|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 801 to 900 out of 939 for Parp1

0.036s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Protein
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
Publication
First Author: Zhang N
Year: 2020
Journal: Cell Death Differ
Title: Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling.
Volume: 27
Issue: 9
Pages: 2605-2619
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Protein Domain
Type: Domain
Description: TXK is a member of the Tec family, which is a group of nonreceptor tyrosine kinases containing Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. It also contains an N-terminal cysteine-rich region. TXK forms a complex with EF-1alpha and PARP1 that regulates interferon-gamma gene transcription in Th1 cells []. This entry represents the SH3 domain of TXK.
Publication
First Author: Sokolowski K
Year: 2016
Journal: Neural Dev
Title: Molecular and behavioral profiling of Dbx1-derived neurons in the arcuate, lateral and ventromedial hypothalamic nuclei.
Volume: 11
Issue: 1
Pages: 12
Publication
First Author: Gresakova V
Year: 2021
Journal: Exp Cell Res
Title: Dual role of Fam208a during zygotic cleavage and early embryonic development.
Volume: 406
Issue: 2
Pages: 112723
Publication
First Author: Chang HY
Year: 2011
Journal: Cancer Res
Title: hPuf-A/KIAA0020 modulates PARP-1 cleavage upon genotoxic stress.
Volume: 71
Issue: 3
Pages: 1126-34
Publication
First Author: Qiu C
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: A divergent Pumilio repeat protein family for pre-rRNA processing and mRNA localization.
Volume: 111
Issue: 52
Pages: 18554-9
Publication
First Author: Gu W
Year: 2004
Journal: Genes Dev
Title: A new yeast PUF family protein, Puf6p, represses ASH1 mRNA translation and is required for its localization.
Volume: 18
Issue: 12
Pages: 1452-65
Protein Domain
Type: Family
Description: Proteins in this family contain a CPL domain, which is a C-terminal domain found in Penguin-like proteins, and Pumilio RNA-binding repeats. Proteins include the following:Pumilio homologue 3 (PUM3; also known as Puf-A), which inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress []. Tertiary structure determination has revealed that PUM3 has eleven PUM repeats arranged in an L-shape, and in contrast to classical PUF proteins, PUM3 forms sequence-independent interactions with DNA or RNA, mediated by conserved basic residues [].Pumilio homology domain family member 6 from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which is an RNA-binding protein involved in post-transcriptional regulation and represses ASH1 mRNA translation. ASH1 is a a protein determinant for mating-type switching [].Protein penguin from Drosophila melanogaster.
Allele
Name: poly (ADP-ribose) polymerase family, member 1; targeted mutation 2.1, Alexander Burkle
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: poly (ADP-ribose) polymerase family, member 1; targeted mutation 1.1, Alexander Burkle
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
HT Experiment
Series Id: GSE62194
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication
First Author: Liu C
Year: 2013
Journal: Nucleic Acids Res
Title: CHFR is important for the first wave of ubiquitination at DNA damage sites.
Volume: 41
Issue: 3
Pages: 1698-710
Publication  
First Author: Rai R
Year: 2016
Journal: Nat Commun
Title: TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions.
Volume: 7
Pages: 10881
Publication
First Author: Gogola E
Year: 2018
Journal: Cancer Cell
Title: Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.
Volume: 33
Issue: 6
Pages: 1078-1093.e12
Publication
First Author: Schmitt A
Year: 2017
Journal: Cancer Res
Title: ATM Deficiency Is Associated with Sensitivity to PARP1- and ATR Inhibitors in Lung Adenocarcinoma.
Volume: 77
Issue: 11
Pages: 3040-3056
Publication
First Author: Margalef P
Year: 2018
Journal: Cell
Title: Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe.
Volume: 172
Issue: 3
Pages: 439-453.e14
Publication
First Author: Le BV
Year: 2020
Journal: Cell Rep
Title: TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment.
Volume: 33
Issue: 1
Pages: 108221
Publication
First Author: Sun X
Year: 2016
Journal: PLoS Biol
Title: Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation.
Volume: 14
Issue: 9
Pages: e1002543
Publication  
First Author: Liu X
Year: 2013
Journal: Nat Commun
Title: Loss of TRPM2 function protects against irradiation-induced salivary gland dysfunction.
Volume: 4
Pages: 1515
Publication
First Author: Lee G
Year: 2022
Journal: Cell Metab
Title: SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity.
