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Search results 301 to 343 out of 343 for Fxr1

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Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:7464393
Assay Type: Northern blot
Annotation Date: 2023-04-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:7464699
Age: embryonic day 18.0
Image: 1
Specimen Label: fxr1 KO
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:7464393
Assay Type: Northern blot
Annotation Date: 2023-04-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:7464699
Age: embryonic day 18.0
Image: 1
Specimen Label: fxr1 KO
Detected: true
Specimen Num: 6
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Publication
7489725 | J:59611
First Author: Zhang Y
Year: 1995
Journal: EMBO J
Title: The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2.
Volume: 14
Issue: 21
Pages: 5358-66
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Publication
9642279 | J:48488
First Author: Bolívar J
Year: 1998
Journal: J Biol Chem
Title: The fragile-X-related gene FXR1 is a human autoantigen processed during apoptosis.
Volume: 273
Issue: 27
Pages: 17122-7
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Allele
Fxr1<tm1Dln> | MGI:3046846
Name: FMR1 autosomal homolog 1; targeted mutation 1, David L Nelson
Allele Type: Targeted
Attribute String: Conditional ready, Hypomorph, Modified isoform(s)
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Interaction Experiment
Qie S (2017)
Description: Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma.
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Publication
21072162 | -
First Author: Adams-Cioaba MA
Year: 2010
Journal: PLoS One
Title: Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2.
Volume: 5
Issue: 11
Pages: e13559
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DO Term
DOID:0081344 | congenital myopathy 9B
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DO Term
DOID:0081343 | congenital myopathy 9A
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Protein
A0A0G2JGH0
Organism: Mus musculus/domesticus
Length: 54  
Fragment?: false
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Publication
30115809 | -
First Author: Greenblatt EJ
Year: 2018
Journal: Science
Title: Fragile X mental retardation 1 gene enhances the translation of large autism-related proteins.
Volume: 361
Issue: 6403
Pages: 709-712
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Publication
1710175 | -
First Author: Verkerk AJ
Year: 1991
Journal: Cell
Title: Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome.
Volume: 65
Issue: 5
Pages: 905-14
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Publication
7781595 | -
First Author: Siomi MC
Year: 1995
Journal: EMBO J
Title: FXR1, an autosomal homolog of the fragile X mental retardation gene.
Volume: 14
Issue: 11
Pages: 2401-8
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Publication
19669947 | -
First Author: Li X
Year: 2009
Journal: Neuromolecular Med
Title: Macro role(s) of microRNAs in fragile X syndrome?
Volume: 11
Issue: 3
Pages: 200-7
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Publication
18957214 | -
First Author: Bassell GJ
Year: 2008
Journal: Neuron
Title: Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function.
Volume: 60
Issue: 2
Pages: 201-14
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Protein Domain
IPR040148 | FMR1
Type: Family
Description: Fragile X messenger ribonucleoprotein 1 (FMRP/FMR1), and its paralogues, FXR1 and FXR2 (RNA-binding protein FXR1 and 2, respectively), comprise a family of RNA-binding proteins [].FMR1 protein is a multifunctional polyribosome-associated protein that plays a central role in neuronal development and synaptic plasticity. It regulates alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs [, , ]. FMR1 is thought to bind target mRNA in the nucleus to form a ribonucleoprotein complex which is transported to dendrites and spines []. It is also required for ovary development and function []. FMR1 has also been shown to interact with components of the miRNA pathway []. A large expansion of the CGG trinucleotide repeat in the 5'-untranslated region of the FMR1 gene causes Fragile X syndrome (FXS), an inherited developmental disorder that causes a broad range of intellectual and physical challenges [].FXR1 and FXR2 interact with FMR1 and seem to have a related role; therefore they are likely to play important roles in the function of FMR1 and in the pathogenesis of the FXS syndrome [, ]. FXR1 is highly expressed in vertebrates muscle cells and is required for proper development of this tissue [, ].
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Protein
Q925S6
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: true
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Protein
Q925S7
Organism: Mus musculus/domesticus
Length: 35  
Fragment?: true
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Protein
A0A0G2JGL6
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: true
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Publication
10556305 | J:58813
First Author: Bardoni B
Year: 1999
Journal: Hum Mol Genet
Title: A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein.
Volume: 8
Issue: 13
Pages: 2557-66
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Publication
28960184 | -
 
First Author: Hagerman RJ
Year: 2017
Journal: Nat Rev Dis Primers
Title: Fragile X syndrome.
Volume: 3
Pages: 17065
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Publication
29713264 | -
 
First Author: Drozd M
Year: 2018
Journal: Front Mol Neurosci
Title: Modeling Fragile X Syndrome in Drosophila.
Volume: 11
Pages: 124
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Publication
16319129 | J:104472
First Author: Stetler A
Year: 2006
Journal: Hum Mol Genet
Title: Identification and characterization of the methyl arginines in the fragile X mental retardation protein Fmrp.
Volume: 15
Issue: 1
Pages: 87-96
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Publication
23235829 | J:194411
First Author: Ascano M Jr
Year: 2012
Journal: Nature
Title: FMRP targets distinct mRNA sequence elements to regulate protein expression.
Volume: 492
Issue: 7429
Pages: 382-6
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Publication
10912798 | J:63269
First Author: Bakker CE
Year: 2000
Journal: Exp Cell Res
Title: Immunocytochemical and biochemical characterization of FMRP, FXR1P, and FXR2P in the mouse.
Volume: 258
Issue: 1
Pages: 162-70
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Publication
25464849 | J:232981
First Author: Kenny PJ
Year: 2014
Journal: Cell Rep
Title: MOV10 and FMRP regulate AGO2 association with microRNA recognition elements.
Volume: 9
Issue: 5
Pages: 1729-41
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Protein
Q8C7U4
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: true
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Protein
Q8BPK8
Organism: Mus musculus/domesticus
Length: 357  
Fragment?: true
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Protein
Q8BPN5
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: true
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Protein
Q61584
Organism: Mus musculus/domesticus
Length: 677  
Fragment?: false
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Protein
Q9WVR4
Organism: Mus musculus/domesticus
Length: 673  
Fragment?: false
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Protein
P35922
Organism: Mus musculus/domesticus
Length: 614  
Fragment?: false
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Protein
A0A0G2JEP0
Organism: Mus musculus/domesticus
Length: 568  
Fragment?: false
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Protein
Q6P5B5
Organism: Mus musculus/domesticus
Length: 674  
Fragment?: false
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Protein
Q6AXB7
Organism: Mus musculus/domesticus
Length: 614  
Fragment?: false
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Protein
E9QAS8
Organism: Mus musculus/domesticus
Length: 631  
Fragment?: false
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Protein
E9QAT0
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: false
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Protein
E9QAS9
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: false
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Protein
Q3TA75
Organism: Mus musculus/domesticus
Length: 655  
Fragment?: true
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Protein
A0A0H2UH27
Organism: Mus musculus/domesticus
Length: 454  
Fragment?: false
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Protein
E9QNF5
Organism: Mus musculus/domesticus
Length: 593  
Fragment?: false
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Protein
D3Z6U8
Organism: Mus musculus/domesticus
Length: 591  
Fragment?: false
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Protein
Q547R0
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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