure . Name: bone marrow
Notes: LSK cells from Setd2 KO; the authors were not clear on which Cre allele was used to generate this sample; it is possible another was used
Curation Status: Curated
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HT Sample
GSM3813921
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal week 6-8
Stage: 28
Structure . Name: bone marrow
Notes: LSK cells from Setd2 KO; the authors were not clear on which Cre allele was used to generate this sample; it is possible another was used
Curation Status: Curated
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HT Sample
GSM3790241
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal week 8
Stage: 28
Structure . Name: bone marrow
Notes: primary proB cells from Setd2 knockout animals; the authors were not clear on which Cre allele was used to generate this sample; it is possible another was used
Curation Status: Curated
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HT Sample
GSM3790242
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal week 8
Stage: 28
Structure . Name: bone marrow
Notes: primary proB cells from Setd2 knockout animals; the authors were not clear on which Cre allele was used to generate this sample; it is possible another was used
Curation Status: Curated
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HT Sample
GSM3790244
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal week 8
Stage: 28
Structure . Name: bone marrow
Notes: primary proB cells from Setd2 knockout animals; the authors were not clear on which Cre allele was used to generate this sample; it is possible another was used
Curation Status: Curated
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HT Sample
GSM3790246
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal week 8
Stage: 28
Structure . Name: bone marrow
Notes: primary proB cells from Setd2 knockout animals; the authors were not clear on which Cre allele was used to generate this sample; it is possible another was used
Curation Status: Curated
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HT Sample
GSM3813922
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal week 6-8
Stage: 28
Structure . Name: bone marrow
Notes: LSK cells from Setd2 KO; the authors were not clear on which Cre allele was used to generate this sample; it is possible another was used
Curation Status: Curated
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HT Sample
GSM3813923
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal week 6-8
Stage: 28
Structure . Name: bone marrow
Notes: LSK cells from Setd2 KO; the authors were not clear on which Cre allele was used to generate this sample; it is possible another was used
Curation Status: Curated
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HT Sample
GSM3813924
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal week 6-8
Stage: 28
Structure . Name: bone marrow
Notes: LSK cells from Setd2 KO; the authors were not clear on which Cre allele was used to generate this sample; it is possible another was used
Curation Status: Curated
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Protein
Q8BL12
Organism: Mus musculus/domesticus
Length: 236  
Fragment?: true
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Publication
16118227 | -
First Author: Sun XJ
Year: 2005
Journal: J Biol Chem
Title: Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase.
Volume: 280
Issue: 42
Pages: 35261-71
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Protein Domain
IPR042294 | SETD2_animal
Type: Family
Description: SETD2 is a histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate [, ]. It is required for DNA double-strand break repair and activation of the p53-mediated checkpoint []. SETD2-inactivation has been linked to tumour development []. SETD2 also methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy []. Moreover, SETD2 is also involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription [].
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Publication
19141475 | J:200392
First Author: Yoh SM
Year: 2008
Journal: Genes Dev
Title: The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation.
Volume: 22
Issue: 24
Pages: 3422-34
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Publication
27191891 | -
First Author: Li J
Year: 2016
Journal: Oncotarget
Title: SETD2: an epigenetic modifier with tumor suppressor functionality.
Volume: 7
Issue: 31
Pages: 50719-50734
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Publication
22914091 | -
First Author: Venkatesh S
Year: 2012
Journal: Nature
Title: Set2 methylation of histone H3 lysine 36 suppresses histone exchange on transcribed genes.
Volume: 489
Issue: 7416
Pages: 452-5
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Publication
28256625 | -
 
First Author: Zhang Y
Year: 2017
Journal: Sci Rep
Title: Molecular basis for the role of oncogenic histone mutations in modulating H3K36 methylation.
Volume: 7
Pages: 43906
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Publication
27317772 | -
First Author: Tlemsani C
Year: 2016
Journal: J Med Genet
Title: SETD2 and DNMT3A screen in the Sotos-like syndrome French cohort.
Volume: 53
Issue: 11
Pages: 743-751
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Publication
20054297 | -
First Author: Dalgliesh GL
Year: 2010
Journal: Nature
Title: Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes.
Volume: 463
Issue: 7279
Pages: 360-3
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Publication
19915673 | -
First Author: Grini PE
Year: 2009
Journal: PLoS One
Title: The ASH1 HOMOLOG 2 (ASHH2) histone H3 methyltransferase is required for ovule and anther development in Arabidopsis.
