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Search results 601 to 700 out of 744 for Vav1

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Type Details Score
Publication
27396339 | J:238674
First Author: Barrett NA
Year: 2016
Journal: Cell Rep
Title: Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development.
Volume: 16
Issue: 4
Pages: 1039-1054
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Publication
23704093 | J:201181
First Author: Niebuhr B
Year: 2013
Journal: Blood
Title: Runx1 is essential at two stages of early murine B-cell development.
Volume: 122
Issue: 3
Pages: 413-23
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Publication
20421388 | J:160938
First Author: Lehnertz B
Year: 2010
Journal: J Exp Med
Title: Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function.
Volume: 207
Issue: 5
Pages: 915-22
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Publication
29348130 | J:261492
First Author: Arndt K
Year: 2018
Journal: Blood
Title: SETD1A protects HSCs from activation-induced functional decline in vivo.
Volume: 131
Issue: 12
Pages: 1311-1324
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Publication
22514136 | J:231132
First Author: Rohwedder I
Year: 2012
Journal: EMBO Mol Med
Title: Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation.
Volume: 4
Issue: 7
Pages: 564-76
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Publication
28975680 | J:249974
First Author: Tarnawsky SP
Year: 2017
Journal: Dev Dyn
Title: Yolk sac erythromyeloid progenitors expressing gain of function PTPN11 have functional features of JMML but are not sufficient to cause disease in mice.
Volume: 246
Issue: 12
Pages: 1001-1014
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Publication
28077417 | J:240697
First Author: Kunimoto H
Year: 2017
Journal: Blood
Title: Aid is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells.
Volume: 129
Issue: 13
Pages: 1779-1790
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Publication
22759635 | J:185343
First Author: Huang H
Year: 2012
Journal: Genes Dev
Title: A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation.
Volume: 26
Issue: 14
Pages: 1587-601
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Publication
27125305 | J:236122
First Author: Gekas C
Year: 2016
Journal: Leukemia
Title: β-Catenin is required for T-cell leukemia initiation and MYC transcription downstream of Notch1.
Volume: 30
Issue: 10
Pages: 2002-2010
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Publication
23122289 | J:193722
First Author: Hidalgo I
Year: 2012
Journal: Cell Stem Cell
Title: Ezh1 is required for hematopoietic stem cell maintenance and prevents senescence-like cell cycle arrest.
Volume: 11
Issue: 5
Pages: 649-62
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Publication
27114551 | J:232194
First Author: Rabacal W
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Transcription factor KLF2 regulates homeostatic NK cell proliferation and survival.
Volume: 113
Issue: 19
Pages: 5370-5
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Publication
18246069 | J:131810
First Author: Sebzda E
Year: 2008
Journal: Nat Immunol
Title: Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns.
Volume: 9
Issue: 3
Pages: 292-300
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Publication
26538284 | J:237572
First Author: Balestrini A
Year: 2016
Journal: Mol Cancer Res
Title: Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model.
Volume: 14
Issue: 2
Pages: 185-95
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Publication
31285322 | J:277750
First Author: Kim JH
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Nbn-Mre11 interaction is required for tumor suppression and genomic integrity.
Volume: 116
Issue: 30
Pages: 15178-15183
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Publication
28104688 | J:240959
First Author: Payne H
Year: 2017
Journal: Blood
Title: Mice with a deficiency in CLEC-2 are protected against deep vein thrombosis.
Volume: 129
Issue: 14
Pages: 2013-2020
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Publication
26036803 | J:225918
First Author: Lee SC
Year: 2015
Journal: Blood
Title: Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis.
Volume: 126
Issue: 2
Pages: 167-75
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Publication
- | J:331302
First Author: Spivak JL, Williams DM, Zhao ZJ, Rogers O, Duffield AS, Hankins WD, Moliterno AR
Year: 2015
Journal: Blood
Title: MPL SV, a Unique MPN MPL Splice Variant, Provokes a Fulminant Myeloid Leukemia in a JAK2 V617F Transgenic Mouse Model of Polycythemia Vera
Volume: 126
Issue: 23
Pages: 484
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Publication
38155245 | J:345789
First Author: Parriott G
Year: 2024
Journal: Leukemia
Title: Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T-ALL.
