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Search results 201 to 300 out of 333 for Nop2

0.068s
Type Details Score
GXD Expression
Probe: MGI:5771819
Assay Type: Immunohistochemistry
Annotation Date: 2016-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Pattern: Not Specified
Stage: TS03
Assay Id: MGI:5771821
Age: embryonic day 2.0
Image: 1A 4 cell
Note: Expression is especially concentrated in the nuclei.
Specimen Label: 1A 4 cell
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:5771819
Assay Type: Immunohistochemistry
Annotation Date: 2016-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318653
Pattern: Not Specified
Stage: TS03
Assay Id: MGI:5771821
Age: embryonic day 2.5
Image: 1A 8 cell
Note: Expression is especially concentrated in the nuclei.
Specimen Label: 1A 8 cell
Detected: true
Specimen Num: 5
GXD Expression
Probe: MGI:5771819
Assay Type: Immunohistochemistry
Annotation Date: 2016-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160404
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:5771821
Age: embryonic day 3.0
Image: 1A Morula
Note: This is the time of peak expression.
Specimen Label: 1A Morula
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:5771819
Assay Type: Immunohistochemistry
Annotation Date: 2016-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360354
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:5771821
Age: embryonic day 3.5
Image: 1A Blastocyst
Specimen Label: 1A Blastocyst
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:5771819
Assay Type: Immunohistochemistry
Annotation Date: 2016-05-26
Strength: Weak
Sex: Female
Emaps: EMAPS:3102528
Pattern: Widespread
Stage: TS28
Assay Id: MGI:5771821
Age: postnatal
Image: 1A MII oocyte
Specimen Label: 1A MII oocyte
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4429843
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3594415
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:7463904
Age: embryonic day 9.5
Specimen Label: Table S1 E9.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4429843
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3116915
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:7463904
Age: embryonic day 9.5
Specimen Label: Table S1 E9.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4429843
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611715
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:7463904
Age: embryonic day 9.5
Specimen Label: Table S1 E9.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4429843
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608915
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:7463904
Age: embryonic day 9.5
Specimen Label: Table S1 E9.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4429843
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3594417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7463904
Age: embryonic day 10.5
Specimen Label: Table S1 E10.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4429843
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3116917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7463904
Age: embryonic day 10.5
Specimen Label: Table S1 E10.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4429843
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7463904
Age: embryonic day 10.5
Specimen Label: Table S1 E10.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4429843
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3007417
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:7463904
Age: embryonic day 10.5
Note: Expression was in external genitalia.
Specimen Label: Table S1 E10.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4429843
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3594419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:7463904
Age: embryonic day 11.5
Specimen Label: Table S1 E11.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:4429843
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3116919
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:7463904
Age: embryonic day 11.5
Specimen Label: Table S1 E11.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:4429843
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611719
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:7463904
Age: embryonic day 11.5
Specimen Label: Table S1 E11.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:4429843
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:7463904
Age: embryonic day 11.5
Specimen Label: Table S1 E11.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:4429843
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:7463904
Age: embryonic day 11.5
Specimen Label: Table S1 E11.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:4429843
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609219
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:7463904
Age: embryonic day 11.5
Specimen Label: Table S1 E11.5
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4429843
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1738219
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:7463904
Age: embryonic day 11.5
Note: Expression was in external genitalia.
Specimen Label: Table S1 E11.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:4429843
Assay Type: RNA in situ
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7463904
Age: embryonic day 10.5
Specimen Label: Table S1 E10.5
Detected: true
Specimen Num: 2
Publication    
First Author: Strausberg R
Year: 2001
Journal: GenBank Submission
Title: Mus musculus, clone MGC: 7905 IMAGE: 3583039, mRNA, complete cds
Pages: BC004733
Publication
First Author: Gajović S
Year: 1998
Journal: Exp Cell Res
Title: Genes expressed after retinoic acid-mediated differentiation of embryoid bodies are likely to be expressed during embryo development.
Volume: 242
Issue: 1
Pages: 138-43
Protein
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
Publication  
First Author: Cui W
Year: 2016
Journal: Sci Rep
Title: Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos.
Volume: 6
Pages: 37396
Publication
First Author: Sharma S
Year: 2013
Journal: Nucleic Acids Res
Title: Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively.
Volume: 41
Issue: 19
Pages: 9062-76
Publication
First Author: Brady KP
Year: 1997
Journal: Genome Res
Title: Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis.
Volume: 7
Issue: 11
Pages: 1085-93
Publication
First Author: Shimizu H
Year: 2013
Journal: PLoS One
Title: The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.
Volume: 8
Issue: 10
Pages: e75754
Publication      
First Author: The Jackson Laboratory Backcross DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX BSS Panel Mapping Data
Publication
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
Publication        
First Author: Haiming Tang, Dustin Ebert, Matthias Blum, Robert Finn, Paul Thomas
Year: 2023
Title: TreeGrafter-generated GO annotations
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: frog, African clawed
Publication
First Author: Valdez BC
Year: 1992
Journal: Cancer Res
Title: A region of antisense RNA from human p120 cDNA with high homology to mouse p120 cDNA inhibits NIH 3T3 proliferation.
Volume: 52
Issue: 20
Pages: 5681-6
Publication  
First Author: King M
Year: 1999
Journal: Biochem J
Title: A conserved motif in the yeast nucleolar protein Nop2p contains an essential cysteine residue.
Volume: 337 ( Pt 1)
Pages: 29-35
Publication  
First Author: Gustafson WC
Year: 1998
Journal: Biochem J
Title: Nucleolar protein p120 contains an arginine-rich domain that binds to ribosomal RNA.
