Phosphoinositide-Binding Protein (PIRT) is thought to have a role in positively regulating transient receptor potential vanilloid 1 (TRPV1) channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2) []. TRPV1 is a molecular sensor of noxious heat and capsaicin.PIRT is predicted to be a multi-pass membrane protein and is located in the cell membrane [].