Volume: 38
Issue: 3
Pages: 491-501
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Publication
32492429 | J:323578
First Author: Walpole GFW
Year: 2020
Journal: Cell Rep
Title: Inactivation of Rho GTPases by Burkholderia cenocepacia Induces a WASH-Mediated Actin Polymerization that Delays Phagosome Maturation.
Volume: 31
Issue: 9
Pages: 107721
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Publication
36509284 | J:332130
 
First Author: Kennel KB
Year: 2022
Journal: JCI Insight
Title: The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer.
Volume: 7
Issue: 22
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Publication
27135740 | J:239471
First Author: Lee SC
Year: 2016
Journal: Nat Med
Title: Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins.
Volume: 22
Issue: 6
Pages: 672-8
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Publication
38017104 | J:344860
First Author: Sui P
Year: 2024
Journal: Leukemia
Title: SRSF2 mutation cooperates with ASXL1 truncated alteration to accelerate leukemogenesis.
Volume: 38
Issue: 2
Pages: 408-411
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Publication
35705252 | J:344983
First Author: Thompson PK
Year: 2022
Journal: J Immunol
Title: Realization of the T Lineage Program Involves GATA-3 Induction of Bcl11b and Repression of Cdkn2b Expression.
Volume: 209
Issue: 1
Pages: 77-92
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Publication
23863895 | J:202234
First Author: Hasan S
Year: 2013
Journal: Blood
Title: JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNα.
Volume: 122
Issue: 8
Pages: 1464-77
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Publication
24237791 | J:205523
First Author: Bartalucci N
Year: 2013
Journal: J Cell Mol Med
Title: Co-targeting the PI3K/mTOR and JAK2 signalling pathways produces synergistic activity against myeloproliferative neoplasms.
Volume: 17
Issue: 11
Pages: 1385-96
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Publication
30635286 | J:276224
First Author: Uras IZ
Year: 2019
Journal: Blood
Title: CDK6 coordinates JAK2 V617F mutant MPN via NF-κB and apoptotic networks.
Volume: 133
Issue: 15
Pages: 1677-1690
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Publication
34699595 | J:322740
First Author: You X
Year: 2022
Journal: Blood
Title: Asxl1 loss cooperates with oncogenic Nras in mice to reprogram the immune microenvironment and drive leukemic transformation.
Volume: 139
Issue: 7
Pages: 1066-1079
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Publication
25281607 | J:220795
First Author: Chen E
Year: 2015
Journal: Blood
Title: Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms.
Volume: 125
Issue: 2
Pages: 327-35
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Publication
29983349 | J:272671
 
First Author: Kiers D
Year: 2018
Journal: EBioMedicine
Title: Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation.
Volume: 33
Pages: 144-156
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Publication
35469841 | J:325680
     
First Author: Longé C
Year: 2022
Journal: J Allergy Clin Immunol
Title: Rab44 regulates murine mast cell-driven anaphylaxis through kinesin-1-dependent secretory granule translocation.
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Publication
25873173 | J:220302
First Author: Shih AH
Year: 2015
Journal: Cancer Cell
Title: Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia.
Volume: 27
Issue: 4
Pages: 502-15
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Publication
30274972 | J:268224
First Author: Dominguez PM
Year: 2018
Journal: Cancer Discov
Title: TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis.
Volume: 8
Issue: 12
Pages: 1632-1653
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Publication
26773157 | J:284551
First Author: Chen Y
Year: 2016
Journal: J Immunol
Title: Kras Is Critical for B Cell Lymphopoiesis.
Volume: 196
Issue: 4
Pages: 1678-85
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Publication
24286824 | J:206595
First Author: Ueno M
Year: 2013
Journal: Dev Cell
Title: c-Met-dependent multipotent labyrinth trophoblast progenitors establish placental exchange interface.