Volume: 4
Issue: 11
Pages: e7817
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Protein Domain
IPR044437 | SETD2/Set2_SET
Type: Domain
Description: This entry represents the SET domain found in SETD2 from animals, ASHH2 from plants and Set2 from fungi. Proteins containing this domain are a group of histone methyltransferases that methylates histone H3 to form H3K36me [, ].Yeast Set2 is involved in transcription elongation as well as in transcription repression []. The methyltransferase activity of budding yeast Set2 requires the recruitment to the RNA polymerase II, which is CTK1 dependent [, , , , , , ]. Plant ASHH2 is required for the correct expression of genes essential to reproductive development [].SETD2 acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate [, ]. SETD2 is also required for DNA double-strand break repair and activation of the p53-mediated checkpoint []. SETD2-inactivation has been linked to tumour development []. SETD2 also methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy []. Moreover, SETD2 is also involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription [].SETD2 has been linked to several human diseases, including Renal cell carcinoma (RCC) [], Luscan-Lumish syndrome (LLS) [], Leukemia, acute lymphoblastic (ALL) []and Leukemia, acute myelogenous (AML) [, ].
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HT Experiment
GSE148150 | NSD1-deposited H3K36me2 directs de novo methylation in the mouse male germline and counteracts Polycomb-associated silencing
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
11839797 | -
First Author: Strahl BD
Year: 2002
Journal: Mol Cell Biol
Title: Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression.
Volume: 22
Issue: 5
Pages: 1298-306
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Publication
12629047 | -
First Author: Xiao T
Year: 2003
Journal: Genes Dev
Title: Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast.
Volume: 17
Issue: 5
Pages: 654-63
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Publication
12773564 | -
First Author: Krogan NJ
Year: 2003
Journal: Mol Cell Biol
Title: Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II.
Volume: 23
Issue: 12
Pages: 4207-18
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Publication
12917322 | -
First Author: Landry J
Year: 2003
Journal: Mol Cell Biol
Title: Set2-catalyzed methylation of histone H3 represses basal expression of GAL4 in Saccharomyces cerevisiae.
Volume: 23
Issue: 17
Pages: 5972-8
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Publication
12736296 | -
First Author: Schaft D
Year: 2003
Journal: Nucleic Acids Res
Title: The histone 3 lysine 36 methyltransferase, SET2, is involved in transcriptional elongation.
Volume: 31
Issue: 10
Pages: 2475-82
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Publication
16227595 | -
First Author: Rao B
Year: 2005
Journal: Mol Cell Biol
Title: Dimethylation of histone H3 at lysine 36 demarcates regulatory and nonregulatory chromatin genome-wide.
Volume: 25
Issue: 21
Pages: 9447-59
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Publication
16087749 | -
First Author: Morris SA
Year: 2005
Journal: Eukaryot Cell
Title: Histone H3 K36 methylation is associated with transcription elongation in Schizosaccharomyces pombe.
Volume: 4
Issue: 8
Pages: 1446-54
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Publication
16314571 | -
First Author: Li M
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1.
Volume: 102
Issue: 49
Pages: 17636-41
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Publication
15798214 | -
First Author: Kizer KO
Year: 2005
Journal: Mol Cell Biol
Title: A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation.
Volume: 25
Issue: 8
Pages: 3305-16
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Publication
23832661 | J:199228
First Author: Peña-Llopis S
Year: 2013
Journal: Cancer Res
Title: Cooperation and antagonism among cancer genes: the renal cancer paradigm.
Volume: 73
Issue: 14
Pages: 4173-9
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Publication
25873528 | J:224950
First Author: Liao L
Year: 2015
Journal: Cancer Genet
Title: The roles of chromatin-remodelers and epigenetic modifiers in kidney cancer.
Volume: 208
Issue: 5
Pages: 206-14
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Publication
26370508 | J:235842
First Author: Ohhata T
Year: 2015
Journal: Mol Cell Biol
Title: Histone H3 Lysine 36 Trimethylation Is Established over the Xist Promoter by Antisense Tsix Transcription and Contributes to Repressing Xist Expression.
Volume: 35
Issue: 22
Pages: 3909-20
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Publication
15368895 | J:92575
First Author: Okazaki N
Year: 2004
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 11
Issue: 3
Pages: 205-18
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Publication
19144319 | J:143718
First Author: Trost M
Year: 2009
Journal: Immunity
Title: The phagosomal proteome in interferon-gamma-activated macrophages.
Volume: 30
Issue: 1
Pages: 143-54
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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