Nus1 (also known as Nogo-B receptor, NgBR) is a subunit of cis-prenyltransferase, a enzymatic activity critical for the synthesis of dolichol, an obligate carrier of oligosaccharides for protein glycosylation reactions []. It plays an essential role in angiogenesis during wound healing and embryonic development. In mice, it is essential for endothelial cell glycosylation and vascular development []. In zebrafish, it is bound by Nogo-B ligand that activates Akt pathway to stimulate endothelial cell chemotaxis []. In humans, it is involved in breast cancer cell growth through modulating Ras signaling [].
