Type |
Details |
Score |
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
492
|
Fragment?: |
false |
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•
•
•
•
|
Publication |
First Author: |
Zhang N |
Year: |
2020 |
Journal: |
Cell Death Differ |
Title: |
Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling. |
Volume: |
27 |
Issue: |
9 |
Pages: |
2605-2619 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
TXK is a member of the Tec family, which is a group of nonreceptor tyrosine kinases containing Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. It also contains an N-terminal cysteine-rich region. TXK forms a complex with EF-1alpha and PARP1 that regulates interferon-gamma gene transcription in Th1 cells []. This entry represents the SH3 domain of TXK. |
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•
•
•
•
•
|
Publication |
First Author: |
Sokolowski K |
Year: |
2016 |
Journal: |
Neural Dev |
Title: |
Molecular and behavioral profiling of Dbx1-derived neurons in the arcuate, lateral and ventromedial hypothalamic nuclei. |
Volume: |
11 |
Issue: |
1 |
Pages: |
12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gresakova V |
Year: |
2021 |
Journal: |
Exp Cell Res |
Title: |
Dual role of Fam208a during zygotic cleavage and early embryonic development. |
Volume: |
406 |
Issue: |
2 |
Pages: |
112723 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chang HY |
Year: |
2011 |
Journal: |
Cancer Res |
Title: |
hPuf-A/KIAA0020 modulates PARP-1 cleavage upon genotoxic stress. |
Volume: |
71 |
Issue: |
3 |
Pages: |
1126-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qiu C |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A divergent Pumilio repeat protein family for pre-rRNA processing and mRNA localization. |
Volume: |
111 |
Issue: |
52 |
Pages: |
18554-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gu W |
Year: |
2004 |
Journal: |
Genes Dev |
Title: |
A new yeast PUF family protein, Puf6p, represses ASH1 mRNA translation and is required for its localization. |
Volume: |
18 |
Issue: |
12 |
Pages: |
1452-65 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Proteins in this family contain a CPL domain, which is a C-terminal domain found in Penguin-like proteins, and Pumilio RNA-binding repeats. Proteins include the following:Pumilio homologue 3 (PUM3; also known as Puf-A), which inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress []. Tertiary structure determination has revealed that PUM3 has eleven PUM repeats arranged in an L-shape, and in contrast to classical PUF proteins, PUM3 forms sequence-independent interactions with DNA or RNA, mediated by conserved basic residues [].Pumilio homology domain family member 6 from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which is an RNA-binding protein involved in post-transcriptional regulation and represses ASH1 mRNA translation. ASH1 is a a protein determinant for mating-type switching [].Protein penguin from Drosophila melanogaster. |
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•
•
•
•
•
|
Allele |
Name: |
poly (ADP-ribose) polymerase family, member 1; targeted mutation 2.1, Alexander Burkle |
Allele Type: |
Targeted |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
poly (ADP-ribose) polymerase family, member 1; targeted mutation 1.1, Alexander Burkle |
Allele Type: |
Targeted |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE62194 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu C |
Year: |
2013 |
Journal: |
Nucleic Acids Res |
Title: |
CHFR is important for the first wave of ubiquitination at DNA damage sites. |
Volume: |
41 |
Issue: |
3 |
Pages: |
1698-710 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rai R |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions. |
Volume: |
7 |
|
Pages: |
10881 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gogola E |
Year: |
2018 |
Journal: |
Cancer Cell |
Title: |
Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality. |
Volume: |
33 |
Issue: |
6 |
Pages: |
1078-1093.e12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schmitt A |
Year: |
2017 |
Journal: |
Cancer Res |
Title: |
ATM Deficiency Is Associated with Sensitivity to PARP1- and ATR Inhibitors in Lung Adenocarcinoma. |
Volume: |
77 |
Issue: |
11 |
Pages: |
3040-3056 |
|
•
•
•
•
•
|
Publication |
First Author: |
Margalef P |
Year: |
2018 |
Journal: |
Cell |
Title: |
Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe. |
Volume: |
172 |
Issue: |
3 |
Pages: |
439-453.e14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Le BV |
Year: |
2020 |
Journal: |
Cell Rep |
Title: |
TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment. |
Volume: |
33 |
Issue: |
1 |
Pages: |
108221 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun X |
Year: |
2016 |
Journal: |
PLoS Biol |
Title: |
Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation. |
Volume: |
14 |
Issue: |
9 |
Pages: |
e1002543 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu X |
