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Search results 701 to 800 out of 825 for Cebpb

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Type Details Score
Publication
17218383 | J:145326
First Author: Roy CN
Year: 2007
Journal: Blood
Title: Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation.
Volume: 109
Issue: 9
Pages: 4038-44
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Publication
36525476 | J:333515
First Author: Dhanasekaran R
Year: 2023
Journal: Cancer Res
Title: MYC Overexpression Drives Immune Evasion in Hepatocellular Carcinoma That Is Reversible through Restoration of Proinflammatory Macrophages.
Volume: 83
Issue: 4
Pages: 626-640
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Publication
19061838 | J:142029
First Author: Cairo S
Year: 2008
Journal: Cancer Cell
Title: Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer.
Volume: 14
Issue: 6
Pages: 471-84
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Publication
21262914 | J:170758
First Author: Cao Z
Year: 2011
Journal: Cancer Res
Title: MYC phosphorylation, activation, and tumorigenic potential in hepatocellular carcinoma are regulated by HMG-CoA reductase.
Volume: 71
Issue: 6
Pages: 2286-97
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Publication
21389265 | J:170992
First Author: Chow EK
Year: 2011
Journal: Sci Transl Med
Title: Nanodiamond therapeutic delivery agents mediate enhanced chemoresistant tumor treatment.
Volume: 3
Issue: 73
Pages: 73ra21
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Publication
27197165 | J:232786
First Author: Kress TR
Year: 2016
Journal: Cancer Res
Title: Identification of MYC-Dependent Transcriptional Programs in Oncogene-Addicted Liver Tumors.
Volume: 76
Issue: 12
Pages: 3463-72
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Genotype
Genotype
Symbol: Tg(tetO-MYC)36aBop/? Tg(Cebpb-tTA)5Bjd/?
Background: involves: FVB/N * NMRI
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Col1a1/Col1a1<+> Tg(Cebpb-tTA)5Bjd/?
Background: involves: 129S4/SvJae * C57BL/6 * NMRI
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Col1a1/Col1a1<+> Tg(Cebpb-tTA)5Bjd/?
Background: involves: 129S4/SvJae * C57BL/6 * NMRI
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Col1a1/Col1a1<+> Tg(Cebpb-tTA)#Bjd/?
Background: B6.Cg-Col1a1 Tg(Cebpb-tTA)#Bjd
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Col1a1/Col1a1 Tg(Cebpb-tTA)#Bjd/?
Background: B6.Cg-Col1a1 Tg(Cebpb-tTA)#Bjd
Zygosity: cx
Has Mutant Allele: true
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Publication
1427819 | J:2156
First Author: Hendricks-Taylor LR
Year: 1992
Journal: Genomics
Title: The CCAAT/enhancer binding protein (C/EBP alpha) gene (CEBPA) maps to human chromosome 19q13.1 and the related nuclear factor NF-IL6 (C/EBP beta) gene (CEBPB) maps to human chromosome 20q13.1.
Volume: 14
Issue: 1
Pages: 12-7
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Strain
MGI:6195656 | BALB/cJ-Cebpb<tm1.1Elgaz> Lyz2<em1.1Elgaz>/Elgaz
Attribute String: mutant strain, endonuclease-mediated mutation, coisogenic, targeted mutation
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Publication
21573126 | J:172430
First Author: Saddic LA
Year: 2011
Journal: PLoS One
Title: Functional interactions between retinoblastoma and c-MYC in a mouse model of hepatocellular carcinoma.
Volume: 6
Issue: 5
Pages: e19758
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Publication
20214788 | J:326688
 
First Author: Bitton-Worms K
Year: 2010
Journal: Mol Cancer
Title: The AP-1 repressor protein, JDP2, potentiates hepatocellular carcinoma in mice.
Volume: 9
Pages: 54
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Publication
34326210 | J:308844
 
