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Search results 101 to 109 out of 109 for Mastl

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0.015s

Type

Details

Score

Publication

28636940 | -

First Author:	Li Z
Year:	2017
Journal:	Cell Rep
Title:	HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients.
Volume:	19
Issue:	12
Pages:	2515-2528

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Publication

23358872 | -

First Author:	Li Y
Year:	2013
Journal:	Neoplasia
Title:	The HECTD3 E3 ubiquitin ligase suppresses cisplatin-induced apoptosis via stabilizing MALT1.
Volume:	15
Issue:	1
Pages:	39-48

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Protein Domain

IPR042469 | HECTD3

Type:	Family
Description:	E3 ubiquitin-protein ligase HECTD3 is an E3 ubiquitin ligase that regulates ubiquitination and degradation of Tara [], MASTL and LKB1 []. HECTD3 interacts with HSP90 and is involved in the HSP90-dependent degradation of CRAF protein []. It has been shown to interact and stabilize MALT1 (mucosa-associated lymphoid tissue 1), and may hence promote cell survival [].

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Publication

22754657 | -

First Author:	Glover DM
Year:	2012
Journal:	Open Biol
Title:	The overlooked greatwall: a new perspective on mitotic control.
Volume:	2
Issue:	3
Pages:	120023

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Publication

22469975 | -

First Author:	Lorca T
Year:	2013
Journal:	Oncogene
Title:	The Greatwall kinase: a new pathway in the control of the cell cycle.
Volume:	32
Issue:	5
Pages:	537-43

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Publication

21708943 | -

First Author:	Peng A
Year:	2011
Journal:	J Biol Chem
Title:	Greatwall and Polo-like kinase 1 coordinate to promote checkpoint recovery.
Volume:	286
Issue:	33
Pages:	28996-9004

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Protein Domain

IPR037638 | MASTL_STKc

Type:

Domain

Description:

The MASTL kinases carry only a catalytic domain, which contains a long insertion relative to MAST kinases. MASTL, also called greatwall kinase (Gwl), is involved in the regulation of mitotic entry, which is controlled by the coordinated activities of protein kinases and opposing protein phosphatases (PPs) []. The cyclin B/CDK1 complex induces entry into M-phase while PP2A-B55 shows anti-mitotic activity. MASTL/Gwl is activated downstream of cyclin B/CDK1 and indirectly inhibits PP2A-B55 by phosphorylating the small protein alpha-endosulfine (Ensa) or the cAMP-regulated phosphoprotein 19 (Arpp19), resulting in M-phase progression []. Gwl kinase may also play roles in mRNA stabilization and DNA checkpoint recovery [, ]. The human MASTL gene has also been named FLJ14813; a missense mutation in FLJ14813 is associated with autosomal dominant thrombocytopenia [].

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Publication

21156286 | J:167609

First Author:	Manchado E
Year:	2010
Journal:	Cancer Cell
Title:	Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase.
Volume:	18
Issue:	6
Pages:	641-54

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Protein

Q3U487

Organism:	Mus musculus/domesticus
Length:	861
Fragment?:	false

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