Cytoplasmic protein NCK2 (NCK2) is a non-enzymatic adaptor protein composed of three SH3 (Src homology 3) domains and a C-terminal SH2 domain. There are two vertebrate NCK proteins, NCK1 and NCK2. NCK2 mediates Slit-induced cortical neurite outgrowth []. NCK2 interacts with focal adhesion kinase (FAK) and this interaction suggests a role of NCK2 in the modulation of cell motility []. It also interacts with DOCK1 [], LIMS1 [].