Volume: 34
Issue: 5
Pages: 702-718.e5
Publication
First Author: Sambeat A
Year: 2019
Journal: Nat Commun
Title: Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage.
Volume: 10
Issue: 1
Pages: 4291
Publication
First Author: Scheibye-Knudsen M
Year: 2014
Journal: Cell Metab
Title: A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.
Volume: 20
Issue: 5
Pages: 840-55
Publication
First Author: Dantzer F
Year: 2013
Journal: FEBS J
Title: The expanding role of PARPs in the establishment and maintenance of heterochromatin.
Volume: 280
Issue: 15
Pages: 3508-18
Publication
First Author: Li J
Year: 2017
Journal: Science
Title: A conserved NAD+ binding pocket that regulates protein-protein interactions during aging.
Volume: 355
Issue: 6331
Pages: 1312-1317
Publication
First Author: Pyndiah S
Year: 2011
Journal: Sci Signal
Title: c-MYC suppresses BIN1 to release poly(ADP-ribose) polymerase 1: a mechanism by which cancer cells acquire cisplatin resistance.
Volume: 4
Issue: 166
Pages: ra19
Publication
First Author: Azad GK
Year: 2018
Journal: J Cell Biol
Title: PARP1-dependent eviction of the linker histone H1 mediates immediate early gene expression during neuronal activation.
Volume: 217
Issue: 2
Pages: 473-481
Publication
First Author: Hanzlikova H
Year: 2018
Journal: Mol Cell
Title: The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication.
Volume: 71
Issue: 2
Pages: 319-331.e3
Publication
First Author: Schmutz I
Year: 2017
Journal: Nat Struct Mol Biol
Title: TRF2 binds branched DNA to safeguard telomere integrity.
Volume: 24
Issue: 9
Pages: 734-742
Publication
First Author: Brabson JP
Year: 2023
Journal: Cell Rep
Title: Oxidized mC modulates synthetic lethality to PARP inhibitors for the treatment of leukemia.
Volume: 42
Issue: 1
Pages: 112027
Publication
First Author: Forwood JK
Year: 2001
Journal: J Biol Chem
Title: The C-terminal nuclear localization signal of the sex-determining region Y (SRY) high mobility group domain mediates nuclear import through importin beta 1.
Volume: 276
Issue: 49
Pages: 46575-82
Publication
First Author: Anson BJ
Year: 1967
Journal: Arch Otolaryngol
Title: The vestibular system. Anatomic considerations.
Volume: 85
Issue: 5
Pages: 497-514
Publication
First Author: Phillips NB
Year: 2006
Journal: J Mol Biol
Title: SRY and human sex determination: the basic tail of the HMG box functions as a kinetic clamp to augment DNA bending.
Volume: 358
Issue: 1
Pages: 172-92
Publication
First Author: Kellermayer R
Year: 2005
Journal: Diagn Mol Pathol
Title: A novel frame shift mutation in the HMG box of the SRY gene in a patient with complete 46,XY pure gonadal dysgenesis.
Volume: 14
Issue: 3
Pages: 159-63
Publication
First Author: Ogata T
Year: 1995
Journal: Hum Genet
Title: Turner syndrome and female sex chromosome aberrations: deduction of the principal factors involved in the development of clinical features.
Volume: 95
Issue: 6
Pages: 607-29
Publication
First Author: Maier EM
Year: 2003
Journal: J Pediatr Endocrinol Metab
Title: True hermaphroditism in an XY individual due to a familial point mutation of the SRY gene.
Volume: 16
Issue: 4
Pages: 575-80
Protein Domain
Type: Family
Description: This entry represents the testis-determining factor Sry (Sex-determining Region Y). Sry is a transcriptional activator that regulates a genetic switch inmale development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells []. Sry is involved in different aspects of gene regulation including promoter activation or repression and contains a high-mobility-group (HMG) box that recognises DNA by partial intercalation in the minor groove []. It binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. Sry also facilitates DNA bending and is involved in pre-mRNA splicing. It is also involved in maintenance of motor functions of dopaminergic neurons in the male adult brain. Sry interacts with a number of partners, including CALM, EP300 (modulates Sry DNA-binding activity), HDAC3, KPNB1, ZNF208 isoform KRAB-O, PARP1 (impaired Sry DNA-binding activity), SLC9A3R2 and WT1. The C-terminal nuclear localization signal in Sry HMG-box domain mediates nuclear import through importin beta 1 [].Defects in Sry can cause gonadal dysgenesis XY female type (GDXY) (OMIM:306100), which is also known as 'XY females' or Swyer syndrome []. Patients suffer rapid and early degeneration of their gonads, which prevents the development secondary sexual characteristics at puberty. Defects in Sry are also found Turner's Syndrome, a disease characterised by gonadal dysgenesis in a 45,X female type []. Defects in Sry can also cause true hermaphroditism (OMIM:235600), genetically heterogeneous condition whre patients have both mature ovarian and mature testicular tissue (46,XX, 46,XY or a mosaic of 46,XX/46,XY) [].
Publication
First Author: García-Frigola C
Year: 2004
Journal: Brain Res Mol Brain Res
Title: A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain.
Volume: 122
Issue: 2
Pages: 133-50
Publication
First Author: Liu H
Year: 2018
Journal: Nature
Title: Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
Volume: 563
Issue: 7729
Pages: 131-136
Publication
First Author: Kornberg MD
Year: 2010
Journal: Nat Cell Biol
Title: GAPDH mediates nitrosylation of nuclear proteins.
Volume: 12
Issue: 11
Pages: 1094-100
Publication
First Author: Robert I
Year: 2015
Journal: PLoS Genet
Title: Parp3 negatively regulates immunoglobulin class switch recombination.
Volume: 11
Issue: 5
Pages: e1005240
Publication
First Author: Kang HC
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage.
Volume: 108
Issue: 34
Pages: 14103-8
Publication
First Author: Lottersberger F
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Role of 53BP1 oligomerization in regulating double-strand break repair.
Volume: 110
Issue: 6
Pages: 2146-51
Publication
First Author: Yi T
Year: 2022
Journal: Exp Biol Med (Maywood)
Title: Ubiquinol-cytochrome c reductase core protein 1 contributes to cardiac tolerance to acute exhaustive exercise.
Volume: 247
Issue: 2
Pages: 165-173
Publication
First Author: Liu Z
Year: 2021
Journal: Biochim Biophys Acta Mol Basis Dis
Title: San1 deficiency leads to cardiomyopathy due to excessive R-loop-associated DNA damage and cardiomyocyte hypoplasia.
Volume: 1867
Issue: 11
Pages: 166237
Publication
First Author: Hay T
Year: 2005
Journal: Cancer Res
Title: Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy.
Volume: 65
Issue: 22
Pages: 10145-8
Publication
First Author: Blaise S
Year: 2012
Journal: PLoS One
Title: In vivo evidence that TRAF4 is required for central nervous system myelin homeostasis.
Volume: 7
Issue: 2
Pages: e30917
Publication
First Author: Quénet D
Year: 2009
Journal: Exp Cell Res
Title: Parp2 is required for the differentiation of post-meiotic germ cells: identification of a spermatid-specific complex containing Parp1, Parp2, TP2 and HSPA2.
Volume: 315
Issue: 16
Pages: 2824-34
Publication
First Author: Lee JY
Year: 2023
Journal: PLoS One
Title: PHRF1 promotes the class switch recombination of IgA in CH12F3-2A cells.
Volume: 18
Issue: 8
Pages: e0285159
Publication
First Author: Srinivasan G
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers.
Volume: 116
Issue: 35
Pages: 17438-17443
Publication
First Author: Ganesan S
Year: 2014
Journal: Toxicol Appl Pharmacol
Title: Enhanced susceptibility of ovaries from obese mice to 7,12-dimethylbenz[a]anthracene-induced DNA damage.
Volume: 281
Issue: 2
Pages: 203-10
Publication
First Author: Ordonez LD
Year: 2019
Journal: Oncotarget
Title: Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours.
Volume: 10
Issue: 27
Pages: 2586-2606
Publication
First Author: Vidal-Gil L
Year: 2019
Journal: Sci Rep
Title: Poly ADP ribosylation and extracellular vesicle activity in rod photoreceptor degeneration.
Volume: 9
Issue: 1
Pages: 3758
Publication
First Author: Shahzad K
Year: 2016
Journal: J Am Soc Nephrol
Title: Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy.
Volume: 27
Issue: 8
Pages: 2270-5
Publication
First Author: Huna A
Year: 2021
Journal: Cell Death Dis
Title: PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging.
Volume: 12
Issue: 2
Pages: 190
Publication
First Author: Santos L
Year: 2019
Journal: Sci Rep
Title: A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo.
