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Search results 401 to 500 out of 538 for Hnf1a

0.036s
Type Details Score
Publication  
First Author: Monica Shih MC
Year: 2021
Journal: Endocrinology
Title: Embryonic Steroids Control Developmental Programming of Energy Balance.
Volume: 162
Issue: 12
Publication
First Author: Oliver-Krasinski JM
Year: 2009
Journal: J Clin Invest
Title: The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice.
Volume: 119
Issue: 7
Pages: 1888-98
Publication
First Author: Duncan SA
Year: 2000
Journal: Dev Dyn
Title: Transcriptional regulation of liver development.
Volume: 219
Issue: 2
Pages: 131-42
Publication  
First Author: Hoffman BG
Year: 2008
Journal: BMC Dev Biol
Title: Expression of Groucho/TLE proteins during pancreas development.
Volume: 8
Pages: 81
Publication
First Author: Abdellatif AM
Year: 2016
Journal: PLoS One
Title: β-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development.
Volume: 11
Issue: 2
Pages: e0150010
Publication  
First Author: Niborski LL
Year: 2021
Journal: Dis Model Mech
Title: Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model.
Volume: 14
Issue: 5
Publication
First Author: Kaminski MM
Year: 2016
Journal: Nat Cell Biol
Title: Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors.
Volume: 18
Issue: 12
Pages: 1269-1280
Publication
First Author: Tatarakis A
Year: 2008
Journal: Mol Cell
Title: Dominant and redundant functions of TFIID involved in the regulation of hepatic genes.
Volume: 31
Issue: 4
Pages: 531-43
Publication
First Author: Decaens T
Year: 2008
Journal: Hepatology
Title: Stabilization of beta-catenin affects mouse embryonic liver growth and hepatoblast fate.
Volume: 47
Issue: 1
Pages: 247-58
Publication
First Author: Suzuki A
Year: 2008
Journal: Development
Title: Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression.
Volume: 135
Issue: 9
Pages: 1589-95
Publication      
First Author: Mori K
Year: 2018
Journal: Mol Cell Biol
Title: Id2 determines intestinal identity through repression of the foregut transcription factor, Irx5.
Publication
First Author: Seth A
Year: 2014
Journal: Development
Title: Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment.
Volume: 141
Issue: 3
Pages: 538-47
Publication
First Author: Briançon N
Year: 2006
Journal: EMBO J
Title: In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping.
Volume: 25
Issue: 6
Pages: 1253-62
Publication
First Author: Qu F
Year: 2023
Journal: Nat Commun
Title: Three-dimensional molecular architecture of mouse organogenesis.
Volume: 14
Issue: 1
Pages: 4599
Publication
First Author: Tang F
Year: 2011
Journal: PLoS One
Title: Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Volume: 6
Issue: 6
Pages: e21208
Publication  
First Author: Wiese CB
Year: 2012
Journal: Front Neurosci
Title: A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.
Volume: 6
Pages: 130
Publication        
First Author: International Committee on Standardized Genetic Nomenclature for Mice
Year: 1993
Title: Nomenclature rule change to delete hyphens and parentheses from mouse locus symbols
Publication
First Author: Guo G
Year: 2010
Journal: Dev Cell
Title: Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Volume: 18
Issue: 4
Pages: 675-85
Publication
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
Publication
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
Publication
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Allele
Name: transgene insertion 2, Kazuya Yamagata
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Transgene
Type: transgene
Organism: mouse, laboratory
Allele
Name: transgene insertion, Claes B Wollheim
Allele Type: Transgenic
Attribute String: Dominant negative, Inserted expressed sequence
Transgene
Type: transgene
Organism: mouse, laboratory
Genotype
Symbol: Tg(Ins2-TCF1*P291)2Kya/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(Ins2-Hnf1a)#Cbw/?
Background: involves: C57BL/6 * CBA/J
Zygosity: ot
Has Mutant Allele: true
DO Term
DO Term
Publication
First Author: Liu M
Year: 2023
Journal: iScience
Title: Dominant-negative HNF1α mutant promotes liver steatosis and inflammation by regulating hepatic complement factor D.