Volume: 331 ( Pt 2)
Pages: 387-93
Publication
First Author: Koonin EV
Year: 1994
Journal: Nucleic Acids Res
Title: Prediction of an rRNA methyltransferase domain in human tumor-specific nucleolar protein P120.
Volume: 22
Issue: 13
Pages: 2476-8
Publication
First Author: Sloan KE
Year: 2013
Journal: Cell Rep
Title: The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress.
Volume: 5
Issue: 1
Pages: 237-47
Protein Domain
Type: Family
Description: RNA (C5-cytosine) methyltransferases (RCMTs) catalyse the transfer of a methyl group to the 5th carbon of a cytosine base in RNA sequences to produce C5-methylcytosine. RCMTs use the cofactor S-adenosyl-L-methionine (SAM) as a methyl donor []. The catalytic mechanism of RCMTs involves an attack by the thiolate of a Cys residue on position 6 of the target cytosine base to form a covalent link, thereby activating C5 for methyl-group transfer. Following the addition of the methyl group, a second Cys residue acts as a general base in the beta-elimination of the proton from the methylated cytosine ring. The free enzyme is restored and the methylated product is released [].Numerous putative RCMTs have been identified in archaea, bacteria and eukaryota [, ]; most are predicted to be nuclear or nucleolar proteins []. The Escherichia coli Ribosomal RNA Small-subunit Methyltransferase Beta (RSMB) FMU (FirMicUtes) represents the first protein identified and characterised as a cytosine-specific RNA methyltransferase. RSMB was reported to catalyse the formation of C5-methylcytosine at position 967 of 16S rRNA [, ].A classification of RCMTs has been proposed on the basis of sequence similarity []. According to this classification, RCMTs are divided into 8 distinct subfamilies []. Recently, a new RCMT subfamily, termed RCMT9, was identified []. Members of the RCMT contain a core domain, responsible for the cytosine-specific RNA methyltransferase activity. This 'catalytic' domain adopts the Rossman fold for the accommodation of the cofactor SAM []. The RCMT subfamilies are also distinguished by N-terminal and C-terminal extensions, variable both in size and sequence [].The prototypical member of the Nucleolar Protein 2 RCMT subfamily, the S.cerevisiae NOP2, is an essential nucleolar protein required for pre-rRNA processing and 60S ribosomal subunit assembly []that acts as a ribosomal RNA methyltransferase [, ]. Its human homologue, the proliferation-associated nucleolar antigen P120, is a promising tumour marker []. P120 has been demonstrated to be implicated in rRNA biogenesis [, ], and is also proposed to act as an rRNA methyltransferase [].
Allele    
Name: NOP2 nucleolar protein; wild type
Allele  
Name: NOP2 nucleolar protein; gene trap CSD204, BayGenomics
Allele Type: Gene trapped
Allele  
Name: NOP2 nucleolar protein; gene trap XH759, BayGenomics
Allele Type: Gene trapped
Allele  
Name: NOP2 nucleolar protein; gene trap YHB081, BayGenomics
Allele Type: Gene trapped
Allele  
Name: NOP2 nucleolar protein; gene trap YHC435, BayGenomics
Allele Type: Gene trapped
Allele  
Name: NOP2 nucleolar protein; gene trap RRR102, BayGenomics
Allele Type: Gene trapped
Allele  
Name: NOP2 nucleolar protein; gene trap PST59, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
Allele  
Name: NOP2 nucleolar protein; gene trap OST364218, Lexicon Genetics
Allele Type: Gene trapped
Allele
Name: NOP2 nucleolar protein; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele
Name: NOP2 nucleolar protein; endonuclease-mediated mutation 2, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele  
Name: NOP2 nucleolar protein; gene trap PST11122, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
Allele  
Name: NOP2 nucleolar protein; gene trap A060D08, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: NOP2 nucleolar protein; gene trap PST3254, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
Allele  
Name: NOP2 nucleolar protein; gene trap OST119338, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: NOP2 nucleolar protein; gene trap PST13863, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
Allele  
Name: NOP2 nucleolar protein; gene trap PST12185, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
Allele  
Name: NOP2 nucleolar protein; gene trap PST4460, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
Allele  
Name: NOP2 nucleolar protein; gene trap PST23820, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
Allele  
Name: NOP2 nucleolar protein; gene trap XP0179, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
Allele  
Name: NOP2 nucleolar protein; gene trap OST461252, Lexicon Genetics
Allele Type: Gene trapped
Allele
Name: NOP2 nucleolar protein; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
Allele  
Name: NOP2 nucleolar protein; gene trap PST2363, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
Allele
Name: NOP2 nucleolar protein; gene trap 1, Srecko Gajovic
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
Publication
First Author: Motorin Y
Year: 1999
Journal: RNA
Title: Multisite-specific tRNA:m5C-methyltransferase (Trm4) in yeast Saccharomyces cerevisiae: identification of the gene and substrate specificity of the enzyme.
Volume: 5
Issue: 8
Pages: 1105-18
Publication
First Author: de Beus E
Year: 1994
Journal: J Cell Biol
Title: Yeast NOP2 encodes an essential nucleolar protein with homology to a human proliferation marker.
Volume: 127
Issue: 6 Pt 2
Pages: 1799-813
Allele  
Name: NOP2 nucleolar protein; gene trap 320H4, Centre for Modeling Human Disease
Allele Type: Gene trapped
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Allele  
Name: NOP2 nucleolar protein; gene trap IST13520C8, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped