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Search results 1701 to 1797 out of 1797 for Cx3cr1

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Type Details Score
Publication
7590284 | -
First Author: Raport CJ
Year: 1995
Journal: Gene
Title: The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues.
Volume: 163
Issue: 2
Pages: 295-9
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Publication
17479179 | -
First Author: Ludwig A
Year: 2007
Journal: Thromb Haemost
Title: Transmembrane chemokines: versatile 'special agents' in vascular inflammation.
Volume: 97
Issue: 5
Pages: 694-703
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Publication
12714508 | -
First Author: Hundhausen C
Year: 2003
Journal: Blood
Title: The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.
Volume: 102
Issue: 4
Pages: 1186-95
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Publication
11495925 | -
First Author: Garton KJ
Year: 2001
Journal: J Biol Chem
Title: Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1).
Volume: 276
Issue: 41
Pages: 37993-8001
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Publication
12969992 | -
First Author: Umehara H
Year: 2004
Journal: Arterioscler Thromb Vasc Biol
Title: Fractalkine in vascular biology: from basic research to clinical disease.
Volume: 24
Issue: 1
Pages: 34-40
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Protein Domain
IPR005387 | Chemokine_CX3CR1
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).The only CX3C chemokine identified to date is CX3C chemokine ligand 1 (CX3CL1), also known as fractalkine or neurotactin. It is a transmembrane molecule containing a chemokine domain on an extended mucin-like stalk []. Both the adhesive and chemotactic effects of CX3CL1 are mediated through CX3C chemokine receptor type 1 (CX3CR1), also known as fractalkine receptor []. The receptor is expressed specifically on T cells, natural killer cells and monocytes [, ]. Coupling of the receptor to pertussis toxin-sensitive Gi proteins leads to calcium mobilisation and chemotaxis []. In contrast, adhesion mediated by the receptor is insensitive to pertussis toxin and does not appear to involve calcium mobilisation. CX3CR1 has also been found to act as a weak fusion cofactor for some HIV-1 strains, an interaction that can be potently and specifically blocked by CX3CL1 [].
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Protein Domain
IPR008097 | CX3CL1
Type: Family
Description: The only CX3C chemokine identified to date is CX3C chemokine ligand 1 (CX3CL1), also known as fractalkine or neurotactin. With its unique CX3CR1 receptor [], it is involved in adherence to the endothelium of the inflammatory monocyte population [].CX3CL1 and CXCL16 represent two exceptions among the members of the chemokine family. In addition to their chemokine domain, they possess three other domains: a mucin-like stalk, a transmembrane (TM) domain, and a cytosolic tail [, ]. When interacting with their cognate receptors (CX3CR1 and CXCR6, respectively), these chemokines induce cell-cell adhesion []. CX3CL1 and CXCL16 can also be cleaved by metalloproteinases to yield a soluble form that is chemotactic [, ]. CX3CL1 also binds and activates integrins through its chemokine domain in a CX3CR1-dependent and independent manner, binding to the classical ligand-binding site (RGD-binding site, site 1) or to a second site (site 2) in integrins, respectively [].Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions,and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).
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Publication
30447281 | J:336190
 
