This entry represents the N-terminal domain of proteins from photosynthetic organisms including plants and cyanobacteria, such as Tab2 proteins. Tab2 was first identified in Chlamydomonas reinhardtii as a RNA binding protein required for translation of the chloroplast PsaB photosystem I subunit []. Later, the Tab2 homologue (ATAB2) from Arabidopsis was found involved in the signalling pathway of light-controlled synthesis of photosystem proteins during early plant development [], presumably functioning as an activator of translation with targets at PSI and PSII [].
This entry represents the C-terminal domain of Tab2 from plants and cyanobacteria. Tab2 was first identified in Chlamydomonas reinhardtii ([swissprot]:Q7X8Y6) as a RNA-binding protein required for translation of the chloroplast PsaB photosystem I subunit []. Later, the Tab2 homologue from Arabidopsis (ATAB2) was found involved in the signalling pathway of light-controlled synthesis of photosystem proteins during early plant development, presumably functioning as an activator of translation with targets at PSI and PSII [, ]. Directed mutagenesis experiments carried out in Tab2 from C.reinhardtii indicated the importance of a highly conserved C-terminal tripeptide WLL for normal psaB translation [].
TAB2 (TGF-beta-activated kinase 1 and MAP3K7-binding protein 2) is an adaptor protein that regulates activation of TAK1, a MAP kinase kinase kinase (MAPKKK), through linking TAK1 to TRAF6 in the Interleukin-1 (IL-1) induced NF-kappaB activation pathway []. TAB3 is a TAB2-like TAK1-binding protein that activates NF-kappaB similar to TAB2 []. It activates TAK1 and regulates its association with TRAF2 and TRAF6. Moreover, TAB3 interacts with TRAF6 and TRAF2 in an IL-1- and a TNF-dependent manner, respectively. TAB2 and TAB3 function redundantly as mediators of TAK1 activation in IL-1 and TNF signal transduction []. Both of them contain an N-terminal CUE domain, a coiled-coil (CC) region, a TAK1-binding domain and a C-terminal Npl4 zinc finger (NZF) ubiquitin-binding domain (UBD) [].This entry represents the CUE domain found in TAB2 and TAB3.
Tab2 was first identified in Chlamydomonas reinhardtii as a RNA binding protein required for translation of the chloroplast PsaB photosystem I subunit []. Later, the Tab2 homologue from Arabidopsis was found involved in the signalling pathway of light-controlled synthesis of photosystem proteins during early plant development, that probably functions as an activator of translation with targets at PSI and PSII [, ]. Proteins in this entry are from photosynthetic organisms including plants and cyanobacteria.
