|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 301 to 400 out of 441 for Mlkl

0.037s
Type Details Score
Publication
First Author: Motwani M
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Hierarchy of clinical manifestations in SAVI N153S and V154M mouse models.
Volume: 116
Issue: 16
Pages: 7941-7950
Publication
First Author: Ke FFS
Year: 2022
Journal: Cell Death Dis
Title: Some mice lacking intrinsic, as well as death receptor induced apoptosis and necroptosis, can survive to adulthood.
Volume: 13
Issue: 4
Pages: 317
Publication
First Author: Shen C
Year: 2017
Journal: Biochim Biophys Acta
Title: Aldehyde dehydrogenase 2 deficiency negates chronic low-to-moderate alcohol consumption-induced cardioprotecion possibly via ROS-dependent apoptosis and RIP1/RIP3/MLKL-mediated necroptosis.
Volume: 1863
Issue: 8
Pages: 1912-1918
Publication
First Author: Liccardi G
Year: 2019
Journal: Mol Cell
Title: RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation.
Volume: 73
Issue: 3
Pages: 413-428.e7
Publication
First Author: Gitlin AD
Year: 2020
Journal: Nature
Title: Integration of innate immune signalling by caspase-8 cleavage of N4BP1.
Volume: 587
Issue: 7833
Pages: 275-280
Publication
First Author: Banoth B
Year: 2020
Journal: J Biol Chem
Title: ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis).
Volume: 295
Issue: 52
Pages: 18276-18283
Publication
First Author: Höckendorf U
Year: 2016
Journal: Cancer Cell
Title: RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells.
Volume: 30
Issue: 1
Pages: 75-91
Publication
First Author: Günther C
Year: 2019
Journal: Gastroenterology
Title: Interferon Lambda Promotes Paneth Cell Death Via STAT1 Signaling in Mice and Is Increased in Inflamed Ileal Tissues of Patients With Crohn's Disease.
Volume: 157
Issue: 5
Pages: 1310-1322.e13
Publication
First Author: Saleh D
Year: 2017
Journal: J Immunol
Title: Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-β Synthesis Induced by Lipopolysaccharide.
Volume: 198
Issue: 11
Pages: 4435-4447
Publication
First Author: Cao M
Year: 2019
Journal: Cell Death Differ
Title: Dectin-1-induced RIPK1 and RIPK3 activation protects host against Candida albicans infection.
Volume: 26
Issue: 12
Pages: 2622-2636
Publication
First Author: Sreenivasan K
Year: 2020
Journal: Cell Rep
Title: Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles.
Volume: 31
Issue: 7
Pages: 107652
Publication  
First Author: Chun N
Year: 2021
Journal: JCI Insight
Title: T cell-derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death.
Volume: 6
Issue: 24
Publication
First Author: Hubbard NW
Year: 2022
Journal: Nature
Title: ADAR1 mutation causes ZBP1-dependent immunopathology.
Volume: 607
Issue: 7920
Pages: 769-775
Publication  
First Author: Müller K
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: JNK signaling prevents biliary cyst formation through a CASPASE-8-dependent function of RIPK1 during aging.
Volume: 118
Issue: 12
Publication
First Author: Daniels BP
Year: 2019
Journal: Immunity
Title: The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons.
Volume: 50
Issue: 1
Pages: 64-76.e4
Publication
First Author: Kaiser WJ
Year: 2013
Journal: J Biol Chem
Title: Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.
Volume: 288
Issue: 43
Pages: 31268-79
Publication
First Author: Rickard JA
Year: 2014
Journal: Cell
Title: RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.
Volume: 157
Issue: 5
Pages: 1175-88
Publication
First Author: Donado CA
Year: 2020
Journal: Cell Rep
Title: A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling.
Volume: 31
Issue: 1
Pages: 107466
Publication  
First Author: Malireddi RKS
Year: 2020
Journal: J Exp Med
Title: Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity-independent pyroptosis, apoptosis, necroptosis, and inflammatory disease.
Volume: 217
Issue: 3
Publication
First Author: Zhao Y
Year: 2015
Journal: Diabetologia
Title: Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes.