First Author: Grunewald M
Year: 2021
Journal: Science
Title: Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span.
Volume: 373
Issue: 6554
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Strain
MGI:6450908 | B6.Cg-Gt(ROSA)26Sor<tm3(CEBPB)Myz>/J
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:6197222 | B6J.Cg-Tg(Cebpb-tTA)5Bjd Tg(tetO-MYC,-OVAL)#Gtgm
Attribute String: congenic, mutant strain, transgenic
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Publication
33087321 | J:300140
First Author: Thomann S
Year: 2020
Journal: Cancer Res
Title: YAP Orchestrates Heterotypic Endothelial Cell Communication via HGF/c-MET Signaling in Liver Tumorigenesis.
Volume: 80
Issue: 24
Pages: 5502-5514
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Publication
11381087 | J:69731
First Author: Wang R
Year: 2001
Journal: J Cell Biol
Title: Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice.
Volume: 153
Issue: 5
Pages: 1023-34
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Publication
21949730 | J:177679
First Author: Ivanovska I
Year: 2011
Journal: PLoS One
Title: Gene signatures derived from a c-MET-driven liver cancer mouse model predict survival of patients with hepatocellular carcinoma.
Volume: 6
Issue: 9
Pages: e24582
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Publication
17785413 | J:124960
First Author: Tward AD
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Distinct pathways of genomic progression to benign and malignant tumors of the liver.
Volume: 104
Issue: 37
Pages: 14771-6
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Allele
Cebpa<tm1.1(Cebpb)Ylee> | MGI:2183333
Name: CCAAT/enhancer binding protein alpha; targeted mutation 1.1, Ying-Hue Lee
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Null/knockout
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Genotype
Genotype
Symbol: Tg(tetO-MET)23Rwng/? Tg(Cebpb-tTA)5Bjd/?
Background: involves: FVB/N * NMRI
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rb1/Rb1 Tg(tetO-MYC)36aBop/? Tg(Cebpb-tTA)5Bjd/?
Background: involves: FVB/N * NMRI
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Col1a1/Col1a1<+> Tg(Cebpb-tTA)5Bjd/?
Background: involves: 129S4/SvJae * C57BL/6 * NMRI
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cebpb/Cebpb Lyz2/Lyz2<+>
Background: BALB/cJ-Cebpb Lyz2/Elgaz
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Cebpb-tTA)5Bjd/? Tg(tetO-MYC,-OVAL)#Gtgm/?
Background: B6J.Cg-Tg(Cebpb-tTA)5Bjd Tg(tetO-MYC,-OVAL)#Gtgm
Zygosity: cx
Has Mutant Allele: true
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HT Experiment
E-GEOD-15315 | ERK1/2 in Ovarian Granulosa Cells are Essential for Female Fertility
Series Id: GSE15315
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
19359353 | J:149907
First Author: Foreman JE
Year: 2009
Journal: Toxicol Sci
Title: Differential hepatic effects of perfluorobutyrate mediated by mouse and human PPAR-alpha.
Volume: 110
Issue: 1
Pages: 204-11
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Publication
15172993 | J:90303
First Author: Cheung C
Year: 2004
Journal: Cancer Res
Title: Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha.
Volume: 64
Issue: 11
Pages: 3849-54
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Publication
34081128 | J:331739
First Author: Foreman JE
Year: 2021
Journal: Toxicol Sci
Title: Diminished Hepatocarcinogenesis by a Potent, High-Affinity Human PPARα Agonist in PPARA-Humanized Mice.
Volume: 183
Issue: 1
Pages: 70-80
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Publication
26934227 | J:229665
First Author: Ma C
Year: 2016
Journal: Nature
Title: NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis.
Volume: 531
Issue: 7593
Pages: 253-7
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Publication
17298173 | J:141590
First Author: Kornmann B
Year: 2007
Journal: PLoS Biol
Title: System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock.
Volume: 5
Issue: 2
Pages: e34
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Publication
15455033 | J:93372
First Author: Beer S
Year: 2004
Journal: PLoS Biol
Title: Developmental context determines latency of MYC-induced tumorigenesis.
Volume: 2
Issue: 11
Pages: e332
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Publication
37628798 | J:339619
 
First Author: Schmidt AV
Year: 2023
Journal: Int J Mol Sci
Title: A Novel Transgenic Mouse Model Implicates Sirt2 as a Promoter of Hepatocellular Carcinoma.
Volume: 24
Issue: 16
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Publication
17589519 | J:125802
First Author: Goga A
Year: 2007
Journal: Nat Med
Title: Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC.
Volume: 13
Issue: 7
Pages: 820-7
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Publication
31933479 | J:283336
   
