SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 (SMARCD3 or BAF60C) is a component of several complexes that remodel chromatin, a mechanism by which selected genes are transcriptionally activated or repressed. The complexes are SWI/SNF, which changes chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner []; BAF []; and the npBAF and nBAF, which are neuron-specific []. SMARCD3 is known to interact with a number of proteins, including SMARCA4/BRG1/BAF190A []and the homeobox protein PBX1 [].
