Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:5771819 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2016-05-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:318643 |
Pattern: |
Not Specified |
Stage: |
TS03 |
Assay Id: |
MGI:5771821 |
Age: |
embryonic day 2.0 |
Image: |
1A 4 cell |
Note: |
Expression is especially concentrated in the nuclei. |
Specimen Label: |
1A 4 cell |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5771819 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2016-05-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:318653 |
Pattern: |
Not Specified |
Stage: |
TS03 |
Assay Id: |
MGI:5771821 |
Age: |
embryonic day 2.5 |
Image: |
1A 8 cell |
Note: |
Expression is especially concentrated in the nuclei. |
Specimen Label: |
1A 8 cell |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5771819 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2016-05-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160404 |
Pattern: |
Not Specified |
Stage: |
TS04 |
Assay Id: |
MGI:5771821 |
Age: |
embryonic day 3.0 |
Image: |
1A Morula |
Note: |
This is the time of peak expression. |
Specimen Label: |
1A Morula |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5771819 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2016-05-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360354 |
Pattern: |
Not Specified |
Stage: |
TS04 |
Assay Id: |
MGI:5771821 |
Age: |
embryonic day 3.5 |
Image: |
1A Blastocyst |
|
Specimen Label: |
1A Blastocyst |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5771819 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2016-05-26 |
Strength: |
Weak |
Sex: |
Female |
Emaps: |
EMAPS:3102528 |
Pattern: |
Widespread |
Stage: |
TS28 |
Assay Id: |
MGI:5771821 |
Age: |
postnatal |
Image: |
1A MII oocyte |
|
Specimen Label: |
1A MII oocyte |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4429843 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-04-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3594415 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:7463904 |
Age: |
embryonic day 9.5 |
|
|
Specimen Label: |
Table S1 E9.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4429843 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-04-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3116915 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:7463904 |
Age: |
embryonic day 9.5 |
|
|
Specimen Label: |
Table S1 E9.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4429843 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-04-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1611715 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:7463904 |
Age: |
embryonic day 9.5 |
|
|
Specimen Label: |
Table S1 E9.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4429843 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-04-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1608915 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:7463904 |
Age: |
embryonic day 9.5 |
|
|
Specimen Label: |
Table S1 E9.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4429843 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-04-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3594417 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:7463904 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
Table S1 E10.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4429843 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-04-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3116917 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:7463904 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
Table S1 E10.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4429843 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-04-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1611717 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:7463904 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
Table S1 E10.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4429843 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-04-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3007417 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:7463904 |
Age: |
embryonic day 10.5 |
|
Note: |
Expression was in external genitalia. |
Specimen Label: |
Table S1 E10.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4429843 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-04-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3594419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:7463904 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S1 E11.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4429843 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-04-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3116919 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:7463904 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S1 E11.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4429843 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-04-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1611719 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:7463904 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S1 E11.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4429843 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-04-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1619819 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:7463904 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S1 E11.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4429843 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-04-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:7463904 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S1 E11.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4429843 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-04-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1609219 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:7463904 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S1 E11.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4429843 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-04-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1738219 |
Pattern: |
Regionally restricted |
Stage: |
TS19 |
Assay Id: |
MGI:7463904 |
Age: |
embryonic day 11.5 |
|
Note: |
Expression was in external genitalia. |
Specimen Label: |