Volume: 58
Issue: 1
Pages: 140-8
Publication
First Author: Allam R
Year: 2014
Journal: EMBO Rep
Title: Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming.
Volume: 15
Issue: 9
Pages: 982-90
Publication
First Author: Wang X
Year: 2014
Journal: Nat Immunol
Title: RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway.
Volume: 15
Issue: 12
Pages: 1126-33
Publication
First Author: Taraborrelli L
Year: 2018
Journal: Nat Commun
Title: LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L.
Volume: 9
Issue: 1
Pages: 3910
Publication
First Author: Wong WW
Year: 2014
Journal: Blood
Title: cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner.
Volume: 123
Issue: 16
Pages: 2562-72
Publication
First Author: Yang ZH
Year: 2020
Journal: Mol Cell
Title: A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade.
Volume: 80
Issue: 2
Pages: 296-310.e6
Publication
First Author: Vucur M
Year: 2023
Journal: Immunity
Title: Sublethal necroptosis signaling promotes inflammation and liver cancer.
Volume: 56
Issue: 7
Pages: 1578-1595.e8
Publication
First Author: Muendlein HI
Year: 2020
Journal: Cell Rep
Title: Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation.
Volume: 30
Issue: 3
Pages: 699-713.e4
Publication
First Author: Seehawer M
Year: 2018
Journal: Nature
Title: Necroptosis microenvironment directs lineage commitment in liver cancer.
Volume: 562
Issue: 7725
Pages: 69-75
Publication
First Author: Verboom L
Year: 2020
Journal: Cell Rep
Title: OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis.
Volume: 30
Issue: 7
Pages: 2237-2247.e6
Publication
First Author: Sharma D
Year: 2020
Journal: J Immunol
Title: RIPK3 Promotes Mefv Expression and Pyrin Inflammasome Activation via Modulation of mTOR Signaling.
Volume: 205
Issue: 10
Pages: 2778-2785
Publication
First Author: Polykratis A
Year: 2019
Journal: Nat Cell Biol
Title: A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain.
Volume: 21
Issue: 6
Pages: 731-742
Publication
First Author: Zheng M
Year: 2020
Journal: J Biol Chem
Title: Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection.
Volume: 295
Issue: 41
Pages: 14040-14052
Publication
First Author: Malireddi RKS
Year: 2018
Journal: J Exp Med
Title: TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation.
Volume: 215
Issue: 4
Pages: 1023-1034
Publication    
First Author: Kim EH
Year: 2020
Journal: Elife
Title: Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway.
Volume: 9
Publication
First Author: Liu Y
Year: 2017
Journal: Cell Death Differ
Title: RIP1 kinase activity-dependent roles in embryonic development of Fadd-deficient mice.
Volume: 24
Issue: 8
Pages: 1459-1469
Publication
First Author: Newton K
Year: 2019
Journal: Nature
Title: Activity of caspase-8 determines plasticity between cell death pathways.
Volume: 575
Issue: 7784
Pages: 679-682
Publication
First Author: Ke FFS
Year: 2018
Journal: Cell
Title: Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK.
Volume: 173
Issue: 5
Pages: 1217-1230.e17
Publication
First Author: Anderton H
Year: 2019
Journal: Cell Death Differ
Title: RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development.
Volume: 26
Issue: 5
Pages: 877-889
Publication
First Author: Zhang X
Year: 2019
Journal: Nat Commun
Title: Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis.
Volume: 10
Issue: 1
Pages: 4158
Publication
First Author: Jiao H
Year: 2020
Journal: Nature
Title: Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation.
Volume: 580
Issue: 7803
Pages: 391-395
Publication
First Author: Newton K
Year: 2014
Journal: Science
Title: Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis.
Volume: 343
Issue: 6177
Pages: 1357-60
Publication
First Author: Zhang Y
Year: 2021
Journal: PLoS Biol
Title: A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5.
Volume: 19
Issue: 8
Pages: e3001304
Publication
First Author: Dziedzic SA
Year: 2018
Journal: Nat Cell Biol
Title: ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC.
Volume: 20
Issue: 1
Pages: 58-68
Publication
First Author: Yamashita M
Year: 2019
Journal: Cell Stem Cell
Title: TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.