First Author: Dhanasekaran R
Year: 2020
Journal: Elife
Title: MYC and Twist1 cooperate to drive metastasis by eliciting crosstalk between cancer and innate immunity.
Volume: 9
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Publication
25915584 | J:222972
First Author: Xiang Y
Year: 2015
Journal: J Clin Invest
Title: Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.
Volume: 125
Issue: 6
Pages: 2293-306
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Genotype
Genotype
Symbol: Tg(tetO-Kdr*)4377.5Rwng/? Tg(Cebpb-tTA)5Bjd/?
Background: involves: FVB/N * NMRI
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cebpa/Cebpa
Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Col1a1/Col1a1<+> Tg(Cebpb-tTA)#Bjd/?
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
27984734 | J:238054
First Author: Jaitin DA
Year: 2016
Journal: Cell
Title: Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq.
Volume: 167
Issue: 7
Pages: 1883-1896.e15
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Publication
28273455 | J:250762
First Author: Itoh-Nakadai A
Year: 2017
Journal: Cell Rep
Title: A Bach2-Cebp Gene Regulatory Network for the Commitment of Multipotent Hematopoietic Progenitors.
Volume: 18
Issue: 10
Pages: 2401-2414
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Publication
29617644 | J:261999
First Author: Bahrami-Nejad Z
Year: 2018
Journal: Cell Metab
Title: A Transcriptional Circuit Filters Oscillating Circadian Hormonal Inputs to Regulate Fat Cell Differentiation.
Volume: 27
Issue: 4
Pages: 854-868.e8
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Publication
34550736 | J:314547
First Author: Greco CM
Year: 2021
Journal: Sci Adv
Title: Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms.
Volume: 7
Issue: 39
Pages: eabi7828
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Publication
16861620 | J:116525
First Author: Sun Y
Year: 2006
Journal: J Lipid Res
Title: Conditional expression of human acid beta-glucosidase improves the visceral phenotype in a Gaucher disease mouse model.
Volume: 47
Issue: 10
Pages: 2161-70
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Strain
MGI:6378451 | B6.Cg-Trp53<tm1Gev> Col1a1<tm1(tetO-URI1)Ndj> Tg(Cebpb-tTA)#Bjd
Attribute String: transgenic, targeted mutation, mutant strain, congenic
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Publication
27505673 | J:234982
First Author: Burén S
Year: 2016
Journal: Cancer Cell
Title: Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms.
Volume: 30
Issue: 2
Pages: 290-307
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Publication
17980593 | J:141457
First Author: Camargo FD
Year: 2007
Journal: Curr Biol
Title: YAP1 increases organ size and expands undifferentiated progenitor cells.
Volume: 17
Issue: 23
Pages: 2054-60
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Publication
27411590 | J:233522
First Author: Gomes AL
Year: 2016
Journal: Cancer Cell
Title: Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma.
Volume: 30
Issue: 1
Pages: 161-175
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Publication
31128214 | J:276355
 
First Author: He J
Year: 2019
Journal: Cancer Lett
Title: Block of NF-kB signaling accelerates MYC-driven hepatocellular carcinogenesis and modifies the tumor phenotype towards combined hepatocellular cholangiocarcinoma.
Volume: 458
Pages: 113-122
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Publication
23620592 | J:199603
First Author: Tao GZ
Year: 2013
Journal: J Biol Chem
Title: Wnt/β-catenin signaling protects mouse liver against oxidative stress-induced apoptosis through the inhibition of forkhead transcription factor FoxO3.
Volume: 288
Issue: 24
Pages: 17214-24
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Publication
18004726 | J:133545
First Author: Gupta A
Year: 2008
Journal: Prostate
Title: Neuroendocrine differentiation in the 12T-10 transgenic prostate mouse model mimics endocrine differentiation of pancreatic beta cells.
Volume: 68
Issue: 1
Pages: 50-60
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Publication
31447321 | J:283755
First Author: Gouw AM
Year: 2019
Journal: Cell Metab
Title: The MYC Oncogene Cooperates with Sterol-Regulated Element-Binding Protein to Regulate Lipogenesis Essential for Neoplastic Growth.
Volume: 30
Issue: 3
Pages: 556-572.e5
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Publication
26259151 | J:224997
 
