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Search results 201 to 220 out of 220 for Kmt2b

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Type Details Score
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Kmt2b<tm1Smoc> | MGI:7290748
Name: lysine (K)-specific methyltransferase 2B; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Strain
MGI:6354974 | C57BL/6J-Kmt2b<tm1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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DO Term
DOID:0060936 | dystonia 28, childhood-onset
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Publication
10637508 | -
First Author: Huntsman DG
Year: 1999
Journal: Oncogene
Title: MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines.
Volume: 18
Issue: 56
Pages: 7975-84
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Publication
10409430 | -
First Author: FitzGerald KT
Year: 1999
Journal: Genomics
Title: MLL2: A new mammalian member of the trx/MLL family of genes.
Volume: 59
Issue: 2
Pages: 187-92
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Publication
29323282 | J:308602
First Author: Hanna CW
Year: 2018
Journal: Nat Struct Mol Biol
Title: MLL2 conveys transcription-independent H3K4 trimethylation in oocytes.
Volume: 25
Issue: 1
Pages: 73-82
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Protein Domain
IPR041959 | KMT2B_ePHD
Type: Domain
Description: The extended plant homeodomain (ePHD) zinc finger is characterized as Cys2HisCys5HisCys2His. This entry represents the ePHD finger of Histone-lysine N-methyltransferase 2B (KMT2B), also known as MLL2. KMT2B is a second human homologue of Drosophila trithorax, located on chromosome 19 [, ]. It belongs to the MLL subfamily of H3K4-specific histone lysine methyltransferases (KMT2) and is vital for normal mammalian embryonic development []. KMT2B functions as the catalytic subunit in the MLL2 complex, which contains WDR5, RbBP5, ASH2L and DPY30 as integral core subunits required for the efficient methylation activity of the complex. The MLL2 complex is highly active and specific for histone 3 lysine 4 (H3K4) methylation, which stimulates chromatin transcription in a SAM- and H3K4-dependent manner []. Moreover, KMT2B plays a critical role in memory formation by mediating hippocampal H3K4 di- and trimethylation []. It is also required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter []. KMT2B contains a CxxC (x for any residue) zinc finger domain, three PHD fingers, this ePHD finger, two FY (phenylalanine tyrosine)-rich domains, and a SET (Suppressor of variegation, Enhancer of zeste, Trithorax) domain.
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HT Experiment
GSE185182 | Postnatal SETD1B is essential for learning and the regulation of neuronal plasticity genes [WT scRNA-seq]
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
34806773 | J:317835
First Author: Michurina A
Year: 2022
Journal: EMBO J
Title: Postnatal expression of the lysine methyltransferase SETD1B is essential for learning and the regulation of neuron-enriched genes.
Volume: 41
Issue: 1
Pages: e106459
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HT Experiment
GSE125318 | Epigenomic analysis of gastrulation identifies a unique chromatin state for primed pluripotency
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
27801610 | J:317252
First Author: Lin W
Year: 2016
Journal: Cancer Biol Ther
Title: Kmt2a cooperates with menin to suppress tumorigenesis in mouse pancreatic islets.
Volume: 17
Issue: 12
Pages: 1274-1281
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Protein
Q8CHH1
Organism: Mus musculus/domesticus
Length: 1744  
Fragment?: true
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Protein
O08550
Organism: Mus musculus/domesticus
Length: 2713  
Fragment?: false
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Protein
F8WJ40
Organism: Mus musculus/domesticus
Length: 2721  
Fragment?: false
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Protein
Q6PHU4
Organism: Mus musculus/domesticus
Length: 2013  
Fragment?: true
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Protein
F6W623
Organism: Mus musculus/domesticus
Length: 2014  
Fragment?: true
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