Year: |
2013 |
Journal: |
Nat Commun |
Title: |
Loss of TRPM2 function protects against irradiation-induced salivary gland dysfunction. |
Volume: |
4 |
|
Pages: |
1515 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee G |
Year: |
2022 |
Journal: |
Cell Metab |
Title: |
SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity. |
Volume: |
34 |
Issue: |
5 |
Pages: |
702-718.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sambeat A |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage. |
Volume: |
10 |
Issue: |
1 |
Pages: |
4291 |
|
•
•
•
•
•
|
Publication |
First Author: |
Scheibye-Knudsen M |
Year: |
2014 |
Journal: |
Cell Metab |
Title: |
A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome. |
Volume: |
20 |
Issue: |
5 |
Pages: |
840-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dantzer F |
Year: |
2013 |
Journal: |
FEBS J |
Title: |
The expanding role of PARPs in the establishment and maintenance of heterochromatin. |
Volume: |
280 |
Issue: |
15 |
Pages: |
3508-18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li J |
Year: |
2017 |
Journal: |
Science |
Title: |
A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. |
Volume: |
355 |
Issue: |
6331 |
Pages: |
1312-1317 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pyndiah S |
Year: |
2011 |
Journal: |
Sci Signal |
Title: |
c-MYC suppresses BIN1 to release poly(ADP-ribose) polymerase 1: a mechanism by which cancer cells acquire cisplatin resistance. |
Volume: |
4 |
Issue: |
166 |
Pages: |
ra19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Azad GK |
Year: |
2018 |
Journal: |
J Cell Biol |
Title: |
PARP1-dependent eviction of the linker histone H1 mediates immediate early gene expression during neuronal activation. |
Volume: |
217 |
Issue: |
2 |
Pages: |
473-481 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hanzlikova H |
Year: |
2018 |
Journal: |
Mol Cell |
Title: |
The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication. |
Volume: |
71 |
Issue: |
2 |
Pages: |
319-331.e3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schmutz I |
Year: |
2017 |
Journal: |
Nat Struct Mol Biol |
Title: |
TRF2 binds branched DNA to safeguard telomere integrity. |
Volume: |
24 |
Issue: |
9 |
Pages: |
734-742 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brabson JP |
Year: |
2023 |
Journal: |
Cell Rep |
Title: |
Oxidized mC modulates synthetic lethality to PARP inhibitors for the treatment of leukemia. |
Volume: |
42 |
Issue: |
1 |
Pages: |
112027 |
|
•
•
•
•
•
|
Publication |
First Author: |
Forwood JK |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
The C-terminal nuclear localization signal of the sex-determining region Y (SRY) high mobility group domain mediates nuclear import through importin beta 1. |
Volume: |
276 |
Issue: |
49 |
Pages: |
46575-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Anson BJ |
Year: |
1967 |
Journal: |
Arch Otolaryngol |
Title: |
The vestibular system. Anatomic considerations. |
Volume: |
85 |
Issue: |
5 |
Pages: |
497-514 |
|
•
•
•
•
•
|
Publication |
First Author: |
Phillips NB |
Year: |
2006 |
Journal: |
J Mol Biol |
Title: |
SRY and human sex determination: the basic tail of the HMG box functions as a kinetic clamp to augment DNA bending. |
Volume: |
358 |
Issue: |
1 |
Pages: |
172-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kellermayer R |
Year: |
2005 |
Journal: |
Diagn Mol Pathol |
Title: |
A novel frame shift mutation in the HMG box of the SRY gene in a patient with complete 46,XY pure gonadal dysgenesis. |
Volume: |
14 |
Issue: |
3 |
Pages: |
159-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ogata T |
Year: |
1995 |
Journal: |
Hum Genet |
Title: |
Turner syndrome and female sex chromosome aberrations: deduction of the principal factors involved in the development of clinical features. |
Volume: |
95 |
Issue: |
6 |
Pages: |
607-29 |
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•
•
•
•
•
|
Publication |
First Author: |
Maier EM |
Year: |
2003 |
Journal: |
J Pediatr Endocrinol Metab |
Title: |
True hermaphroditism in an XY individual due to a familial point mutation of the SRY gene. |
Volume: |
16 |
Issue: |
4 |
Pages: |
575-80 |
|
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•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents the testis-determining factor Sry (Sex-determining Region Y). Sry is a transcriptional activator that regulates a genetic switch inmale development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells []. Sry is involved in different aspects of gene regulation including promoter activation or repression and contains a high-mobility-group (HMG) box that recognises DNA by partial intercalation in the minor groove []. It binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. Sry also facilitates DNA bending and is involved in pre-mRNA splicing. It is also involved in maintenance of motor functions of dopaminergic neurons in the male adult brain. Sry