Volume: 9
Issue: 1
Pages: 14381
Publication
First Author: Kaminker PG
Year: 2001
Journal: J Biol Chem
Title: TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression.
Volume: 276
Issue: 38
Pages: 35891-9
Publication
First Author: Guastafierro T
Year: 2013
Journal: Biochem J
Title: ADP-ribose polymer depletion leads to nuclear Ctcf re-localization and chromatin rearrangement(1).
Volume: 449
Issue: 3
Pages: 623-30
Publication
First Author: Tseng SH
Year: 2015
Journal: Int J Cancer
Title: K14-EGFP-miR-31 transgenic mice have high susceptibility to chemical-induced squamous cell tumorigenesis that is associating with Ku80 repression.
Volume: 136
Issue: 6
Pages: 1263-75
Publication
First Author: Badie S
Year: 2015
Journal: EMBO J
Title: BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.
Volume: 34
Issue: 3
Pages: 410-24
Publication
First Author: Gaur U
Year: 2017
Journal: PLoS One
Title: Molecular evolutionary patterns of NAD+/Sirtuin aging signaling pathway across taxa.
Volume: 12
Issue: 8
Pages: e0182306
Publication
First Author: Mirman Z
Year: 2018
Journal: Nature
Title: 53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in.
Volume: 560
Issue: 7716
Pages: 112-116
Publication
First Author: Maruyama T
Year: 2007
Journal: Clin Exp Immunol
Title: Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells.
Volume: 147
Issue: 1
Pages: 164-75
Publication
First Author: Sun Y
Year: 2014
Journal: Am J Respir Cell Mol Biol
Title: Rapamycin-resistant poly (ADP-ribose) polymerase-1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis.
Volume: 51
Issue: 6
Pages: 738-49
Publication  
First Author: Uhlemeyer C
Year: 2023
Journal: Mol Metab
Title: Selective ablation of P53 in pancreatic beta cells fails to ameliorate glucose metabolism in genetic, dietary and pharmacological models of diabetes mellitus.
Volume: 67
Pages: 101650
Publication
First Author: Chandrasekaran K
Year: 2019
Journal: Brain
Title: Overexpression of Sirtuin 1 protein in neurons prevents and reverses experimental diabetic neuropathy.
Volume: 142
Issue: 12
Pages: 3737-3752
Publication  
First Author: Zrimšek M
Year: 2022
Journal: Cells
Title: Quantitative Acetylomics Uncover Acetylation-Mediated Pathway Changes Following Histone Deacetylase Inhibition in Anaplastic Large Cell Lymphoma.
Volume: 11
Issue: 15
Publication
First Author: Waldman M
Year: 2018
Journal: Exp Cell Res
Title: PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1α axis.
Volume: 373
Issue: 1-2
Pages: 112-118
Publication
First Author: Husain K
Year: 2013
Journal: Cancer Prev Res (Phila)
Title: Vitamin E δ-tocotrienol prolongs survival in the LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) transgenic mouse model of pancreatic cancer.
Volume: 6
Issue: 10
Pages: 1074-83
Publication
First Author: Tomasetti M
Year: 2012
Journal: PLoS One
Title: Alpha-tocopheryl succinate inhibits autophagic survival of prostate cancer cells induced by vitamin K3 and ascorbate to trigger cell death.
Volume: 7
Issue: 12
Pages: e52263
Publication
First Author: Huang CT
Year: 2014
Journal: Biochim Biophys Acta
Title: Energy adaptive response during parthanatos is enhanced by PD98059 and involves mitochondrial function but not autophagy induction.
Volume: 1843
Issue: 3
Pages: 531-43
Publication  
First Author: Zheng Q
Year: 2020
Journal: Brain Res Bull
Title: TRPM2 ion channel is involved in the aggravation of cognitive impairment and down regulation of epilepsy threshold in pentylenetetrazole-induced kindling mice.
Volume: 155
Pages: 48-60
Protein
Organism: Mus musculus/domesticus
Length: 647  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 226  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 404  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 648  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: false
Publication  
First Author: Bencsics M
Year: 2023
Journal: Front Immunol
Title: PARP2 downregulation in T cells ameliorates lipopolysaccharide-induced inflammation of the large intestine.
Volume: 14
Pages: 1135410
Publication  
First Author: Edwards SK
Year: 2014
Journal: J Hematol Oncol
Title: Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes.
Volume: 7
Pages: 56
Protein
Organism: Mus musculus/domesticus
Length: 392  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 234  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 416  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 374  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: true