Volume: 26
Issue: 10
Pages: 108018
Allele
Name: intergenic site 2; endonuclease-mediated mutation 1, Peng Lu
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, Dominant negative, Humanized sequence, Inserted expressed sequence
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
Allele
Name: HNF1 homeobox A; targeted mutation 1.1, Ying-Hue Lee
Allele Type: Targeted
Attribute String: Null/knockout
DO Term
Allele
Name: HNF1 homeobox A, opposite strand transcript cluster; targeted mutation 1.1, Jorge Ferrer
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: transgene insertion X, Naoyuki Miura
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Genotype
Symbol: Hnf1a/Hnf1a
Background: involves: 129X1/SvJ * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
Allele
Name: regulatory region 124128; targeted mutation 1.2, Jorge Ferrer
Allele Type: Targeted
Attribute String: Modified regulatory region, Null/knockout
Allele
Name: regulatory region 124128; targeted mutation 1.1, Jorge Ferrer
Allele Type: Targeted
Attribute String: Conditional ready, Modified regulatory region
Publication  
First Author: Braun T
Year: 2023
Journal: JCI Insight
Title: Mucosal transcriptomics highlight lncRNAs implicated in ulcerative colitis, Crohn's disease, and celiac disease.
Volume: 8
Issue: 14
Publication
First Author: Wang B
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Liver tumor formation by a mutant retinoblastoma protein in the transgenic mice is caused by an upregulation of c-Myc target genes.
Volume: 417
Issue: 1
Pages: 601-6
Genotype
Symbol: Tg(Hnf1a-RB1*)XMiu/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Rr124128/Rr124128
Background: involves: C57BL/6 * FVB/N
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Rr124128/Rr124128 Tg(Pdx1-cre)6Tuv/?
Background: involves: C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Naqvi AAT
Year: 2018
Journal: Pancreatology
Title: Investigating the role of transcription factors of pancreas development in pancreatic cancer.
Volume: 18
Issue: 2
Pages: 184-190
Publication
First Author: Bach I
Year: 1991
Journal: Nucleic Acids Res
Title: Two members of an HNF1 homeoprotein family are expressed in human liver.
Volume: 19
Issue: 13
Pages: 3553-9
Publication
First Author: Yang R
Year: 2016
Journal: Biochim Biophys Acta
Title: Hepatocyte nuclear factor 1 coordinates multiple processes in a model of intestinal epithelial cell function.
Volume: 1859
Issue: 4
Pages: 591-8
Protein Domain
Type: Family
Description: Hepatocyte nuclear factor 1-alpha (HNF1A, TCF1) and hepatocyte nuclear factor 1-beta (HNF1B, TCF2) are homeodomain-containing transcription factors expressed in the pancreas, liver, kidney, and intestine, where they direct tissue-specific gene regulation [, ]. They play an essential role in the development and differentiation of pancreatic precursor cells [, ]. Mutations in HNF1beta and HNF1alpha cause autosomal dominant diabetes maturity-onset diabetes of the young (MODY), which is a monogenic form of non-insulin-dependent type 2 diabetes. Mutations in HNF1A are responsible for type 3 MODY (MODY3) [], whereas the HNF1B gene is linked to a rare case of type 5 MODY (MODY5) [].
Publication
First Author: Ellard S
Year: 2006
Journal: Hum Mutat
Title: Mutations in the genes encoding the transcription factors hepatocyte nuclear factor 1 alpha (HNF1A) and 4 alpha (HNF4A) in maturity-onset diabetes of the young.
Volume: 27
Issue: 9
Pages: 854-69
Publication
First Author: Ryffel GU
Year: 2001
Journal: J Mol Endocrinol
Title: Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences.
Volume: 27
Issue: 1
Pages: 11-29
Publication  
First Author: Maestro MA
Year: 2007
Journal: Endocr Dev
Title: Distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth.
Volume: 12
Pages: 33-45
Publication
First Author: Qu M
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks.
Volume: 115
Issue: 52
Pages: E12305-E12312
Protein
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
Publication
First Author: Adamson AW
Year: 2006
Journal: Biochem J
Title: Hepatocyte nuclear factor-4alpha contributes to carbohydrate-induced transcriptional activation of hepatic fatty acid synthase.
Volume: 399
Issue: 2
Pages: 285-95
Publication
First Author: Gupta RK
Year: 2005
Journal: J Clin Invest
Title: The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion.
Volume: 115
Issue: 4
Pages: 1006-15
Publication
First Author: DeLaForest A
Year: 2011
Journal: Development
Title: HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells.
Volume: 138
Issue: 19
Pages: 4143-53
Publication
First Author: Yamagata K
Year: 1996
Journal: Nature
Title: Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)
Volume: 384
Issue: 6608
Pages: 458-60
Publication
First Author: Hayhurst GP
Year: 2001
Journal: Mol Cell Biol
Title: Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis.