First Author: Rivera PD
Year: 2019
Journal: Brain Behav Immun
Title: Removal of microglial-specific MyD88 signaling alters dentate gyrus doublecortin and enhances opioid addiction-like behaviors.
Volume: 76
Pages: 104-115
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Publication
24584051 | J:212017
First Author: Crotti A
Year: 2014
Journal: Nat Neurosci
Title: Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors.
Volume: 17
Issue: 4
Pages: 513-21
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Publication
30816678 | J:294699
First Author: Schuett J
Year: 2019
Journal: Cell Physiol Biochem
Title: Suppressor of Cytokine Signaling 1 is Involved in Gene Regulation Which Controls the Survival of Ly6Clow Monocytes in Mice.
Volume: 52
Issue: 2
Pages: 336-353
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Publication
15596719 | J:95279
First Author: Teupser D
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic root.
Volume: 101
Issue: 51
Pages: 17795-800
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Publication
22575169 | J:186182
First Author: Gardner CR
Year: 2012
Journal: Toxicol Appl Pharmacol
Title: Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase.
Volume: 262
Issue: 2
Pages: 139-48
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Publication
25767273 | J:241334
First Author: Ebrahimian T
Year: 2015
Journal: Arterioscler Thromb Vasc Biol
Title: Absence of Four-and-a-Half LIM Domain Protein 2 Decreases Atherosclerosis in ApoE-/- Mice.
Volume: 35
Issue: 5
Pages: 1190-7
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Publication
23029290 | J:191975
First Author: Reed JR
Year: 2012
Journal: PLoS One
Title: Fibroblast growth factor receptor 1 activation in mammary tumor cells promotes macrophage recruitment in a CX3CL1-dependent manner.
Volume: 7
Issue: 9
Pages: e45877
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Publication
26348210 | J:243007
First Author: Kim YG
Year: 2015
Journal: PLoS One
Title: Pathogenic Role of a Proliferation-Inducing Ligand (APRIL) in Murine IgA Nephropathy.
Volume: 10
Issue: 9
Pages: e0137044
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Publication
29401617 | J:274296
First Author: Song C
Year: 2018
Journal: FASEB J
Title: REV-ERB agonism suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss partially via FABP4 upregulation.
Volume: 32
Issue: 6
Pages: 3215-3228
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Protein
O35188
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
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Protein
Q8C9Y1
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
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Protein
A0A1D5RMK8
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: false
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Publication
9024663 | J:42645
First Author: Bazan JF
Year: 1997
Journal: Nature
Title: A new class of membrane-bound chemokine with a CX3C motif.
Volume: 385
Issue: 6617
Pages: 640-4
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Publication
34644537 | J:319416
First Author: Faas M
Year: 2021
Journal: Immunity
Title: IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation.
Volume: 54
Issue: 11
Pages: 2531-2546.e5
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Publication
28910620 | J:250402
First Author: Hwang HW
Year: 2017
Journal: Neuron
Title: cTag-PAPERCLIP Reveals Alternative Polyadenylation Promotes Cell-Type Specific Protein Diversity and Shifts Araf Isoforms with Microglia Activation.
Volume: 95
Issue: 6
Pages: 1334-1349.e5
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Publication
33051350 | J:298595
First Author: Freria CM
Year: 2020
Journal: J Neurosci
Title: Serial Systemic Injections of Endotoxin (LPS) Elicit Neuroprotective Spinal Cord Microglia through IL-1-Dependent Cross Talk with Endothelial Cells.
Volume: 40
Issue: 47
Pages: 9103-9120
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Publication
31228609 | J:286472
 
First Author: Zhu L
Year: 2019
Journal: Brain Behav Immun
Title: Interleukin-1 causes CNS inflammatory cytokine expression via endothelia-microglia bi-cellular signaling.
Volume: 81
Pages: 292-304
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Publication
38116004 | J:343624
 