Volume: 27
Issue: 4
Pages: 373-86
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Publication
26972179 | J:238116
First Author: Damnernsawad A
Year: 2016
Journal: Stem Cells
Title: Kras is Required for Adult Hematopoiesis.
Volume: 34
Issue: 7
Pages: 1859-71
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Publication
29150563 | J:253410
First Author: Tellechea M
Year: 2018
Journal: J Immunol
Title: NFAT5-Regulated Macrophage Polarization Supports the Proinflammatory Function of Macrophages and T Lymphocytes.
Volume: 200
Issue: 1
Pages: 305-315
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Publication
20610818 | J:165872
First Author: Pajerowski AG
Year: 2010
Journal: Blood
Title: Adult hematopoietic stem cells require NKAP for maintenance and survival.
Volume: 116
Issue: 15
Pages: 2684-93
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Publication
28899870 | J:247049
First Author: Loughran SJ
Year: 2017
Journal: J Exp Med
Title: Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program.
Volume: 214
Issue: 10
Pages: 3085-3104
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Publication
20724987 | J:165595
First Author: Gan T
Year: 2010
Journal: Leukemia
Title: Developmentally induced Mll1 loss reveals defects in postnatal haematopoiesis.
Volume: 24
Issue: 10
Pages: 1732-41
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Publication
34635784 | J:321560
First Author: Zhou C
Year: 2022
Journal: Leukemia
Title: Insufficiency of FZR1 disturbs HSC quiescence by inhibiting ubiquitin-dependent degradation of RUNX1 in aplastic anemia.
Volume: 36
Issue: 3
Pages: 834-846
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Publication
22145044 | J:182271
First Author: Cai X
Year: 2011
Journal: PLoS One
Title: Runx1 loss minimally impacts long-term hematopoietic stem cells.
Volume: 6
Issue: 12
Pages: e28430
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Publication
22162244 | J:190512
First Author: Kassmer SH
Year: 2012
Journal: Stem Cells
Title: Nonhematopoietic cells are the primary source of bone marrow-derived lung epithelial cells.
Volume: 30
Issue: 3
Pages: 491-9
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Publication
31816635 | J:289860
 
First Author: Huerga Encabo H
Year: 2020
Journal: J Exp Med
Title: The transcription factor NFAT5 limits infection-induced type I interferon responses.
Volume: 217
Issue: 3
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Publication
18083846 | J:133470
First Author: Ghiaur G
Year: 2008
Journal: Blood
Title: Rac1 is essential for intraembryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells.
Volume: 111
Issue: 7
Pages: 3313-21
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Publication
14975238 | J:89785
First Author: Croker BA
Year: 2004
Journal: Immunity
Title: SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis.
Volume: 20
Issue: 2
Pages: 153-65
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Publication
37917239 | J:344091
 
First Author: Ge G
Year: 2024
Journal: J Clin Invest
Title: Targeting lysine demethylase 6B ameliorates ASXL1 truncation-mediated myeloid malignancies in preclinical models.
Volume: 134
Issue: 1
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Publication
31455666 | J:282446
First Author: Woo AJ
Year: 2019
Journal: Blood Adv
Title: Zfp281 (ZBP-99) plays a functionally redundant role with Zfp148 (ZBP-89) during erythroid development.
Volume: 3
Issue: 16
Pages: 2499-2511
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Publication
31628323 | J:280695
First Author: Menzl I
Year: 2019
Journal: Nat Commun
Title: A kinase-independent role for CDK8 in BCR-ABL1+ leukemia.
Volume: 10
Issue: 1
Pages: 4741
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Publication
30936419 | J:287809
First Author: Mallaney C
Year: 2019
Journal: Leukemia
Title: Kdm6b regulates context-dependent hematopoietic stem cell self-renewal and leukemogenesis.
Volume: 33
Issue: 10
Pages: 2506-2521
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Publication
20435883 | J:162796
First Author: Hill GR
Year: 2010
Journal: Blood
Title: SOCS3 regulates graft-versus-host disease.
