Protein FAM3C, also known as interleukin-like EMT inducer (ILEI), participates in the formation of TGF-beta1-induced renal tubular epithelial-to-mesenchymal transition (EMT) and has been linked to EMT in some diseases []. It is a hepatokine that suppresses hepatic gluconeogenic gene expression and insulin-independent gluconeogenesis by activating the HSF1-CaM-Akt pathway. It activates transcriptor heat shock factor 1 (HSF1) to induce CALM1 gene expression and increase calmodulin (CaM) protein level. An increase in CaM protein level suppresses glucose production by inducing Akt activation [, ].
