Type |
Details |
Score |
Allele |
Name: |
transgene insertion 1, Arikuni Uchimura |
Allele Type: |
Transgenic |
Attribute String: |
Recombinase |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain, coisogenic, transgenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain, coisogenic, transgenic |
|
•
•
•
•
•
|
Allele |
Name: |
synaptonemal complex protein 1; endonuclease-mediated mutation 1, Synbal |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Endonuclease, Reporter |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
171
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
177
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
171
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The synaptonemal complex (SC) is a tripartite structure that physically links homologous chromosomes during prophase I. The SC has a zipper-like structure composed of two lateral elements (LEs) and a central element (CE). Transverse filaments, composed of SYCP1 molecules, bridge the gap between one LE and the CE.Syce2/CESC1 localises to the CE and interacts with the transverse filament protein SYCP1. Its localization to the CE is dependent on recruitment by SYCP1 []. Syce2/ CESC1 is required for synaptonemal complex assembly and also for double strand break repair and homologous recombination []. |
|
•
•
•
•
•
|
Allele |
Name: |
myocardial infarction associated transcript (non-protein coding); targeted mutation 1, Shinichi Nakagawa |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Publication |
First Author: |
Ip JY |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine. |
Volume: |
6 |
|
Pages: |
27204 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang L |
Year: |
2021 |
Journal: |
Theranostics |
Title: |
Ablation of lncRNA Miat attenuates pathological hypertrophy and heart failure. |
Volume: |
11 |
Issue: |
16 |
Pages: |
7995-8007 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Miat/Miat |
Background: |
B6.Cg-Miat/Shna |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Uchimura A |
Year: |
2009 |
Journal: |
PLoS One |
Title: |
DNA polymerase delta is required for early mammalian embryogenesis. |
Volume: |
4 |
Issue: |
1 |
Pages: |
e4184 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park M |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
SOHLH2 is essential for synaptonemal complex formation during spermatogenesis in early postnatal mouse testes. |
Volume: |
6 |
|
Pages: |
20980 |
|
•
•
•
•
•
|
Publication |
First Author: |
Biswas U |
Year: |
2016 |
Journal: |
PLoS Genet |
Title: |
Distinct Roles of Meiosis-Specific Cohesin Complexes in Mammalian Spermatogenesis. |
Volume: |
12 |
Issue: |
10 |
Pages: |
e1006389 |
|
•
•
•
•
•
|
Publication |
First Author: |
Galán-Martínez J |
Year: |
2022 |
Journal: |
Sci Rep |
Title: |
TCFL5 deficiency impairs the pachytene to diplotene transition during spermatogenesis in the mouse. |
Volume: |
12 |
Issue: |
1 |
Pages: |
10956 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hernández-Hernández A |
Year: |
2016 |
Journal: |
J Cell Sci |
Title: |
The central element of the synaptonemal complex in mice is organized as a bilayered junction structure. |
Volume: |
129 |
Issue: |
11 |
Pages: |
2239-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fraune J |
Year: |
2013 |
Journal: |
Genetics |
Title: |
Phylogenies of central element proteins reveal the dynamic evolutionary history of the mammalian synaptonemal complex: ancient and recent components. |
Volume: |
195 |
Issue: |
3 |
Pages: |
781-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li Y |
Year: |
2019 |
Journal: |
Mol Reprod Dev |
Title: |
Sohlh1 is required for synaptonemal complex formation by transcriptionally regulating meiotic genes during spermatogenesis in mice. |
Volume: |
86 |
Issue: |
3 |
Pages: |
252-264 |
|
•
•
•
•
•
|
Publication |
First Author: |
Onishi K |
Year: |
2017 |
Journal: |
J Neurosci |
Title: |
Genome Stability by DNA Polymerase β in Neural Progenitors Contributes to Neuronal Differentiation in Cortical Development. |
Volume: |
37 |
Issue: |
35 |
Pages: |
8444-8458 |
|
•
•
•
•
•
|
Publication |
First Author: |
Toyoda S |
Year: |
2014 |
Journal: |
Neuron |
Title: |
Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity. |
Volume: |
82 |
Issue: |
1 |
Pages: |
94-108 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guiraldelli MF |
Year: |
2018 |
Journal: |
PLoS Genet |
Title: |
SHOC1 is a ERCC4-(HhH)2-like protein, integral to the formation of crossover recombination intermediates during mammalian meiosis. |
Volume: |
14 |
Issue: |
5 |
Pages: |
e1007381 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koornneef L |
Year: |
2022 |
Journal: |
PLoS Genet |
Title: |
Multi-color dSTORM microscopy in Hormad1-/- spermatocytes reveals alterations in meiotic recombination intermediates and synaptonemal complex structure. |
Volume: |
18 |
Issue: |
7 |
Pages: |
e1010046 |
|
•
•
•
•
•
|
Publication |
First Author: |
Peng KL |
Year: |
2022 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Miat and interacting protein Metadherin maintain a stem-like niche to promote medulloblastoma tumorigenesis and treatment resistance. |
Volume: |
119 |
Issue: |
37 |
Pages: |
e2203738119 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tarusawa E |
Year: |
2016 |
Journal: |
BMC Biol |
Title: |
Establishment of high reciprocal connectivity between clonal cortical neurons is regulated by the Dnmt3b DNA methyltransferase and clustered protocadherins. |
Volume: |
14 |
Issue: |
1 |
Pages: |
103 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katori S |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Protocadherin-αC2 is required for diffuse projections of serotonergic axons. |
Volume: |
7 |
Issue: |
1 |
Pages: |
15908 |
|
•
•
•
•
•
|
Publication |
First Author: |
Noguchi Y |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
Total expression and dual gene-regulatory mechanisms maintained in deletions and duplications of the Pcdha cluster. |
Volume: |
284 |
Issue: |
46 |
Pages: |
32002-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hasegawa S |
Year: |
2016 |
Journal: |
Front Mol Neurosci |
Title: |
Distinct and Cooperative Functions for the Protocadherin-α, -β and -γ Clusters in Neuronal Survival and Axon Targeting. |
Volume: |
9 |
|
Pages: |
155 |
|
•
•
•
•
•
|
Publication |
First Author: |
The RIKEN BioResource Center |
Year: |
2006 |
Journal: |
Unpublished |
Title: |
Information obtained from The RIKEN BioResource Center |
|
|
|
|
•
•
•
•
•
|