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Search results 301 to 315 out of 315 for Ccn3

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Type Details Score
Publication
28288125 | J:245842
First Author: Dombrowski Y
Year: 2017
Journal: Nat Neurosci
Title: Regulatory T cells promote myelin regeneration in the central nervous system.
Volume: 20
Issue: 5
Pages: 674-680
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Protein Domain
IPR043973 | TSP1_CCN
Type: Domain
Description: Proteins from the CCN family are intercellular signalling proteins that includes six homologous members: cysteine-rich 61(Cyr61)/CCN1, connective tissue growth factor (Ctgf)/CCN2, nephroblastoma overexpressed gene (Nov)/CCN3, Wnt-induced secreted protein 1 (Wisp1)/CCN4, Wisp2/CCN5, and Wisp3/CCN6. They are involved in many biological processes, such as angiogenesis, wound healing, and tumorigenesis, by regulating the proliferation, migration, and differentiation of the target cells []. They interact with extracellular matrix components and growth factors via one of their four domains. In particular CNN3 (previously known as Nov) plays an important role in the generation of various types of tissues, such as muscle, fat, cartilage, and bone. CCN3 is expressed in notochord and presomitic mesoderm in early stage development, and in adults it is expressed in diverse tissues, including the nervous system, muscle, cartilage, and bone [].This entry represents a sub-type of thrombospondin module 1 (TSP1) domains found in matricellular CCN proteins which shares a similar three-stranded fold with the thrombospondin type 1 repeats of thrombospondin-1 and spondin-1. This domain has an alternative disulphide binding pattern compared to the canonical TSP1 domain and a conserved charged cluster in the centre of the domain which suggests to have a potential functional binding site for heparan sulfate [].
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Publication
12826661 | J:85278
First Author: Leu SJ
Year: 2003
Journal: J Biol Chem
Title: Identification of a novel integrin alpha 6 beta 1 binding site in the angiogenic inducer CCN1 (CYR61).
Volume: 278
Issue: 36
Pages: 33801-8
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Publication
9745429 | J:49843
First Author: Baxter RC
Year: 1998
Journal: J Clin Endocrinol Metab
Title: Recommendations for nomenclature of the insulin-like growth factor binding protein superfamily.
Volume: 83
Issue: 9
Pages: 3213
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Protein
P29268
Organism: Mus musculus/domesticus
Length: 348  
Fragment?: false
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Protein
Q64299
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: false
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Protein
D3Z5L9
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: false
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Protein
O54775
Organism: Mus musculus/domesticus
Length: 367  
Fragment?: false
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Protein
P18406
Organism: Mus musculus/domesticus
Length: 379  
Fragment?: false
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Protein
Q3U2X7
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: false
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Protein
Q3UFJ5
Organism: Mus musculus/domesticus
Length: 367  
Fragment?: false
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Protein
Q3TX21
Organism: Mus musculus/domesticus
Length: 379  
Fragment?: false
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Protein
Q9Z0G4
Organism: Mus musculus/domesticus
Length: 251  
Fragment?: false
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Protein
A2AHD1
Organism: Mus musculus/domesticus
Length: 251  
Fragment?: false
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Protein
H3BJW0
Organism: Mus musculus/domesticus
Length: 293  
Fragment?: false
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