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Search results 401 to 500 out of 509 for Suz12

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Type Details Score
Allele
Suz12<Gt(OST427518)Lex> | MGI:4313556
 
Name: SUZ12 polycomb repressive complex 2 subunit; gene trap OST427518, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Suz12<Gt(D170E09)Wrst> | MGI:3892780
 
Name: SUZ12 polycomb repressive complex 2 subunit; gene trap D170E09, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Suz12<Gt(OST57135)Lex> | MGI:4165302
 
Name: SUZ12 polycomb repressive complex 2 subunit; gene trap OST57135, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Suz12<Gt(OST405895)Lex> | MGI:4307538
 
Name: SUZ12 polycomb repressive complex 2 subunit; gene trap OST405895, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Suz12<Gt(EUCE0230b03)Hmgu> | MGI:4385794
 
Name: SUZ12 polycomb repressive complex 2 subunit; gene trap EUCE0230b03, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Suz12<Gt(OST314374)Lex> | MGI:4276647
 
Name: SUZ12 polycomb repressive complex 2 subunit; gene trap OST314374, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Suz12<tm1.1Mag> | MGI:6858079
Name: SUZ12 polycomb repressive complex 2 subunit; targeted mutation 1.1, Terry Magnuson
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Publication
15516932 | J:94241
First Author: Umlauf D
Year: 2004
Journal: Nat Genet
Title: Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes.
Volume: 36
Issue: 12
Pages: 1296-300
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Publication
15684044 | -
First Author: Kuzmichev A
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation.
Volume: 102
Issue: 6
Pages: 1859-64
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Publication
16415857 | J:129406
First Author: Kalantry S
Year: 2006
Journal: Nat Cell Biol
Title: The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation.
Volume: 8
Issue: 2
Pages: 195-202
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Publication
19026780 | J:142193
First Author: Shen X
Year: 2008
Journal: Mol Cell
Title: EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.
Volume: 32
Issue: 4
Pages: 491-502
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Allele
Suz12<Gt(Ayu21-W423)Imeg> | MGI:4368110
 
Name: SUZ12 polycomb repressive complex 2 subunit; gene trap Ayu21-W423, Institute of Molecular Embryology and Genetics
Allele Type: Gene trapped
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Allele
Suz12<Gt(IST11594B6)Tigm> | MGI:5146126
 
Name: SUZ12 polycomb repressive complex 2 subunit; gene trap IST11594B6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Suz12<Gt(IST14544G5)Tigm> | MGI:5241835
 
Name: SUZ12 polycomb repressive complex 2 subunit; gene trap IST14544G5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Suz12<Gt(IST14435E12)Tigm> | MGI:5232003
 
Name: SUZ12 polycomb repressive complex 2 subunit; gene trap IST14435E12, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Strain
MGI:6866870 | STOCK Suz12<tm1.1Mag>/Mmnc
Attribute String: mutant stock, targeted mutation
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Genotype
Genotype
Symbol: Suz12/Suz12
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Suz12/Suz12
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Suz12/Suz12
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Suz12/Suz12<+>
Background: involves: 129 * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Strain
MGI:3796827 | B6.Cg-Mpl<tm1Wsa> Suz12<Plt8>
Attribute String: targeted mutation, congenic, chemically induced mutation
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Genotype
Genotype
Symbol: Mpl/Mpl Suz12/Suz12
Background: B6.Cg-Mpl Suz12
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Suz12/Suz12
Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Suz12/Suz12<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Suz12/Suz12<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Suz12/Suz12<+>
Background: involves: 129P2/OlaHsd
Zygosity: ht
Has Mutant Allele: true
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Strain
MGI:5699611 | B6;129-Trp53<tm1Tyj> Nf1<tm1Tyj> Suz12<Gt(Betageo)1Khe>/KcichJ
Attribute String: mutant stock, targeted mutation, gene trap
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Genotype
Genotype
Symbol: Mpl/Mpl Suz12/Suz12<+>
Background: B6.Cg-Mpl Suz12
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mpl/Mpl Suz12/Suz12<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mtf2/Mtf2 Suz12/Suz12<+>
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf1/Nf1<+> Suz12/Suz12<+>
Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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GO Term
GO:0035098 | ESC/E(Z) complex
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Publication
22226355 | -
First Author: Morey L
Year: 2012
Journal: Cell Stem Cell
Title: Nonoverlapping functions of the Polycomb group Cbx family of proteins in embryonic stem cells.
Volume: 10
Issue: 1
Pages: 47-62
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Publication
23970558 | J:201058
First Author: Nguyen KD
Year: 2013
Journal: Science
Title: Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes.
Volume: 341
Issue: 6153
Pages: 1483-8
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Publication
27122193 | -
 