First Author: Chai X
Year: 2015
Journal: Nat Commun
Title: Oestrogen sulfotransferase ablation sensitizes mice to sepsis.
Volume: 6
Pages: 7979
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Publication
32424001 | J:318042
First Author: Silva Barbosa AC
Year: 2020
Journal: J Am Soc Nephrol
Title: Inhibition of Estrogen Sulfotransferase (SULT1E1/EST) Ameliorates Ischemic Acute Kidney Injury in Mice.
Volume: 31
Issue: 7
Pages: 1496-1508
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Publication
31837219 | J:283561
 
First Author: Xie Y
Year: 2020
Journal: Endocrinology
Title: Hepatic Estrogen Sulfotransferase Distantly Sensitizes Mice to Hemorrhagic Shock-Induced Acute Lung Injury.
Volume: 161
Issue: 1
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Publication
28273073 | J:242065
First Author: Suresh S
Year: 2017
Journal: PLoS Genet
Title: SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer.
Volume: 13
Issue: 3
Pages: e1006650
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Publication
28356389 | J:241856
First Author: Bakiri L
Year: 2017
Journal: J Exp Med
Title: Liver carcinogenesis by FOS-dependent inflammation and cholesterol dysregulation.
Volume: 214
Issue: 5
Pages: 1387-1409
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Publication
29141911 | J:260431
First Author: Croci O
Year: 2017
Journal: Genes Dev
Title: Transcriptional integration of mitogenic and mechanical signals by Myc and YAP.
Volume: 31
Issue: 20
Pages: 2017-2022
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Genotype
Genotype
Symbol: Cebpa/Cebpa
Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Col1a1/Col1a1<+> Tg(Cebpb-tTA)#Bjd/? Trp53/Trp53<+>
Background: B6.Cg-Trp53 Col1a1 Tg(Cebpb-tTA)#Bjd
Zygosity: cx
Has Mutant Allele: true
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Publication
31908399 | J:285493
 
First Author: Minogue PJ
Year: 2019
Journal: Mol Vis
Title: CHOP is dispensable for lens transparency in wild-type and connexin50 mutant mice.
Volume: 25
Pages: 535-545
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Publication
34215679 | J:322358
 
First Author: Bechara R
Year: 2021
Journal: Sci Immunol
Title: The m6A reader IMP2 directs autoimmune inflammation through an IL-17- and TNFα-dependent C/EBP transcription factor axis.
Volume: 6
Issue: 61
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Publication
34653294 | J:316402
First Author: Kurata M
Year: 2021
Journal: Cancer Sci
Title: C/EBPβ induces B-cell acute lymphoblastic leukemia and cooperates with BLNK mutations.
Volume: 112
Issue: 12
Pages: 4920-4930
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Publication
31067509 | J:294404
First Author: de Paula GSM
Year: 2019
Journal: J Mol Endocrinol
Title: Neuromedin B receptor disruption impairs adipogenesis in mice and 3T3-L1 cells.
Volume: 63
Issue: 1
Pages: 93-102
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Publication
25567987 | J:223231
First Author: Antonini D
Year: 2015
Journal: Nucleic Acids Res
Title: A composite enhancer regulates p63 gene expression in epidermal morphogenesis and in keratinocyte differentiation by multiple mechanisms.
Volume: 43
Issue: 2
Pages: 862-74
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Publication
25535333 | J:224297
First Author: Salotti J
Year: 2015
Journal: Mol Cell Biol
Title: An Arf-Egr-C/EBPβ pathway linked to ras-induced senescence and cancer.
Volume: 35
Issue: 5
Pages: 866-83
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Publication
35002622 | J:317693
 