Volume: 116
Issue: 2
Pages: 287-96
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Genotype
Genotype
Symbol: Klf2/Klf2 Tg(VAV1-cre)1Graf/?
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lcp2/Lcp2 Tg(VAV1-cre)1Graf/? Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ncstn/Ncstn Tet2/Tet2 Tg(VAV1-cre)1Graf/?
Background: involves: 129S/SvEv * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Flt3/Flt3<+> Tet2/Tet2 Tg(VAV1-cre)1Graf/?
Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Jmjd1c/Jmjd1c Tg(VAV1-cre)1Graf/?
Background: involves: C57BL/6N
Zygosity: cn
Has Mutant Allele: true
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Publication
20141838 | -
First Author: Yu B
Year: 2010
Journal: Cell
Title: Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1.
Volume: 140
Issue: 2
Pages: 246-56
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Publication
26353933 | -
First Author: Katzav S
Year: 2015
Journal: Oncotarget
Title: Vav1: A Dr. Jekyll and Mr. Hyde protein--good for the hematopoietic system, bad for cancer.
Volume: 6
Issue: 30
Pages: 28731-42
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Publication
10669724 | -
First Author: Bustelo XR
Year: 2000
Journal: Mol Cell Biol
Title: Regulatory and signaling properties of the Vav family.
Volume: 20
Issue: 5
Pages: 1461-77
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Protein Domain
IPR037832 | PH_Vav
Type: Domain
Description: Vav acts as a guanosine nucleotide exchange factor (GEF) for Rho/Rac proteins. They control processes including T cell activation, phagocytosis, and migration of cells. The Vav subgroup of Dbl GEFs consists of three family members (Vav1, Vav2, and Vav3) in mammals []. Vav1 is preferentially expressed in the hematopoietic system, while Vav2 and Vav3 are described by broader expression patterns []. Mammalian Vav proteins consist of a calponin homology (CH) domain, an acidic region, a catalytic Dbl homology (DH) domain, a PH domain, a zinc finger cysteine rich domain (C1/CRD), and an SH2 domain, flanked by two SH3 domains. In invertebrates such as Drosophila and C. elegans, Vav is missing the N-terminal SH3 domain. The DH domain is involved in RhoGTPase recognition and selectivity and stimulates the reorganization of the switch regions for GDP/GTP exchange []. The PH domain is implicated in directing membrane localization, allosteric regulation of guanine nucleotide exchange activity, and as a phospholipid-dependent regulator of GEF activity []. Vavs bind RhoGTPases including Rac1, RhoA, and RhoG, while other members of the GEF family are specific for a single RhoGTPase. This promiscuity is thought to be a result of its CRD [].PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner []. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity[]. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane []. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes [].
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Protein
Q60631-1
 
Organism: Mus musculus/domesticus
Length:  
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Publication
25470037 | J:219495
First Author: Rutz S
Year: 2015
Journal: Nature
Title: Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
Volume: 518
Issue: 7539
Pages: 417-21
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Publication
32634119 | J:290037
     
First Author: Crispin A
Year: 2020
Journal: J Clin Invest
Title: Mutations in the iron-sulfur cluster biogenesis protein HSCB cause congenital sideroblastic anemia.
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Publication
36352193 | J:332752
First Author: Jimbo K
Year: 2023
Journal: Leukemia
Title: Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia.
Volume: 37
Issue: 1
Pages: 122-133
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Publication
18505785 | J:138422
First Author: Guo F
Year: 2008
Journal: Blood
Title: Lack of nuclear factor-kappa B2/p100 causes a RelB-dependent block in early B lymphopoiesis.
Volume: 112
Issue: 3
Pages: 551-9
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Publication
31415243 | J:282057
First Author: Pawlak JB
Year: 2019
Journal: J Clin Invest
Title: Lymphatic mimicry in maternal endothelial cells promotes placental spiral artery remodeling.