First Author: Brooun A
Year: 2016
Journal: Nat Commun
Title: Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance.
Volume: 7
Pages: 11384
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Protein Domain
IPR040968 | Ezh2_MCSS
Type: Domain
Description: Polycomb repressive complex 2 (PRC2) carries out the methylation of lysine 27 of histone H3, a hallmark of repressive chromatin. Three core subunits make up the catalytic core of PRC2; the SET domain containing EZH2, the zinc-finger containing SUZ12 and the WD40 repeat protein EED. The complex forms a compact arrangement of three lobes. The middle lobe largely comprises two domains that mark the beginning of the carboxy (C)-terminal region of EZH2 (MCSS and SANT2) and the helical, C-terminal, component of the Suz12 Vefs domain. This entry describes the MCSS (also known as SANT2L) domain. There is one zinc binding (Zn1Cys3His1) which is formed solely by MCSS [, ].
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Publication
27121947 | -
 
First Author: Justin N
Year: 2016
Journal: Nat Commun
Title: Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.
Volume: 7
Pages: 11316
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Protein Domain
IPR040595 | EZH2_N
Type: Domain
Description: Polycomb repressive complex 2 (PRC2) carries out the methylation of lysine 27 of histone H3, a hallmark of repressive chromatin. Three core subunits make up the catalytic core of PRC2; the SET domain containing EZH2, the zinc-finger containing SUZ12 and the WD40 repeat protein EED. The complex forms a compact arrangement of three lobes. This is the N-terminal domain of EZH2 [].
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Genotype
Genotype
Symbol: Nf1/Nf1<+> Suz12/Suz12<+> Trp53/Trp53<+>
Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
21248841 | -
First Author: Margueron R
Year: 2011
Journal: Nature
Title: The Polycomb complex PRC2 and its mark in life.
Volume: 469
Issue: 7330
Pages: 343-9
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Publication
28072869 | -
First Author: Li L
Year: 2017
Journal: PLoS One
Title: Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED.
Volume: 12
Issue: 1
Pages: e0169855
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Publication
12408863 | -
First Author: Czermin B
Year: 2002
Journal: Cell
Title: Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites.
Volume: 111
Issue: 2
Pages: 185-96
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Publication
12408864 | -
First Author: Müller J
Year: 2002
Journal: Cell
Title: Histone methyltransferase activity of a Drosophila Polycomb group repressor complex.
Volume: 111
Issue: 2
Pages: 197-208
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Publication
18276122 | -
First Author: Ohno K
Year: 2008
Journal: Mech Dev
Title: ESC, ESCL and their roles in Polycomb Group mechanisms.
Volume: 125
Issue: 5-6
Pages: 527-41
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Protein Domain
IPR041343 | PRC2_HTH_1
Type: Domain
Description: This domain can be found in the polycomb repressive complex 2 (PRC2) subunits EZH1 and EZH2. Three core subunits make up the catalytic core of PRC2: EZH1 or EZH2, the zinc-finger containing SUZ12 and EED. Polycomb complexes maintain repressive chromatin states by silencing gene expression. PRC2 does this by methylating lysine 27 of histone H3 []. This domain makes up part of the N-lobe which consists of EED and the N-terminal region of EZH2, and is involved in regulation [].
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Protein Domain
IPR037352 | Polycomb_EED
Type: Family
Description: The WD40 domain-containing protein EED is the regulatory subunit of Polycomb repressive complex 2 (PRC2) [, ], which mediates gene silencing primarily through methylation of lysine-27 of histone H3 []. The core subunits of the complex in mammals include EED, EZH2, SUZ12 and RBBP4. PRC2 is well conserved throughout evolution. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12 [, ]. Drosophila has two copies of the Eed homologue, Esc and Esc-like [].
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Protein
E9PWK3
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: true
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Protein
Q3U575
Organism: Mus musculus/domesticus
Length: 391  
Fragment?: true
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Protein
Q8C2I5
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: true
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Protein Domain
IPR044438 | EZH1_SET
Type: Domain
Description: This entry represents the SET domain found in EZH1.The Polycomb Repressive Complex 2 (PRC2) is a chromatin modifying complex that consists of three core components: EED, SUZ12 and one of the two histone H3K27 methyltransferases, EZH1 or EZH2 []. The PRC2 complex catalyses di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), which has a repressive role. Even though EZH1 and EZH2 form similar PRC2 complexes, they exhibit contrasting repressive roles. In terms of their expression in mice, EZH1 is more abundant in nonproliferative adult organs, while EZH2 expression is tightly associated with proliferation [].
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Protein Domain
IPR044439 | EZH2_SET
Type: Domain