Table S1 E11.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4429843 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-04-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689417 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:7463904 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
Table S1 E10.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Strausberg R |
Year: |
2001 |
Journal: |
GenBank Submission |
Title: |
Mus musculus, clone MGC: 7905 IMAGE: 3583039, mRNA, complete cds |
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|
Pages: |
BC004733 |
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•
•
•
•
•
|
Publication |
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Gajović S |
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1998 |
Journal: |
Exp Cell Res |
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Genes expressed after retinoic acid-mediated differentiation of embryoid bodies are likely to be expressed during embryo development. |
Volume: |
242 |
Issue: |
1 |
Pages: |
138-43 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
432
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
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Cui W |
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2016 |
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Sci Rep |
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Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. |
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6 |
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37396 |
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•
•
•
•
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9062-76 |
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•
•
•
•
•
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Publication |
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Genome Res |
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Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. |
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•
•
•
•
•
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Publication |
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•
•
•
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JAX BSS Panel Mapping Data |
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•
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•
•
•
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•
•
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•
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•
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Publication |
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Wellcome Trust Sanger Institute |
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MGI Direct Data Submission |
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Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
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•
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Title: |
Mouse Synonym Curation |
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Proc Natl Acad Sci U S A |
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Database Release |
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Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Annotation inferences using phylogenetic trees |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
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Allen Institute for Brain Science |
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Allen Institute |
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Allen Brain Atlas: mouse riboprobes |
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Mouse Genome Informatics Scientific Curators |
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Database Download |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
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•
•
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•
•
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•
•
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Publication |
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Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Gene |
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Gene |
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Gene |
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Gene |
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Gene |
Type: |
gene |
Organism: |
frog, African clawed |
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Publication |
First Author: |
Valdez BC |
Year: |
1992 |
Journal: |
Cancer Res |
Title: |
A region of antisense RNA from human p120 cDNA with high homology to mouse p120 cDNA inhibits NIH 3T3 proliferation. |
Volume: |
52 |
Issue: |
20 |
Pages: |
5681-6 |
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Publication |
First Author: |
King M |
Year: |
1999 |
Journal: |
Biochem J |
Title: |
A conserved motif in the yeast nucleolar protein Nop2p contains an essential cysteine residue. |
Volume: |
337 ( Pt 1) |
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Pages: |
29-35 |
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Publication |
First Author: |
Gustafson WC |
Year: |
1998 |
Journal: |
Biochem J |
Title: |
Nucleolar protein p120 contains an arginine-rich domain that binds to ribosomal RNA. |
Volume: |
331 ( Pt 2) |
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Pages: |
387-93 |
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Publication |
First Author: |
Koonin EV |
Year: |
1994 |
Journal: |
Nucleic Acids Res |
Title: |
Prediction of an rRNA methyltransferase domain in human tumor-specific nucleolar protein P120. |
Volume: |
22 |
Issue: |
13 |
Pages: |
2476-8 |
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Publication |
First Author: |
Sloan KE |
Year: |
2013 |
Journal: |
Cell Rep |
Title: |
The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress. |
Volume: |
5 |
Issue: |
1 |
Pages: |
237-47 |
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Protein Domain |
Type: |
Family |
Description: |