Volume: 129
Issue: 11
Pages: 4912-4921
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Publication
26338970 | J:314981
First Author: Wang Z
Year: 2015
Journal: Oncotarget
Title: Stat5-deficient hematopoiesis is permissive for Myc-induced B-cell leukemogenesis.
Volume: 6
Issue: 30
Pages: 28961-72
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Publication
24239285 | J:205522
First Author: Xie H
Year: 2014
Journal: Cell Stem Cell
Title: Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner.
Volume: 14
Issue: 1
Pages: 68-80
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Publication
19129762 | J:145700
First Author: Chen MJ
Year: 2009
Journal: Nature
Title: Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter.
Volume: 457
Issue: 7231
Pages: 887-91
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Publication
25542002 | J:237548
First Author: Song Y
Year: 2014
Journal: PLoS One
Title: ARAP3 functions in hematopoietic stem cells.
Volume: 9
Issue: 12
Pages: e116107
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Publication
32924017 | J:334571
First Author: McCarter AC
Year: 2020
Journal: Blood Cancer Discov
Title: Combinatorial ETS1-dependent control of oncogenic NOTCH1 enhancers in T-cell leukemia.
Volume: 1
Issue: 2
Pages: 178-197
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Publication
21562564 | J:172442
First Author: Klinakis A
Year: 2011
Journal: Nature
Title: A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.
Volume: 473
Issue: 7346
Pages: 230-3
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Publication
23533276 | J:196179
First Author: Tang JZ
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia.
Volume: 110
Issue: 15
Pages: 6091-6
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Publication
30377195 | J:269361
First Author: You X
Year: 2018
Journal: Blood
Title: Unique dependence on Sos1 in Kras G12D -induced leukemogenesis.
Volume: 132
Issue: 24
Pages: 2575-2579
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Publication
31235823 | J:278637
First Author: Singh T
Year: 2019
Journal: Sci Rep
Title: Loss of MafA and MafB expression promotes islet inflammation.
Volume: 9
Issue: 1
Pages: 9074
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Publication
30917956 | J:276439
First Author: Mack EA
Year: 2019
Journal: Blood
Title: Trib1 regulates eosinophil lineage commitment and identity by restraining the neutrophil program.
Volume: 133
Issue: 22
Pages: 2413-2426
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Publication
24218140 | J:208092
First Author: Abdel-Wahab O
Year: 2013
Journal: J Exp Med
Title: Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo.
Volume: 210
Issue: 12
Pages: 2641-59
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Publication
30283071 | J:279150
First Author: Oladipupo SS
Year: 2018
Journal: Sci Rep
Title: Impaired tumor growth and angiogenesis in mice heterozygous for Vegfr2 (Flk1).
Volume: 8
Issue: 1
Pages: 14724
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Publication
37595362 | J:343530
First Author: Miller PG
Year: 2023
Journal: Blood
Title: PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy.
Volume: 142
Issue: 24
Pages: 2079-2091
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Publication
28193779 | J:241017
First Author: Shih AH
Year: 2017
Journal: Cancer Discov
Title: Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2- and TET2-Mutant Acute Myeloid Leukemia.
Volume: 7
Issue: 5
Pages: 494-505
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Publication
23290137 | J:194929
First Author: Yu WM
Year: 2013
Journal: Cell Stem Cell
Title: Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation.
Volume: 12
Issue: 1
Pages: 62-74
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Publication
15576407 | J:127936
First Author: Stadtfeld M
Year: 2005
Journal: Development
Title: Assessing the role of hematopoietic plasticity for endothelial and hepatocyte development by non-invasive lineage tracing.
Volume: 132
Issue: 1
Pages: 203-13
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Publication
30423295 | J:266851
First Author: Celik H
Year: 2018
Journal: Cancer Cell
Title: JARID2 Functions as a Tumor Suppressor in Myeloid Neoplasms by Repressing Self-Renewal in Hematopoietic Progenitor Cells.
Volume: 34
Issue: 5
Pages: 741-756.e8
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Publication
27668798 | J:258583
First Author: King B
Year: 2016
Journal: Nat Immunol
Title: The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells.