Description: This entry represents the SET domain found in EZH2.The Polycomb Repressive Complex 2 (PRC2) is a chromatin modifying complex that consists of three core components: EED, SUZ12 and one of the two histone H3K27 methyltransferases, EZH1 or EZH2 []. The PRC2 complex catalyses di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), which has a repressive role. Even though EZH1 and EZH2 form similar PRC2 complexes, they exhibit contrasting repressive roles. In terms of their expression in mice, EZH1 is more abundant in nonproliferative adult organs, while EZH2 expression is tightly associated with proliferation [].
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Protein Domain
IPR032926 | EZH1
Type: Family
Description: The Polycomb Repressive Complex 2 (PRC2) is a chromatin modifying complex that consists of three core components: EED, SUZ12 and one of the two histone H3K27 methyltransferases, EZH1 or EZH2 []. The PRC2 complex catalyses di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), which has a repressive role. Even though EZH1 and EZH2 form similar PRC2 complexes, they exhibit contrasting repressive roles. In terms of their expression in mice, EZH1 is more abundant in nonproliferative adult organs, while EZH2 expression is tightly associated with proliferation [].This family consists of EZH1 [].
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Protein Domain
IPR021654 | EZH1/EZH2
Type: Family
Description: The Polycomb Repressive Complex 2 (PRC2) is a chromatin modifying complex that consists of three core components: EED, SUZ12 and one of the two histone H3K27 methyltransferases, EZH1 or EZH2 []. The PRC2 complex catalyses di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), which has a repressive role. Even though EZH1 and EZH2 form similar PRC2 complexes, they exhibit contrasting repressive roles. In terms of their expression in mice, EZH1 is more abundant in nonproliferative adult organs, while EZH2 expression is tightly associated with proliferation [].
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Protein
A0A0N4SUQ7
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: false
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Protein
F7AQX0
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: true
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Publication
19026781 | J:142192
First Author: Margueron R
Year: 2008
Journal: Mol Cell
Title: Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.
Volume: 32
Issue: 4
Pages: 503-18
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Publication
24951427 | J:214525
First Author: Zhang Y
Year: 2014
Journal: Blood
Title: The polycomb repressive complex 2 governs life and death of peripheral T cells.
Volume: 124
Issue: 5
Pages: 737-49
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Publication
23548571 | J:201207
First Author: Osada T
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Poly(ADP-ribosylation) regulates chromatin organization through histone H3 modification and DNA methylation of the first cell cycle of mouse embryos.
Volume: 434
Issue: 1
Pages: 15-21
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Publication
22237151 | J:196546
First Author: Ntziachristos P
Year: 2012
Journal: Nat Med
Title: Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia.
Volume: 18
Issue: 2
Pages: 298-301
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Publication
24882207 | J:228104
First Author: Cifuentes-Rojas C
Year: 2014
Journal: Mol Cell
Title: Regulatory interactions between RNA and polycomb repressive complex 2.
Volume: 55
Issue: 2
Pages: 171-85
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Publication
25271128 | J:242817
First Author: Vizán P
Year: 2015
Journal: FEBS J
Title: Role of PRC2-associated factors in stem cells and disease.
Volume: 282
Issue: 9
Pages: 1723-35
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Protein
F6T3Z0
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: true
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Protein
F7CW38
Organism: Mus musculus/domesticus
Length: 52  
Fragment?: true
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Protein Domain
IPR045318 | EZH1/2-like
Type: Family
Description: This entry represents a group of histone-lysine N-methyltransferases that belong to the Polycomb group (Pc-G), including:Drosophila melanogaster Enhancer of zeste E(z).Mammalian EZH-1 and EZH-2.Arabidopsis thaliana CURLY LEAF (CLF), a transcriptional repressor of floral homeotic gene AGAMOUS.Arabidopsis thaliana CLF-like.Arabidopsis thaliana MEDEA (MEA), a suppressor of endosperm development.Arabidopsis thaliana EZA1.The Polycomb Repressive Complex 2 (PRC2) is a chromatin modifying complex that consists of three core components: EED, SUZ12 and one of the two histone H3K27 methyltransferases, EZH1 or EZH2 []. The PRC2 complex catalyses di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), which has a repressive role. Even though EZH1 and EZH2 form similar PRC2 complexes, they exhibit contrasting repressive roles. In terms of their expression in mice, EZH1 is more abundant in nonproliferative adult organs, while EZH2 expression is tightly associated with proliferation [].
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Protein Coding Gene
MGI:2143991 | Epop
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
15916951 | J:99186
First Author: Montgomery ND
Year: 2005
Journal: Curr Biol
Title: The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation.
Volume: 15
Issue: 10