Volume: 25
Issue: 3
Pages: 357-372.e7
Publication  
First Author: Kuriakose T
Year: 2016
Journal: Sci Immunol
Title: ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways.
Volume: 1
Issue: 2
Publication
First Author: Karki R
Year: 2021
Journal: Cell
Title: Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes.
Volume: 184
Issue: 1
Pages: 149-168.e17
Publication
First Author: Xu D
Year: 2018
Journal: Cell
Title: TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging.
Volume: 174
Issue: 6
Pages: 1477-1491.e19
Publication
First Author: Simpson DS
Year: 2022
Journal: Immunity
Title: Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway.
Volume: 55
Issue: 3
Pages: 423-441.e9
Publication
First Author: Gurung P
Year: 2017
Journal: Immunity
Title: Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease.
Volume: 46
Issue: 4
Pages: 635-648
Publication
First Author: Piao X
Year: 2019
Journal: J Allergy Clin Immunol
Title: Blockade of TNF receptor superfamily 1 (TNFR1)-dependent and TNFR1-independent cell death is crucial for normal epidermal differentiation.
Volume: 143
Issue: 1
Pages: 213-228.e10
Publication      
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
Publication      
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Allele  
Name: mixed lineage kinase domain-like; endonuclease-mediated mutation 2, Xiaodong Wang
Allele Type: Endonuclease-mediated
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Quarato G
Year: 2016
Journal: Mol Cell
Title: Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis.
Volume: 61
Issue: 4
Pages: 589-601
Publication
First Author: Kim SK
Year: 2015
Journal: J Invest Dermatol
Title: Upregulated RIP3 Expression Potentiates MLKL Phosphorylation-Mediated Programmed Necrosis in Toxic Epidermal Necrolysis.
Volume: 135
Issue: 8
Pages: 2021-2030
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Chen J
Year: 2019
Journal: J Biol Chem
Title: Interferon-γ induces the cell surface exposure of phosphatidylserine by activating the protein MLKL in the absence of caspase-8 activity.
Volume: 294
Issue: 32
Pages: 11994-12006
Publication
First Author: Mohammed S
Year: 2023
Journal: Mol Cancer Res
Title: Absence of Either Ripk3 or Mlkl Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis.
Volume: 21
Issue: 9
Pages: 933-946
Interaction Experiment
Description: Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes.
Publication
First Author: Liu S
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis.
Volume: 114
Issue: 36
Pages: E7450-E7459
Allele
Name: mixed lineage kinase domain-like; endonuclease-mediated mutation 3, Xiaodong Wang
Allele Type: Endonuclease-mediated
Attribute String: Epitope tag, Humanized sequence
Publication
First Author: Yoon S
Year: 2022
Journal: Cell Death Differ
Title: Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes.
Volume: 29
Issue: 2
Pages: 306-322
Allele
Name: mixed lineage kinase domain-like; endonuclease-mediated mutation 2, Manolis Pasparakis
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: mixed lineage kinase domain-like; mutation 4, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
Allele  
Name: mixed lineage kinase domain-like; endonuclease-mediated mutation 1, Ayaz Najafov
Allele Type: Endonuclease-mediated
Strain
Attribute String: chemically induced mutation, coisogenic, mutant strain
Genotype
Symbol: Mlkl/Mlkl
Background: C57BL/6J-Mlkl
Zygosity: hm
Has Mutant Allele: true
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Publication
First Author: Xu M
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929.
Volume: 463
Issue: 3
Pages: 275-9
Publication  
First Author: Fan W
Year: 2019
Journal: Sci Signal
Title: Flotillin-mediated endocytosis and ALIX-syntenin-1-mediated exocytosis protect the cell membrane from damage caused by necroptosis.
Volume: 12
Issue: 583
Publication
First Author: Wang Z
Year: 2012
Journal: Cell
Title: The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways.
Volume: 148
Issue: 1-2
Pages: 228-43
Publication
First Author: Thapa RJ
Year: 2016
Journal: Cell Host Microbe
Title: DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.
Volume: 20
Issue: 5
Pages: 674-681