First Author: Akbarzadeh R
Year: 2023
Journal: Front Immunol
Title: Monocyte populations are involved in the pathogenesis of experimental epidermolysis bullosa acquisita.
Volume: 14
Pages: 1241461
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Publication
26782291 | J:278712
First Author: Ding XM
Year: 2016
Journal: Int J Mol Med
Title: Baicalin exerts protective effects against lipopolysaccharide-induced acute lung injury by regulating the crosstalk between the CX3CL1-CX3CR1 axis and NF-κB pathway in CX3CL1-knockout mice.
Volume: 37
Issue: 3
Pages: 703-15
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Protein
O35903
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: false
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Protein
P84444
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: false
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Protein
P86793
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: false
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Protein
P86792
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: false
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Protein
Q7TMS1
Organism: Mus musculus/domesticus
Length: 65  
Fragment?: false
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Protein
B1AVL8
Organism: Mus musculus/domesticus
Length: 85  
Fragment?: false
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Protein
D3YWJ1
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: false
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Protein
V6AW11
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: true
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Protein
D3Z470
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
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Protein
F8VQM2
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: false
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Protein
Q3V144
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: true
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Protein
Q5C9Q0
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: false
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Protein
Q3V2F3
Organism: Mus musculus/domesticus
Length: 134  
Fragment?: false
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Publication
33761330 | J:306900
First Author: Friščić J
Year: 2021
Journal: Immunity
Title: The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts.
Volume: 54
Issue: 5
Pages: 1002-1021.e10
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Publication
32805279 | J:305340
First Author: Willers M
Year: 2020
Journal: Gastroenterology
Title: S100A8 and S100A9 Are Important for Postnatal Development of Gut Microbiota and Immune System in Mice and Infants.
Volume: 159
Issue: 6
Pages: 2130-2145.e5
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Protein
O88430
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: false
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Protein
Q9JKC0
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: false
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Protein
P48298
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: false
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Protein
Q62401
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: false
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Protein
O70460
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
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Protein
Q9Z121
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: false
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Protein
P30882
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: false
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Protein
P27784
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: false
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Protein
Q03366
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: false
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Protein
P14097
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: false
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Protein
P10855
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: false
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Protein
P10148
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: false
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Protein
P51670
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: false
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Protein
P10146
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: false
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Protein
O89093
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: false
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Protein
P47993
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: false
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Protein
Q543X3
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: false
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Protein
Q3U9T8
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: false
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Protein
Q546S6
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: false
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Protein
Q5QNV9
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: false
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Protein
Q5XZF2
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: false
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Protein
Q149U7
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: false
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Protein
Q5QNW0
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: false
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Protein
A9Z1Z1
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: false
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Protein
Q3U5S8
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: false
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Protein
Q3U6F9
Organism: Mus musculus/domesticus
Length: 74  
Fragment?: true
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Protein
F8WHA7
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: false
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Protein
Q9R043
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: true
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Protein
Q8CBJ0
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: false
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Protein
Q8BR50
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: false
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Protein
Q9QZU2
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: false
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Protein
Q3U5L6
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: false
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Protein
Q545B5
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: false
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Protein
Q54AI7
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: false
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Protein
F6R5P4
Organism: Mus musculus/domesticus
Length: 103  
Fragment?: false
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Protein
Q0VB35
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: false
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Protein
Q2M4I0
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: false
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Protein
Q3U3N8
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: false
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Protein
Q642U4
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: false
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Protein
A0A4D6YWC7
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: false
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Protein
A0A0N4SUZ8
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: false
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Protein
Q542T1
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: false
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Protein
Q548P0
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
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Protein
Q5SVU3
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: false
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Protein
Q9WUZ6
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: false
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Protein
Q3U0A4
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: false
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Publication
9632725 | J:172918
First Author: Yoshida T
Year: 1998
Journal: J Biol Chem
Title: Identification of single C motif-1/lymphotactin receptor XCR1.
Volume: 273
Issue: 26
Pages: 16551-4
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Publication
30683620 | J:282496
First Author: Liu X
Year: 2019
Journal: Immunity
Title: Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities.
Volume: 50
Issue: 2
Pages: 317-333.e6
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Publication
24857755 | J:230410
 
First Author: Abram CL
Year: 2014
Journal: J Immunol Methods
Title: Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice.
Volume: 408
Pages: 89-100
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Publication
9689100 | J:49070
First Author: Ma Q
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.
Volume: 95
Issue: 16
Pages: 9448-53
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Publication
11544102 | -
First Author: Horuk R
Year: 2001
Journal: Cytokine Growth Factor Rev
Title: Chemokine receptors.
Volume: 12
Issue: 4
Pages: 313-35
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Publication
10601351 | -
First Author: Charbonnier AS
Year: 1999
Journal: J Exp Med
Title: Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells.
Volume: 190
Issue: 12
Pages: 1755-68
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Publication
9500790 | -
First Author: Sallusto F
Year: 1998
Journal: J Exp Med
Title: Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes.
Volume: 187
Issue: 6
Pages: 875-83
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Publication
7592998 | -
First Author: Strieter RM
Year: 1995
Journal: J Biol Chem
Title: The functional role of the ELR motif in CXC chemokine-mediated angiogenesis.
Volume: 270
Issue: 45
Pages: 27348-57
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Publication
10714678 | -
First Author: Zlotnik A
Year: 2000
Journal: Immunity
Title: Chemokines: a new classification system and their role in immunity.
Volume: 12
Issue: 2
Pages: 121-7
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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Cambridge CB2 3EH, United Kingdom