Volume: 21
Issue: 4
Pages: 1393-403
Protein Domain
Type: Family
Description: Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) () phosphorylates serine, threonine and tyrosine residues in proteins such as CRY2, FOXO1 and SIRT1 [, , , ]. It can be activated by tyrosine autophosphorylation [, ]. DYRK1A play a role in a signaling pathway regulating nuclear functions of cell proliferation. DYRK1A is a neurogenesis regulator and plays an important role in altered brain development in Down syndrome [, ]. Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B also known as Mirk) also phosphorylates serine, threonine and tyrosine residues, and has been shown to enhance the transcriptional activity of HNF1A and FOXO1 []. Mirk is reported to be an inhibitor of epithelial cell migration [], and appears to mediate carcinoma cell survival in specific environments [].This entry also includes mnb from Drosophila melanogaster. It plays a role in the specific control of proper proliferation of optic lobe neuronal progeny [].
Protein Domain
Type: Domain
Description: Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) () phosphorylates serine, threonine and tyrosine residues in proteins such as CRY2, FOXO1 and SIRT1 [, , , ]. It can be activated by tyrosine autophosphorylation [, ]. DYRK1A play a role in a signaling pathway regulating nuclear functions of cell proliferation. DYRK1A is a neurogenesis regulator and plays an important role in altered brain development in Down syndrome [, ]. Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B also known as Mirk) also phosphorylates serine, threonine and tyrosine residues, and has been shown to enhance the transcriptional activity of HNF1A and FOXO1 []. Mirk is reported to be an inhibitor of epithelial cell migration [], and appears to mediate carcinoma cell survival in specific environments [].This entry also includes mnb from Drosophila melanogaster. It plays a role in the specific control of proper proliferation of optic lobe neuronal progeny [].This entry represents the catalytic domain found in DYRK1A and DYRK1B.
Protein Domain
Type: Family
Description: HNF4A (also known as TCF14) is a member of the steroid-thyroid hormone receptor superfamily. HNF4A interacts with regulatory elements in promoters and enhancers of the genes involved in cholesterol fatty acid and glucose metabolism [, ]. It is an upstream regulator of HNF1A expression []. HNF4A regulates the expression of genes in the liver, pancreas, kidney, intestine, and other tissues. It is essential for development of the liver [, ]and regulates growth and function of islet beta-cells in the pancreas [, ]. Mutations in the HFN4A gene result in type 1 MODY (MODY1), a monogenic form of non-insulin-dependent type 2 diabetes [, ]. HNF4A is also involved in circadian rhythm maintenance in liver and colon cells as it transrepresses CLOCK:BMAL1 heterodimer activity [].
Publication
First Author: Kurabayashi N
Year: 2010
Journal: Mol Cell Biol
Title: DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping.
Volume: 30
Issue: 7
Pages: 1757-68
Publication
First Author: Guo X
Year: 2010
Journal: J Biol Chem
Title: DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.
Volume: 285
Issue: 17
Pages: 13223-32
Publication
First Author: Shindoh N
Year: 1996
Journal: Biochem Biophys Res Commun
Title: Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from "the Down syndrome critical region" of chromosome 21.
Volume: 225
Issue: 1
Pages: 92-9
Publication
First Author: Tejedor FJ
Year: 2011
Journal: FEBS J
Title: MNB/DYRK1A as a multiple regulator of neuronal development.
Volume: 278
Issue: 2
Pages: 223-35
Publication
First Author: Park J
Year: 2009
Journal: Cell Mol Life Sci
Title: Function and regulation of Dyrk1A: towards understanding Down syndrome.
Volume: 66
Issue: 20
Pages: 3235-40
Publication
First Author: Walte A
Year: 2013
Journal: FEBS J
Title: Mechanism of dual specificity kinase activity of DYRK1A.
Volume: 280
Issue: 18
Pages: 4495-511
Publication
First Author: Kentrup H
Year: 1996
Journal: J Biol Chem
Title: Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII.
Volume: 271
Issue: 7
Pages: 3488-95
Publication
First Author: Hong SH
Year: 2012
Journal: PLoS Genet
Title: Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals.
Volume: 8
Issue: 8
Pages: e1002857
Publication
First Author: Tejedor F
Year: 1995
Journal: Neuron
Title: minibrain: a new protein kinase family involved in postembryonic neurogenesis in Drosophila.
Volume: 14
Issue: 2
Pages: 287-301