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Search results 101 to 200 out of 271 for Itk

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Type Details Score
Publication
23851691 | J:205691
First Author: Dervovic DD
Year: 2013
Journal: J Immunol
Title: Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch.
Volume: 191
Issue: 4
Pages: 1704-15
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Publication
20974963 | J:167374
First Author: Rochman Y
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling.
Volume: 107
Issue: 45
Pages: 19455-60
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Publication
19449311 | J:149450
First Author: Clarke RL
Year: 2009
Journal: Eur J Immunol
Title: A new function for LAT and CD8 during CD8-mediated apoptosis that is independent of TCR signal transduction.
Volume: 39
Issue: 6
Pages: 1619-31
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Protein Coding Gene
MGP_CAROLIEiJ_G0016242 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0018192 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0018164 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0018129 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0018133 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0017947 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_96621 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0018587 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0017510 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0017919 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0018029 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0018023 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0018101 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0018047 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0018626 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0017290 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0017560 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0017378 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0017083 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
8421704 | J:3730
First Author: Heyeck SD
Year: 1993
Journal: Proc Natl Acad Sci U S A
Title: Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk.
Volume: 90
Issue: 2
Pages: 669-73
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Publication
- | J:254826
     
First Author: Zhong X
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for goodnow
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Publication
- | J:236673
     
First Author: Yue T
Year: 2016
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for itxaro
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Publication
22988097 | J:190112
First Author: Qiao Y
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells.
Volume: 109
Issue: 40
Pages: 16264-9
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Publication
31757864 | J:294119
First Author: Shao B
Year: 2020
Journal: J Immunol
Title: Th1 Cells Rolling on Selectins Trigger DAP12-Dependent Signals That Activate Integrin αLβ2.
Volume: 204
Issue: 1
Pages: 37-48
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Publication
8476425 | J:20701
First Author: Yamada N
Year: 1993
Journal: Biochem Biophys Res Commun
Title: Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells.
Volume: 192
Issue: 1
Pages: 231-40
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Publication
2357970 | J:33070
First Author: Bernards A
Year: 1990
Journal: EMBO J
Title: The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator.
Volume: 9
Issue: 7
Pages: 2279-87
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Publication
7522330 | J:20460
First Author: Yao L
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C.
Volume: 91
Issue: 19
Pages: 9175-9
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Publication
21497118 | J:171335
First Author: Chang JT
Year: 2011
Journal: Immunity
Title: Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division.
Volume: 34
Issue: 4
Pages: 492-504
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Publication
19597499 | J:151074
First Author: Fu G
Year: 2009
Journal: Nat Immunol
Title: Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling.
Volume: 10
Issue: 8
Pages: 848-56
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Publication
25105474 | J:274172
 
First Author: Pereira RM
Year: 2014
Journal: Nat Commun
Title: Jarid2 is induced by TCR signalling and controls iNKT cell maturation.
Volume: 5
Pages: 4540
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Publication
23562159 | J:196163
First Author: Malhotra N
Year: 2013
Journal: Immunity
Title: A network of high-mobility group box transcription factors programs innate interleukin-17 production.
Volume: 38
Issue: 4
Pages: 681-93
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Publication
15662016 | J:245321
First Author: Hwang ES
Year: 2005
Journal: Science
Title: T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.
Volume: 307
Issue: 5708
Pages: 430-3
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Publication
31591574 | J:282407
First Author: Voisinne G
Year: 2019
Journal: Nat Immunol
Title: Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics.
Volume: 20
Issue: 11
Pages: 1530-1541
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Publication
9177770 | J:40728
First Author: Krulová M
Year: 1997
Journal: Genomics
Title: IL-2-induced proliferative response is controlled by loci Cinda1 and Cinda2 on mouse chromosomes 11 and 12: a distinct control of the response induced by different IL-2 concentrations.
Volume: 42
Issue: 1
Pages: 11-5
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Publication
9070927 | J:37827
First Author: Watkins-Chow DE
Year: 1997
Journal: Genomics
Title: Genetic mapping of 21 genes on mouse chromosome 11 reveals disruptions in linkage conservation with human chromosome 5.
Volume: 40
Issue: 1
Pages: 114-22
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Publication
23793062 | J:205441
First Author: Liang Y
Year: 2013
Journal: Nat Immunol
Title: The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Volume: 14
Issue: 8
Pages: 858-66
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Publication
- | J:103485
     
First Author: Lexicon Genetics Inc
Year: 2005
Journal: MGI Direct Data Submission
Title: NIH initiative supporting placement of Lexicon Genetics, Inc. mice into public repositories
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Publication
- | J:342612
       
