A-kinase anchoring protein GSKIP is a cytosolic scaffolding protein that binds GSK3B (glycogen synthase kinase 3-beta) and PKA (protein kinase A). Both interactions with GSK3B and PKA are required for the regulation of beta-catenin, and thus Wnt signaling [].
This domain is found in GSK3-beta interaction protein (GSKIP), which binds to GSK3beta []. It is also found as a short domain towards the N terminus in clustered mitochondria protein, also known as clueless in Drosophila, which is involved in proper cytoplasmic distribution of mitochondria [, , ].
This superfamily represents the structural domain of GSK3-beta interaction protein (GSKIP), which binds to GSK3beta []. It is also found as a short domain towards the N terminus in clustered mitochondria protein, also known as clueless in Drosophila, which is involved in proper cytoplasmic distribution of mitochondria [, , ].