First Author: Desouza LA
Year: 2021
Journal: Front Mol Neurosci
Title: The Hallucinogenic Serotonin2A Receptor Agonist, 2,5-Dimethoxy-4-Iodoamphetamine, Promotes cAMP Response Element Binding Protein-Dependent Gene Expression of Specific Plasticity-Associated Genes in the Rodent Neocortex.
Volume: 14
Pages: 790213
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Publication
24244176 | J:223045
First Author: Clementi C
Year: 2013
Journal: PLoS Genet
Title: Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans.
Volume: 9
Issue: 11
Pages: e1003863
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Publication
29259016 | J:257824
First Author: Basu SK
Year: 2018
Journal: Cancer Res
Title: Oncogenic RAS-Induced Perinuclear Signaling Complexes Requiring KSR1 Regulate Signal Transmission to Downstream Targets.
Volume: 78
Issue: 4
Pages: 891-908
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Publication
32929361 | J:313550
First Author: Qie C
Year: 2020
Journal: Theranostics
Title: Single-cell RNA-Seq reveals the transcriptional landscape and heterogeneity of skin macrophages in Vsir-/- murine psoriasis.
Volume: 10
Issue: 23
Pages: 10483-10497
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Publication
17572676 | J:123006
First Author: Dickins RA
Year: 2007
Journal: Nat Genet
Title: Tissue-specific and reversible RNA interference in transgenic mice.
Volume: 39
Issue: 7
Pages: 914-21
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Publication
11252052 | J:127660
First Author: Hasan MT
Year: 2001
Journal: Genesis
Title: Long-term, noninvasive imaging of regulated gene expression in living mice.
Volume: 29
Issue: 3
Pages: 116-22
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Publication
25270420 | J:219679
First Author: Ueberham E
Year: 2015
Journal: Mol Cancer Res
Title: Global increase of p16INK4a in APC-deficient mouse liver drives clonal growth of p16INK4a-negative tumors.
Volume: 13
Issue: 2
Pages: 239-49
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Publication
8855286 | J:93000
First Author: Kistner A
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice.
Volume: 93
Issue: 20
Pages: 10933-8
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Publication
24166715 | J:207718
First Author: Avraham-Davidi I
Year: 2013
Journal: J Exp Med
Title: On-site education of VEGF-recruited monocytes improves their performance as angiogenic and arteriogenic accessory cells.
Volume: 210
Issue: 12
Pages: 2611-25
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Publication
25453901 | J:217463
First Author: Tummala KS
Year: 2014
Journal: Cancer Cell
Title: Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.
Volume: 26
Issue: 6
Pages: 826-839
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Publication
25117712 | J:214596
First Author: Nguyen LH
Year: 2014
Journal: Cancer Cell
Title: Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models.
Volume: 26
Issue: 2
Pages: 248-61
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Strain
MGI:3704925 | STOCK Dbt<tm1Geh> Tg(Cebpb-tTA)5Bjd Tg(tetO-DBT)A1Geh/J
Attribute String: transgenic, targeted mutation, mutant stock
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Publication
19699299 | J:164850
First Author: Skvorak KJ
Year: 2009
Journal: Biochim Biophys Acta
Title: Hepatocyte transplantation (HTx) corrects selected neurometabolic abnormalities in murine intermediate maple syrup urine disease (iMSUD).
Volume: 1792
Issue: 10
Pages: 1004-10
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Publication
27373929 | J:257303
 
