TMX2 contain the TRX domain, an N-terminal signal peptide, a potential transmembrane domain, an Myb DNA-binding domain repeat signature, an endoplasmic reticulum (ER) membrane retention signal (KKXX-like motif), and a dileucine motif in the tail. In TMX2, the TRX domain redox active CXXC motif is replaced with SXXC [, ]. Its function is not clear. Homologues are found only in metazoa.
This entry represents the thioredoxin (TRX) domain found in thioredoxin-related transmembrane protein 2 (TMX2). In TMX2, the TRX domain redox active CXXC motif is replaced with SXXC. In addition to the TRX domain, TMX2 may contain an N-terminal signal peptide, a potential transmembrane domain, an Myb DNA-binding domain repeat signature, an endoplasmic reticulum (ER) membrane retention signal (KKXX-like motif), and a dileucine motif in the tail [, ].