First Author: UniProt curators
Year: 2014
Title: Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
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Publication
11114734 | J:66153
First Author: Robinson DR
Year: 2000
Journal: Oncogene
Title: The protein tyrosine kinase family of the human genome.
Volume: 19
Issue: 49
Pages: 5548-57
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Publication
22967998 | J:190524
First Author: Shalom-Barak T
Year: 2012
Journal: Dev Biol
Title: Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.
Volume: 372
Issue: 1
Pages: 143-55
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:72245
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:345476
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2023
Title: TreeGrafter-generated GO annotations
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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UniProt Feature
UniProt Feature
Begin: 256
Description: Phosphotyrosine; by ITK
Type: modified residue
End: 256
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UniProt Feature
UniProt Feature
Begin: 525
Description: Phosphotyrosine; by ITK
Type: modified residue
End: 525
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Publication
21362141 | J:190801
First Author: Qi Q
Year: 2011
Journal: FEBS J
Title: Tec family kinases: Itk signaling and the development of NKT αβ and γδ T cells.
Volume: 278
Issue: 12
Pages: 1970-9
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Allele
Zkscan3<tm1.1Itl> | MGI:6863903
Name: zinc finger with KRAB and SCAN domains 3; targeted mutation 1.1, inGenious Targeting Laboratory
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Zkscan3<tm1.2Itl> | MGI:6863904
Name: zinc finger with KRAB and SCAN domains 3; targeted mutation 1.2, inGenious Targeting Laboratory
Allele Type: Targeted
Attribute String: Null/knockout
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DO Term
DOID:0060704 | lymphoproliferative syndrome
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Publication
21362139 | J:190803
First Author: Gomez-Rodriguez J
Year: 2011
Journal: FEBS J
Title: Tec family kinases Itk and Rlk / Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates.
Volume: 278
Issue: 12
Pages: 1980-9
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Publication
21518255 | J:190798
First Author: Hussain A
Year: 2011
Journal: FEBS J
Title: TEC family kinases in health and disease--loss-of-function of BTK and ITK and the gain-of-function fusions ITK-SYK and BTK-SYK.
Volume: 278
Issue: 12
Pages: 2001-10
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Publication
16931156 | -
First Author: Kosaka Y
Year: 2006
Journal: Trends Immunol
Title: Itk and Th2 responses: action but no reaction.
Volume: 27
Issue: 10
Pages: 453-60
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Publication
37144628 | J:335763
First Author: Ouyang X
Year: 2023
Journal: Physiol Rep
Title: Cardiomyocyte ZKSCAN3 regulates remodeling following pressure-overload.
Volume: 11
Issue: 9
Pages: e15686
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Strain
MGI:6863907 | B6.Cg-Zkscan3<tm1.2Itl>
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Zkscan3/Zkscan3
Background: B6.Cg-Zkscan3
Zygosity: hm
Has Mutant Allele: true
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Publication
19290924 | -
First Author: Prince AL
Year: 2009
Journal: Immunol Rev
Title: The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development.
Volume: 228
Issue: 1
Pages: 115-31
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Publication
17060314 | -
First Author: Qi Q
Year: 2006
Journal: J Biol Chem
Title: Tec kinase Itk forms membrane clusters specifically in the vicinity of recruiting receptors.
Volume: 281
Issue: 50
Pages: 38529-34
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Publication
9701039 | -
First Author: King PD
Year: 1998
Journal: Int Immunol
Title: CD2-mediated activation of the Tec-family tyrosine kinase ITK is controlled by proline-rich stretch-4 of the CD2 cytoplasmic tail.
Volume: 10
Issue: 7
Pages: 1009-16
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Publication
34504306 | J:318724
First Author: Ouyang X
Year: 2021
Journal: Lab Invest
Title: ZKSCAN3 in severe bacterial lung infection and sepsis-induced immunosuppression.
Volume: 101
Issue: 11
Pages: 1467-1474
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Publication
17420479 | -
First Author: Bogin Y
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK.
Volume: 104
Issue: 16
Pages: 6638-43
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Publication
19290923 | -
First Author: Readinger JA
Year: 2009
Journal: Immunol Rev
Title: Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk.
Volume: 228
Issue: 1
Pages: 93-114
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Allele
Itk<em1Smoc> | MGI:7290621
Name: IL2 inducible T cell kinase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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DO Term
DOID:0060707 | lymphoproliferative syndrome 1
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Publication
16436281 | -
First Author: Pletneva EV
Year: 2006
Journal: J Mol Biol
Title: Molecular details of Itk activation by prolyl isomerization and phospholigand binding: the NMR structure of the Itk SH2 domain bound to a phosphopeptide.
Volume: 357
Issue: 2
Pages: 550-61
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Allele
Gt(ROSA)26Sor<tm2(ITK/Syk)Hjum> | MGI:5586728
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Hassan Jumaa
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence
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Publication
17479128 | -
First Author: Berg LJ
Year: 2007
Journal: Nat Rev Immunol
Title: Signalling through TEC kinases regulates conventional versus innate CD8(+) T-cell development.
Volume: 7
Issue: 6
Pages: 479-85
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Protein Domain
IPR035583 | ITK_SH3
Type: Domain
Description: ITK (also known as Tsk or Emt) is a member of the Tec family, which is a group of nonreceptor tyrosine kinases containing Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. It also contains an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation [], and the Tec homology (TH) domain, which contains proline-rich and zinc-binding regions. ITK is expressed in T-cells and mast cells, and is important in their development and differentiation [, ]. Of the three Tec kinases expressed in T-cells, ITK plays the predominant role in T-cell receptor (TCR) signaling. It is activated by phosphorylation upon TCR crosslinking and is involved in the pathway resulting in phospholipase C-gamma1 activation and actin polymerization []. It also plays a role in the downstream signaling of the T-cell costimulatory receptor CD28 [], the T-cell surface receptor CD2 [], and the chemokine receptor CXCR4 []. In addition, ITK is crucial for the development of T-helper(Th)2 effector responses []. This entry represents the SH3 domain of ITK.
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Allele
Itk<tm1Litt> | MGI:2178820
Name: IL2 inducible T cell kinase; targeted mutation 1, Dan R Littman
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:3842200 | B6.129S4-Itk<tm1Litt>
Attribute String: targeted mutation, congenic
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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