First Author: S Sonnet D
Year: 2016
Journal: Sci Rep
Title: Metformin inhibits Branched Chain Amino Acid (BCAA) derived ketoacidosis and promotes metabolic homeostasis in MSUD.
Volume: 6
Pages: 28775
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Publication
22820288 | J:190067
First Author: Hsu SH
Year: 2012
Journal: J Clin Invest
Title: Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver.
Volume: 122
Issue: 8
Pages: 2871-83
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Genotype
Genotype
Symbol: Dbt/Dbt Tg(tetO-DBT)A1Geh/? Tg(Cebpb-tTA)5Bjd/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dbt/Dbt Tg(tetO-DBT)525AGeh/? Tg(Cebpb-tTA)5Bjd/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kdr/Kdr<+> Tg(tetO-Kdr*)4377.5Rwng/? Tg(Cebpb-tTA)5Bjd/?
Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * NMRI
Zygosity: cx
Has Mutant Allele: true
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Protein
E9Q1F7
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: true
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Protein
F6ZCH1
Organism: Mus musculus/domesticus
Length: 66  
Fragment?: true
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Protein
F6SIC5
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
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Publication
9224714 | -
First Author: Grant PA
Year: 1997
Journal: Genes Dev
Title: Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.
Volume: 11
Issue: 13
Pages: 1640-50
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Protein Domain
IPR037800 | GCN5
Type: Family
Description: This entry includes histone acetyltransferases GCN5, KAT2A and KAT2B (all of which are included in ). GCN5 acetylates histones H2B, H3 and H4, providing a specific tag for epigenetic transcription activation. GCN5 is a component of the transcription regulatory histone acetylation (HAT) complexes SAGA [], SLIK [], SALSA []and ADA []. Mammals have two paralogues: KAT2A (also known as GCN5) and KAT2B. KAT2A acetylates core histones to provide a specific tag for epigenetic transcription activation, but not nucleosome core particles. It also acetylates proteins such as CEBPB []. KAT2A is a component of the ATAC complex, which has acetyltransferase activity on histones H3 and H4 []. KAT2B (also known as P300/calcium-binding protein (CBP)-associated factor or PCAF) can acetylate the core histones H3 and H4 as well as nucleosome core particles and non-histone proteins such as ACLY [].The transcription regulatory histone acetylation complex Spt-Ada-Gcn5 acetyltransferase (SAGA) is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. SAGA preferentially acetylates histones H3 and H2B and deubiquitinates histone H2B []. SAGA is known as PCAF in vertebrates and PCAF acetylates nucleosomal histone H3 []. The SAGA complex consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1, and some of these components are present as two copies. The complex is built up from distinct modules, each of which has a separate function and crosslinks with either other proteins or other modules in the complex [].SLIK (SAGA-like) is a multi-subunit histone acetyltransferase complex that preferentially acetylates histones H3 and H2B and deubiquitinates histone H2B. It is an embellishment of the SAGA complex. The yeast SLIK complex consists of at least TRA1, CHD1, SPT7, CC TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8 (a deubiquitinase), GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9 [, ].The yeast SALSA complex is an altered form of the SAGA complex and consists of at least TRA1, SPT7 (C-terminal truncated form), TAF5, ADA3, SPT20, TAF12, TAF6, HFI1, GCN5, ADA2 and SPT3 [].The ADA complex is a transcription regulatory histone acetylation (HAT) complex. ADA preferentially acetylates nucleosomal histones H3 (at 'Lys-14' and 'Lys-18') and H2B. The complex consists of at least ADA2, ADA3, AHC1, and GCN5. AHC1 is required for the overall structural integrity of the ADA complex [].
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Publication
22190699 | J:185769
First Author: Le JA
Year: 2012
Journal: Biol Reprod
Title: Generation of mice expressing only the long form of the prolactin receptor reveals that both isoforms of the receptor are required for normal ovarian function.
Volume: 86
Issue: 3
Pages: 86
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Publication
20640885 | J:172622
First Author: Schönig K
Year: 2011
Journal: Transgenic Res
Title: Development of a BAC vector for integration-independent and tight regulation of transgenes in rodents via the Tet system.
Volume: 20
Issue: 3
Pages: 709-20
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Publication
26655697 | J:235897
First Author: Li Z
Year: 2015
Journal: Cell Metab
Title: Hypothalamic Amylin Acts in Concert with Leptin to Regulate Food Intake.
Volume: 22
Issue: 6
Pages: 1059-67
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Publication
19105207 | J:186226
First Author: Ney JT
Year: 2009
Journal: Hepatology
Title: Autochthonous liver tumors induce systemic T cell tolerance associated with T cell receptor down-modulation.
Volume: 49
Issue: 2
Pages: 471-81
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Publication
36055226 | J:328531
First Author: Ma C
Year: 2022
Journal: Cancer Cell
Title: Platelets control liver tumor growth through P2Y12-dependent CD40L release in NAFLD.
Volume: 40
Issue: 9
Pages: 986-998.e5
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Publication
22556267 | J:184782
First Author: O'Donnell KA
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer.
Volume: 109
Issue: 21
Pages: E1377-86
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Publication
23932781 | -
First Author: Lin R
Year: 2013
Journal: Mol Cell
Title: Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth.
Volume: 51
Issue: 4
Pages: 506-518
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Publication
10026213 | -
First Author: Grant PA
Year: 1999
Journal: J Biol Chem
Title: Expanded lysine acetylation specificity of Gcn5 in native complexes.
Volume: 274
Issue: 9
Pages: 5895-900
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