Volume: 17
Issue: 11
Pages: 1312-1321
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Publication
27598373 | J:246762
First Author: Oudhoff MJ
Year: 2016
Journal: PLoS Pathog
Title: Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection.
Volume: 12
Issue: 9
Pages: e1005876
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Publication
19570513 | J:151639
First Author: Schindler JW
Year: 2009
Journal: Cell Stem Cell
Title: TEL-AML1 corrupts hematopoietic stem cells to persist in the bone marrow and initiate leukemia.
Volume: 5
Issue: 1
Pages: 43-53
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Publication
36596811 | J:340917
First Author: Villatoro A
Year: 2023
Journal: Nat Commun
Title: Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation.
Volume: 14
Issue: 1
Pages: 12
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Publication
35210475 | J:321689
First Author: Rodriguez Y Baena A
Year: 2022
Journal: Sci Rep
Title: New transgenic mouse models enabling pan-hematopoietic or selective hematopoietic stem cell depletion in vivo.
Volume: 12
Issue: 1
Pages: 3156
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Genotype
Genotype
Symbol: Tg(VAV1-cre)1Graf/? Gt(ROSA)26Sor/? Trip11/Trip11
Background: involves: 129/Sv * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
24072822 | J:202829
First Author: Shan M
Year: 2013
Journal: Science
Title: Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals.
Volume: 342
Issue: 6157
Pages: 447-53
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Publication
20595512 | J:165879
First Author: Satyanarayana A
Year: 2010
Journal: Blood
Title: RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis.
Volume: 116
Issue: 16
Pages: 2921-31
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Publication
33711283 | J:303313
     
First Author: Lv K
Year: 2021
Journal: Cell Stem Cell
Title: HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.
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Publication
32883883 | J:296224
First Author: Hsu J
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation.
Volume: 117
Issue: 38
Pages: 23626-23635
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Publication
28122244 | J:240315
First Author: Mgbemena VE
Year: 2017
Journal: Cell Rep
Title: Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function.
Volume: 18
Issue: 4
Pages: 947-960
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Publication
23237953 | J:191046
First Author: Stan RV
Year: 2012
Journal: Dev Cell
Title: The diaphragms of fenestrated endothelia: gatekeepers of vascular permeability and blood composition.
Volume: 23
Issue: 6
Pages: 1203-18
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Publication
29244050 | J:274081
First Author: Rashidi M
Year: 2018
Journal: Cell Death Differ
Title: CD52 inhibits Toll-like receptor activation of NF-κB and triggers apoptosis to suppress inflammation.
Volume: 25
Issue: 2
Pages: 392-405
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Publication
29470558 | J:277542
First Author: Burrows K
Year: 2018
Journal: PLoS Pathog
Title: HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasis.
Volume: 14
Issue: 2
Pages: e1006869
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Publication
27082941 | J:332230
First Author: Rauner M
Year: 2016
Journal: J Bone Miner Res
Title: Increased EPO Levels Are Associated With Bone Loss in Mice Lacking PHD2 in EPO-Producing Cells.
Volume: 31
Issue: 10
Pages: 1877-1887
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Publication
23359070 | J:196407
First Author: Lobry C
Year: 2013
Journal: J Exp Med
Title: Notch pathway activation targets AML-initiating cell homeostasis and differentiation.
Volume: 210
Issue: 2
Pages: 301-19
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Publication
17141159 | J:127228
First Author: Lee JS
Year: 2006
Journal: Dev Cell
Title: Klf2 is an essential regulator of vascular hemodynamic forces in vivo.
Volume: 11
Issue: 6
Pages: 845-57
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Publication
37335136 | J:339597
First Author: Dressel N
Year: 2023
Journal: Cancer Res
Title: Activation of the cGAS/STING Axis in Genome-Damaged Hematopoietic Cells Does Not Impact Blood Cell Formation or Leukemogenesis.
Volume: 83
Issue: 17
Pages: 2858-2872
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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