C-type lectin domain family 7 member A (CLEC7A), also known as Dectin-1, is a beta-glucan receptor that binds beta-1,3 and beta-1,6 glucans and collaborates with with TLR2 to activate a macrophage's proinflammatory response to a mycobacterial infection []. It is a type II transmembrane protein of the C-type lectin family with single carbohydrate recognition domains (CRDs) in their extracellular region []. Its cytoplasmic tail contains an immunoreceptor tyrosine based activation motif (ITAM) that signals in part through the spleen tyrosine kinase and in collaboration with Toll-like receptors. It plays an important role in the host defense against fungal infection [, ].