interacts with a number of partners, including CALM, EP300 (modulates Sry DNA-binding activity), HDAC3, KPNB1, ZNF208 isoform KRAB-O, PARP1 (impaired Sry DNA-binding activity), SLC9A3R2 and WT1. The C-terminal nuclear localization signal in Sry HMG-box domain mediates nuclear import through importin beta 1 [].Defects in Sry can cause gonadal dysgenesis XY female type (GDXY) (OMIM:306100), which is also known as 'XY females' or Swyer syndrome []. Patients suffer rapid and early degeneration of their gonads, which prevents the development secondary sexual characteristics at puberty. Defects in Sry are also found Turner's Syndrome, a disease characterised by gonadal dysgenesis in a 45,X female type []. Defects in Sry can also cause true hermaphroditism (OMIM:235600), genetically heterogeneous condition whre patients have both mature ovarian and mature testicular tissue (46,XX, 46,XY or a mosaic of 46,XX/46,XY) []. |
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•
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Publication |
First Author: |
GarcÃa-Frigola C |
Year: |
2004 |
Journal: |
Brain Res Mol Brain Res |
Title: |
A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. |
Volume: |
122 |
Issue: |
2 |
Pages: |
133-50 |
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•
•
•
•
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Publication |
First Author: |
Liu H |
Year: |
2018 |
Journal: |
Nature |
Title: |
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis. |
Volume: |
563 |
Issue: |
7729 |
Pages: |
131-136 |
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•
•
•
•
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Publication |
First Author: |
Kornberg MD |
Year: |
2010 |
Journal: |
Nat Cell Biol |
Title: |
GAPDH mediates nitrosylation of nuclear proteins. |
Volume: |
12 |
Issue: |
11 |
Pages: |
1094-100 |
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•
•
•
•
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Publication |
First Author: |
Robert I |
Year: |
2015 |
Journal: |
PLoS Genet |
Title: |
Parp3 negatively regulates immunoglobulin class switch recombination. |
Volume: |
11 |
Issue: |
5 |
Pages: |
e1005240 |
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•
•
•
•
•
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Publication |
First Author: |
Kang HC |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage. |
Volume: |
108 |
Issue: |
34 |
Pages: |
14103-8 |
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•
•
•
•
•
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Publication |
First Author: |
Lottersberger F |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Role of 53BP1 oligomerization in regulating double-strand break repair. |
Volume: |
110 |
Issue: |
6 |
Pages: |
2146-51 |
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•
•
•
•
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Publication |
First Author: |
Yi T |
Year: |
2022 |
Journal: |
Exp Biol Med (Maywood) |
Title: |
Ubiquinol-cytochrome c reductase core protein 1 contributes to cardiac tolerance to acute exhaustive exercise. |
Volume: |
247 |
Issue: |
2 |
Pages: |
165-173 |
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•
•
•
•
|
Publication |
First Author: |
Liu Z |
Year: |
2021 |
Journal: |
Biochim Biophys Acta Mol Basis Dis |
Title: |
San1 deficiency leads to cardiomyopathy due to excessive R-loop-associated DNA damage and cardiomyocyte hypoplasia. |
Volume: |
1867 |
Issue: |
11 |
Pages: |
166237 |
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•
•
•
•
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Publication |
First Author: |
Hay T |
Year: |
2005 |
Journal: |
Cancer Res |
Title: |
Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy. |
Volume: |
65 |
Issue: |
22 |
Pages: |
10145-8 |
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•
•
•
•
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Publication |
First Author: |
Blaise S |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
In vivo evidence that TRAF4 is required for central nervous system myelin homeostasis. |
Volume: |
7 |
Issue: |
2 |
Pages: |
e30917 |
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•
•
•
•
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Publication |
First Author: |
Quénet D |
Year: |
2009 |
Journal: |
Exp Cell Res |
Title: |
Parp2 is required for the differentiation of post-meiotic germ cells: identification of a spermatid-specific complex containing Parp1, Parp2, TP2 and HSPA2. |
Volume: |
315 |
Issue: |
16 |
Pages: |
2824-34 |
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•
•
•
•
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Publication |
First Author: |
Lee JY |
Year: |
2023 |
Journal: |
PLoS One |
Title: |
PHRF1 promotes the class switch recombination of IgA in CH12F3-2A cells. |
Volume: |
18 |
Issue: |
8 |
Pages: |
e0285159 |
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•
•
•
•