RNA (C5-cytosine) methyltransferases (RCMTs) catalyse the transfer of a methyl group to the 5th carbon of a cytosine base in RNA sequences to produce C5-methylcytosine. RCMTs use the cofactor S-adenosyl-L-methionine (SAM) as a methyl donor []. The catalytic mechanism of RCMTs involves an attack by the thiolate of a Cys residue on position 6 of the target cytosine base to form a covalent link, thereby activating C5 for methyl-group transfer. Following the addition of the methyl group, a second Cys residue acts as a general base in the beta-elimination of the proton from the methylated cytosine ring. The free enzyme is restored and the methylated product is released [].Numerous putative RCMTs have been identified in archaea, bacteria and eukaryota [, ]; most are predicted to be nuclear or nucleolar proteins []. The Escherichia coli Ribosomal RNA Small-subunit Methyltransferase Beta (RSMB) FMU (FirMicUtes) represents the first protein identified and characterised as a cytosine-specific RNA methyltransferase. RSMB was reported to catalyse the formation of C5-methylcytosine at position 967 of 16S rRNA [, ].A classification of RCMTs has been proposed on the basis of sequence similarity []. According to this classification, RCMTs are divided into 8 distinct subfamilies []. Recently, a new RCMT subfamily, termed RCMT9, was identified []. Members of the RCMT contain a core domain, responsible for the cytosine-specific RNA methyltransferase activity. This 'catalytic' domain adopts the Rossman fold for the accommodation of the cofactor SAM []. The RCMT subfamilies are also distinguished by N-terminal and C-terminal extensions, variable both in size and sequence [].The prototypical member of the Nucleolar Protein 2 RCMT subfamily, the S.cerevisiae NOP2, is an essential nucleolar protein required for pre-rRNA processing and 60S ribosomal subunit assembly []that acts as a ribosomal RNA methyltransferase [, ]. Its human homologue, the proliferation-associated nucleolar antigen P120, is a promising tumour marker []. P120 has been demonstrated to be implicated in rRNA biogenesis [, ], and is also proposed to act as an rRNA methyltransferase []. |
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Allele |
Name: |
NOP2 nucleolar protein; wild type |
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Allele |
Name: |
NOP2 nucleolar protein; gene trap CSD204, BayGenomics |
Allele Type: |
Gene trapped |
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Allele |
Name: |
NOP2 nucleolar protein; gene trap XH759, BayGenomics |
Allele Type: |
Gene trapped |
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Allele |
Name: |
NOP2 nucleolar protein; gene trap YHB081, BayGenomics |
Allele Type: |
Gene trapped |
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Allele |
Name: |
NOP2 nucleolar protein; gene trap YHC435, BayGenomics |
Allele Type: |
Gene trapped |
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Allele |
Name: |
NOP2 nucleolar protein; gene trap RRR102, BayGenomics |
Allele Type: |
Gene trapped |
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Allele |
Name: |
NOP2 nucleolar protein; gene trap PST59, Mammalian Functional Genomics Centre |
Allele Type: |
Gene trapped |
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Allele |
Name: |
NOP2 nucleolar protein; gene trap OST364218, Lexicon Genetics |
Allele Type: |
Gene trapped |
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Allele |
Name: |
NOP2 nucleolar protein; targeted mutation 1e, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
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Allele |
Name: |
NOP2 nucleolar protein; endonuclease-mediated mutation 2, Cyagen Biosciences |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
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Allele |
Name: |
NOP2 nucleolar protein; gene trap PST11122, Mammalian Functional Genomics Centre |
Allele Type: |
Gene trapped |
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Allele |
Name: |
NOP2 nucleolar protein; gene trap A060D08, German Gene Trap Consortium |
Allele Type: |
Gene trapped |
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Allele |
Name: |
NOP2 nucleolar protein; gene trap PST3254, Mammalian Functional Genomics Centre |
Allele Type: |
Gene trapped |
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Allele |
Name: |
NOP2 nucleolar protein; gene trap OST119338, Lexicon Genetics |
Allele Type: |
Gene trapped |
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Allele |
Name: |
NOP2 nucleolar protein; gene trap PST13863, Mammalian Functional Genomics Centre |
Allele Type: |
Gene trapped |
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Allele |
Name: |
NOP2 nucleolar protein; gene trap PST12185, Mammalian Functional Genomics Centre |
Allele Type: |
Gene trapped |
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Allele |
Name: |
NOP2 nucleolar protein; gene trap PST4460, Mammalian Functional Genomics Centre |
Allele Type: |
Gene trapped |
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Allele |
Name: |
NOP2 nucleolar protein; gene trap PST23820, Mammalian Functional Genomics Centre |
Allele Type: |
Gene trapped |
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Allele |
Name: |
NOP2 nucleolar protein; gene trap XP0179, Wellcome Trust Sanger Institute |
Allele Type: |
Gene trapped |
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Allele |
Name: |
NOP2 nucleolar protein; gene trap OST461252, Lexicon Genetics |
Allele Type: |
Gene trapped |
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Allele |
Name: |
NOP2 nucleolar protein; targeted mutation 1a, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
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Allele |
Name: |
NOP2 nucleolar protein; gene trap PST2363, Mammalian Functional Genomics Centre |
Allele Type: |
Gene trapped |
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Allele |
Name: |
NOP2 nucleolar protein; gene trap 1, Srecko Gajovic |
Allele Type: |
Gene trapped |
Attribute String: |
Null/knockout, Reporter |
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Publication |
First Author: |
Motorin Y |
Year: |
1999 |
Journal: |
RNA |
Title: |
Multisite-specific tRNA:m5C-methyltransferase (Trm4) in yeast Saccharomyces cerevisiae: identification of the gene and substrate specificity of the enzyme. |
Volume: |
5 |
Issue: |
8 |
Pages: |
1105-18 |
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Publication |
First Author: |
de Beus E |
Year: |
1994 |
Journal: |
J Cell Biol |
Title: |
Yeast NOP2 encodes an essential nucleolar protein with homology to a human proliferation marker. |
Volume: |
127 |
Issue: |
6 Pt 2 |
Pages: |
1799-813 |
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Allele |
Name: |
NOP2 nucleolar protein; gene trap 320H4, Centre for Modeling Human Disease |
Allele Type: |
Gene trapped |
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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Allele |
Name: |
NOP2 nucleolar protein; gene trap IST13520C8, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
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