Pages: 942-7
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Publication
25645357 | J:222052
First Author: Kinkel SA
Year: 2015
Journal: Blood
Title: Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2.
Volume: 125
Issue: 12
Pages: 1890-900
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Publication
25778535 | J:223783
First Author: Alemdehy MF
Year: 2015
Journal: Blood
Title: ICL-induced miR139-3p and miR199a-3p have opposite roles in hematopoietic cell expansion and leukemic transformation.
Volume: 125
Issue: 25
Pages: 3937-48
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Publication
36639541 | J:333939
First Author: Säisä-Borreill S
Year: 2023
Journal: Cell Death Differ
Title: General transcription factor TAF4 antagonizes epigenetic silencing by Polycomb to maintain intestine stem cell functions.
Volume: 30
Issue: 3
Pages: 839-853
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Publication
35676242 | J:325564
First Author: Lian WS
Year: 2022
Journal: Cell Death Dis
Title: Histone H3K27 demethylase UTX compromises articular chondrocyte anabolism and aggravates osteoarthritic degeneration.
Volume: 13
Issue: 6
Pages: 538
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Publication
25516969 | J:217678
First Author: Karamitros D
Year: 2015
Journal: Development
Title: Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors.
Volume: 142
Issue: 1
Pages: 70-81
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Publication
18662993 | J:140351
First Author: Li T
Year: 2008
Journal: Mol Cell Biol
Title: CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop.
Volume: 28
Issue: 20
Pages: 6473-82
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Publication
23836662 | J:198788
First Author: Hwang-Verslues WW
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy.
Volume: 110
Issue: 30
Pages: 12331-6
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Publication
23852375 | J:228607
First Author: Ridinger-Saison M
Year: 2013
Journal: Cell Death Differ
Title: Epigenetic silencing of Bim transcription by Spi-1/PU.1 promotes apoptosis resistance in leukaemia.
Volume: 20
Issue: 9
Pages: 1268-78
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Publication
31004482 | J:273642
First Author: Pepin ME
Year: 2019
Journal: Endocrinology
Title: Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islets.
Volume: 160
Issue: 5
Pages: 1150-1163
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Publication
31023785 | J:277111
First Author: Korfhage J
Year: 2019
Journal: Mol Cancer Res
Title: Malignant Peripheral Nerve Sheath Tumors: From Epigenome to Bedside.
Volume: 17
Issue: 7
Pages: 1417-1428
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ncRNA Gene
MGI:5624990 | Chaer1
Type: lncRNA_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1338038 | Aebp2
Type: protein_coding_gene
Organism: mouse, laboratory
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ncRNA Gene
MGI:2442953 | 9630013A20Rik
Type: lncRNA_gene
Organism: mouse, laboratory
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Publication
20052282 | J:156685
First Author: Maenner S
Year: 2010
Journal: PLoS Biol
Title: 2-D structure of the A region of Xist RNA and its implication for PRC2 association.
Volume: 8
Issue: 1
Pages: e1000276
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Protein
P70351
Organism: Mus musculus/domesticus
Length: 747  
Fragment?: false
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Protein
A0A0R4J1C0
Organism: Mus musculus/domesticus
Length: 750  
Fragment?: false
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Protein Coding Gene
MGI:98647 | Phf1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1921266 | Phf19
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q61188
Organism: Mus musculus/domesticus
Length: 746  
Fragment?: false
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Protein
Q3TZH6
Organism: Mus musculus/domesticus
Length: 746  
Fragment?: false
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Protein
Q571L5
Organism: Mus musculus/domesticus
Length: 779  
Fragment?: true
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Protein
D3Z774
Organism: Mus musculus/domesticus
Length: 707  
Fragment?: false
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Protein
Q6AXH7
Organism: Mus musculus/domesticus
Length: 742  
Fragment?: false
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Protein Coding Gene
MGI:105050 | Mtf2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
A0A140LIN6
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
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Protein Coding Gene
MGI:1859287 | Dnmt3l
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2153072 | Trim37
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1097695 | Ezh1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104813 | Jarid2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1194912 | Rbbp4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95286 | Eed
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1194910 | Rbbp7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q921E6
Organism: Mus musculus/domesticus
Length: 441  
Fragment?: false
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Protein
A0A5F8MPX8
Organism: Mus musculus/domesticus
Length: 500  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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