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Publication |
First Author: |
Srinivasan G |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers. |
Volume: |
116 |
Issue: |
35 |
Pages: |
17438-17443 |
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•
•
•
•
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Publication |
First Author: |
Ganesan S |
Year: |
2014 |
Journal: |
Toxicol Appl Pharmacol |
Title: |
Enhanced susceptibility of ovaries from obese mice to 7,12-dimethylbenz[a]anthracene-induced DNA damage. |
Volume: |
281 |
Issue: |
2 |
Pages: |
203-10 |
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•
•
•
•
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Publication |
First Author: |
Ordonez LD |
Year: |
2019 |
Journal: |
Oncotarget |
Title: |
Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours. |
Volume: |
10 |
Issue: |
27 |
Pages: |
2586-2606 |
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•
•
•
•
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Publication |
First Author: |
Vidal-Gil L |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
Poly ADP ribosylation and extracellular vesicle activity in rod photoreceptor degeneration. |
Volume: |
9 |
Issue: |
1 |
Pages: |
3758 |
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•
•
•
•
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Publication |
First Author: |
Shahzad K |
Year: |
2016 |
Journal: |
J Am Soc Nephrol |
Title: |
Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy. |
Volume: |
27 |
Issue: |
8 |
Pages: |
2270-5 |
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•
•
•
•
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Publication |
First Author: |
Huna A |
Year: |
2021 |
Journal: |
Cell Death Dis |
Title: |
PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging. |
Volume: |
12 |
Issue: |
2 |
Pages: |
190 |
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•
•
•
•
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Publication |
First Author: |
Santos L |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
14381 |
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•
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•
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Publication |
First Author: |
Kaminker PG |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression. |
Volume: |
276 |
Issue: |
38 |
Pages: |
35891-9 |
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•
•
•
•
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Publication |
First Author: |
Guastafierro T |
Year: |
2013 |
Journal: |
Biochem J |
Title: |
ADP-ribose polymer depletion leads to nuclear Ctcf re-localization and chromatin rearrangement(1). |
Volume: |
449 |
Issue: |
3 |
Pages: |
623-30 |
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•
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Publication |
First Author: |
Tseng SH |
Year: |
2015 |
Journal: |
Int J Cancer |
Title: |
K14-EGFP-miR-31 transgenic mice have high susceptibility to chemical-induced squamous cell tumorigenesis that is associating with Ku80 repression. |
Volume: |
136 |
Issue: |
6 |
Pages: |
1263-75 |
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•
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Publication |
First Author: |
Badie S |
Year: |
2015 |
Journal: |
EMBO J |
Title: |
BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres. |
Volume: |
34 |
Issue: |
3 |
Pages: |
410-24 |
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•
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•
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Publication |
First Author: |
Gaur U |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
Molecular evolutionary patterns of NAD+/Sirtuin aging signaling pathway across taxa. |
Volume: |
12 |
Issue: |
8 |
Pages: |
e0182306 |
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•
•
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•
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Publication |
First Author: |
Mirman Z |
Year: |
2018 |
Journal: |
Nature |
Title: |
53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in. |
Volume: |
560 |
Issue: |
7716 |
Pages: |
112-116 |
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•
•
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•
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Publication |
First Author: |
Maruyama T |
Year: |
2007 |
Journal: |
Clin Exp Immunol |
Title: |
Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells. |
Volume: |
147 |
Issue: |
1 |
Pages: |
164-75 |
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•
•
•
•
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Publication |
First Author: |
Sun Y |
Year: |
2014 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
Rapamycin-resistant poly (ADP-ribose) polymerase-1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis. |
Volume: |
51 |
Issue: |
6 |
Pages: |
738-49 |
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•
•
•
•
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Publication |
First Author: |
Uhlemeyer C |
Year: |
2023 |
Journal: |
Mol Metab |
Title: |
Selective ablation of P53 in pancreatic beta cells fails to ameliorate glucose metabolism in genetic, dietary and pharmacological models of diabetes mellitus. |
Volume: |
67 |
|
Pages: |
101650 |
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•
•
•
•
•
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Publication |
First Author: |
Chandrasekaran K |
Year: |
2019 |
Journal: |
Brain |
Title: |
Overexpression of Sirtuin 1 protein in neurons prevents and reverses experimental diabetic neuropathy. |
Volume: |
142 |
Issue: |
12 |
Pages: |
3737-3752 |
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•
•
•
•
•
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Publication |
First Author: |
Zrimšek M |
Year: |
2022 |
Journal: |
Cells |
Title: |
Quantitative Acetylomics Uncover Acetylation-Mediated Pathway Changes Following Histone Deacetylase Inhibition in Anaplastic Large Cell Lymphoma. |
Volume: |
11 |
Issue: |
15 |
|
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•
•
•
•
•
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Publication |
First Author: |
Waldman M |
Year: |
2018 |
Journal: |
Exp Cell Res |
Title: |
PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1α axis. |
Volume: |
373 |
Issue: |
1-2 |
Pages: |
112-118 |
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•
•
•
•
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Publication |
First Author: |
Husain K |
Year: |
2013 |
Journal: |
Cancer Prev Res (Phila) |
Title: |
Vitamin E δ-tocotrienol prolongs survival in the LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) transgenic mouse model of pancreatic cancer. |
Volume: |
6 |
Issue: |
10 |
Pages: |
1074-83 |
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•
•
•
•
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Publication |
First Author: |
Tomasetti M |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Alpha-tocopheryl succinate inhibits autophagic survival of prostate cancer cells induced by vitamin K3 and ascorbate to trigger cell death. |
Volume: |
7 |
Issue: |
12 |
Pages: |
e52263 |
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•
•
•
•
•
|
Publication |
First Author: |
Huang CT |
Year: |
2014 |
Journal: |
Biochim Biophys Acta |
Title: |
Energy adaptive response during parthanatos is enhanced by PD98059 and involves mitochondrial function but not autophagy induction. |
Volume: |
1843 |
Issue: |
3 |
Pages: |
531-43 |
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•
•
•
•
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Publication |
First Author: |
Zheng Q |
Year: |
2020 |
Journal: |
Brain Res Bull |
Title: |
TRPM2 ion channel is involved in the aggravation of cognitive impairment and down regulation of epilepsy threshold in pentylenetetrazole-induced kindling mice. |
Volume: |
155 |
|
Pages: |
48-60 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
647
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
226
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
300
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
404
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
648
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
250
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Bencsics M |
Year: |
2023 |
Journal: |
Front Immunol |
Title: |
PARP2 downregulation in T cells ameliorates lipopolysaccharide-induced inflammation of the large intestine. |
Volume: |
14 |
|
Pages: |
1135410 |
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•
•
•
•
•
|
Publication |
First Author: |
Edwards SK |
Year: |
2014 |
Journal: |
J Hematol Oncol |
Title: |
Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes. |
Volume: |
7 |
|
Pages: |
56 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
392
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
234
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
233
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
416
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
302
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
300
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
232
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
231
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
395
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
315
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
304
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
232
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
317
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
306
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
374
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
303
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
315
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
233
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
143
|
Fragment?: |
true |
|
•
•
•
•
•
|